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The map label for this gene is 116873495

Identifier: 116873495

GI number: 116873495

Start: 2113430

End: 2114173

Strand: Direct

Name: 116873495

Synonym: lwe2079

Alternate gene names: NA

Gene position: 2113430-2114173 (Clockwise)

Preceding gene: 116873494

Following gene: 116873499

Centisome position: 75.1

GC content: 33.74

Gene sequence:

>744_bases
TTGGATAAAACAAAGAGAAGAATGATTTATGAGACTTTTATGCTTATTCTCATATTACTTTCCCTTGCGTTATTACCATA
CAGAAATAACTTTACATTTATATTAAATTGGATTATTTGGGTGATTTTTACACTTGATTATCTTGTTCGATTTCATAGAG
CTGATAATAAATGGCATTACGTTAAAACCCATCCGTTTCAGCTGATTGCGATTATTCCATTTTACGGTGGTTTTAGAGCG
GCTCGGATTGTTAGTTTTGTCCATCTTTTAAGCATTACAGCGATGGGAAGACGTTATATTGTTCCAATTTATAGTTTTTT
CCGTTCAAATGGATTAAATCGCTTTTTAATGATTTTTGTCTTACTTGTAATTATTATTCCAGTTCCAATGGTATTTATCG
AGCCTGAAATAAACAACTATCCCGATGCTCTTTGGTGGGCAATTGTAACTGCCACTACGGTTGGGTATGGTGATATTGTC
CCTGTAACACCAATTGGACGAATCTTGGCTTCCATCATGATGCTCTTCGGGATAGCCTTTATCGGGATGATTACAAGTAC
AATAACTAATTTTTTCCGGACCAAAAAAACGACAACTTCTAGTACTCAAAGAACCAACAAAATTACCCAATTAATTGCAG
ATACACCTGAACTGACTAAAGAAGAAATTGCGATAGTGGAACAATTTTTGAATTTGCGAAAAAAAGAATTAGCTGATGAT
AATATAAAAAGTGATAGCAAATGA

Upstream 100 bases:

>100_bases
GGCTGGTAACTTTTGTTGCCGGCTTTTTTTATTTATCTGCGGCTTTTATATCGTTTTATGCTAAAATAAATGAGAGTATA
TGTTAAATGAGGTGAATAAC

Downstream 100 bases:

>100_bases
TGCTATCACTTTTTGATTAGTTTTTCGACTTGATTACGGTAACGTTCAGATAAAGCTTCCACCGCTAAAATACGTTCAAA
ATCTTCTTTTGTTCCTTTTT

Product: ion transport protein, putative

Products: NA

Alternate protein names: KvAP [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MDKTKRRMIYETFMLILILLSLALLPYRNNFTFILNWIIWVIFTLDYLVRFHRADNKWHYVKTHPFQLIAIIPFYGGFRA
ARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFVLLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIV
PVTPIGRILASIMMLFGIAFIGMITSTITNFFRTKKTTTSSTQRTNKITQLIADTPELTKEEIAIVEQFLNLRKKELADD
NIKSDSK

Sequences:

>Translated_247_residues
MDKTKRRMIYETFMLILILLSLALLPYRNNFTFILNWIIWVIFTLDYLVRFHRADNKWHYVKTHPFQLIAIIPFYGGFRA
ARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFVLLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIV
PVTPIGRILASIMMLFGIAFIGMITSTITNFFRTKKTTTSSTQRTNKITQLIADTPELTKEEIAIVEQFLNLRKKELADD
NIKSDSK
>Mature_247_residues
MDKTKRRMIYETFMLILILLSLALLPYRNNFTFILNWIIWVIFTLDYLVRFHRADNKWHYVKTHPFQLIAIIPFYGGFRA
ARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFVLLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIV
PVTPIGRILASIMMLFGIAFIGMITSTITNFFRTKKTTTSSTQRTNKITQLIADTPELTKEEIAIVEQFLNLRKKELADD
NIKSDSK

Specific function: Mediates a strong voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassi

COG id: COG1226

COG function: function code P; Kef-type K+ transport systems, predicted NAD-binding component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the potassium channel family [H]

Homologues:

Organism=Homo sapiens, GI27436974, Length=255, Percent_Identity=25.0980392156863, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI4826784, Length=198, Percent_Identity=26.2626262626263, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI20070166, Length=194, Percent_Identity=29.3814432989691, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI9789987, Length=201, Percent_Identity=25.8706467661692, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71989369, Length=198, Percent_Identity=29.7979797979798, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989381, Length=198, Percent_Identity=29.7979797979798, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989361, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71989376, Length=198, Percent_Identity=29.7979797979798, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365536, Length=186, Percent_Identity=24.7311827956989, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007764, Length=186, Percent_Identity=24.7311827956989, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656289, Length=186, Percent_Identity=24.7311827956989, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656294, Length=186, Percent_Identity=24.7311827956989, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737641, Length=204, Percent_Identity=25, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161084970, Length=204, Percent_Identity=25, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013099 [H]

Pfam domain/function: PF07885 Ion_trans_2 [H]

EC number: NA

Molecular weight: Translated: 28698; Mature: 28698

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKTKRRMIYETFMLILILLSLALLPYRNNFTFILNWIIWVIFTLDYLVRFHRADNKWHY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VKTHPFQLIAIIPFYGGFRAARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFV
EEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
LLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIVPVTPIGRILASIMMLFGIAF
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
IGMITSTITNFFRTKKTTTSSTQRTNKITQLIADTPELTKEEIAIVEQFLNLRKKELADD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
NIKSDSK
CCCCCCC
>Mature Secondary Structure
MDKTKRRMIYETFMLILILLSLALLPYRNNFTFILNWIIWVIFTLDYLVRFHRADNKWHY
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
VKTHPFQLIAIIPFYGGFRAARIVSFVHLLSITAMGRRYIVPIYSFFRSNGLNRFLMIFV
EEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHH
LLVIIIPVPMVFIEPEINNYPDALWWAIVTATTVGYGDIVPVTPIGRILASIMMLFGIAF
HHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
IGMITSTITNFFRTKKTTTSSTQRTNKITQLIADTPELTKEEIAIVEQFLNLRKKELADD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
NIKSDSK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]