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The map label for this gene is plsC [H]

Identifier: 116873079

GI number: 116873079

Start: 1675096

End: 1675704

Strand: Direct

Name: plsC [H]

Synonym: lwe1663

Alternate gene names: 116873079

Gene position: 1675096-1675704 (Clockwise)

Preceding gene: 116873069

Following gene: 116873096

Centisome position: 59.52

GC content: 36.12

Gene sequence:

>609_bases
TTGTTTTATCATTTCGCAAAAAACCTCGTTCATTTTATTTTAATTATTATTGGTGGACGATTTCAAGTACAAAACAAAGA
AAAAATTATTGAAGCACCTTATGTTGTTGTGTCTACGCATACGTCTTGGATTGAAATCTTGTACCTTGGTTTCGCCCTAT
CACCAACACCAGTGCATTATATGGCCAAACAAGAGCTATTCAAAGGAAAATTCCTTAACTGGCTAATGACACACCTTAAC
GCCTTCCCTGTCAATCGTGATAATCCTGGACCAAGTGCCATCAAAGCACCAATCCGGATGCTAAAATCTGGCAAAGTAGT
TGGGATTTTTCCGAGTGGTACGAGAAAAACAACCAACCTTCATTTAAAACGCGGCGCTGTAACAATCGCTCATAAAGCAA
AAGTTCCTATGTTGCCCGCTGTTTATGATGGACCAAAAACATTTGGAGAGATTTTAAAACGTAAAAAAATCATTATTCGT
TTTGGTGATCCAGTATTATTCAATGATACCGAACTTGACCAAAAAGAGCTACTAGAAGTTAAGTCTCAAGAATTAATGGC
GACATTCGAACAGCTTCAAAATGAAATTAATCAAACAAAAAATAAATAA

Upstream 100 bases:

>100_bases
TTTTTCTCGGAGATTATTTATTTTTAATGCAAAACTCATCATTTTTAAGTATACTAGATATAGTTTAAAAAAATAACTAG
CAATACTGGGAGTGAAGAAG

Downstream 100 bases:

>100_bases
AACAAAAGACAGCTTCCGCTCGGGAAGCTGTCTTTTGTTTTATCAGGAAGCTGTATCAGTTGTGATGCTTGAAGGATTAA
GTCCAGCATCTTTTAATACG

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase domain-containing protein

Products: [acyl carrier protein]; L-1-phosphatidyl-ethanolamine; AMP; pyrophosphate; acyl-ACP [C]

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; 1-acyl-G3P acyltransferase; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MFYHFAKNLVHFILIIIGGRFQVQNKEKIIEAPYVVVSTHTSWIEILYLGFALSPTPVHYMAKQELFKGKFLNWLMTHLN
AFPVNRDNPGPSAIKAPIRMLKSGKVVGIFPSGTRKTTNLHLKRGAVTIAHKAKVPMLPAVYDGPKTFGEILKRKKIIIR
FGDPVLFNDTELDQKELLEVKSQELMATFEQLQNEINQTKNK

Sequences:

>Translated_202_residues
MFYHFAKNLVHFILIIIGGRFQVQNKEKIIEAPYVVVSTHTSWIEILYLGFALSPTPVHYMAKQELFKGKFLNWLMTHLN
AFPVNRDNPGPSAIKAPIRMLKSGKVVGIFPSGTRKTTNLHLKRGAVTIAHKAKVPMLPAVYDGPKTFGEILKRKKIIIR
FGDPVLFNDTELDQKELLEVKSQELMATFEQLQNEINQTKNK
>Mature_202_residues
MFYHFAKNLVHFILIIIGGRFQVQNKEKIIEAPYVVVSTHTSWIEILYLGFALSPTPVHYMAKQELFKGKFLNWLMTHLN
AFPVNRDNPGPSAIKAPIRMLKSGKVVGIFPSGTRKTTNLHLKRGAVTIAHKAKVPMLPAVYDGPKTFGEILKRKKIIIR
FGDPVLFNDTELDQKELLEVKSQELMATFEQLQNEINQTKNK

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) by incorporating an acyl moiety at the 2 position. This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cytoplasm. Note=Probably associated with the membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320151, Length=205, Percent_Identity=23.9024390243902, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: NA

Molecular weight: Translated: 23029; Mature: 23029

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYHFAKNLVHFILIIIGGRFQVQNKEKIIEAPYVVVSTHTSWIEILYLGFALSPTPVHY
CHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCHHH
MAKQELFKGKFLNWLMTHLNAFPVNRDNPGPSAIKAPIRMLKSGKVVGIFPSGTRKTTNL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEE
HLKRGAVTIAHKAKVPMLPAVYDGPKTFGEILKRKKIIIRFGDPVLFNDTELDQKELLEV
EEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCEEEEEECCEEEECCCCCCHHHHHHH
KSQELMATFEQLQNEINQTKNK
HHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFYHFAKNLVHFILIIIGGRFQVQNKEKIIEAPYVVVSTHTSWIEILYLGFALSPTPVHY
CHHHHHHHHHHHHHHHHCCCEEECCCHHHHCCCEEEEECCHHHHHHHHHHHCCCCCCHHH
MAKQELFKGKFLNWLMTHLNAFPVNRDNPGPSAIKAPIRMLKSGKVVGIFPSGTRKTTNL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEE
HLKRGAVTIAHKAKVPMLPAVYDGPKTFGEILKRKKIIIRFGDPVLFNDTELDQKELLEV
EEECCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCEEEEEECCEEEECCCCCCHHHHHHH
KSQELMATFEQLQNEINQTKNK
HHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-ACP; 2-acyl-sn-glycero-3-phosphoethanolamine; ATP; a fatty acid [C]

Specific reaction: acyl-ACP + 2-acyl-sn-glycero-3-phosphoethanolamine = [acyl carrier protein] + L-1-phosphatidyl-ethanolamine ATP + a fatty acid + [acyl carrier protein] = AMP + pyrophosphate + acyl-ACP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]