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The map label for this gene is nhaK [H]

Identifier: 116872181

GI number: 116872181

Start: 788110

End: 790158

Strand: Direct

Name: nhaK [H]

Synonym: lwe0761

Alternate gene names: 116872181

Gene position: 788110-790158 (Clockwise)

Preceding gene: 116872180

Following gene: 116872182

Centisome position: 28.01

GC content: 37.77

Gene sequence:

>2049_bases
TTGGAGATATTTTTATATGTTTTAGCATTACTTGTTGCCATTTTTATTTCTAACTTACTAAATCGATTTGTTCCCTTTGT
TTCGGTGCCACTGATTCAAATTGGGTTAGGCGTATTCATCGCTGTTATGCCAATTACGTTTGATTTAAAATTAAATCCAG
AACTTTTTCTAGTGATGTTTATTGCACCACTTTTATTTAATGATGGAAAAAGGACGGATAAGACTGCGCTCTGGGGAATG
CGGATGCCGATTTTGGTGCTCGCGCTTGGACTTGTGTTTGCGACAGTAGTTGTGATTGGCTATTTTGTTCACTGGATGAT
TCCGACTATTCCACTTGCGGCGGCTTTTGCGCTTGCAGCAGCACTTGCGCCAACTGATGCAGTGGCAGTGAGTTCTCTTT
CAGGACGAATAAATTTGCCGAAACGTATTATGAATTTGCTTGAAGGAGAGGCCTTGATTAATGATGCATCTGGTTTGGTT
GCTTTCCAATTTGCGATTGCAGCAATGGTTACGGGTGTTTTTAGTTTAGTAGATGCTAGTATTAGCTTTTTTGTAATTGC
TATTGGCGGTATTTTAGTCGGAATGATTCTTAGCTGGTTAAAATTCAGACTGTTAAAATGGGTGCGCGGGTTAGGTATGG
AAGATGTAACTTTTCATATGTTAATCCAAATTTTAACCCCATTTATTATTTATTTAGTTGCCGAGGAACTTCATGTTTCC
GGAATTTTGGCAGTAGTGGCGGCAGGAATAATGCATTCTATGGAACAAAAGAAAATGGATCCACAATTAGTTAAATTAAA
TGTAGTTTCACAAAGTACTTGGTCAGTCATTATTTTCGTTTTGAATGGTTTGGTATTTTTACTACTAGGGACACAATTGC
CTTCTATTACCGAGGTGGTTTGGTATGATTCGGGTAGCAGTAATTTACAAGTCATTGCTTATATTTTATCAATTACGGCC
GCGCTTATTATACTGCGTTTTCTATGGGTATACATATCGTGGAGTATTGGCGCAAAACAACGTCAGAAACAAAATAAAAA
AACGCAATTACCACAACTCAGACCTGTTATGTTAACGTCCCTTTCTGGTGTGCGAGGTGCGGTGACACTTGCCAGTGCGC
TTGCAATCCCGTTTTACCTAGATGATGGGACGCTGTTTCCACAACGCTCACTAATTATTTTTATTGCTTCAGGTGTTATT
CTTTGCACCTTAGTCATTGCGACATTCATTCTTCCTCTACTAGCAAAAAGCGAAGAAGTCACAACAGCGGATGAACGCGC
AGAAATGGCGACGCGGATTCGAATTCTAAGAAATGTTATTAGAGAATTAAAAGAACAGACTTTACCAGAAACAAAGGCAG
CAACAGATGAAGTCATTGAGGACTACCGAAAACGAATTTATGATTTACAGCAAAATAGTAATTCTAGTCGCGGGATGGAT
GAAAGAGAACGTGAAAAACGTTTAGAAATTATCCAGTGGGAACGTGACAACACGCAAAAAATGACAGATGAAGGTCGCAT
CGTGGCTACAGACAGCTACCGTTATCAGCACTATCTTAATATGAGAGAGCAGGCAATTAAACAACGCTTTCGGACAAAAG
TTAAAACCGCATGGATGTTTTTTTATCGTTTACTTATGCTTGTTCTTCATCCAAAAAAATGGGGTAGAGTAACCAATAAA
ATGAAAAAAGGTATTTCTAAGGATAGCGAACGTTTTCAAGCAATCCGCAAATTAAGAGAAGAAAACGAAATACTCGTTAT
TCAAAAGCTCAAAGAACAATTAACAAAAGAAAATGCTGATATTATCGGATCACTTATAACAGAACATACTATTTTTCTAG
AACGTGTTAGAAAAGAACATGGTCCACGAGGAAAACGTGCCAAATTCGAACAGAAAAAAAGAGAAGTACAAGTGATCGCA
TTCCAACTAGAACGAGATATTATTCAAAAAATGTTTGAAACAGGCGGGATTTCAAGAGATTTAGCTAGAGATTTGCGCCA
GAATTTAAATATGATTGAAACGTATTTAGATGCTGATTTTTTAGATTGA

Upstream 100 bases:

>100_bases
AACCAAGTGTTTGCAAAGAAATGAAGCTGTTTTATATTTGCGAGATAGTTTATTTTGCTTCATAATAATATAAGAGAAAA
AGGAAAGGGGACTATACATA

Downstream 100 bases:

>100_bases
AATTGAACTATAAAAAGCCACCAAGATCATCATTTATTCTTGGCGGCTTTTATACTTTTTTAATGTGTAGAAAGCTTCTT
TTTCTTTGTTACAAGACAAT

Product: Na+/H+ antiporter, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 682; Mature: 682

Protein sequence:

>682_residues
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVFIAVMPITFDLKLNPELFLVMFIAPLLFNDGKRTDKTALWGM
RMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAAALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLV
AFQFAIAAMVTGVFSLVDASISFFVIAIGGILVGMILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLVAEELHVS
GILAVVAAGIMHSMEQKKMDPQLVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPSITEVVWYDSGSSNLQVIAYILSITA
ALIILRFLWVYISWSIGAKQRQKQNKKTQLPQLRPVMLTSLSGVRGAVTLASALAIPFYLDDGTLFPQRSLIIFIASGVI
LCTLVIATFILPLLAKSEEVTTADERAEMATRIRILRNVIRELKEQTLPETKAATDEVIEDYRKRIYDLQQNSNSSRGMD
EREREKRLEIIQWERDNTQKMTDEGRIVATDSYRYQHYLNMREQAIKQRFRTKVKTAWMFFYRLLMLVLHPKKWGRVTNK
MKKGISKDSERFQAIRKLREENEILVIQKLKEQLTKENADIIGSLITEHTIFLERVRKEHGPRGKRAKFEQKKREVQVIA
FQLERDIIQKMFETGGISRDLARDLRQNLNMIETYLDADFLD

Sequences:

>Translated_682_residues
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVFIAVMPITFDLKLNPELFLVMFIAPLLFNDGKRTDKTALWGM
RMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAAALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLV
AFQFAIAAMVTGVFSLVDASISFFVIAIGGILVGMILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLVAEELHVS
GILAVVAAGIMHSMEQKKMDPQLVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPSITEVVWYDSGSSNLQVIAYILSITA
ALIILRFLWVYISWSIGAKQRQKQNKKTQLPQLRPVMLTSLSGVRGAVTLASALAIPFYLDDGTLFPQRSLIIFIASGVI
LCTLVIATFILPLLAKSEEVTTADERAEMATRIRILRNVIRELKEQTLPETKAATDEVIEDYRKRIYDLQQNSNSSRGMD
EREREKRLEIIQWERDNTQKMTDEGRIVATDSYRYQHYLNMREQAIKQRFRTKVKTAWMFFYRLLMLVLHPKKWGRVTNK
MKKGISKDSERFQAIRKLREENEILVIQKLKEQLTKENADIIGSLITEHTIFLERVRKEHGPRGKRAKFEQKKREVQVIA
FQLERDIIQKMFETGGISRDLARDLRQNLNMIETYLDADFLD
>Mature_682_residues
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVFIAVMPITFDLKLNPELFLVMFIAPLLFNDGKRTDKTALWGM
RMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAAALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLV
AFQFAIAAMVTGVFSLVDASISFFVIAIGGILVGMILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLVAEELHVS
GILAVVAAGIMHSMEQKKMDPQLVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPSITEVVWYDSGSSNLQVIAYILSITA
ALIILRFLWVYISWSIGAKQRQKQNKKTQLPQLRPVMLTSLSGVRGAVTLASALAIPFYLDDGTLFPQRSLIIFIASGVI
LCTLVIATFILPLLAKSEEVTTADERAEMATRIRILRNVIRELKEQTLPETKAATDEVIEDYRKRIYDLQQNSNSSRGMD
EREREKRLEIIQWERDNTQKMTDEGRIVATDSYRYQHYLNMREQAIKQRFRTKVKTAWMFFYRLLMLVLHPKKWGRVTNK
MKKGISKDSERFQAIRKLREENEILVIQKLKEQLTKENADIIGSLITEHTIFLERVRKEHGPRGKRAKFEQKKREVQVIA
FQLERDIIQKMFETGGISRDLARDLRQNLNMIETYLDADFLD

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239733, Length=397, Percent_Identity=22.4181360201511, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790501, Length=543, Percent_Identity=37.0165745856354, Blast_Score=300, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI25150332, Length=383, Percent_Identity=25.5874673629243, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980847, Length=358, Percent_Identity=22.0670391061453, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987559, Length=267, Percent_Identity=25.0936329588015, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987545, Length=273, Percent_Identity=24.5421245421245, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=352, Percent_Identity=22.7272727272727, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 77454; Mature: 77454

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVFIAVMPITFDLKLNPELFLVMF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IAPLLFNDGKRTDKTALWGMRMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLVAFQFAIAAMVTGVFSLVDAS
HHCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ISFFVIAIGGILVGMILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLVAEELHVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GILAVVAAGIMHSMEQKKMDPQLVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPSITEVV
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEE
WYDSGSSNLQVIAYILSITAALIILRFLWVYISWSIGAKQRQKQNKKTQLPQLRPVMLTS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHH
LSGVRGAVTLASALAIPFYLDDGTLFPQRSLIIFIASGVILCTLVIATFILPLLAKSEEV
HCCHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TTADERAEMATRIRILRNVIRELKEQTLPETKAATDEVIEDYRKRIYDLQQNSNSSRGMD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EREREKRLEIIQWERDNTQKMTDEGRIVATDSYRYQHYLNMREQAIKQRFRTKVKTAWMF
HHHHHHHHHHHEECCCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYRLLMLVLHPKKWGRVTNKMKKGISKDSERFQAIRKLREENEILVIQKLKEQLTKENAD
HHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCHH
IIGSLITEHTIFLERVRKEHGPRGKRAKFEQKKREVQVIAFQLERDIIQKMFETGGISRD
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LARDLRQNLNMIETYLDADFLD
HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEIFLYVLALLVAIFISNLLNRFVPFVSVPLIQIGLGVFIAVMPITFDLKLNPELFLVMF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHH
IAPLLFNDGKRTDKTALWGMRMPILVLALGLVFATVVVIGYFVHWMIPTIPLAAAFALAA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPTDAVAVSSLSGRINLPKRIMNLLEGEALINDASGLVAFQFAIAAMVTGVFSLVDAS
HHCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ISFFVIAIGGILVGMILSWLKFRLLKWVRGLGMEDVTFHMLIQILTPFIIYLVAEELHVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GILAVVAAGIMHSMEQKKMDPQLVKLNVVSQSTWSVIIFVLNGLVFLLLGTQLPSITEVV
HHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHEE
WYDSGSSNLQVIAYILSITAALIILRFLWVYISWSIGAKQRQKQNKKTQLPQLRPVMLTS
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHH
LSGVRGAVTLASALAIPFYLDDGTLFPQRSLIIFIASGVILCTLVIATFILPLLAKSEEV
HCCHHHHHHHHHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TTADERAEMATRIRILRNVIRELKEQTLPETKAATDEVIEDYRKRIYDLQQNSNSSRGMD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
EREREKRLEIIQWERDNTQKMTDEGRIVATDSYRYQHYLNMREQAIKQRFRTKVKTAWMF
HHHHHHHHHHHEECCCCCHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FYRLLMLVLHPKKWGRVTNKMKKGISKDSERFQAIRKLREENEILVIQKLKEQLTKENAD
HHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCHH
IIGSLITEHTIFLERVRKEHGPRGKRAKFEQKKREVQVIAFQLERDIIQKMFETGGISRD
HHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
LARDLRQNLNMIETYLDADFLD
HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]