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The map label for this gene is mutS2 [H]

Identifier: 116872603

GI number: 116872603

Start: 1197926

End: 1200283

Strand: Direct

Name: mutS2 [H]

Synonym: lwe1187

Alternate gene names: 116872603

Gene position: 1197926-1200283 (Clockwise)

Preceding gene: 116872602

Following gene: 116872604

Centisome position: 42.57

GC content: 38.59

Gene sequence:

>2358_bases
ATGGAAAAAAAAGTAGAAGCCATATTAGAATTTGATAAAATAAAAAAACAGCTTACCGAATTTGCTTCTTCTTCACTAGG
GGAGCAAGCTATTTTGGAACTCGCTCCAGCTACAAATTTTCAAGTCGTACAAAAATCACAACTTGAAACCGAAGAAGGAG
CCAAAATTATTCGTTTACGAGGAAGTGCGCCAATTACTGGTTTAACAGATGTTTTTGCCCATTTAAAGCGTCTGGAAATT
GGTGGCGATTTAAACGGTCTGGAAATCTATCAAATTGGTAGCAACTTACGAGTAAGTCGCCAAATGAAAAATTTTATGAC
TGATTTACTAGAAATGGGTGTCGAATTACCATTACTCGGCGCGCTTTCTGATGAACTTTTGGTATTAAAAGAAGTAGAAG
AAGATATTGCCATTTCTGTAGATGAAAGTGGGAAAATATTAGATACAGCAAGTGAGGCGCTAAGCACGATTCGCCGGACA
CTTCGCCGCACGGAAGATCGTGTCCGTGAAAAACTCGAATCTTATTTACGGGATCGAAATGCTTCCAAAATGTTAAGTGA
TGCTGTTATTACAATTCGAAATGATCGTTATGTCATTCCTGTTAAGCAAGAATATAAAGGGCATTATGGCGGGATTGTTC
ACGACCAGTCTGCTTCTGGACAAACCTTGTTCATTGAGCCGCAAAGTGTAGTTGATCTAAATAATGAACGAAAGGCTTTG
CAAGCAAAAGAAAAGCAAGAAATCGAACGAATTCTTGCTGAAATATCAGCATCTTTAGCCGGATGGATTAACGAAATTCA
TCACAATACTTTTATTTTAGGTCGCTATGATTTTATTTTTGCAAAAGCACGTTTTGGTAAAGCAATGAAAGCAGTAACAC
CACATTTAAGTGATGCAGGTATTGTTCATTTAATAGCAGCAAGACATCCGCTCTTAGATGCAGCTAATGTAGTTGCCAAC
GATATTTATTTAGGTGAAGATTTTACTACAATTGTAATCACAGGACCAAATACTGGCGGTAAAACAATAACCTTAAAAAC
ATTAGGACTATTAACATTGATGGCACAATCAGGTTTGCAAATTCCAGCGCAAGAAGATTCTACTATCGCTGTGTTTGAGC
ATGTATTTGCTGATATTGGAGACGAACAATCGATTGAACAAAGCTTGAGCACATTCTCCTCCCATATGACAAACATTGTT
TCCATTTTAGAAAAAGTGAACCATAAGTCGCTTATTTTATATGATGAACTCGGGGCAGGAACAGATCCACAAGAAGGAGC
AGCACTAGCAATTGCAATTCTTGATGCAAGTCATGAAAAAGGCGCAAGTGTTGTTGCAACAACCCATTATCCTGAACTAA
AAGCATATGGCTATAACCGTGTTCATGCAACGAATGCTTCTGTGGAATTTAATGTGGAAACCCTTAGCCCAACGTATAAA
TTACTAATTGGTGTTCCCGGTCGAAGTAATGCTTTTGATATATCGCGCCGTCTCGGTTTAAGTGAAAACATTATTACAGA
AGCAAGAAGCCTTGTAGATACCGAAAGTGCTGATTTAAATGACATGATTTCGAGCTTAGAAGAAAAACGAAATCTAGCAG
AAACGGAATATGAAGAAGCACGGGAACTAGCTCGCGGGGCTGATGCTCTTTTAAAAGATTTACAAAAAGAAATAACGAAT
TACTATCAACAAAAAGATAAATTAATGGAACAAGCAAGGGAGAAAGCTGCAAACATTGTCACAAAAGCAGAAGTAGAAGC
CGAAGAAATTATCCACGAATTGCGCACAATGCAATTAAACGGAGCAGCAGGGATCAAAGAACATGAGCTTATCGATGCAA
AAACAAGACTAGGAAAAGCAAAACCGAAAACAATCAACAAAACCATTCCGCAAGCACCAAAACAAAAACCACATGTCTTC
CAAGTTGGCGACAATGTTCGAGTTTTATCCCTAGGACAAAAAGGAACACTTTTAAACAAAATTAGTGATAAAGAGTGGAA
CGTTCAAATCGGTATTATCAAAATGAAAATCAAGACTACTGATTTAGAATACATTCAACCTGAAACACCCAAAAAACAAC
GCATCATCACATCTGTTCATAGTAGTGACTCACCAGTAAAAAGTGAACTCGATTTGCGCGGTGAACGTTATGAAGACGCT
TTGCAAAAAGTGGATAAATACCTTGATGAAGCCTTGCTTGCAGGATATCCACAAGTAGCCATCATTCACGGTAAAGGAAC
TGGCGCACTGAGAACAGGTGTCACCGAGTATCTGAAAAATCATCGCATGGTTAAATCCATCCGTTTCGGAGCAGCGGCAG
AAGGCGGAAACGGTGTGACGATTGTCGAGTTCAAGTAA

Upstream 100 bases:

>100_bases
AAAGCTTGGTTAGATAAATCCGCAATCCTGAATACAAAATCAGCAAAAGAATTTCAACAATTTATACAGAATAAATAACT
TTTAAAAAGAAGGATGACTC

Downstream 100 bases:

>100_bases
ACAACTGAGCAAAAACATGGCTCCAAATAGGTCTAGGTGCTATACTGTGTGTACAAAAGTCATAAGGAGTGAAATAAATC
ATGGTAAAAGAAATTACAGA

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATNFQVVQKSQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEI
GGDLNGLEIYQIGSNLRVSRQMKNFMTDLLEMGVELPLLGALSDELLVLKEVEEDIAISVDESGKILDTASEALSTIRRT
LRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
QAKEKQEIERILAEISASLAGWINEIHHNTFILGRYDFIFAKARFGKAMKAVTPHLSDAGIVHLIAARHPLLDAANVVAN
DIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIV
SILEKVNHKSLILYDELGAGTDPQEGAALAIAILDASHEKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADALLKDLQKEITN
YYQQKDKLMEQAREKAANIVTKAEVEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGKAKPKTINKTIPQAPKQKPHVF
QVGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPETPKKQRIITSVHSSDSPVKSELDLRGERYEDA
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK

Sequences:

>Translated_785_residues
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATNFQVVQKSQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEI
GGDLNGLEIYQIGSNLRVSRQMKNFMTDLLEMGVELPLLGALSDELLVLKEVEEDIAISVDESGKILDTASEALSTIRRT
LRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
QAKEKQEIERILAEISASLAGWINEIHHNTFILGRYDFIFAKARFGKAMKAVTPHLSDAGIVHLIAARHPLLDAANVVAN
DIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIV
SILEKVNHKSLILYDELGAGTDPQEGAALAIAILDASHEKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADALLKDLQKEITN
YYQQKDKLMEQAREKAANIVTKAEVEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGKAKPKTINKTIPQAPKQKPHVF
QVGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPETPKKQRIITSVHSSDSPVKSELDLRGERYEDA
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK
>Mature_785_residues
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATNFQVVQKSQLETEEGAKIIRLRGSAPITGLTDVFAHLKRLEI
GGDLNGLEIYQIGSNLRVSRQMKNFMTDLLEMGVELPLLGALSDELLVLKEVEEDIAISVDESGKILDTASEALSTIRRT
LRRTEDRVREKLESYLRDRNASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
QAKEKQEIERILAEISASLAGWINEIHHNTFILGRYDFIFAKARFGKAMKAVTPHLSDAGIVHLIAARHPLLDAANVVAN
DIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQIPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIV
SILEKVNHKSLILYDELGAGTDPQEGAALAIAILDASHEKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEARELARGADALLKDLQKEITN
YYQQKDKLMEQAREKAANIVTKAEVEAEEIIHELRTMQLNGAAGIKEHELIDAKTRLGKAKPKTINKTIPQAPKQKPHVF
QVGDNVRVLSLGQKGTLLNKISDKEWNVQIGIIKMKIKTTDLEYIQPETPKKQRIITSVHSSDSPVKSELDLRGERYEDA
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVTIVEFK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=237, Percent_Identity=31.2236286919831, Blast_Score=107, Evalue=6e-23,
Organism=Homo sapiens, GI36949366, Length=227, Percent_Identity=32.15859030837, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI4557761, Length=245, Percent_Identity=30.2040816326531, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI4504191, Length=227, Percent_Identity=29.5154185022026, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI26638666, Length=174, Percent_Identity=33.9080459770115, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI4505253, Length=174, Percent_Identity=33.9080459770115, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI26638664, Length=177, Percent_Identity=35.0282485875706, Blast_Score=80, Evalue=9e-15,
Organism=Homo sapiens, GI262231786, Length=177, Percent_Identity=35.0282485875706, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1789089, Length=330, Percent_Identity=26.6666666666667, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=361, Percent_Identity=24.0997229916898, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17534743, Length=258, Percent_Identity=26.3565891472868, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=172, Percent_Identity=25, Blast_Score=72, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508447, Length=303, Percent_Identity=22.7722772277228, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319935, Length=386, Percent_Identity=28.2383419689119, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324482, Length=360, Percent_Identity=26.6666666666667, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6321912, Length=323, Percent_Identity=24.1486068111455, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6321109, Length=150, Percent_Identity=32, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320302, Length=246, Percent_Identity=28.0487804878049, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320047, Length=284, Percent_Identity=26.4084507042254, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24664545, Length=241, Percent_Identity=28.2157676348548, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24584320, Length=243, Percent_Identity=26.7489711934156, Blast_Score=92, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86843; Mature: 86843

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATNFQVVQKSQLETEEGAKIIRLR
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEE
GSAPITGLTDVFAHLKRLEIGGDLNGLEIYQIGSNLRVSRQMKNFMTDLLEMGVELPLLG
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
ALSDELLVLKEVEEDIAISVDESGKILDTASEALSTIRRTLRRTEDRVREKLESYLRDRN
CCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
HHHHHHCCEEEEECCEEEEECHHHCCCCCCCEEECCCCCCCEEEECCHHHCCCCCHHHHH
QAKEKQEIERILAEISASLAGWINEIHHNTFILGRYDFIFAKARFGKAMKAVTPHLSDAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHEEEHHHHHHHHHHHCCCCCCCC
IVHLIAARHPLLDAANVVANDIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQ
HHHHHHHCCCCHHHHHHHHHHEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCC
IPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIVSILEKVNHKSLILYDELGAG
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
TDPQEGAALAIAILDASHEKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
CCCCCCCEEEEEEEECCCCCCCEEEEEECCCCHHHCCCCEEEECCCEEEEEEEECCCCEE
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEA
EEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RELARGADALLKDLQKEITNYYQQKDKLMEQAREKAANIVTKAEVEAEEIIHELRTMQLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEC
GAAGIKEHELIDAKTRLGKAKPKTINKTIPQAPKQKPHVFQVGDNVRVLSLGQKGTLLNK
CCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCEEEECCCEEEEEECCCCCHHHH
ISDKEWNVQIGIIKMKIKTTDLEYIQPETPKKQRIITSVHSSDSPVKSELDLRGERYEDA
CCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCHHHHHH
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVT
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEE
IVEFK
EEEEC
>Mature Secondary Structure
MEKKVEAILEFDKIKKQLTEFASSSLGEQAILELAPATNFQVVQKSQLETEEGAKIIRLR
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEE
GSAPITGLTDVFAHLKRLEIGGDLNGLEIYQIGSNLRVSRQMKNFMTDLLEMGVELPLLG
CCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCHH
ALSDELLVLKEVEEDIAISVDESGKILDTASEALSTIRRTLRRTEDRVREKLESYLRDRN
CCCCHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ASKMLSDAVITIRNDRYVIPVKQEYKGHYGGIVHDQSASGQTLFIEPQSVVDLNNERKAL
HHHHHHCCEEEEECCEEEEECHHHCCCCCCCEEECCCCCCCEEEECCHHHCCCCCHHHHH
QAKEKQEIERILAEISASLAGWINEIHHNTFILGRYDFIFAKARFGKAMKAVTPHLSDAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHEEEHHHHHHHHHHHCCCCCCCC
IVHLIAARHPLLDAANVVANDIYLGEDFTTIVITGPNTGGKTITLKTLGLLTLMAQSGLQ
HHHHHHHCCCCHHHHHHHHHHEEECCCCEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCC
IPAQEDSTIAVFEHVFADIGDEQSIEQSLSTFSSHMTNIVSILEKVNHKSLILYDELGAG
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCC
TDPQEGAALAIAILDASHEKGASVVATTHYPELKAYGYNRVHATNASVEFNVETLSPTYK
CCCCCCCEEEEEEEECCCCCCCEEEEEECCCCHHHCCCCEEEECCCEEEEEEEECCCCEE
LLIGVPGRSNAFDISRRLGLSENIITEARSLVDTESADLNDMISSLEEKRNLAETEYEEA
EEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RELARGADALLKDLQKEITNYYQQKDKLMEQAREKAANIVTKAEVEAEEIIHELRTMQLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEC
GAAGIKEHELIDAKTRLGKAKPKTINKTIPQAPKQKPHVFQVGDNVRVLSLGQKGTLLNK
CCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCEEEECCCEEEEEECCCCCHHHH
ISDKEWNVQIGIIKMKIKTTDLEYIQPETPKKQRIITSVHSSDSPVKSELDLRGERYEDA
CCCCCCEEEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHCCCHHHHHH
LQKVDKYLDEALLAGYPQVAIIHGKGTGALRTGVTEYLKNHRMVKSIRFGAAAEGGNGVT
HHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEE
IVEFK
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]