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The map label for this gene is gnd [H]

Identifier: 116872808

GI number: 116872808

Start: 1379877

End: 1381295

Strand: Direct

Name: gnd [H]

Synonym: lwe1392

Alternate gene names: 116872808

Gene position: 1379877-1381295 (Clockwise)

Preceding gene: 116872807

Following gene: 116872809

Centisome position: 49.03

GC content: 38.69

Gene sequence:

>1419_bases
ATGGCAAAACAAGAAATTGGCGTTATAGGAATGGGCGTTATGGGTCGTAACTTGGCTCTAAACATTGAAAGTCGTGGTCA
TACAGTATCTATCTTTAACCGTTCTACTGAAAAAACGAAAGCGGTTATGGAAGAAAATGCGGATAAGAAATTAGTACCAA
CTTATAGTTTAGAGGAATTTGTCGAATCTCTTGAAGTGCCTCGCCGTATCCTTATTATGGTAAAAGCTGGCGATGCTACC
GATATGATGATTGAAGCAGTTAAACCTTTCTTAAATGAAGGCGATATTTTAATCGATGGTGGTAATGCATTCTTTAAAGA
TACAATTCGTCGTAATAAAGAACTAAGTGAAGAAGGATTTAACTTTATCGGTACTGGTGTATCTGGTGGGGAAGAAGGCG
CTCTTAAAGGACCTTCCATCATGCCAGGTGGTCAACGCAAGGCATACGACCTTGTAGCCCCTATTTTACGTGAAATTGCT
GCAGTAGCAGACGGAGAACCGTGTGTGACTTATATTGGTCCAGATGGTGCCGGACATTATGTTAAAATGGTCCACAATGG
TATCGAATACGGTGATATGCAATTGATTGCAGAAGCTTACACTATTTTGAAAGAAATTGGTGGATTAAGCCATGATGAAC
TTGCAGACGTATTTGAAGAGTGGAATAACGGTGAACTTGATAGCTATCTAATCGAAATCACTAAAAATATCTTAAAAGTA
AAAGATGAAGAAACAGGTAAACCTATTGTTGATGTTATTCTTGATAAAGCTGGACAAAAAGGTACTGGTAAATGGACAAG
CCAAAGTGCACTTGACCTTGGTGTGCCACTTTCCTTAATTACAGAATCTGTATTTGCACGTTACATCTCTGCATTAAAAG
AAGAACGTGTGTATGCAAGCACTGTTTTACATGGTCCATCTAGCTATCACTTTGACGGTGATAAAAAAGCATTTGTTGAA
TCTGTTCGTCGCGCACTTTATTTCAGCAAAATAGCATCTTATGCACAAGGTTTTGCTCAAATGAGAGCTGCTAGTGAAGA
GTATGATTGGGACTTACAATACGGTGAAATTGCGAAAATTTTCCGTGCTGGTTGTATTATTCGTGCTCGTTTCTTACAAA
AAATTACGGACGCTTATAACCAAGATAAAAATCTTAAAAACTTATTACTCGATCCATATTTCAAAGATATTGCACATAAC
TACCAAGGAGATCTTCGTACAGTTGTTGCAGAAGCTGTAAAAGCTGGAATTCCAGTACCTACATTCACTGCAGCAATCAG
CTACTACGACAGCTATCGTTCTGAAGTATTATCTGCAAATCTAATTCAAGCACAACGCGATTACTTTGGTGCGCATACGT
ATGAGAGAGTCGACAAACCTGGCGTATTCCATACAGAATGGCCACAAGTAGAAGATTGA

Upstream 100 bases:

>100_bases
CAATTCTTTGATATAGTAAATGATGTTGATACTTTTATGTGTCATGTTGAAGTAAGACAGATTTTTCTGCCTTAATAAAC
CGGAAAGGAAGAAGTGCAAA

Downstream 100 bases:

>100_bases
GTTATTAAAAAGGCATTCACTTTTTCGGAGTGAATGCTTTTTTATATGAGATTTAAATTAGTAAATCATGGTAAAGTGGT
AAAAAATGCAGAAAATATCT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MAKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEFVESLEVPRRILIMVKAGDAT
DMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGFNFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIA
AVADGEPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKEERVYASTVLHGPSSYHFDGDKKAFVE
SVRRALYFSKIASYAQGFAQMRAASEEYDWDLQYGEIAKIFRAGCIIRARFLQKITDAYNQDKNLKNLLLDPYFKDIAHN
YQGDLRTVVAEAVKAGIPVPTFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED

Sequences:

>Translated_472_residues
MAKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEFVESLEVPRRILIMVKAGDAT
DMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGFNFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIA
AVADGEPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKEERVYASTVLHGPSSYHFDGDKKAFVE
SVRRALYFSKIASYAQGFAQMRAASEEYDWDLQYGEIAKIFRAGCIIRARFLQKITDAYNQDKNLKNLLLDPYFKDIAHN
YQGDLRTVVAEAVKAGIPVPTFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED
>Mature_471_residues
AKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEFVESLEVPRRILIMVKAGDATD
MMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGFNFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIAA
VADGEPCVTYIGPDGAGHYVKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKVK
DEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKEERVYASTVLHGPSSYHFDGDKKAFVES
VRRALYFSKIASYAQGFAQMRAASEEYDWDLQYGEIAKIFRAGCIIRARFLQKITDAYNQDKNLKNLLLDPYFKDIAHNY
QGDLRTVVAEAVKAGIPVPTFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=470, Percent_Identity=55.1063829787234, Blast_Score=510, Evalue=1e-144,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=75, Blast_Score=719, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17542558, Length=471, Percent_Identity=52.6539278131635, Blast_Score=510, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6321695, Length=456, Percent_Identity=50.6578947368421, Blast_Score=473, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6321977, Length=453, Percent_Identity=52.0971302428256, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24639279, Length=468, Percent_Identity=52.7777777777778, Blast_Score=473, Evalue=1e-133,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52393; Mature: 52262

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEF
CCCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHH
VESLEVPRRILIMVKAGDATDMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGF
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCC
NFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIAAVADGEPCVTYIGPDGAGHY
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKEERVYAS
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TVLHGPSSYHFDGDKKAFVESVRRALYFSKIASYAQGFAQMRAASEEYDWDLQYGEIAKI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
FRAGCIIRARFLQKITDAYNQDKNLKNLLLDPYFKDIAHNYQGDLRTVVAEAVKAGIPVP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
TFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AKQEIGVIGMGVMGRNLALNIESRGHTVSIFNRSTEKTKAVMEENADKKLVPTYSLEEF
CCCCCCEEEECCCCCCEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCCHHHH
VESLEVPRRILIMVKAGDATDMMIEAVKPFLNEGDILIDGGNAFFKDTIRRNKELSEEGF
HHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHCC
NFIGTGVSGGEEGALKGPSIMPGGQRKAYDLVAPILREIAAVADGEPCVTYIGPDGAGHY
CEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHH
VKMVHNGIEYGDMQLIAEAYTILKEIGGLSHDELADVFEEWNNGELDSYLIEITKNILKV
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
KDEETGKPIVDVILDKAGQKGTGKWTSQSALDLGVPLSLITESVFARYISALKEERVYAS
CCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TVLHGPSSYHFDGDKKAFVESVRRALYFSKIASYAQGFAQMRAASEEYDWDLQYGEIAKI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
FRAGCIIRARFLQKITDAYNQDKNLKNLLLDPYFKDIAHNYQGDLRTVVAEAVKAGIPVP
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
TFTAAISYYDSYRSEVLSANLIQAQRDYFGAHTYERVDKPGVFHTEWPQVED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7515042 [H]