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The map label for this gene is hepT [H]

Identifier: 116874007

GI number: 116874007

Start: 2619844

End: 2620824

Strand: Direct

Name: hepT [H]

Synonym: lwe2591

Alternate gene names: 116874007

Gene position: 2619844-2620824 (Clockwise)

Preceding gene: 116874006

Following gene: 116874008

Centisome position: 93.1

GC content: 36.29

Gene sequence:

>981_bases
ATGCAACTTCATGCTATGTGGGATGATTATCCTGCACTTTCTAAAGATTTACAAGAAGTCTTACAAACAATTGAAAAAAA
CATTCAAATTCGAGATAAACACGTAGAAAAGAACGTGAAAGATTTGATTCACGCTGGTGGAAAACTGCTGCGCCCTGCTT
TTGCACTTCTTTCTGCTCAAGCTGGCCCTGAGTTTGATAAAGAACGCGCGGTTTCTATCGCAGCTGCTCTTGAAGTGCTC
CATATGGCGACCTTAATCCACGATGATGTTGTTGATGATTCCCCATTACGCCGCGGTATCCCAACGATTCATTCTAAATA
CGGACGTAATTATGCGGTTTATACAGGAGATTATTTATTCTGTATTTGTTTCAAAATACTATCCGCGCATGCTTCTTCCG
TTGAAAATATCGAATTTAACAGTAAAAATATCGAAAAGATTTTAATGGGTGAATTGGATCAAATGCGCACAAGTTATAAA
ATGAATGTAACCGTCCGTGAATATTTAACACGTATTTCTGGTAAAACTGCCCAACTGTTTGCGCTTAGTTGTTATTCTGG
AGCAACTGGTAGTAAAGCATCACGTATGACTGTAGCAAAATGTTATAATATTGGTCATTATCTTGGCATGGCTTTTCAAA
TTATTGATGATGTACTTGATTATACAAGTACAGATGCAGGGTTAGGAAAACCAGTTTTAAATGATATGAAACAAGGAATT
TATTCACTACCACTTATTTATGCAATGAAAGGACACTTGGCTGAATTTGAGCCACTTCTTTCTCAAAAATTAGATATGAC
TGACGATGCTTCTGAACAGGTTTTAGCACTTATTTCTAAATATAATGGTGTCGAACAGGCATTCAAACTTGCAAATAAAT
ATACGAATAAAGCTCTTCGTGAAATCAAAAAATTACCAGCTGGCGTATATCGTGATGATATGTACCGCTTGACGAAAAGT
ATTTTAGATAGAGAAATCTAA

Upstream 100 bases:

>100_bases
GGCAAACTACTTGCTTAAAAATGTCCAAACTTTGCGGATGTTCGCTGATGCTAAACAAAGTCAAGCAGCACAAAAATAAC
TTTAAAAAAAGGAGTTCAAT

Downstream 100 bases:

>100_bases
GCCGTTTAGAACAATGCTCCTTACTTCTTGAGTTTTGTTCTAAATTTCCCACTCATTTGTGAAAATACAAACATGAAAGC
GTGATTAAACGTGATTCAAT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MQLHAMWDDYPALSKDLQEVLQTIEKNIQIRDKHVEKNVKDLIHAGGKLLRPAFALLSAQAGPEFDKERAVSIAAALEVL
HMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLFCICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYK
MNVTVREYLTRISGKTAQLFALSCYSGATGSKASRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDAGLGKPVLNDMKQGI
YSLPLIYAMKGHLAEFEPLLSQKLDMTDDASEQVLALISKYNGVEQAFKLANKYTNKALREIKKLPAGVYRDDMYRLTKS
ILDREI

Sequences:

>Translated_326_residues
MQLHAMWDDYPALSKDLQEVLQTIEKNIQIRDKHVEKNVKDLIHAGGKLLRPAFALLSAQAGPEFDKERAVSIAAALEVL
HMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLFCICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYK
MNVTVREYLTRISGKTAQLFALSCYSGATGSKASRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDAGLGKPVLNDMKQGI
YSLPLIYAMKGHLAEFEPLLSQKLDMTDDASEQVLALISKYNGVEQAFKLANKYTNKALREIKKLPAGVYRDDMYRLTKS
ILDREI
>Mature_326_residues
MQLHAMWDDYPALSKDLQEVLQTIEKNIQIRDKHVEKNVKDLIHAGGKLLRPAFALLSAQAGPEFDKERAVSIAAALEVL
HMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLFCICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYK
MNVTVREYLTRISGKTAQLFALSCYSGATGSKASRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDAGLGKPVLNDMKQGI
YSLPLIYAMKGHLAEFEPLLSQKLDMTDDASEQVLALISKYNGVEQAFKLANKYTNKALREIKKLPAGVYRDDMYRLTKS
ILDREI

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=317, Percent_Identity=29.6529968454259, Blast_Score=138, Evalue=6e-33,
Organism=Escherichia coli, GI1789578, Length=288, Percent_Identity=31.25, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17505681, Length=309, Percent_Identity=29.7734627831715, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319475, Length=320, Percent_Identity=29.6875, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24651612, Length=287, Percent_Identity=28.5714285714286, Blast_Score=129, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36646; Mature: 36646

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLHAMWDDYPALSKDLQEVLQTIEKNIQIRDKHVEKNVKDLIHAGGKLLRPAFALLSAQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AGPEFDKERAVSIAAALEVLHMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEECHHHH
CICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYKMNVTVREYLTRISGKTAQLF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHE
ALSCYSGATGSKASRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDAGLGKPVLNDMKQGI
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
YSLPLIYAMKGHLAEFEPLLSQKLDMTDDASEQVLALISKYNGVEQAFKLANKYTNKALR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EIKKLPAGVYRDDMYRLTKSILDREI
HHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQLHAMWDDYPALSKDLQEVLQTIEKNIQIRDKHVEKNVKDLIHAGGKLLRPAFALLSAQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHC
AGPEFDKERAVSIAAALEVLHMATLIHDDVVDDSPLRRGIPTIHSKYGRNYAVYTGDYLF
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEECHHHH
CICFKILSAHASSVENIEFNSKNIEKILMGELDQMRTSYKMNVTVREYLTRISGKTAQLF
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHE
ALSCYSGATGSKASRMTVAKCYNIGHYLGMAFQIIDDVLDYTSTDAGLGKPVLNDMKQGI
EEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
YSLPLIYAMKGHLAEFEPLLSQKLDMTDDASEQVLALISKYNGVEQAFKLANKYTNKALR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EIKKLPAGVYRDDMYRLTKSILDREI
HHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]