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The map label for this gene is mngB [H]

Identifier: 116871785

GI number: 116871785

Start: 379932

End: 382559

Strand: Direct

Name: mngB [H]

Synonym: lwe0365

Alternate gene names: 116871785

Gene position: 379932-382559 (Clockwise)

Preceding gene: 116871784

Following gene: 116871786

Centisome position: 13.5

GC content: 37.33

Gene sequence:

>2628_bases
ATGGCTAAAACGAAAGTACATGTAATTCCGCATTCACATTGGGATAGAGAATGGTATTTCACTTCAAGCCGTTCGACAAT
CTATTTAGTGAAGCATTTAAAAGAAGTAATTGAAACTTTAGAAGCGAAAGAAGATTACCATTTTTACTTAATGGATGCTC
AAAGTTCTTTAATAGAAGATTATTTGCGCTACTGCCCGGAAGATAAAACTAGATTAGAAAAACTTATTACTGATAAACGA
CTTATTACAGGACCTTGGTATACACAAACGGACCAATTAGTCATTTCACAAGAGTCGATTGTTCGAAACTTACTATATGG
GACGAGGATTGCATATGAAATGGGGCATAGCATGGCTGTAGGTTATGTCCCGGATGCATTCGGGCAAGGCGGAAATATGC
CGCAAATTTATAAAGAATTTGGGATTTCGAAGTTTCTATTTTGGCGTGGAGTTGCCGATAATCGCTTGAAACAAACGGAA
TTTATCTGGCGTGGCGATGACGGGACAGAAATGCTGGCTGAACAAATCCCGTTCGGCTACTACTATGGAGCCAATATTCC
AGAAAATGAAGCAGAACTAAAAAAATACTTGGATGAACAAATTGGTGCTTTAGAAAAGAAAGCTTTGACGCCAAATGTCT
ATTTTCCAAATGGGTTAGACCAAGCGCCAGTTAGAAAAAATTTACCAGAATTGGTTGCGAAATTTAATGAATTAGATAGC
ACGCGTGAATACCAAATTGCTTCACCAGAAACATTTTTCGCTGATTTAGAACAAGATGTGATGGATTTACCGGTAATTGC
TGGTGAATTGACAGAAGGAAAACATAGTCGCTTGCATAAATCGATTTTTTCCACACGAGCTGATTTAAAACAAGCAAACA
ATGAAATTGAAAACTTTTTGAGCAATGTGTTAGAGCCAGTTCTTTCTGTAAGCTATTCACTTGGAAATCGCTATCCGCAT
AACGAACTCGCAGAAATTTGGAAGTTAATGTTTGAAAATGCTGCGCACGATAGCATTGGTGGCTGTAATAGTGATACTAC
TAATCGCGACGTCAAACATCGGTATAAATTGGCATCTGATTTAGCAACCAATTTACTCGATTTAAACATGCGCCTTATTA
GTGAAAAAATCGAACAAAAACAAGCGTTCCAATTTACCATTTTCAACCCACTTCCATACGAAAAAAGTGGCGTTATCAAA
ATGTCTGCTTATATTCCAGATGACAATTTCACGATGGAAGATACGCAAGGAAACACTCTTCCATATACTATTTTGGAGCA
AACGGACTTAACAGAATATGTCTTAAACCAACATATCGATCTCAACCCAAGTAAAGCCGTTTATTTACCCAAAAAAGTCT
TTTTAGCAACGATGCTTGTAGAAGTAAACAACCTCCCAGCGCTTGGATACGACACGGTTTACTTTAATTTGGAAAAAGAA
ACTGCTGAGCAAGAACCAAAACAATCTACGGCTTCAAAAATCGAAAATGAATTTTATGAAATCCAGTTAGCGGACAACAA
CTCACTAACTATTCATGACAAAAAAGCGAATAGAACTTATACAGATCAAATGGTTTTTGTTGAAAATGGAGACGATGGCG
ATTCCTACAACTATTCTCCGCCTCGTAAAGACCTAGTAATTACATCTAAAGAAGCGGTAGTAGATAGTATGGATTCGAGT
GTATCTAGCGTCAACCAAACATTAACTATTTCCTTCAAGTTAAATGTGCCGTATAATTTAGAAGAACGTGCTAATCGTGA
AAAAAGAAAAGAAATGACTATCAAAACGATAATTTCTTTACGAAAAAACGAAGAACTTATTCGCTTTGATGTTCAAATCG
CTAACAAAGTATTGAGTCATCGTTTATGTGTCACTTTCGCCACCGAAATTGCTAGCAAATTCTCGACAGCCGACCAATTA
TTCGCGCCAATTAAACGTCCTGTTCGACTTCCAGAAATGGATGTATGGGAAGCGGAAGAATGGCAAGAAGCACCAATTTC
AATTGAAGCAATGCAGAGTTTTGTCAGTTTACACGATGAAGTGCACGGGGTTGCTGTTATGACAGAAGGCGTGCGCGAAT
ATGAAATCATTGGTGACAATTATGATACGATTTCGCTAACCTTATTCCGTACATTTAGCCATATGGGTAAAACAGATTTA
CTGTATCGTCCTGGTCGTGCTTCCGGTGAGTCAATTGTTGCGACACCTGATGCGCAACTACTTGGCGAAATAAATGCGAC
ATTCGCGCTCACTTTATTCGAAAGTTCTTTTGACGAAGCGAATATAGCAAAAAAAGCAAAAGAATACCTATCCAATCCAC
CTGTTTATCAAATGTCTGATTTTCTTAACGGCCGGTTGATTTATGTTTATCGCGACGAAGAAAAAACATTAGATGCAACT
TATAGCTTAAAACTTCCAATGTTAGATGGGGCGATTGTTAGTGCAGTGAAAAAAGCTGAAGATAGTGAGGCGTTTATTAC
CCGCTTTTTCAATCCATACTTACAAAAAGAAATTGCTATTCCAGAAATTTTCCAAGGCAAAGAATGTCACTTGGACGAAA
ATAAATCAAATGAGAAACAAACCACATTAAAACATGCAAAAGTCCAAACTTATTTATTTGAAAAATAA

Upstream 100 bases:

>100_bases
CACCGAAGAAGAAACAGCTGCAGCAGACGATGCAGTGGATGATATTGATATTAGTTTTGACGAAATAGAGATTAAATAAT
AGTTGGAGGATTTAATTAAA

Downstream 100 bases:

>100_bases
TGGATAACTACCGTAAAAAGGAGCTGCTAAAATGGGATACTTCGCTTATAAACGTTTGGAAACATTATATGGCATGCTCC
TTGATGCTGGTAGCCACTTA

Product: alpha-mannosidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 875; Mature: 874

Protein sequence:

>875_residues
MAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKEDYHFYLMDAQSSLIEDYLRYCPEDKTRLEKLITDKR
LITGPWYTQTDQLVISQESIVRNLLYGTRIAYEMGHSMAVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQTE
FIWRGDDGTEMLAEQIPFGYYYGANIPENEAELKKYLDEQIGALEKKALTPNVYFPNGLDQAPVRKNLPELVAKFNELDS
TREYQIASPETFFADLEQDVMDLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFLSNVLEPVLSVSYSLGNRYPH
NELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASDLATNLLDLNMRLISEKIEQKQAFQFTIFNPLPYEKSGVIK
MSAYIPDDNFTMEDTQGNTLPYTILEQTDLTEYVLNQHIDLNPSKAVYLPKKVFLATMLVEVNNLPALGYDTVYFNLEKE
TAEQEPKQSTASKIENEFYEIQLADNNSLTIHDKKANRTYTDQMVFVENGDDGDSYNYSPPRKDLVITSKEAVVDSMDSS
VSSVNQTLTISFKLNVPYNLEERANREKRKEMTIKTIISLRKNEELIRFDVQIANKVLSHRLCVTFATEIASKFSTADQL
FAPIKRPVRLPEMDVWEAEEWQEAPISIEAMQSFVSLHDEVHGVAVMTEGVREYEIIGDNYDTISLTLFRTFSHMGKTDL
LYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEANIAKKAKEYLSNPPVYQMSDFLNGRLIYVYRDEEKTLDAT
YSLKLPMLDGAIVSAVKKAEDSEAFITRFFNPYLQKEIAIPEIFQGKECHLDENKSNEKQTTLKHAKVQTYLFEK

Sequences:

>Translated_875_residues
MAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKEDYHFYLMDAQSSLIEDYLRYCPEDKTRLEKLITDKR
LITGPWYTQTDQLVISQESIVRNLLYGTRIAYEMGHSMAVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQTE
FIWRGDDGTEMLAEQIPFGYYYGANIPENEAELKKYLDEQIGALEKKALTPNVYFPNGLDQAPVRKNLPELVAKFNELDS
TREYQIASPETFFADLEQDVMDLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFLSNVLEPVLSVSYSLGNRYPH
NELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASDLATNLLDLNMRLISEKIEQKQAFQFTIFNPLPYEKSGVIK
MSAYIPDDNFTMEDTQGNTLPYTILEQTDLTEYVLNQHIDLNPSKAVYLPKKVFLATMLVEVNNLPALGYDTVYFNLEKE
TAEQEPKQSTASKIENEFYEIQLADNNSLTIHDKKANRTYTDQMVFVENGDDGDSYNYSPPRKDLVITSKEAVVDSMDSS
VSSVNQTLTISFKLNVPYNLEERANREKRKEMTIKTIISLRKNEELIRFDVQIANKVLSHRLCVTFATEIASKFSTADQL
FAPIKRPVRLPEMDVWEAEEWQEAPISIEAMQSFVSLHDEVHGVAVMTEGVREYEIIGDNYDTISLTLFRTFSHMGKTDL
LYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEANIAKKAKEYLSNPPVYQMSDFLNGRLIYVYRDEEKTLDAT
YSLKLPMLDGAIVSAVKKAEDSEAFITRFFNPYLQKEIAIPEIFQGKECHLDENKSNEKQTTLKHAKVQTYLFEK
>Mature_874_residues
AKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKEDYHFYLMDAQSSLIEDYLRYCPEDKTRLEKLITDKRL
ITGPWYTQTDQLVISQESIVRNLLYGTRIAYEMGHSMAVGYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQTEF
IWRGDDGTEMLAEQIPFGYYYGANIPENEAELKKYLDEQIGALEKKALTPNVYFPNGLDQAPVRKNLPELVAKFNELDST
REYQIASPETFFADLEQDVMDLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFLSNVLEPVLSVSYSLGNRYPHN
ELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASDLATNLLDLNMRLISEKIEQKQAFQFTIFNPLPYEKSGVIKM
SAYIPDDNFTMEDTQGNTLPYTILEQTDLTEYVLNQHIDLNPSKAVYLPKKVFLATMLVEVNNLPALGYDTVYFNLEKET
AEQEPKQSTASKIENEFYEIQLADNNSLTIHDKKANRTYTDQMVFVENGDDGDSYNYSPPRKDLVITSKEAVVDSMDSSV
SSVNQTLTISFKLNVPYNLEERANREKRKEMTIKTIISLRKNEELIRFDVQIANKVLSHRLCVTFATEIASKFSTADQLF
APIKRPVRLPEMDVWEAEEWQEAPISIEAMQSFVSLHDEVHGVAVMTEGVREYEIIGDNYDTISLTLFRTFSHMGKTDLL
YRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEANIAKKAKEYLSNPPVYQMSDFLNGRLIYVYRDEEKTLDATY
SLKLPMLDGAIVSAVKKAEDSEAFITRFFNPYLQKEIAIPEIFQGKECHLDENKSNEKQTTLKHAKVQTYLFEK

Specific function: May hydrolyze mannosyl-D-glycerate to mannose-6- phosphate and glycerate [H]

COG id: COG0383

COG function: function code G; Alpha-mannosidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 38 family [H]

Homologues:

Organism=Homo sapiens, GI46852164, Length=343, Percent_Identity=25.0728862973761, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1786952, Length=833, Percent_Identity=35.0540216086435, Blast_Score=564, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011013
- InterPro:   IPR011330
- InterPro:   IPR011682
- InterPro:   IPR015341
- InterPro:   IPR000602 [H]

Pfam domain/function: PF09261 Alpha-mann_mid; PF01074 Glyco_hydro_38; PF07748 Glyco_hydro_38C [H]

EC number: NA

Molecular weight: Translated: 100324; Mature: 100193

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKEDYHFYLMDAQSSLIED
CCCCEEEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHH
YLRYCPEDKTRLEKLITDKRLITGPWYTQTDQLVISQESIVRNLLYGTRIAYEMGHSMAV
HHHHCCCHHHHHHHHHHCCEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCEEE
GYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQTEFIWRGDDGTEMLAEQIPFGY
ECCCHHCCCCCCCHHHHHHHCCHHEEHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCE
YYGANIPENEAELKKYLDEQIGALEKKALTPNVYFPNGLDQAPVRKNLPELVAKFNELDS
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHCCC
TREYQIASPETFFADLEQDVMDLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFL
CCCEEECCCHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNVLEPVLSVSYSLGNRYPHNELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LATNLLDLNMRLISEKIEQKQAFQFTIFNPLPYEKSGVIKMSAYIPDDNFTMEDTQGNTL
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECCCCCCEEECCCCCCC
PYTILEQTDLTEYVLNQHIDLNPSKAVYLPKKVFLATMLVEVNNLPALGYDTVYFNLEKE
CEEEECCCCHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHH
TAEQEPKQSTASKIENEFYEIQLADNNSLTIHDKKANRTYTDQMVFVENGDDGDSYNYSP
HHHCCHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCEECCEEEEEECCCCCCCCCCCC
PRKDLVITSKEAVVDSMDSSVSSVNQTLTISFKLNVPYNLEERANREKRKEMTIKTIISL
CCCCEEEECHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHCHHHHHHHHHHHHHHH
RKNEELIRFDVQIANKVLSHRLCVTFATEIASKFSTADQLFAPIKRPVRLPEMDVWEAEE
HCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
WQEAPISIEAMQSFVSLHDEVHGVAVMTEGVREYEIIGDNYDTISLTLFRTFSHMGKTDL
HHCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCCCEEEEHHHHHHHHCCCCCE
LYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEANIAKKAKEYLSNPPVYQMSD
EECCCCCCCCEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHH
FLNGRLIYVYRDEEKTLDATYSLKLPMLDGAIVSAVKKAEDSEAFITRFFNPYLQKEIAI
HCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCC
PEIFQGKECHLDENKSNEKQTTLKHAKVQTYLFEK
CHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AKTKVHVIPHSHWDREWYFTSSRSTIYLVKHLKEVIETLEAKEDYHFYLMDAQSSLIED
CCCEEEEECCCCCCCCEEEECCCCEEHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHH
YLRYCPEDKTRLEKLITDKRLITGPWYTQTDQLVISQESIVRNLLYGTRIAYEMGHSMAV
HHHHCCCHHHHHHHHHHCCEEECCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCEEE
GYVPDAFGQGGNMPQIYKEFGISKFLFWRGVADNRLKQTEFIWRGDDGTEMLAEQIPFGY
ECCCHHCCCCCCCHHHHHHHCCHHEEHHCCCCCCCCCCCEEEEECCCHHHHHHHHCCCCE
YYGANIPENEAELKKYLDEQIGALEKKALTPNVYFPNGLDQAPVRKNLPELVAKFNELDS
EECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHCCC
TREYQIASPETFFADLEQDVMDLPVIAGELTEGKHSRLHKSIFSTRADLKQANNEIENFL
CCCEEECCCHHHHHHHHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SNVLEPVLSVSYSLGNRYPHNELAEIWKLMFENAAHDSIGGCNSDTTNRDVKHRYKLASD
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LATNLLDLNMRLISEKIEQKQAFQFTIFNPLPYEKSGVIKMSAYIPDDNFTMEDTQGNTL
HHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCEEEEEECCCCCCEEECCCCCCC
PYTILEQTDLTEYVLNQHIDLNPSKAVYLPKKVFLATMLVEVNNLPALGYDTVYFNLEKE
CEEEECCCCHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHH
TAEQEPKQSTASKIENEFYEIQLADNNSLTIHDKKANRTYTDQMVFVENGDDGDSYNYSP
HHHCCHHHHHHHHHCCCEEEEEEECCCEEEEEECCCCCEECCEEEEEECCCCCCCCCCCC
PRKDLVITSKEAVVDSMDSSVSSVNQTLTISFKLNVPYNLEERANREKRKEMTIKTIISL
CCCCEEEECHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCHHHHCHHHHHHHHHHHHHHH
RKNEELIRFDVQIANKVLSHRLCVTFATEIASKFSTADQLFAPIKRPVRLPEMDVWEAEE
HCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
WQEAPISIEAMQSFVSLHDEVHGVAVMTEGVREYEIIGDNYDTISLTLFRTFSHMGKTDL
HHCCCCCHHHHHHHHHHHHHHCCEEEEECCCEEEEEECCCCCEEEEHHHHHHHHCCCCCE
LYRPGRASGESIVATPDAQLLGEINATFALTLFESSFDEANIAKKAKEYLSNPPVYQMSD
EECCCCCCCCEEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHH
FLNGRLIYVYRDEEKTLDATYSLKLPMLDGAIVSAVKKAEDSEAFITRFFNPYLQKEIAI
HCCCEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHCHHHHHHCCC
PEIFQGKECHLDENKSNEKQTTLKHAKVQTYLFEK
CHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 9063979 [H]