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The map label for this gene is yqgN [H]

Identifier: 116872767

GI number: 116872767

Start: 1342863

End: 1343402

Strand: Direct

Name: yqgN [H]

Synonym: lwe1351

Alternate gene names: 116872767

Gene position: 1342863-1343402 (Clockwise)

Preceding gene: 116872766

Following gene: 116872768

Centisome position: 47.72

GC content: 31.85

Gene sequence:

>540_bases
ATGGAAGACAAACGCCTAATTAGAGAAAAAATTTTACGTAACTTAAATAATATAGATAAAATAGAACACCGCGAACGTTC
AATTAAGCTTGCAGAAAAATTATTCCTTTTACCTGAATGGAAAAACGCCAATTCTATTGGAATAACATTAGCTAGACATC
CGGAAATTGAAACAGAAACGATTATTTTACAAGCTAAAAAAGAAGGCAAAACAGTTTTAATACCTAAAACTTATTATCCG
AGTAGGAAAATGGAGTTTAAAAAAATGGATTCTGTTCATCCACTTATCAAATCAAAGTTCGGTATTTTAGAGCCAAATGA
ATTAACAGAAACGGTACCTAAAGAAAAAATAGATTTACTTCTGGTGCCTGGAGTTGCTTTTAATAAATCGCATTTCCGAA
TTGGTTTTGGCGGCGGTTTTTATGATCGTTTTTTAGTTGGTTTTAAAGGCACTACTGTGTCACTATGTCTCTATGAGCAA
CAAATAGAATTTACGCAAGAAAGTCATGATTTACCAGTTTCTATTCTAATTGAAGGTTAA

Upstream 100 bases:

>100_bases
TGTCCAAGATTGCGCCGTGTAACTTTACACCGCGAAACTAAGTAAGCAGCAGGATCTCCATTCTGTTGCTTTTTTTATTA
GACAAAAGGGGGAAGTCAAG

Downstream 100 bases:

>100_bases
AGAAAAATATTTCAAGAGAATACAGGGTGGATTGTTTACAACGCCCCTTTTTTTGCGTATAGTAGTAATTATAATTTGTA
ATGAAAGCAGGGAATTTTTT

Product: 5-formyltetrahydrofolate cyclo-ligase family protein

Products: ADP; phosphate; 5,10-methenyltetrahydrofolate

Alternate protein names: NA

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MEDKRLIREKILRNLNNIDKIEHRERSIKLAEKLFLLPEWKNANSIGITLARHPEIETETIILQAKKEGKTVLIPKTYYP
SRKMEFKKMDSVHPLIKSKFGILEPNELTETVPKEKIDLLLVPGVAFNKSHFRIGFGGGFYDRFLVGFKGTTVSLCLYEQ
QIEFTQESHDLPVSILIEG

Sequences:

>Translated_179_residues
MEDKRLIREKILRNLNNIDKIEHRERSIKLAEKLFLLPEWKNANSIGITLARHPEIETETIILQAKKEGKTVLIPKTYYP
SRKMEFKKMDSVHPLIKSKFGILEPNELTETVPKEKIDLLLVPGVAFNKSHFRIGFGGGFYDRFLVGFKGTTVSLCLYEQ
QIEFTQESHDLPVSILIEG
>Mature_179_residues
MEDKRLIREKILRNLNNIDKIEHRERSIKLAEKLFLLPEWKNANSIGITLARHPEIETETIILQAKKEGKTVLIPKTYYP
SRKMEFKKMDSVHPLIKSKFGILEPNELTETVPKEKIDLLLVPGVAFNKSHFRIGFGGGFYDRFLVGFKGTTVSLCLYEQ
QIEFTQESHDLPVSILIEG

Specific function: Unknown

COG id: COG0212

COG function: function code H; 5-formyltetrahydrofolate cyclo-ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5-formyltetrahydrofolate cyclo-ligase family [H]

Homologues:

Organism=Homo sapiens, GI5453746, Length=165, Percent_Identity=29.0909090909091, Blast_Score=71, Evalue=6e-13,
Organism=Escherichia coli, GI1789278, Length=162, Percent_Identity=24.0740740740741, Blast_Score=63, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321031, Length=203, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002698 [H]

Pfam domain/function: PF01812 5-FTHF_cyc-lig [H]

EC number: 6.3.3.2

Molecular weight: Translated: 20665; Mature: 20665

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDKRLIREKILRNLNNIDKIEHRERSIKLAEKLFLLPEWKNANSIGITLARHPEIETET
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCCEE
IILQAKKEGKTVLIPKTYYPSRKMEFKKMDSVHPLIKSKFGILEPNELTETVPKEKIDLL
EEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEE
LVPGVAFNKSHFRIGFGGGFYDRFLVGFKGTTVSLCLYEQQIEFTQESHDLPVSILIEG
EECCEEECCCEEEEEECCCCHHHEEEECCCCEEEEEEEHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MEDKRLIREKILRNLNNIDKIEHRERSIKLAEKLFLLPEWKNANSIGITLARHPEIETET
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCCCCCCCEEEEEEECCCCCCEE
IILQAKKEGKTVLIPKTYYPSRKMEFKKMDSVHPLIKSKFGILEPNELTETVPKEKIDLL
EEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCEE
LVPGVAFNKSHFRIGFGGGFYDRFLVGFKGTTVSLCLYEQQIEFTQESHDLPVSILIEG
EECCEEECCCEEEEEECCCCHHHEEEECCCCEEEEEEEHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 5-formyltetrahydrofolate

Specific reaction: ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]