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The map label for this gene is atpA

Identifier: 116871843

GI number: 116871843

Start: 444927

End: 446423

Strand: Direct

Name: atpA

Synonym: lwe0423

Alternate gene names: 116871843

Gene position: 444927-446423 (Clockwise)

Preceding gene: 116871842

Following gene: 116871844

Centisome position: 15.81

GC content: 36.21

Gene sequence:

>1497_bases
TTGAAAACAATTCAATTTGATATGAATAAATACGAAACCCATGTAGATTTGGAATATTTAAAAGAACATGGCCGAGTTGA
AAAAATTTCCGATGGTGTTATTTTTTGCTCAGGACTAGAAAATGCAGCGCTCCATCAAGCTGTATTGATTGATGAAAGAC
ACCGAGGCGTAATTCTTGAACTAAACGAAGAATTTGTTGGAATTGGCCTTATTGATAAAACAAGCGATATTTTAGAAGGT
ATGAATGTTTCAGTTACAGATCATTTTATAGAAGTAAACCTTTTTGATGATATGGCAGGACGTATTATTGATACAACAGG
AAAAATGCTTTATGAAGAAAGTGAAGAACAGCCAACATCGTCTTCTCCACTTTTCCGTGTCACACCAGAAATTATGACTA
TTGATAGTGTTACTCGCCCACTTAATACAGGGCTAGCAGTTATTGATTCCATTACACCTATTGGTCGGGGACAACGTCAA
TTAATTCTTGGTAACCGTCAATCGGGTAAAACACAAATTGCTGTAGATACAATTATTAACCAACATGATCAAAACGTACA
TTGTATTTATGTGGCTATTGGTTTAAAAGCAGCTTATATCGCAGAGGTTATTGAAACATTGCGTAATCATGATGCCCTTA
AATATTCTACGGTTGTTGCAACCGCAGCTAGCGATTCTTTAACAGCTCAGTATTTAACTCCATATGCAGGAATGGCTGTC
GCGGAAGCACTACGTGAACAAGGCAAAGATGTATTAATTATTTTTGATGATCTAACAAAACATGCGGATGCTTACCGAGC
AATCACATTACTATTTAACAGACCACCAGGAAGAGAAGCTTATCCAGGAGATAGTTTCTATATTCACTCTAGTCTTTTAG
AAAGAGCAGTTCAAATGAATCCTGAACATGGTGGAGGTTCTATTACAGCATTACCGATGATTGAAACATTATCAGATGAT
GTAACAGCCTATATTCCCACCAATGTTATTTCGATTACTGATGGACAACTATTTTTGAAGTCTGACTTATTCAACCGTGG
GCAAAAGCCGGCAGTGGATGTTGGTGTATCCGTATCAAGAATCGGCGGCGACGCTCAACACCCGATTATTCGTAAATTAA
GTAAAAACTTAACGTTGATTCTTTCGCAATTTGAAGAATTAAAAGAGTTACTTGATTTTGGTAATGGGCTTGATGAAGGA
AGCATGAAAATGGTCACAGATGGCCGGATTTTAACAGAACTCTTTAAACAAAAAATCCTTAGTCCGTTATCAGTAACTGA
TTTGATTGTTATTTTATACGCCTTTCAAAATGGTTTTCTTACAAAAGTTCCACCAGCTAAGATTGAATCGTTCAAAGGCT
TACTTTTAGAGAAAGCTCACGCACGTAATGACTTTATAGCATTTTCTAATGATATTAAAGATATTAGCGAGTTGAGTGAT
GCTCATACAAAAATGTTAGAAGAAATTATTCAGGAAGTGGGGAGGCTTTTTAGTTGA

Upstream 100 bases:

>100_bases
TTGGCGGAGTCATTATTAATTACGGAAGAAAGTCCATTGATATGAGCTACCAGGAATTAATCAAGAGAACAACAGAAAAA
ATGGAAGCGGAAGTGAAATC

Downstream 100 bases:

>100_bases
GTAGTATAAACCAGGCTCGAAAAACAATTAAAGCACTGAACTCAACCTATAAAATTGTCCATGTCACCGAACTGTCAACA
CTTGGAAAACTTTCTGAGCT

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha 1; F-ATPase subunit alpha 1

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MKTIQFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILELNEEFVGIGLIDKTSDILEG
MNVSVTDHFIEVNLFDDMAGRIIDTTGKMLYEESEEQPTSSSPLFRVTPEIMTIDSVTRPLNTGLAVIDSITPIGRGQRQ
LILGNRQSGKTQIAVDTIINQHDQNVHCIYVAIGLKAAYIAEVIETLRNHDALKYSTVVATAASDSLTAQYLTPYAGMAV
AEALREQGKDVLIIFDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMNPEHGGGSITALPMIETLSDD
VTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSRIGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNGLDEG
SMKMVTDGRILTELFKQKILSPLSVTDLIVILYAFQNGFLTKVPPAKIESFKGLLLEKAHARNDFIAFSNDIKDISELSD
AHTKMLEEIIQEVGRLFS

Sequences:

>Translated_498_residues
MKTIQFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILELNEEFVGIGLIDKTSDILEG
MNVSVTDHFIEVNLFDDMAGRIIDTTGKMLYEESEEQPTSSSPLFRVTPEIMTIDSVTRPLNTGLAVIDSITPIGRGQRQ
LILGNRQSGKTQIAVDTIINQHDQNVHCIYVAIGLKAAYIAEVIETLRNHDALKYSTVVATAASDSLTAQYLTPYAGMAV
AEALREQGKDVLIIFDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMNPEHGGGSITALPMIETLSDD
VTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSRIGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNGLDEG
SMKMVTDGRILTELFKQKILSPLSVTDLIVILYAFQNGFLTKVPPAKIESFKGLLLEKAHARNDFIAFSNDIKDISELSD
AHTKMLEEIIQEVGRLFS
>Mature_498_residues
MKTIQFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILELNEEFVGIGLIDKTSDILEG
MNVSVTDHFIEVNLFDDMAGRIIDTTGKMLYEESEEQPTSSSPLFRVTPEIMTIDSVTRPLNTGLAVIDSITPIGRGQRQ
LILGNRQSGKTQIAVDTIINQHDQNVHCIYVAIGLKAAYIAEVIETLRNHDALKYSTVVATAASDSLTAQYLTPYAGMAV
AEALREQGKDVLIIFDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMNPEHGGGSITALPMIETLSDD
VTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSRIGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNGLDEG
SMKMVTDGRILTELFKQKILSPLSVTDLIVILYAFQNGFLTKVPPAKIESFKGLLLEKAHARNDFIAFSNDIKDISELSD
AHTKMLEEIIQEVGRLFS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=490, Percent_Identity=42.6530612244898, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI4757810, Length=490, Percent_Identity=42.6530612244898, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI19913426, Length=331, Percent_Identity=25.6797583081571, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI19913428, Length=334, Percent_Identity=25.4491017964072, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI32189394, Length=454, Percent_Identity=23.7885462555066, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790172, Length=445, Percent_Identity=44.0449438202247, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1788251, Length=398, Percent_Identity=24.6231155778894, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790170, Length=367, Percent_Identity=22.3433242506812, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71988063, Length=490, Percent_Identity=41.6326530612245, Blast_Score=379, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71988080, Length=490, Percent_Identity=41.6326530612245, Blast_Score=378, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71988074, Length=490, Percent_Identity=40.2040816326531, Blast_Score=355, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17570191, Length=337, Percent_Identity=26.1127596439169, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17510931, Length=292, Percent_Identity=27.0547945205479, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI25144756, Length=344, Percent_Identity=24.1279069767442, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319370, Length=468, Percent_Identity=40.3846153846154, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6319603, Length=333, Percent_Identity=27.027027027027, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320016, Length=188, Percent_Identity=26.063829787234, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322581, Length=310, Percent_Identity=22.9032258064516, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24658560, Length=479, Percent_Identity=43.0062630480167, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281361666, Length=321, Percent_Identity=25.8566978193146, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646341, Length=321, Percent_Identity=25.8566978193146, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136796, Length=321, Percent_Identity=25.8566978193146, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24638766, Length=370, Percent_Identity=24.3243243243243, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA1_LISW6 (A0AFQ9)

Other databases:

- EMBL:   AM263198
- RefSeq:   YP_848624.1
- ProteinModelPortal:   A0AFQ9
- SMR:   A0AFQ9
- STRING:   A0AFQ9
- GeneID:   4464983
- GenomeReviews:   AM263198_GR
- KEGG:   lwe:lwe0423
- NMPDR:   fig|386043.6.peg.402
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   DMAGRII
- ProtClustDB:   PRK13343
- BioCyc:   LWEL386043:LWE0423-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55136; Mature: 55136

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIQFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILE
CCEEEECCCHHCHHCCHHHHHHCCCEEEECCCEEEECCCCCHHHHHHHEEECCCCCEEEE
LNEEFVGIGLIDKTSDILEGMNVSVTDHFIEVNLFDDMAGRIIDTTGKMLYEESEEQPTS
ECCCEEEEEEECCCHHHHCCCCCEEEEEEEEEEEEHHHCCCEECCCHHHHHHCCCCCCCC
SSPLFRVTPEIMTIDSVTRPLNTGLAVIDSITPIGRGQRQLILGNRQSGKTQIAVDTIIN
CCCEEEECCCEEEHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCCCCEEEEHHHHHC
QHDQNVHCIYVAIGLKAAYIAEVIETLRNHDALKYSTVVATAASDSLTAQYLTPYAGMAV
CCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCHHHHHH
AEALREQGKDVLIIFDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMN
HHHHHHCCCEEEEEECCHHHHHHHHEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHCC
PEHGGGSITALPMIETLSDDVTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSR
CCCCCCCEEEEHHHHHHCCCCEEEECCCEEEECCCCEEEEHHHHCCCCCCCEECCCCHHH
IGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNGLDEGSMKMVTDGRILTELFKQKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCC
SPLSVTDLIVILYAFQNGFLTKVPPAKIESFKGLLLEKAHARNDFIAFSNDIKDISELSD
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
AHTKMLEEIIQEVGRLFS
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTIQFDMNKYETHVDLEYLKEHGRVEKISDGVIFCSGLENAALHQAVLIDERHRGVILE
CCEEEECCCHHCHHCCHHHHHHCCCEEEECCCEEEECCCCCHHHHHHHEEECCCCCEEEE
LNEEFVGIGLIDKTSDILEGMNVSVTDHFIEVNLFDDMAGRIIDTTGKMLYEESEEQPTS
ECCCEEEEEEECCCHHHHCCCCCEEEEEEEEEEEEHHHCCCEECCCHHHHHHCCCCCCCC
SSPLFRVTPEIMTIDSVTRPLNTGLAVIDSITPIGRGQRQLILGNRQSGKTQIAVDTIIN
CCCEEEECCCEEEHHHHHHHHHCCHHHHHCCCCCCCCCEEEEEECCCCCCEEEEHHHHHC
QHDQNVHCIYVAIGLKAAYIAEVIETLRNHDALKYSTVVATAASDSLTAQYLTPYAGMAV
CCCCCEEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHCCHHHHHH
AEALREQGKDVLIIFDDLTKHADAYRAITLLFNRPPGREAYPGDSFYIHSSLLERAVQMN
HHHHHHCCCEEEEEECCHHHHHHHHEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHHCC
PEHGGGSITALPMIETLSDDVTAYIPTNVISITDGQLFLKSDLFNRGQKPAVDVGVSVSR
CCCCCCCEEEEHHHHHHCCCCEEEECCCEEEECCCCEEEEHHHHCCCCCCCEECCCCHHH
IGGDAQHPIIRKLSKNLTLILSQFEELKELLDFGNGLDEGSMKMVTDGRILTELFKQKIL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHCC
SPLSVTDLIVILYAFQNGFLTKVPPAKIESFKGLLLEKAHARNDFIAFSNDIKDISELSD
CCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHH
AHTKMLEEIIQEVGRLFS
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA