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The map label for this gene is lspA [H]

Identifier: 117676259

GI number: 117676259

Start: 209919

End: 210998

Strand: Reverse

Name: lspA [H]

Synonym: Shewana3_4320

Alternate gene names: 117676259

Gene position: 210998-209919 (Counterclockwise)

Preceding gene: 117676261

Following gene: 117676258

Centisome position: 75.64

GC content: 59.35

Gene sequence:

>1080_bases
ATGAGCTGGAAATTCTTTCTCTACGACTGGGGTGGTCTGAACATCGCGTTGTTCCAAGCCATCAACATGAGCACACCTGC
AGCGCTGGAACCGCTGGCATCGTTCTTCAACCTTGTGATAGGCAACTACTGGACTGCACCACTGATGCTCTTGGCGATGT
GGGGATGGTCAAAGTCGGCACCTGACCCAACGCGGGCCGATGCCATCCGGTACAGACTCAGAGTCTTTAGCGTGGCCTTT
GCGTTGGCATTTCTCGTCGCCACCATCTTGAAGCTATGGATCGACTTTCCACGCCCGCCTGCCGTTTTTGGCGACATGGT
GCGCGTTATCGGGGGCATCGAACGACACTACAGCCTGCCCAGCGGGCATGCCACCTATGCCGCGCTGGTGGTCGGCGCGC
TCTGGCCTTTGATAGGCCGTCGTGGCCGCATCGGCTTGGTGTTGTACGCCGCATTGGTCGGTTGGTCACGCATCGCAGCC
GGAATGCACTTTCCTGCCGATGTGCTGGCGGGGTGGGTACTTGGATTGAGTTGCACGGCGCTCGCCGGGTGGCTGATGCC
GCTGGCCGCCCCTGTGTGGCAATCGGCTCGCCGCACATCGACTTGGGTCTGGTTCGCAGTGGCCGCCAGTGCTGTCATGA
CCGATCAGCTCGCAAAGTTCGCCATCACCCGCACGTTTGCCTACGGTGAACAGGTCGAAGTCACGCCCTTCTTCAACTTC
GTCCATGTCCTGAATCCCGGCGCGGCATTCAGCTTTCTGGCGAACGCTGGCGGCTGGCAACGTTACTTTTTCATCACGCT
GGGCCTGGTCGTTTCTGCTTGGCTGGGACGCATGCTGTGCCAGCAATTGCCCCGTCTCGAAGCGATGGGATACAGCCTGA
TCCTCGGCGGTGCGCTGGGCAATGTCGCGGATCGTGTGCTGCGTGGACAGGTTGTTGATTTCCTTGACTTCCATTGGCGA
CTTGCGCACTGGCCCGCCTTCAACCTCGCTGATGTGGCGATAACTATCGGAGCGCTCTGCCTGTTCTTGACGGTTGTACC
GAAAAGCAGTAAAGGCACAGAGGCCGAGGTGTCCGGTTAA

Upstream 100 bases:

>100_bases
TGCTGACCTTCACGGGTCAAGCGACCATGTGGATGGCGGTGTTTGCTGATATGGGGGCCAGCTTGCTCGTCGTTGGCAAT
GGCTTGAGGCTGTTGCGCAA

Downstream 100 bases:

>100_bases
GCTATACCCTAACCTGATGTCAGATGCCATGTGTAAATTGCGTCAGGATAGGATTGAATTTTGAATTTATTGACATATCT
CGTTGAAGGTCATAGAGTCT

Product: signal peptidase II

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSWKFFLYDWGGLNIALFQAINMSTPAALEPLASFFNLVIGNYWTAPLMLLAMWGWSKSAPDPTRADAIRYRLRVFSVAF
ALAFLVATILKLWIDFPRPPAVFGDMVRVIGGIERHYSLPSGHATYAALVVGALWPLIGRRGRIGLVLYAALVGWSRIAA
GMHFPADVLAGWVLGLSCTALAGWLMPLAAPVWQSARRTSTWVWFAVAASAVMTDQLAKFAITRTFAYGEQVEVTPFFNF
VHVLNPGAAFSFLANAGGWQRYFFITLGLVVSAWLGRMLCQQLPRLEAMGYSLILGGALGNVADRVLRGQVVDFLDFHWR
LAHWPAFNLADVAITIGALCLFLTVVPKSSKGTEAEVSG

Sequences:

>Translated_359_residues
MSWKFFLYDWGGLNIALFQAINMSTPAALEPLASFFNLVIGNYWTAPLMLLAMWGWSKSAPDPTRADAIRYRLRVFSVAF
ALAFLVATILKLWIDFPRPPAVFGDMVRVIGGIERHYSLPSGHATYAALVVGALWPLIGRRGRIGLVLYAALVGWSRIAA
GMHFPADVLAGWVLGLSCTALAGWLMPLAAPVWQSARRTSTWVWFAVAASAVMTDQLAKFAITRTFAYGEQVEVTPFFNF
VHVLNPGAAFSFLANAGGWQRYFFITLGLVVSAWLGRMLCQQLPRLEAMGYSLILGGALGNVADRVLRGQVVDFLDFHWR
LAHWPAFNLADVAITIGALCLFLTVVPKSSKGTEAEVSG
>Mature_358_residues
SWKFFLYDWGGLNIALFQAINMSTPAALEPLASFFNLVIGNYWTAPLMLLAMWGWSKSAPDPTRADAIRYRLRVFSVAFA
LAFLVATILKLWIDFPRPPAVFGDMVRVIGGIERHYSLPSGHATYAALVVGALWPLIGRRGRIGLVLYAALVGWSRIAAG
MHFPADVLAGWVLGLSCTALAGWLMPLAAPVWQSARRTSTWVWFAVAASAVMTDQLAKFAITRTFAYGEQVEVTPFFNFV
HVLNPGAAFSFLANAGGWQRYFFITLGLVVSAWLGRMLCQQLPRLEAMGYSLILGGALGNVADRVLRGQVVDFLDFHWRL
AHWPAFNLADVAITIGALCLFLTVVPKSSKGTEAEVSG

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins [H]

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family [H]

Homologues:

Organism=Escherichia coli, GI1786210, Length=153, Percent_Identity=40.5228758169935, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001872 [H]

Pfam domain/function: PF01252 Peptidase_A8 [H]

EC number: =3.4.23.36 [H]

Molecular weight: Translated: 39394; Mature: 39262

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSWKFFLYDWGGLNIALFQAINMSTPAALEPLASFFNLVIGNYWTAPLMLLAMWGWSKSA
CCEEEEEEECCCCCEEEHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
PDPTRADAIRYRLRVFSVAFALAFLVATILKLWIDFPRPPAVFGDMVRVIGGIERHYSLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
SGHATYAALVVGALWPLIGRRGRIGLVLYAALVGWSRIAAGMHFPADVLAGWVLGLSCTA
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LAGWLMPLAAPVWQSARRTSTWVWFAVAASAVMTDQLAKFAITRTFAYGEQVEVTPFFNF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHH
VHVLNPGAAFSFLANAGGWQRYFFITLGLVVSAWLGRMLCQQLPRLEAMGYSLILGGALG
HHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHEECHHHH
NVADRVLRGQVVDFLDFHWRLAHWPAFNLADVAITIGALCLFLTVVPKSSKGTEAEVSG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
SWKFFLYDWGGLNIALFQAINMSTPAALEPLASFFNLVIGNYWTAPLMLLAMWGWSKSA
CEEEEEEECCCCCEEEHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
PDPTRADAIRYRLRVFSVAFALAFLVATILKLWIDFPRPPAVFGDMVRVIGGIERHYSLP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCC
SGHATYAALVVGALWPLIGRRGRIGLVLYAALVGWSRIAAGMHFPADVLAGWVLGLSCTA
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LAGWLMPLAAPVWQSARRTSTWVWFAVAASAVMTDQLAKFAITRTFAYGEQVEVTPFFNF
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHH
VHVLNPGAAFSFLANAGGWQRYFFITLGLVVSAWLGRMLCQQLPRLEAMGYSLILGGALG
HHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHEECHHHH
NVADRVLRGQVVDFLDFHWRLAHWPAFNLADVAITIGALCLFLTVVPKSSKGTEAEVSG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA