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The map label for this gene is ymfI [H]

Identifier: 116872826

GI number: 116872826

Start: 1400475

End: 1401206

Strand: Direct

Name: ymfI [H]

Synonym: lwe1410

Alternate gene names: 116872826

Gene position: 1400475-1401206 (Clockwise)

Preceding gene: 116872825

Following gene: 116872827

Centisome position: 49.77

GC content: 35.93

Gene sequence:

>732_bases
TTGGATAAAGAAACAAAATATGCTTTTGTTACTGGAGCTAGCGGTGAAATTGGACAAGCGATTTGTATAGCACTTGCAAA
AGCTGGCTGGAACTTGTATCTTCATTATTATCAAAATAGACAAGCTGTGGAAGATATAGTGCCAAAACTACAAGCTGAAA
ACATCGATGTCATATTGATTCAAGCCGATTTTGATGATTTTTCAAGTTTAAAAGAGATAGAAAAGCAAGTTTTTCAAGTA
GATGCATTTATCCATGCAGCAGGGCATTCTCACTATGCTTTATTCCAGGATACTACAGATTTAGATATGACAAAATTATG
GAATGTCCATATGTATATGCCAATGCGTTTAATCCAGATTTTCATACCAAAACTTATGAAAAGTCAGCAAGGAAGAATTG
TTTTCATCAGTTCTATCTGGGGAGAAATTGGCGCGTCAATGGAAGTCGTTTATTCTACAGTAAAAGGCGCTCAAATTGCT
TTTTGTAAGGCTCTTAGTCAAGAAGTTGGACTGTCGGGCATAACTGTTAACGCAGTAACTCCAGGTGTTGTAAAAACGAA
AATGATGGATCAATTTTCGCTGGAAGAAAAAGAAATATTACGTCAGGAAATTCCTTTAAAACGTTTTGCAAAACCGGAAG
AAATTGCAGAAACCGTAGAATTTTTAACAAGTAAAAAAGCAAGCTATATCACTGGAGAAGTTTTGCGCTTAAATGGCGGT
TGGCTTATGTGA

Upstream 100 bases:

>100_bases
ACATATTTATGCCATTTTTTCTTTTTTTAGTATAAAAAATGGCATAAATTCTTAAGTCATGCTATCATAAAAGAAATAGA
CTGGAAAGGGTTGCCTTTTT

Downstream 100 bases:

>100_bases
ATTTTAATAAAAGTGGAAATTTGAATTTAATAATGGTAGGTGTTTAATTTTGACAGAACTCGGTGATAAACTGAAACAAG
CTAGACGTGAAAAAGGACTC

Product: 3-ketoacyl-acyl carrier protein reductase, putative

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MDKETKYAFVTGASGEIGQAICIALAKAGWNLYLHYYQNRQAVEDIVPKLQAENIDVILIQADFDDFSSLKEIEKQVFQV
DAFIHAAGHSHYALFQDTTDLDMTKLWNVHMYMPMRLIQIFIPKLMKSQQGRIVFISSIWGEIGASMEVVYSTVKGAQIA
FCKALSQEVGLSGITVNAVTPGVVKTKMMDQFSLEEKEILRQEIPLKRFAKPEEIAETVEFLTSKKASYITGEVLRLNGG
WLM

Sequences:

>Translated_243_residues
MDKETKYAFVTGASGEIGQAICIALAKAGWNLYLHYYQNRQAVEDIVPKLQAENIDVILIQADFDDFSSLKEIEKQVFQV
DAFIHAAGHSHYALFQDTTDLDMTKLWNVHMYMPMRLIQIFIPKLMKSQQGRIVFISSIWGEIGASMEVVYSTVKGAQIA
FCKALSQEVGLSGITVNAVTPGVVKTKMMDQFSLEEKEILRQEIPLKRFAKPEEIAETVEFLTSKKASYITGEVLRLNGG
WLM
>Mature_243_residues
MDKETKYAFVTGASGEIGQAICIALAKAGWNLYLHYYQNRQAVEDIVPKLQAENIDVILIQADFDDFSSLKEIEKQVFQV
DAFIHAAGHSHYALFQDTTDLDMTKLWNVHMYMPMRLIQIFIPKLMKSQQGRIVFISSIWGEIGASMEVVYSTVKGAQIA
FCKALSQEVGLSGITVNAVTPGVVKTKMMDQFSLEEKEILRQEIPLKRFAKPEEIAETVEFLTSKKASYITGEVLRLNGG
WLM

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=237, Percent_Identity=30.8016877637131, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=26.9387755102041, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI66933014, Length=197, Percent_Identity=29.4416243654822, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI15277342, Length=253, Percent_Identity=25.296442687747, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI5031737, Length=242, Percent_Identity=26.4462809917355, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI59889578, Length=184, Percent_Identity=28.804347826087, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI126723750, Length=249, Percent_Identity=25.3012048192771, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI20149619, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI7705925, Length=239, Percent_Identity=25.9414225941423, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI7706318, Length=191, Percent_Identity=26.7015706806283, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI4503301, Length=122, Percent_Identity=34.4262295081967, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=244, Percent_Identity=32.7868852459016, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082100, Length=248, Percent_Identity=29.8387096774194, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI2367175, Length=244, Percent_Identity=29.0983606557377, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=25.5144032921811, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=25.3012048192771, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=25, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789378, Length=243, Percent_Identity=26.7489711934156, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=23.3606557377049, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI2367365, Length=237, Percent_Identity=23.2067510548523, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786812, Length=261, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=22.7091633466135, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789057, Length=255, Percent_Identity=23.5294117647059, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=32.1285140562249, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555706, Length=254, Percent_Identity=29.9212598425197, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=29.2682926829268, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=30.241935483871, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=27.1255060728745, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17508651, Length=250, Percent_Identity=28.4, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=26.8292682926829, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17561402, Length=248, Percent_Identity=27.8225806451613, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=272, Percent_Identity=25.3676470588235, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=241, Percent_Identity=24.0663900414938, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=24.3445692883895, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=259, Percent_Identity=25.4826254826255, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=25.3846153846154, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=246, Percent_Identity=26.0162601626016, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24639444, Length=241, Percent_Identity=28.6307053941909, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24643142, Length=242, Percent_Identity=28.9256198347107, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=27.2357723577236, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=28.4552845528455, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=26.6129032258064, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=26.4822134387352, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358495, Length=192, Percent_Identity=28.6458333333333, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24644337, Length=117, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 27380; Mature: 27380

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKETKYAFVTGASGEIGQAICIALAKAGWNLYLHYYQNRQAVEDIVPKLQAENIDVILI
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCEEEE
QADFDDFSSLKEIEKQVFQVDAFIHAAGHSHYALFQDTTDLDMTKLWNVHMYMPMRLIQI
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FIPKLMKSQQGRIVFISSIWGEIGASMEVVYSTVKGAQIAFCKALSQEVGLSGITVNAVT
HHHHHHCCCCCCEEEEEEHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCC
PGVVKTKMMDQFSLEEKEILRQEIPLKRFAKPEEIAETVEFLTSKKASYITGEVLRLNGG
CCHHHHHHHHHHCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCC
WLM
CCC
>Mature Secondary Structure
MDKETKYAFVTGASGEIGQAICIALAKAGWNLYLHYYQNRQAVEDIVPKLQAENIDVILI
CCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHCCCCCCEEEE
QADFDDFSSLKEIEKQVFQVDAFIHAAGHSHYALFQDTTDLDMTKLWNVHMYMPMRLIQI
EECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FIPKLMKSQQGRIVFISSIWGEIGASMEVVYSTVKGAQIAFCKALSQEVGLSGITVNAVT
HHHHHHCCCCCCEEEEEEHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCC
PGVVKTKMMDQFSLEEKEILRQEIPLKRFAKPEEIAETVEFLTSKKASYITGEVLRLNGG
CCHHHHHHHHHHCCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCC
WLM
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]