Click here to switch to the map view.

The map label for this gene is ung2 [H]

Identifier: 116872598

GI number: 116872598

Start: 1193501

End: 1194175

Strand: Direct

Name: ung2 [H]

Synonym: lwe1182

Alternate gene names: 116872598

Gene position: 1193501-1194175 (Clockwise)

Preceding gene: 116872597

Following gene: 116872600

Centisome position: 42.41

GC content: 36.0

Gene sequence:

>675_bases
ATGATCAAACTCGAAAATGACTGGGATGAGTTACTAAAAGATGAGTTTAACCAATCTTATTATTTAAAACTTCGCCAGTT
CCTAAAAATAGAATACCAAACCAAAAAAGTCTTTCCAGATATGTATGATATTTTTAATGCCTTAAAACACACTGCATATA
AAGATGTAAAAGTAGTTATCCTTGGTCAAGATCCATATCACGGACCAGGGCAAGCACACGGACTCTCTTTTTCAGTACAA
AAAGGAGTGCCAATTCCACCCTCGTTACAAAATATTTATACTGAATTACATCAGGATTTAAATTGTGAGATTCCAAACAA
CGGCTACTTAATACCTTGGGCAGAACAAGGCGTACTTTTGTTAAACACGGTACTAACCGTTCGTGCAGGTCAGGCCAATT
CTCACCGTGGTCAAGGATGGGAAACGTTAACCACACGTATCATCGAAATGATTAACCAAAAAGAAGAGCCAGTAGTTTTT
TTGCTTTGGGGGAATAATGCAAAAGAGAAATTACCATTATTAACTAATCCAAAACATATTGCATTCACTTCCGTTCATCC
TAGCCCGCTATCCGCTTCACATGGTTTTATGGGATGTAAACATTTTTCTAAAACAAATCAATTTTTAGCGCAAAATGGTA
TCAAACCAATTGATTGGCAAATTCCTTCTATATAA

Upstream 100 bases:

>100_bases
GAACCGCATTCCTACATAGGGAGTGCGGTTTTTAGTTTAATTTAAAATACTAATTTGCTAAGATATATGTAGAGAGAAGC
AAAAAAGGAGATGGAATCAG

Downstream 100 bases:

>100_bases
TTAATAGCGCCTCGTCTTTAGTTGACGGGGCGCTTTTTCATTTTTTAGCAATTTTCAGGGCTTTTTCTGTATTAGCAAAA
TGCTGTTTGGTATATTTAGC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG 2 [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIKLENDWDELLKDEFNQSYYLKLRQFLKIEYQTKKVFPDMYDIFNALKHTAYKDVKVVILGQDPYHGPGQAHGLSFSVQ
KGVPIPPSLQNIYTELHQDLNCEIPNNGYLIPWAEQGVLLLNTVLTVRAGQANSHRGQGWETLTTRIIEMINQKEEPVVF
LLWGNNAKEKLPLLTNPKHIAFTSVHPSPLSASHGFMGCKHFSKTNQFLAQNGIKPIDWQIPSI

Sequences:

>Translated_224_residues
MIKLENDWDELLKDEFNQSYYLKLRQFLKIEYQTKKVFPDMYDIFNALKHTAYKDVKVVILGQDPYHGPGQAHGLSFSVQ
KGVPIPPSLQNIYTELHQDLNCEIPNNGYLIPWAEQGVLLLNTVLTVRAGQANSHRGQGWETLTTRIIEMINQKEEPVVF
LLWGNNAKEKLPLLTNPKHIAFTSVHPSPLSASHGFMGCKHFSKTNQFLAQNGIKPIDWQIPSI
>Mature_224_residues
MIKLENDWDELLKDEFNQSYYLKLRQFLKIEYQTKKVFPDMYDIFNALKHTAYKDVKVVILGQDPYHGPGQAHGLSFSVQ
KGVPIPPSLQNIYTELHQDLNCEIPNNGYLIPWAEQGVLLLNTVLTVRAGQANSHRGQGWETLTTRIIEMINQKEEPVVF
LLWGNNAKEKLPLLTNPKHIAFTSVHPSPLSASHGFMGCKHFSKTNQFLAQNGIKPIDWQIPSI

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=220, Percent_Identity=50, Blast_Score=224, Evalue=6e-59,
Organism=Homo sapiens, GI6224979, Length=220, Percent_Identity=50, Blast_Score=223, Evalue=9e-59,
Organism=Escherichia coli, GI1788934, Length=217, Percent_Identity=54.3778801843318, Blast_Score=236, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=48.6111111111111, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6323620, Length=235, Percent_Identity=46.8085106382979, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25580; Mature: 25580

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLENDWDELLKDEFNQSYYLKLRQFLKIEYQTKKVFPDMYDIFNALKHTAYKDVKVVI
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEE
LGQDPYHGPGQAHGLSFSVQKGVPIPPSLQNIYTELHQDLNCEIPNNGYLIPWAEQGVLL
ECCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCEECCCCEEEEECCCCEEE
LNTVLTVRAGQANSHRGQGWETLTTRIIEMINQKEEPVVFLLWGNNAKEKLPLLTNPKHI
EEHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEE
AFTSVHPSPLSASHGFMGCKHFSKTNQFLAQNGIKPIDWQIPSI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure
MIKLENDWDELLKDEFNQSYYLKLRQFLKIEYQTKKVFPDMYDIFNALKHTAYKDVKVVI
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEE
LGQDPYHGPGQAHGLSFSVQKGVPIPPSLQNIYTELHQDLNCEIPNNGYLIPWAEQGVLL
ECCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCCEECCCCEEEEECCCCEEE
LNTVLTVRAGQANSHRGQGWETLTTRIIEMINQKEEPVVFLLWGNNAKEKLPLLTNPKHI
EEHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEE
AFTSVHPSPLSASHGFMGCKHFSKTNQFLAQNGIKPIDWQIPSI
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]