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The map label for this gene is ilvC [H]

Identifier: 116873421

GI number: 116873421

Start: 2032656

End: 2033651

Strand: Direct

Name: ilvC [H]

Synonym: lwe2005

Alternate gene names: 116873421

Gene position: 2032656-2033651 (Clockwise)

Preceding gene: 116873420

Following gene: 116873422

Centisome position: 72.23

GC content: 39.36

Gene sequence:

>996_bases
ATGACAAAAGTTTATTATGAAGATGCAGTAAAAAATAACGCACTAGAAGGTAAAACAGTAGCAGTAATCGGGTATGGTTC
GCAAGGGCATGCACATTCTCAAAATCTACGTGATAATGGTAATAATGTTATTATCGGCATCCGCGAAGGAAAATCTGCTG
AATCTGCTAGAAACGATGGCTTTGATGTTTATTCTGTCAGTGAAGCCGCTGAAAAAGCAGATGTTATCATGATTCTTTTG
CCAGATGAAACACAAGGTGAAACATATGAAAACGAAATCAAACCTAACTTAAAAGCTGGTAACTCCCTCGTTTTCGCTCA
CGGTTTTAACATTCATTTTGATGTAATTAACCCTCCAAATGATGTAGATGTTTTCCTAGTAGCTCCAAAAGGCCCTGGTC
ACTTAGTTCGTCGTACATTCGTCGAAGGTGGCGCGGTACCTTCCCTATTTGCTATTTACCAAGATGCAACTGGAAACGCT
CGTGAAACAGCACTTTCTTATGCAAAAGGTATTGGAGCAACTCGTGCTGGCGTTATTGAAACAACTTTCAAGGAAGAAAC
AGAAACCGATCTATTTGGCGAACAAGCAGTTCTTTGTGGGGGTGCGACTCATCTTATCCAAGCAGGATTCGAAACACTTG
TGGAAGCTGGCTATCAACCCGAACTTGCTTATTTTGAAGTACTACATGAAATGAAGCTAATTGTTGATTTGATGTATGAA
GGTGGTATGGAGAAAATGCGCCACTCTATCTCAAATACAGCTGAATATGGTGATTATGTATCTGGTCCGCGTGTTGTTAC
AGCAGATACAAAGAAAGCAATGAAAGAAGTACTTACTGACATTCAAAATGGTAACTTTGCCAAGTCTTTCATCGATGATA
ACAAAAATGGCTTTAAAGAATTCCATAGAATGCGCAAAGAACAACAAGGCCATCAAATTGAAAAAGTCGGTGCAGAACTT
CGAGAAATGATGCCATTTGTCAAACCACAACATTAA

Upstream 100 bases:

>100_bases
TAAAATCATTGACTACAAAGCAATTCGTTGCTTTGTTAGCATCAGATAAGCACATTGCTATTCTGAAATATAAAAAGAAA
CTAGTTGGAGGTTAGGAAAA

Downstream 100 bases:

>100_bases
TACTTAACTCGGATTGCTAGGTGAAATTCTCACCTAGCAACCGTTTATCCTTTTTTCCATATGAGTTTAAGGAAGAACCT
ATTTCTTTCCTAAACTGATA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDGFDVYSVSEAAEKADVIMILL
PDETQGETYENEIKPNLKAGNSLVFAHGFNIHFDVINPPNDVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNA
RETALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKEFHRMRKEQQGHQIEKVGAEL
REMMPFVKPQH

Sequences:

>Translated_331_residues
MTKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDGFDVYSVSEAAEKADVIMILL
PDETQGETYENEIKPNLKAGNSLVFAHGFNIHFDVINPPNDVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNA
RETALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKEFHRMRKEQQGHQIEKVGAEL
REMMPFVKPQH
>Mature_330_residues
TKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDGFDVYSVSEAAEKADVIMILLP
DETQGETYENEIKPNLKAGNSLVFAHGFNIHFDVINPPNDVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNAR
ETALSYAKGIGATRAGVIETTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYEG
GMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKEFHRMRKEQQGHQIEKVGAELR
EMMPFVKPQH

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=309, Percent_Identity=31.7152103559871, Blast_Score=139, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=37.962962962963, Blast_Score=165, Evalue=9e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 36440; Mature: 36309

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDG
CCEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCC
FDVYSVSEAAEKADVIMILLPDETQGETYENEIKPNLKAGNSLVFAHGFNIHFDVINPPN
CCEEEHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEEECCEEEEEECCCCC
DVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNARETALSYAKGIGATRAGVIE
CCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
HHHHHCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKE
CCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEHHHHCCCCHHHHH
FHRMRKEQQGHQIEKVGAELREMMPFVKPQH
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKVYYEDAVKNNALEGKTVAVIGYGSQGHAHSQNLRDNGNNVIIGIREGKSAESARNDG
CEEEEHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCCCCHHCCCC
FDVYSVSEAAEKADVIMILLPDETQGETYENEIKPNLKAGNSLVFAHGFNIHFDVINPPN
CCEEEHHHHHCCCCEEEEEECCCCCCCCCHHHCCCCCCCCCEEEEEECCEEEEEECCCCC
DVDVFLVAPKGPGHLVRRTFVEGGAVPSLFAIYQDATGNARETALSYAKGIGATRAGVIE
CCEEEEECCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEE
TTFKEETETDLFGEQAVLCGGATHLIQAGFETLVEAGYQPELAYFEVLHEMKLIVDLMYE
HHHHHCHHHHHCCCCEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
GGMEKMRHSISNTAEYGDYVSGPRVVTADTKKAMKEVLTDIQNGNFAKSFIDDNKNGFKE
CCHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEHHHHCCCCHHHHH
FHRMRKEQQGHQIEKVGAELREMMPFVKPQH
HHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]