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The map label for this gene is tkt [H]

Identifier: 116872736

GI number: 116872736

Start: 1310672

End: 1312666

Strand: Direct

Name: tkt [H]

Synonym: lwe1320

Alternate gene names: 116872736

Gene position: 1310672-1312666 (Clockwise)

Preceding gene: 116872735

Following gene: 116872737

Centisome position: 46.57

GC content: 39.45

Gene sequence:

>1995_bases
TTGTTCGATAACACAGATAGTTTAGCAGTAAATACAATTCGTACTTTATCAATGGATGCAATTCAAAAAGCAAATTCTGG
TCATCCAGGGCTACCAATGGGAGCTGCACCAATGGCTTATGCACTTTGGTCTCGCGTATTAAATACAAATCCTAAGAATT
CACATTGGTTCAATCGAGATCGTTTTGTGCTTTCTGCTGGACATGGTTCGATGCTTTTATATAGTTTATTACATTTGAGC
GGATTTAAATTAGAATTAGAAGACCTTAAAAACTTCCGTCAATGGGAAAGTAAAACTCCAGGTCACCCAGAATATCGCTA
TACAGACGGTGTAGATGCTACTACTGGTCCACTTGGTCAAGGTATTGCAATGGCTGTTGGTATGGCTATGGCAGAAAGAC
ACTTAGAAGCGAAATATAATAAAGATGAATTTCCTGTAGTGGATCATTATACGTATGCGCTATGCGGAGATGGTGATTTA
ATGGAAGGTGTTGCTTCTGAAGCTGCTTCTTACGCTGGACACCAACAATTAGGAAGATTAGTTCTTTTATATGATTCCAA
TGACATTTCACTTGATGGAGATTTAGATAAGTCTTTCTCAGAAAATGTAAAACAACGCTTTGAAGCATATGGTTGGGAGC
ATTTACTAGTAAAAGATGGTAACGATACAGCAGAAATATTAGCTGCAATTGAAAAAGCTAAACAAAATACTTCTCAACCT
ACCATGATTGAAGTGAAAACGGTTATTGGATTTGGTGCGCCAAATGCTGGTACTAGTAAAGTTCATGGCGCTCCACTTGG
TGATGAAGGTATTTTAGCTGCGAAAAAAGCATATGGCTGGGACTACGAAGAAAAATTCTTTGTTCCGGAAGAAGTTACTG
CTCGCTTTAAAGAAACAATTGGCGAACGCGGTGAAAAAGCAGAGGCAGCATGGAACGAATTATTTGCTTCTTATAAAGCG
AAATACCCAGAGCTTGCTAAACAATTAGAAGATAGCTTAAATAACAAGTTACCAGCTGATTGGGATGCAGAGCTTCCAGT
ATATGACGATTCTAAAGCACTTGCTAGCCGTGCTTCAAGTGGTGAAGTTATTAATGCATTAGCTGCTAAAATCCCAACTA
TTTTTGGTGGTTCAGCAGACCTTGCTGGTTCTAATAATACAACGATTAAAACAGATGGTGAATTCACTAAAAAAACTCCT
GCAGAACGCAATATCTGGTTTGGTGTTCGTGAATTTGCAATGGGTGCAGCGTTAAACGGTATGGCTCTCCACGGAGGGCT
ACAAGTATACGGAGGTACATTCTTTGTATTCTCTGACTATGTACGTGCTGCGATTCGTTTATCCGCAATCCAACATTTAC
CTGTAACTTATGTTATGACACATGATAGTATTGCTGTTGGGGAAGATGGTCCAACACATGAGCCAATCGAGCAACTTGCA
AGCTTACGTGCTATGCCAGGACTTTCTGTTATCCGTCCTGCTGATGGAAATGAAGTAGTAGAAGCTTGGAAACTAGCGAT
TACTTCGACAGATACTCCACATGTACTTGTTCTTACTCGTCAAGGCTTACCAACATTGCCAAACTCTGCTAAATTGACTG
CAGAAGGCGTTAAAAAAGGTGCTTATGTTATTTCACCAGCTAAAAATGAAGTTCCGGAAGCAATAATTCTTGCAAGCGGC
TCTGAAGTGAATTTAGCTGTTGAAGCACAACAAGAACTTCAAGCACAAGGAACAGATGTATCGGTTGTAAGTGTGCCATC
ATTTGATCTATTTGAACAACAATCAGCTGAATACAAAGAAAGCGTCTTACCAAATGCTGTTAGAAAACGTGTAGCAGTAG
AAATGGGTGCTAGCTTTGGATGGGAACGCTATGTTGGTTTAGACGGAAAAGTTATTGGCATCGACAAATTTGGTGCTTCT
GCTCCAGGTGAAACAGTAATTAAAAATTATGGATTTACAGTTGAAAACGTGGTAAACACAGTGAAATCACTTTAA

Upstream 100 bases:

>100_bases
AATCAATTAAGCAATTTAAAGCAATTATTGGTTGTGTTAATTGCTTTTTAGGCTTATTATTAAAAGTAGTTAAAATTATA
TTTAAGAGAGGATGTTTCAC

Downstream 100 bases:

>100_bases
TTAAACAAACAGACCGCTACTTATTTTTATTAGGGCGGTCTGTTTTTTTTATGCTTTTTTTAGATTGCGCAAGTGGTGCC
TTTAATGTTATAATTACGAG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRDRFVLSAGHGSMLLYSLLHLS
GFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQGIAMAVGMAMAERHLEAKYNKDEFPVVDHYTYALCGDGDL
MEGVASEAASYAGHQQLGRLVLLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILAAKKAYGWDYEEKFFVPEEVTARFKETIGERGEKAEAAWNELFASYKA
KYPELAKQLEDSLNNKLPADWDAELPVYDDSKALASRASSGEVINALAAKIPTIFGGSADLAGSNNTTIKTDGEFTKKTP
AERNIWFGVREFAMGAALNGMALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
SLRAMPGLSVIRPADGNEVVEAWKLAITSTDTPHVLVLTRQGLPTLPNSAKLTAEGVKKGAYVISPAKNEVPEAIILASG
SEVNLAVEAQQELQAQGTDVSVVSVPSFDLFEQQSAEYKESVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGAS
APGETVIKNYGFTVENVVNTVKSL

Sequences:

>Translated_664_residues
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRDRFVLSAGHGSMLLYSLLHLS
GFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQGIAMAVGMAMAERHLEAKYNKDEFPVVDHYTYALCGDGDL
MEGVASEAASYAGHQQLGRLVLLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILAAKKAYGWDYEEKFFVPEEVTARFKETIGERGEKAEAAWNELFASYKA
KYPELAKQLEDSLNNKLPADWDAELPVYDDSKALASRASSGEVINALAAKIPTIFGGSADLAGSNNTTIKTDGEFTKKTP
AERNIWFGVREFAMGAALNGMALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
SLRAMPGLSVIRPADGNEVVEAWKLAITSTDTPHVLVLTRQGLPTLPNSAKLTAEGVKKGAYVISPAKNEVPEAIILASG
SEVNLAVEAQQELQAQGTDVSVVSVPSFDLFEQQSAEYKESVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGAS
APGETVIKNYGFTVENVVNTVKSL
>Mature_664_residues
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRDRFVLSAGHGSMLLYSLLHLS
GFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQGIAMAVGMAMAERHLEAKYNKDEFPVVDHYTYALCGDGDL
MEGVASEAASYAGHQQLGRLVLLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILAAKKAYGWDYEEKFFVPEEVTARFKETIGERGEKAEAAWNELFASYKA
KYPELAKQLEDSLNNKLPADWDAELPVYDDSKALASRASSGEVINALAAKIPTIFGGSADLAGSNNTTIKTDGEFTKKTP
AERNIWFGVREFAMGAALNGMALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
SLRAMPGLSVIRPADGNEVVEAWKLAITSTDTPHVLVLTRQGLPTLPNSAKLTAEGVKKGAYVISPAKNEVPEAIILASG
SEVNLAVEAQQELQAQGTDVSVVSVPSFDLFEQQSAEYKESVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGAS
APGETVIKNYGFTVENVVNTVKSL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=509, Percent_Identity=28.8801571709234, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI4507521, Length=509, Percent_Identity=28.8801571709234, Blast_Score=156, Evalue=6e-38,
Organism=Homo sapiens, GI133778974, Length=578, Percent_Identity=26.2975778546713, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI225637463, Length=434, Percent_Identity=24.1935483870968, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637459, Length=434, Percent_Identity=24.1935483870968, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637461, Length=434, Percent_Identity=24.1935483870968, Blast_Score=95, Evalue=2e-19,
Organism=Escherichia coli, GI48994911, Length=660, Percent_Identity=48.030303030303, Blast_Score=616, Evalue=1e-177,
Organism=Escherichia coli, GI1788808, Length=654, Percent_Identity=46.3302752293578, Blast_Score=592, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17539652, Length=673, Percent_Identity=24.3684992570579, Blast_Score=155, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=664, Percent_Identity=47.5903614457831, Blast_Score=597, Evalue=1e-171,
Organism=Saccharomyces cerevisiae, GI6319593, Length=669, Percent_Identity=46.0388639760837, Blast_Score=577, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24666278, Length=499, Percent_Identity=27.8557114228457, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI45551847, Length=579, Percent_Identity=25.73402417962, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI45550715, Length=579, Percent_Identity=25.73402417962, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645119, Length=550, Percent_Identity=25.4545454545455, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 71954; Mature: 71954

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCC
GIAMAVGMAMAERHLEAKYNKDEFPVVDHYTYALCGDGDLMEGVASEAASYAGHQQLGRL
HHHHHHHHHHHHHHHHHCCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHCCHHHHCCE
VLLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
EEEECCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILAAKKAYGWDYEEKFFVPEEVTARFKETI
EEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHH
GERGEKAEAAWNELFASYKAKYPELAKQLEDSLNNKLPADWDAELPVYDDSKALASRASS
HCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCC
GEVINALAAKIPTIFGGSADLAGSNNTTIKTDGEFTKKTPAERNIWFGVREFAMGAALNG
CHHHHHHHHHCCHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
MALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
EEEECCEEEECCEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAMPGLSVIRPADGNEVVEAWKLAITSTDTPHVLVLTRQGLPTLPNSAKLTAEGVKKG
HHHCCCCCCEECCCCCHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEHHHHCCC
AYVISPAKNEVPEAIILASGSEVNLAVEAQQELQAQGTDVSVVSVPSFDLFEQQSAEYKE
CEEECCCCCCCCCEEEEECCCCEEEEEEEHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
SVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGASAPGETVIKNYGFTVENVVNT
HHCHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHH
VKSL
HHCC
>Mature Secondary Structure
MFDNTDSLAVNTIRTLSMDAIQKANSGHPGLPMGAAPMAYALWSRVLNTNPKNSHWFNRD
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGFKLELEDLKNFRQWESKTPGHPEYRYTDGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCC
GIAMAVGMAMAERHLEAKYNKDEFPVVDHYTYALCGDGDLMEGVASEAASYAGHQQLGRL
HHHHHHHHHHHHHHHHHCCCCCCCCEECCEEEEEECCCHHHHHHHHHHHHHCCHHHHCCE
VLLYDSNDISLDGDLDKSFSENVKQRFEAYGWEHLLVKDGNDTAEILAAIEKAKQNTSQP
EEEECCCCEEECCCCCHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCC
TMIEVKTVIGFGAPNAGTSKVHGAPLGDEGILAAKKAYGWDYEEKFFVPEEVTARFKETI
EEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCCCCCCHHHHHHHHHHH
GERGEKAEAAWNELFASYKAKYPELAKQLEDSLNNKLPADWDAELPVYDDSKALASRASS
HCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCCC
GEVINALAAKIPTIFGGSADLAGSNNTTIKTDGEFTKKTPAERNIWFGVREFAMGAALNG
CHHHHHHHHHCCHHCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCC
MALHGGLQVYGGTFFVFSDYVRAAIRLSAIQHLPVTYVMTHDSIAVGEDGPTHEPIEQLA
EEEECCEEEECCEEEHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHH
SLRAMPGLSVIRPADGNEVVEAWKLAITSTDTPHVLVLTRQGLPTLPNSAKLTAEGVKKG
HHHCCCCCCEECCCCCHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCEEEHHHHCCC
AYVISPAKNEVPEAIILASGSEVNLAVEAQQELQAQGTDVSVVSVPSFDLFEQQSAEYKE
CEEECCCCCCCCCEEEEECCCCEEEEEEEHHHHHHCCCCEEEEECCCHHHHHHHHHHHHH
SVLPNAVRKRVAVEMGASFGWERYVGLDGKVIGIDKFGASAPGETVIKNYGFTVENVVNT
HHCHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEECCCCCCCCHHHHHHCCCCHHHHHHH
VKSL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9384377; 9068642 [H]