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The map label for this gene is argH [H]

Identifier: 116873528

GI number: 116873528

Start: 2143794

End: 2145164

Strand: Direct

Name: argH [H]

Synonym: lwe2112

Alternate gene names: 116873528

Gene position: 2143794-2145164 (Clockwise)

Preceding gene: 116873527

Following gene: 116873529

Centisome position: 76.18

GC content: 37.2

Gene sequence:

>1371_bases
ATGGAAAAATTATGGGGTGGCCGTTTTCAAGGAAAAAGTGAAGCGTGGATTGATGACTTTGGCGCTTCAATTTCTTTCGA
TCAAAAAATGGCAAAAGAAGATTTGACGGGAAGTTTGGCGCATGTCGCAATGCTTGGCAAATGTGGTATTATTTCTGATG
CTGAGGCAGCTGAAATTACGGCTGGTTTAAAAATTATGCAAGAAAAATTAGCGCTTGGTGAACTTGAATTCAGTACCGCA
AACGAAGATATTCATTTAAATATTGAAACATTGTTATACACGGAAATTGGTCCTATCGCTGGGAAACTTCATACAGCACG
TAGTCGAAATGACCAAGTTGCGACAGATATGCATTTATATTTAAAACAAGCCGTTGCAGATATTATCCACTCGTTAAAAC
ATTTACGGGAGGTACTTGTGCAAAAAGCCGGATTCCATGTTGAAACAATTATGCCAGGCTATACACACTTACAACACGCC
CAACCTATATCTTTTGCTCATCATTTGCTTGCTTATTTTGGGATGTTTACAAGAGATTTAGAGCGTTTAGAAGAGAGTGT
CAAGCGGATTGATATTTCCCCTCTCGGTTCTGCCGCGCTAGCTGGGACGACTTTTCCAATTGACCGGGCTTATAGTGCAG
AACTACTTGGCTTTTCTGCTATTTATGAAAATAGTTTGGATGGCGTGAGTGATCGTGATTTTATTATTGAATTTCTTAGT
AATAGTTCAATTTTAATGATGCATTTATCGCGTTTTTGTGAAGAACTGATACTTTGGACAAGTCATGAATTTCAATTTGT
TGAGTTAACGGATGCTTTTTCAACGGGTAGTTCGATTATGCCGCAAAAGAAAAATCCAGATATGGCTGAATTAATCCGCG
GGAAAACAGGCCGAGTGTATGGAAATCTTTTCGGTATGTTAACGGTTTTGAAAGGGTTACCGCTAGCTTATAATAAAGAC
TTGCAAGAAGATAAAGAAGGTATGTTTGATACGGTTGAGACGGTTCAAACAAGCTTAGATATATTTGCGGGAATGATTGA
AACGATGAAGGTCAATGAGGAAATTATGGAAGAATCTACTCAAAAAGATTTTTCGAATGCTACAGAATTAGCGGATTATT
TAGCGAAAAAAGGGGTTCCTTTTAGAGAAGCGCATGAAATTGTTGGTAAATTAGTACTTGAATGTACGCAAAATGGAATT
TATTTGCAAGATGTTCCTTTTAGTCGTTATCAAGAAATAAATCCGCTTATTGAAAAGGATATTTACGATGTTCTTTCTTC
TAAAACAGCTGTTCAGAAGAGAAATTCATATGGTGGAACAGGTTTTGACCAAATTAAAGTGGCACTCGCTAATGCGAAAA
AATCATTATAA

Upstream 100 bases:

>100_bases
TCAAGATGCAGCAGTTGGTTTCATCAAGCTTTGGGGTTTACCAACTAAAGTAAGCGCAGAAGTCAATTCAAAAGTTACAA
TAACAACCGAGGTGTAAAAA

Downstream 100 bases:

>100_bases
TACGAGCTGGAGCGCTTATGAGTGTTCCAGTTTTTATTTTTTCCGAGGGATCAACACGGATTGTCAAACCACTGTTTTTT
TTGTTAATATAAAAAAGATG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLTGSLAHVAMLGKCGIISDAEAAEITAGLKIMQEKLALGELEFSTA
NEDIHLNIETLLYTEIGPIAGKLHTARSRNDQVATDMHLYLKQAVADIIHSLKHLREVLVQKAGFHVETIMPGYTHLQHA
QPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKD
LQEDKEGMFDTVETVQTSLDIFAGMIETMKVNEEIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGI
YLQDVPFSRYQEINPLIEKDIYDVLSSKTAVQKRNSYGGTGFDQIKVALANAKKSL

Sequences:

>Translated_456_residues
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLTGSLAHVAMLGKCGIISDAEAAEITAGLKIMQEKLALGELEFSTA
NEDIHLNIETLLYTEIGPIAGKLHTARSRNDQVATDMHLYLKQAVADIIHSLKHLREVLVQKAGFHVETIMPGYTHLQHA
QPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKD
LQEDKEGMFDTVETVQTSLDIFAGMIETMKVNEEIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGI
YLQDVPFSRYQEINPLIEKDIYDVLSSKTAVQKRNSYGGTGFDQIKVALANAKKSL
>Mature_456_residues
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLTGSLAHVAMLGKCGIISDAEAAEITAGLKIMQEKLALGELEFSTA
NEDIHLNIETLLYTEIGPIAGKLHTARSRNDQVATDMHLYLKQAVADIIHSLKHLREVLVQKAGFHVETIMPGYTHLQHA
QPISFAHHLLAYFGMFTRDLERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFGMLTVLKGLPLAYNKD
LQEDKEGMFDTVETVQTSLDIFAGMIETMKVNEEIMEESTQKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGI
YLQDVPFSRYQEINPLIEKDIYDVLSSKTAVQKRNSYGGTGFDQIKVALANAKKSL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=443, Percent_Identity=44.4695259593679, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI68303542, Length=443, Percent_Identity=44.4695259593679, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI68303549, Length=438, Percent_Identity=42.0091324200913, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI68303547, Length=443, Percent_Identity=41.5349887133183, Blast_Score=345, Evalue=4e-95,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=46.4757709251101, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321806, Length=458, Percent_Identity=44.5414847161572, Blast_Score=389, Evalue=1e-109,
Organism=Drosophila melanogaster, GI221473854, Length=454, Percent_Identity=40.7488986784141, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78706858, Length=454, Percent_Identity=40.7488986784141, Blast_Score=361, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50874; Mature: 50874

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLTGSLAHVAMLGKCGIISDAEAAEIT
CCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AGLKIMQEKLALGELEFSTANEDIHLNIETLLYTEIGPIAGKLHTARSRNDQVATDMHLY
HHHHHHHHHHHHCCCEECCCCCCEEEEEHHHEEHHHCHHHHHHHHHCCCCCCHHHHHHHH
LKQAVADIIHSLKHLREVLVQKAGFHVETIMPGYTHLQHAQPISFAHHLLAYFGMFTRDL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
ERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
HHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFGMLTVLKGLPLAYNKDLQEDKEGMFDTVETVQTSLDIFAGMIETMKVNEEIMEEST
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGIYLQDVPFSRYQEINPLIEKD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
IYDVLSSKTAVQKRNSYGGTGFDQIKVALANAKKSL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEKLWGGRFQGKSEAWIDDFGASISFDQKMAKEDLTGSLAHVAMLGKCGIISDAEAAEIT
CCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
AGLKIMQEKLALGELEFSTANEDIHLNIETLLYTEIGPIAGKLHTARSRNDQVATDMHLY
HHHHHHHHHHHHCCCEECCCCCCEEEEEHHHEEHHHCHHHHHHHHHCCCCCCHHHHHHHH
LKQAVADIIHSLKHLREVLVQKAGFHVETIMPGYTHLQHAQPISFAHHLLAYFGMFTRDL
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHH
ERLEESVKRIDISPLGSAALAGTTFPIDRAYSAELLGFSAIYENSLDGVSDRDFIIEFLS
HHHHHHHHHCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHC
NSSILMMHLSRFCEELILWTSHEFQFVELTDAFSTGSSIMPQKKNPDMAELIRGKTGRVY
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHH
GNLFGMLTVLKGLPLAYNKDLQEDKEGMFDTVETVQTSLDIFAGMIETMKVNEEIMEEST
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKDFSNATELADYLAKKGVPFREAHEIVGKLVLECTQNGIYLQDVPFSRYQEINPLIEKD
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHH
IYDVLSSKTAVQKRNSYGGTGFDQIKVALANAKKSL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]