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The map label for this gene is mutL [H]

Identifier: 116872836

GI number: 116872836

Start: 1411901

End: 1413712

Strand: Direct

Name: mutL [H]

Synonym: lwe1420

Alternate gene names: 116872836

Gene position: 1411901-1413712 (Clockwise)

Preceding gene: 116872835

Following gene: 116872837

Centisome position: 50.17

GC content: 36.87

Gene sequence:

>1812_bases
ATGGCTAAACATATTGTTGAATTAACCGATGCTTTATCCAATAAAATAGCGGCGGGAGAAGTTGTAGAAAGACCTGCTTC
TGTTGTTAAAGAATTAGTAGAAAATGCCATTGACGCAGGGAGCACCGTTATCGATATTTTGGTGGAAGAAGCGGGATTAA
ATAAAATTACAATTATTGATAACGGTAGTGGTATTGAAGAAGAAGATGTTGCAACCGCATTTCTACGCCACGCCACAAGT
AAAATCAAAAATGAAGCAGATTTATTCCGTGTGCATACACTAGGTTTCCGCGGTGAAGCTTTACCTAGTATAGCTTCGGT
TTCCCATTTATCCATGGAAACCTCTACTGGCGAAACAAAGGGAACGACTATTTCCCTTGAGGGCGGAAAAATCATGGAGC
AAAAAAGCGGCCATGCCAGAAAAGGAACGCAAATCGAAGTTTCGCAACTATTCTTTAATACACCAGCTCGATTAAAATAC
TTAAAAAGTTTACCAACGGAACTTGGAAATATTACCGACATTTTAAATCGACTTGCCTTAGCACATCCGGATATTAGTTT
CCGCTTTTCGCATAACGGAAAACCTTTACTACAAACAAATGGTAATGGTGATTTGCGACAAGTCATTGCAGCTATTTATG
GCGTTTCAATTGCTCGGAAATCAATTCCAGTGAAAGCAGAGTCACTCGATTTTAACATTTCAGGATACGCTGTGTTGCCA
GAAGTGAATCGTTCTAATCGTAACTATATCTCGACCATTATTAATGGCCGCTTTATCAAAAATTTTGCATTAGTTAAAGC
AATTCAAGAAGGATATCACACACTTCTACCTATTGGGCGTTTTCCAATTATCGTTTTACAAATTGAAATGGATCCAATTA
TTGTAGATGTCAATGTTCATCCTGCAAAATTAGAAGTTCGTTTGAGTAAAGAAAAAGAACTTGGCCAGCTCATTAGTCAA
ATGATTAAAGAGGCTTTTCATCAATTGCAATTAATACCAGATGGAGAAGTTTCGAAAAAACAAAAAGAGCAACAAAAATC
TGAACAAATTCAGATGTCATTTGAAGAAAATAAGCTACCAAAAGAAACACCAACACTTTTCTCCAAACCGAATGTCCCAG
AATATGTTCCTTCTGATGAAGATACATCTCGAGAAGACGATTTTATTTTAGAAACACTGCCTACTTATGATTCAAAAATT
CAACCTGAACAAGCAGAAGAGCCAAAAGAACGGATTCCTAAAATGTATCCAATTGGTCAAATGCATGCAACCTATATCTT
TGCTCAAAACGAAAATGGTTTGTATATTATTGACCAACATGCCGCACAGGAACGGATTAAATATGAATTTTATCGGGAGA
AAATTGGCGAAGTAAGCCGCGAACTGCAAGAATTACTAGTACCAATCGTCTTAGAATTCCCAACAGATGAATATGTTCGT
TTGGAAGAACAAAAAACAAAATTAGAAGAAGTTGGTGTTTTTCTTGAAAACTTCGGACAAAATAGCTTTATTATCCGTGC
ACATCCAACTTGGTTTCCAAAAAATCAAGAAGAGGAAATGTTGCGGGAAATTATCGATGAAGCACTTTCGGCGCCGAGTA
TCAGCATTCATAAGTTAAGAGAAGATACAGCGATTATGATGAGTTGCAAAAAATCAATTAAAGCAAATCACTATTTGACT
ATGCAAGATATGGAAGCTTTGCTTGATACACTGAGAGAAGCAAGCGATCCATTCACATGTCCCCATGGTCGTCCTGTTAT
TATTCAATATTCGACTTACGAACTGGAAAAAATGTTTAAACGCGTAATGTAA

Upstream 100 bases:

>100_bases
TGCATCGATGAATATTATGCAAATGACACCCATGGACGCAATGAACAAGCTATACGAGCTTCAAAGCAAAATCCATTAAA
AGAGAAAGGCGGGTTTTTGA

Downstream 100 bases:

>100_bases
AAGAGGAGGAATATCATTGGAGTTACCATTCTCTGGTCAACCGATCATCCCAGCAGCGCACAATCAAAAAGATATGGAAA
AAATATTAGAACTAGATTTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATS
KIKNEADLFRVHTLGFRGEALPSIASVSHLSMETSTGETKGTTISLEGGKIMEQKSGHARKGTQIEVSQLFFNTPARLKY
LKSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIARKSIPVKAESLDFNISGYAVLP
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQ
MIKEAFHQLQLIPDGEVSKKQKEQQKSEQIQMSFEENKLPKETPTLFSKPNVPEYVPSDEDTSREDDFILETLPTYDSKI
QPEQAEEPKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPTDEYVR
LEEQKTKLEEVGVFLENFGQNSFIIRAHPTWFPKNQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLT
MQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM

Sequences:

>Translated_603_residues
MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATS
KIKNEADLFRVHTLGFRGEALPSIASVSHLSMETSTGETKGTTISLEGGKIMEQKSGHARKGTQIEVSQLFFNTPARLKY
LKSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIARKSIPVKAESLDFNISGYAVLP
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQ
MIKEAFHQLQLIPDGEVSKKQKEQQKSEQIQMSFEENKLPKETPTLFSKPNVPEYVPSDEDTSREDDFILETLPTYDSKI
QPEQAEEPKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPTDEYVR
LEEQKTKLEEVGVFLENFGQNSFIIRAHPTWFPKNQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLT
MQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM
>Mature_602_residues
AKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIIDNGSGIEEEDVATAFLRHATSK
IKNEADLFRVHTLGFRGEALPSIASVSHLSMETSTGETKGTTISLEGGKIMEQKSGHARKGTQIEVSQLFFNTPARLKYL
KSLPTELGNITDILNRLALAHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIARKSIPVKAESLDFNISGYAVLPE
VNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVHPAKLEVRLSKEKELGQLISQM
IKEAFHQLQLIPDGEVSKKQKEQQKSEQIQMSFEENKLPKETPTLFSKPNVPEYVPSDEDTSREDDFILETLPTYDSKIQ
PEQAEEPKERIPKMYPIGQMHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPTDEYVRL
EEQKTKLEEVGVFLENFGQNSFIIRAHPTWFPKNQEEEMLREIIDEALSAPSISIHKLREDTAIMMSCKKSIKANHYLTM
QDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFKRVM

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=330, Percent_Identity=36.969696969697, Blast_Score=196, Evalue=6e-50,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=31.8713450292398, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=31.8713450292398, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI4505911, Length=312, Percent_Identity=30.7692307692308, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI189458898, Length=318, Percent_Identity=30.188679245283, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI189458896, Length=301, Percent_Identity=31.2292358803987, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=30.0675675675676, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI263191589, Length=232, Percent_Identity=32.7586206896552, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI91992162, Length=261, Percent_Identity=28.735632183908, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI91992160, Length=261, Percent_Identity=28.735632183908, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790612, Length=531, Percent_Identity=32.015065913371, Blast_Score=233, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71991825, Length=306, Percent_Identity=33.9869281045752, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17562796, Length=351, Percent_Identity=29.9145299145299, Blast_Score=135, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323819, Length=332, Percent_Identity=36.4457831325301, Blast_Score=183, Evalue=8e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=378, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6325093, Length=384, Percent_Identity=24.21875, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=338, Percent_Identity=24.8520710059172, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17136968, Length=324, Percent_Identity=34.8765432098765, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI17136970, Length=348, Percent_Identity=28.448275862069, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68156; Mature: 68025

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIID
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEE
NGSGIEEEDVATAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLSMETSTGETK
CCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCHHHHHHHHEEECCCCCCC
GTTISLEGGKIMEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLAL
CCEEEECCCCHHHCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIARKSIPVKAESLDFNISGYAVLP
CCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCEEECCCCEEEEC
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVH
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEECCCEEEEEECC
PAKLEVRLSKEKELGQLISQMIKEAFHQLQLIPDGEVSKKQKEQQKSEQIQMSFEENKLP
CCEEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHEEHHHHCCCC
KETPTLFSKPNVPEYVPSDEDTSREDDFILETLPTYDSKIQPEQAEEPKERIPKMYPIGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCHHHHCCCCCCCCC
MHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPTDEYVR
EEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHEE
LEEQKTKLEEVGVFLENFGQNSFIIRAHPTWFPKNQEEEMLREIIDEALSAPSISIHKLR
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
EDTAIMMSCKKSIKANHYLTMQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFK
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHH
RVM
HCC
>Mature Secondary Structure 
AKHIVELTDALSNKIAAGEVVERPASVVKELVENAIDAGSTVIDILVEEAGLNKITIID
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEE
NGSGIEEEDVATAFLRHATSKIKNEADLFRVHTLGFRGEALPSIASVSHLSMETSTGETK
CCCCCCHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCHHHHHHHHEEECCCCCCC
GTTISLEGGKIMEQKSGHARKGTQIEVSQLFFNTPARLKYLKSLPTELGNITDILNRLAL
CCEEEECCCCHHHCCCCCCCCCCEEEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AHPDISFRFSHNGKPLLQTNGNGDLRQVIAAIYGVSIARKSIPVKAESLDFNISGYAVLP
CCCCCEEEECCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEECCEEECCCCEEEEC
EVNRSNRNYISTIINGRFIKNFALVKAIQEGYHTLLPIGRFPIIVLQIEMDPIIVDVNVH
CCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCHHHHCCCCCCCEEEEEEECCCEEEEEECC
PAKLEVRLSKEKELGQLISQMIKEAFHQLQLIPDGEVSKKQKEQQKSEQIQMSFEENKLP
CCEEEEEECCHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHEEHHHHCCCC
KETPTLFSKPNVPEYVPSDEDTSREDDFILETLPTYDSKIQPEQAEEPKERIPKMYPIGQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHCCCHHHHCCCCCCCCC
MHATYIFAQNENGLYIIDQHAAQERIKYEFYREKIGEVSRELQELLVPIVLEFPTDEYVR
EEEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHEE
LEEQKTKLEEVGVFLENFGQNSFIIRAHPTWFPKNQEEEMLREIIDEALSAPSISIHKLR
HHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHH
EDTAIMMSCKKSIKANHYLTMQDMEALLDTLREASDPFTCPHGRPVIIQYSTYELEKMFK
HHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHH
RVM
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]