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The map label for this gene is clpP [H]

Identifier: 116873833

GI number: 116873833

Start: 2453649

End: 2454245

Strand: Direct

Name: clpP [H]

Synonym: lwe2417

Alternate gene names: 116873833

Gene position: 2453649-2454245 (Clockwise)

Preceding gene: 116873831

Following gene: 116873880

Centisome position: 87.19

GC content: 37.19

Gene sequence:

>597_bases
ATGAACTTAATTCCAACAGTAATTGAACAAACAAGCCGTGGTGAACGCGCATATGACATTTATTCACGTTTATTAAAAGA
CAGAATTATTATGTTAGGCTCTGCAATTGATGATAACGTTGCTAACTCTATCGTTTCTCAATTATTATTCCTTGATGCAC
AAGATCCTGAAAAAGATATTTTCTTATATATCAATTCTCCAGGAGGAAGTATTTCAGCTGGTATGGCGATTTATGATACA
ATGAATTTCGTTAAAGCAGATGTGCAAACTATTGGTATGGGGATGGCTGCTTCCATGGGATCATTCTTACTAACAGCCGG
TGCAAACGGTAAACGCTTTGCCTTACCAAATGCGGAAATCATGATTCACCAACCACTTGGTGGCGCTCAAGGTCAAGCAA
CTGAAATCGAAATTGCTGCTCGTCACATTTTGAAAATCAAAGAACGTATGAATACTATTATGTCTGAAAAAACTGGTCAA
CCATATGAAGTTATTGCTCGTGATACAGATCGTGATAATTTCATGACTGCTCAAGAAGCAAAAGATTACGGCTTAATTGA
TGATATCATCGTAAACAAAGCTGGCTTAAAGGGCTAA

Upstream 100 bases:

>100_bases
GTTTATGCTTCAAACTTTATCATTTGACCTAATTTGACCATTCGTGTATGATATAAACAAAGCTAATTCAAAATTTACAT
TTAACAGGAGGAATCTTGAT

Downstream 100 bases:

>100_bases
TAACTATAAAAAGTGGGTTTGCAATTGCAAACCCACTTTTTTGTTGCCTTATTTTAAACGTAGCTCAGAATGTCTTCGTC
CATAAAATACATAAACAATA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDT
MNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMSEKTGQ
PYEVIARDTDRDNFMTAQEAKDYGLIDDIIVNKAGLKG

Sequences:

>Translated_198_residues
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDT
MNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMSEKTGQ
PYEVIARDTDRDNFMTAQEAKDYGLIDDIIVNKAGLKG
>Mature_198_residues
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDIFLYINSPGGSISAGMAIYDT
MNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEIMIHQPLGGAQGQATEIEIAARHILKIKERMNTIMSEKTGQ
PYEVIARDTDRDNFMTAQEAKDYGLIDDIIVNKAGLKG

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=51.0416666666667, Blast_Score=215, Evalue=2e-56,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=66.3212435233161, Blast_Score=278, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=52.1505376344086, Blast_Score=208, Evalue=1e-54,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=55.7894736842105, Blast_Score=223, Evalue=7e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21605; Mature: 21605

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDI
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSISAGMAIYDTMNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEI
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCEEEEECCCCCEEECCCCEE
MIHQPLGGAQGQATEIEIAARHILKIKERMNTIMSEKTGQPYEVIARDTDRDNFMTAQEA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHH
KDYGLIDDIIVNKAGLKG
CCCCCHHHHHHCCCCCCC
>Mature Secondary Structure
MNLIPTVIEQTSRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLDAQDPEKDI
CCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSISAGMAIYDTMNFVKADVQTIGMGMAASMGSFLLTAGANGKRFALPNAEI
EEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCEEEEECCCCCEEECCCCEE
MIHQPLGGAQGQATEIEIAARHILKIKERMNTIMSEKTGQPYEVIARDTDRDNFMTAQEA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEHHHH
KDYGLIDDIIVNKAGLKG
CCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]