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The map label for this gene is treR [H]

Identifier: 116872688

GI number: 116872688

Start: 1261749

End: 1262462

Strand: Direct

Name: treR [H]

Synonym: lwe1272

Alternate gene names: 116872688

Gene position: 1261749-1262462 (Clockwise)

Preceding gene: 116872683

Following gene: 116872691

Centisome position: 44.84

GC content: 35.29

Gene sequence:

>714_bases
TTGAATAAGAAAAATAAATTTTTTGACATATATTTAGAATTAGAGCAAGATATTACATCAGGCGTTTATCCAGCAGGCAC
ACTACTTCCAAGTGAAAATGTCCTGGCCAAGCGTTTTTCGGTATCCCGTGAAACCATTAGAAAAGCACTTGTCTTGTTAC
TTGAGAATGGCTGTATTCAAAAACTCCAAGGAAAAGGTTCTATTGTCATTGATCGTGAACGTTATTCGTTTCCTGTTTCA
GGTTTGACGAGTTTTAAAGAGTTGCAAAAATCGGAACATATGAATGCTACAACAAAAGTTATTAGAAATGAACAAACTAT
ATTACCAAATCGGATTGCTGATTTCGCTGGTCTGCCACATGGTTCGAGCTGTTTAGCAATTCTTAGAGTGCGTTATTTAG
AAGGCGAGGCTACAATTTTAGATTATGATTATTTACTCGACAAGACAGAGCCAATTGCAAATGAGGTTTTAGAGGACTCT
CTATATCAATACTTAGAAAATGAAAAGAATTATGAAATTAGCTATGCTCAAAAAGAAATAACGGTTGAGCCGCTGAACGC
AGAAGATAAAAAATACTTAGCACTACACGGAGATACACATGTTGTGGTTGTAAAAAGTACCGTATTCTTAAAAGATACAA
CACTTTTTCAATACACAGAATCGCGACATCGTCTTGATAAATTCCGCTTTATTGATTTTGCTAGAAGACGCTAA

Upstream 100 bases:

>100_bases
ATAGTGTAACAAATTTTACAAGATTTTGGTAATAAAGTGAGTTAATAATTTCGGTTACAATTACGTGTAAATGTGCTACA
ATAACGGTGGGTGAGTAAAT

Downstream 100 bases:

>100_bases
AAAGCCCGAGATACAAATCTCGAGCTTTTTTTTATTGTATTAACGTCAATGTTTCATAGGGAGCTAATTCGATTTCAGAA
CTAATTTCTGTACGCTCATG

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQKLQGKGSIVIDRERYSFPVS
GLTSFKELQKSEHMNATTKVIRNEQTILPNRIADFAGLPHGSSCLAILRVRYLEGEATILDYDYLLDKTEPIANEVLEDS
LYQYLENEKNYEISYAQKEITVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR

Sequences:

>Translated_237_residues
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQKLQGKGSIVIDRERYSFPVS
GLTSFKELQKSEHMNATTKVIRNEQTILPNRIADFAGLPHGSSCLAILRVRYLEGEATILDYDYLLDKTEPIANEVLEDS
LYQYLENEKNYEISYAQKEITVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR
>Mature_237_residues
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQKLQGKGSIVIDRERYSFPVS
GLTSFKELQKSEHMNATTKVIRNEQTILPNRIADFAGLPHGSSCLAILRVRYLEGEATILDYDYLLDKTEPIANEVLEDS
LYQYLENEKNYEISYAQKEITVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR

Specific function: Repressor for the trehalose operon (treP and treA). Binds trehalose-6-phosphate, which probably acts as an inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=238, Percent_Identity=25.2100840336134, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082252, Length=181, Percent_Identity=28.7292817679558, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790540, Length=229, Percent_Identity=24.8908296943231, Blast_Score=70, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000524
- InterPro:   IPR012770
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27351; Mature: 27351

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQ
CCCCCCEEEEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KLQGKGSIVIDRERYSFPVSGLTSFKELQKSEHMNATTKVIRNEQTILPNRIADFAGLPH
HHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHCCCCC
GSSCLAILRVRYLEGEATILDYDYLLDKTEPIANEVLEDSLYQYLENEKNYEISYAQKEI
CHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECEEE
TVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR
EEECCCCCCCEEEEEECCEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKKNKFFDIYLELEQDITSGVYPAGTLLPSENVLAKRFSVSRETIRKALVLLLENGCIQ
CCCCCCEEEEEEEEEHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHH
KLQGKGSIVIDRERYSFPVSGLTSFKELQKSEHMNATTKVIRNEQTILPNRIADFAGLPH
HHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHCCCCC
GSSCLAILRVRYLEGEATILDYDYLLDKTEPIANEVLEDSLYQYLENEKNYEISYAQKEI
CHHHHHHHHHHHCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECEEE
TVEPLNAEDKKYLALHGDTHVVVVKSTVFLKDTTLFQYTESRHRLDKFRFIDFARRR
EEECCCCCCCEEEEEECCEEEEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8917076; 8969503; 9384377; 7651129; 8755887 [H]