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The map label for this gene is aroE [H]

Identifier: 116873669

GI number: 116873669

Start: 2293231

End: 2294100

Strand: Direct

Name: aroE [H]

Synonym: lwe2253

Alternate gene names: 116873669

Gene position: 2293231-2294100 (Clockwise)

Preceding gene: 116873668

Following gene: 116873670

Centisome position: 81.49

GC content: 37.01

Gene sequence:

>870_bases
GTGGAAAAAAGAATTTCCGGCTCAACCCGACTTTTAAGTTTAATCGGAACACCCATAGACCATTCAAAATCTCCCATTAT
GTACAATTACAGTTTTGAAAAAGCTGGTTTAGATTATGCTTATCTTGCATTTGATATTCCAGTGAACAAAGTCGCTGATG
CAATTACTGCAATAAAGACTTTTAATCTACGTGGTTCTAACGTAACCATGCCTTGTAAAAGTGAAGTTTTAAAATACATG
GATGACCTTTCCCCTGCCGCTCGAATGATTGGCGCTGTTAACACTATCGTAAATGAAAACGGGAAACTAACTGGGCATAT
AACTGATGGCCTTGGTTTTGTAACAAATTTACGTGATTCTAGTGTAGATGTTTCCGGCAAAAAAATGACTATTATTGGGG
CTGGTGGCGCAGCAACAGCTATCCAAGTCCAGTGTGCACTAGATGGGGTCAAGGAAATCGCCATTTTTAATATTCAAGAT
GATTTTTATGAAAAAGCAAAACAAACTGTCGCTTCGATTAAAGAAGAAGTTCCTGAATGTAGTGTACATATTTATGACTT
AAGTGACACAAAAAAATTATATGCAGAAATTGCAACGAGTGATATTTTAGTGAACGCAACACTAGTTGGTATGCATCCGC
ATGAAAATGAAACACCTGTCAAAGATACAACTGTTTTTAGAAAGGACCTAATCGTTGCCGACATTATTTACACACCAAAG
AAAACCAGGCTTTTATTAGATGCAGAAGCGGCAGGTGCTAAGACTGTTGGTGGATTAGGAATGCTTTTATGGCAAGGAGC
CGAAGCATATAAGTTGTTTACTGGTAAAGATATGCCAGTTGCAGAAATAAAAGAACTATATTTTAATTAA

Upstream 100 bases:

>100_bases
CGCAACAAAAGAAGCATTAGACGCTGTATTGCAATTATAATTCGTGGCTATACTCGCTGTTTCGGCAGCGGGTATAAACC
CACTTGGAGGTAAGTGAAAC

Downstream 100 bases:

>100_bases
TAAATTCATCAGGATTTTGAGAGGAGAAAAAAATGAACGCAAAAAGATTTTATCCAACAGCAATAGCACTTTATTTTACT
TATTTTATTCATGGTATTGG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MEKRISGSTRLLSLIGTPIDHSKSPIMYNYSFEKAGLDYAYLAFDIPVNKVADAITAIKTFNLRGSNVTMPCKSEVLKYM
DDLSPAARMIGAVNTIVNENGKLTGHITDGLGFVTNLRDSSVDVSGKKMTIIGAGGAATAIQVQCALDGVKEIAIFNIQD
DFYEKAKQTVASIKEEVPECSVHIYDLSDTKKLYAEIATSDILVNATLVGMHPHENETPVKDTTVFRKDLIVADIIYTPK
KTRLLLDAEAAGAKTVGGLGMLLWQGAEAYKLFTGKDMPVAEIKELYFN

Sequences:

>Translated_289_residues
MEKRISGSTRLLSLIGTPIDHSKSPIMYNYSFEKAGLDYAYLAFDIPVNKVADAITAIKTFNLRGSNVTMPCKSEVLKYM
DDLSPAARMIGAVNTIVNENGKLTGHITDGLGFVTNLRDSSVDVSGKKMTIIGAGGAATAIQVQCALDGVKEIAIFNIQD
DFYEKAKQTVASIKEEVPECSVHIYDLSDTKKLYAEIATSDILVNATLVGMHPHENETPVKDTTVFRKDLIVADIIYTPK
KTRLLLDAEAAGAKTVGGLGMLLWQGAEAYKLFTGKDMPVAEIKELYFN
>Mature_289_residues
MEKRISGSTRLLSLIGTPIDHSKSPIMYNYSFEKAGLDYAYLAFDIPVNKVADAITAIKTFNLRGSNVTMPCKSEVLKYM
DDLSPAARMIGAVNTIVNENGKLTGHITDGLGFVTNLRDSSVDVSGKKMTIIGAGGAATAIQVQCALDGVKEIAIFNIQD
DFYEKAKQTVASIKEEVPECSVHIYDLSDTKKLYAEIATSDILVNATLVGMHPHENETPVKDTTVFRKDLIVADIIYTPK
KTRLLLDAEAAGAKTVGGLGMLLWQGAEAYKLFTGKDMPVAEIKELYFN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=43.2624113475177, Blast_Score=260, Evalue=8e-71,
Organism=Escherichia coli, GI1789675, Length=266, Percent_Identity=29.3233082706767, Blast_Score=106, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320332, Length=149, Percent_Identity=35.5704697986577, Blast_Score=84, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31451; Mature: 31451

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRISGSTRLLSLIGTPIDHSKSPIMYNYSFEKAGLDYAYLAFDIPVNKVADAITAIKT
CCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCEEEEEEECCHHHHHHHHHHHHE
FNLRGSNVTMPCKSEVLKYMDDLSPAARMIGAVNTIVNENGKLTGHITDGLGFVTNLRDS
EECCCCCEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCCCC
SVDVSGKKMTIIGAGGAATAIQVQCALDGVKEIAIFNIQDDFYEKAKQTVASIKEEVPEC
CCCCCCCEEEEEECCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCC
SVHIYDLSDTKKLYAEIATSDILVNATLVGMHPHENETPVKDTTVFRKDLIVADIIYTPK
EEEEEECCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHEEEEEEECCC
KTRLLLDAEAAGAKTVGGLGMLLWQGAEAYKLFTGKDMPVAEIKELYFN
CCEEEEECCCCCCCHHCCHHHEEECCCCEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure
MEKRISGSTRLLSLIGTPIDHSKSPIMYNYSFEKAGLDYAYLAFDIPVNKVADAITAIKT
CCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEHHHCCCCEEEEEEECCHHHHHHHHHHHHE
FNLRGSNVTMPCKSEVLKYMDDLSPAARMIGAVNTIVNENGKLTGHITDGLGFVTNLRDS
EECCCCCEECCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCCCC
SVDVSGKKMTIIGAGGAATAIQVQCALDGVKEIAIFNIQDDFYEKAKQTVASIKEEVPEC
CCCCCCCEEEEEECCCCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCC
SVHIYDLSDTKKLYAEIATSDILVNATLVGMHPHENETPVKDTTVFRKDLIVADIIYTPK
EEEEEECCCHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHEEEEEEECCC
KTRLLLDAEAAGAKTVGGLGMLLWQGAEAYKLFTGKDMPVAEIKELYFN
CCEEEEECCCCCCCHHCCHHHEEECCCCEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]