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The map label for this gene is pphA [H]

Identifier: 116872043

GI number: 116872043

Start: 660852

End: 661559

Strand: Direct

Name: pphA [H]

Synonym: lwe0623

Alternate gene names: 116872043

Gene position: 660852-661559 (Clockwise)

Preceding gene: 116872042

Following gene: 116872045

Centisome position: 23.48

GC content: 38.42

Gene sequence:

>708_bases
ATGAAACCGATTTTTGCTGTAGGAGATGTACACGGAGAAATTACACTGTTGGATGAGTTGCTGGAAAACTGGAATAGAGA
GCGAGAACGCCTTTTATTTGTAGGCGATTTAATTGACCGCGGGGAAAATCCAGCAGCAGTCCTTAGACGAGTGAAAGAGT
TATCCGATGAAGCGGAAGTTATTACTTTAAAAGGCAACCATGAACAAATGTTACTTGATTTTTTAGAAAAGCCTTCGGAA
AAAATGCATTATTATTTAAGTCAAGGCGGCATGGAAACCATTCAATCTTTAATTGGCGACTCATTAAATAAAAAAATGAC
ACCAGAAGGGTTAGCTAAGCGAATTAAAGAAGAGGCTTCAGACCTTATCGATTTTATCCAAAGTCTGCCACTTTATTATG
AAGAAGGTAAGTATGTGTTTGTCCATGCGGGCGTGGATTTTTCTAAACGCGATTGGCATGATACTGACGAGCATGATTTT
TTCTGGATACGGGAACCATTTTTATTTGGGAAAAATAATACTGGAAAAGTCTTTATTTTTGGACATACACCGGTGCAAAA
TTTACATAGTGACGAAAGTTCGGGTATATGGGTTTCGGAAGATAGAACTCGACTTGATATTGATGGTGGCGCAGTTTTTG
GCGGGGAGCTTCATGGGGTTGTAGTTGAGGAAAATGTTGTCACAAAAAGTTTTTCTGCAAAAAAATAA

Upstream 100 bases:

>100_bases
AAAAAAGTAGAAGGTAACACCAAATAAGGAAAAGACGTCCTTTTGCTAATGTCATTTTAGCGGAAGGGCGTTTCTTTTAC
GACCGTTTGGAGGAATAACA

Downstream 100 bases:

>100_bases
GCATCAATAGGGGCTTTTTTAAAGCGCGCATTTGATGCTTTTTTTATTTAATAATATGGTGCCATAAATAAGTATACTAG
TACGCCAGTTAAGCTGACAT

Product: serine/threonine protein phosphatase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKPIFAVGDVHGEITLLDELLENWNRERERLLFVGDLIDRGENPAAVLRRVKELSDEAEVITLKGNHEQMLLDFLEKPSE
KMHYYLSQGGMETIQSLIGDSLNKKMTPEGLAKRIKEEASDLIDFIQSLPLYYEEGKYVFVHAGVDFSKRDWHDTDEHDF
FWIREPFLFGKNNTGKVFIFGHTPVQNLHSDESSGIWVSEDRTRLDIDGGAVFGGELHGVVVEENVVTKSFSAKK

Sequences:

>Translated_235_residues
MKPIFAVGDVHGEITLLDELLENWNRERERLLFVGDLIDRGENPAAVLRRVKELSDEAEVITLKGNHEQMLLDFLEKPSE
KMHYYLSQGGMETIQSLIGDSLNKKMTPEGLAKRIKEEASDLIDFIQSLPLYYEEGKYVFVHAGVDFSKRDWHDTDEHDF
FWIREPFLFGKNNTGKVFIFGHTPVQNLHSDESSGIWVSEDRTRLDIDGGAVFGGELHGVVVEENVVTKSFSAKK
>Mature_235_residues
MKPIFAVGDVHGEITLLDELLENWNRERERLLFVGDLIDRGENPAAVLRRVKELSDEAEVITLKGNHEQMLLDFLEKPSE
KMHYYLSQGGMETIQSLIGDSLNKKMTPEGLAKRIKEEASDLIDFIQSLPLYYEEGKYVFVHAGVDFSKRDWHDTDEHDF
FWIREPFLFGKNNTGKVFIFGHTPVQNLHSDESSGIWVSEDRTRLDIDGGAVFGGELHGVVVEENVVTKSFSAKK

Specific function: Plays a key role in signaling protein misfolding via the CpxR/CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr an

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPP phosphatase family. PP-1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081988, Length=233, Percent_Identity=31.7596566523605, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR006186 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: =3.1.3.16 [H]

Molecular weight: Translated: 26827; Mature: 26827

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIFAVGDVHGEITLLDELLENWNRERERLLFVGDLIDRGENPAAVLRRVKELSDEAEV
CCCEEEECCCCCHHHHHHHHHHHHCHHHHHEEEEEHHHHCCCCHHHHHHHHHHCCCCCEE
ITLKGNHEQMLLDFLEKPSEKMHYYLSQGGMETIQSLIGDSLNKKMTPEGLAKRIKEEAS
EEEECCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DLIDFIQSLPLYYEEGKYVFVHAGVDFSKRDWHDTDEHDFFWIREPFLFGKNNTGKVFIF
HHHHHHHHCCCEEECCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEECCCCCCEEEEE
GHTPVQNLHSDESSGIWVSEDRTRLDIDGGAVFGGELHGVVVEENVVTKSFSAKK
ECCCHHHHCCCCCCCEEEECCCEEEEECCCEEECCCEEEEEEECCEEECCCCCCC
>Mature Secondary Structure
MKPIFAVGDVHGEITLLDELLENWNRERERLLFVGDLIDRGENPAAVLRRVKELSDEAEV
CCCEEEECCCCCHHHHHHHHHHHHCHHHHHEEEEEHHHHCCCCHHHHHHHHHHCCCCCEE
ITLKGNHEQMLLDFLEKPSEKMHYYLSQGGMETIQSLIGDSLNKKMTPEGLAKRIKEEAS
EEEECCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
DLIDFIQSLPLYYEEGKYVFVHAGVDFSKRDWHDTDEHDFFWIREPFLFGKNNTGKVFIF
HHHHHHHHCCCEEECCCEEEEECCCCCCCCCCCCCCCCCEEEEECCEEECCCCCCEEEEE
GHTPVQNLHSDESSGIWVSEDRTRLDIDGGAVFGGELHGVVVEENVVTKSFSAKK
ECCCHHHHCCCCCCCEEEECCCEEEEECCCEEECCCEEEEEEECCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9130712; 9097040; 9278503 [H]