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The map label for this gene is serA [H]

Identifier: 116871770

GI number: 116871770

Start: 370463

End: 371512

Strand: Direct

Name: serA [H]

Synonym: lwe0350

Alternate gene names: 116871770

Gene position: 370463-371512 (Clockwise)

Preceding gene: 116871769

Following gene: 116871771

Centisome position: 13.16

GC content: 38.57

Gene sequence:

>1050_bases
ATGAAAATCGTTGTTGTAGGAGATGCTCTAGTGGCAAGCTCGGATTTAGAAAAAGCCGCTCAAGAGTTAAATGTAAACGA
GGAAGTGCAAGTAGAAAAATTCGAATGGTATTCCGATTTGTCTAAAGAAGCTTTTCAAGAAAAAATTCTAGCAATTGAAA
AAGGTGGCTCAGAAGCAGTTGAAATTCCAGCAGGTATATGCGAAGCGCTAGTAGACGCTGATATTTTGCTCGTCCACATT
GCCCCCGTTTCCAAAAAAATGATTGCATCTGCTAAAAAATTACGCTTAATCGGTGCGTCAAGAGGTGGTATGGAAAATGT
AGCAGTAGAAGCTGCAACTGAACGGAAAATACCAGTTATTCATGTCATTCGTAATGCGGAACCAGTGGCAGACTTCACGG
TAGCCCTTATGTATGCTGAAACTCGAAATATCGCCAGAGCGCATTTATCTATTAAAAATGGTCGCTGGGATAAAGGATTC
TCAAATGATGCGTATAAAACTACTTTAGCAAAACACACGGTCGGACTAATTGGCTTAGGCTATATAGGAAAGCTTGTTGC
GAAACGTCTGAATGGTCTAGGAGTTAAAGTAATTGCATATGACCCATTTATTGATCCTAAAAAATTAGTGGATGAAGGGC
TAGACATTGAATTAAAAGGACTTCATGAAGTGTTCCGAGAAGCTGATATTATTTCCCTTCATATGCGGGTCACGAAAGAA
ACAACGAATATGATTAATGCTGAATTAATCGGAATGATGAAACCGAGTGCCTATTTAATCAATACAGCTAGGGCAGCGGT
ATTAGATGAATCAGCGTTAATTAATGCTTTAGAAGCTAAACAAATTGCTGGTGCAGCTATCGACGTGTTTTGGGAAGAAC
CAATCCCTAGCCATAGCCCACTTTTAACATTAGATAATATTACATTAACCACACATATCGCTGGGGATACGATTGACGCT
ATTCCACATTCACCTTATCTTCTTAGAGATGTCATTAATGACTATTTTGAAAAAGGTGTTAGTGATATGCAAGTTAATCT
AAAATCCTAA

Upstream 100 bases:

>100_bases
AAACAAACCACGGATTCACGAATACTTAGAACGCCAAGCACTAGGTGAAGAGTACCAAGTAGCAGAAACCACTTAATGAA
CGGAATTGGAGTGAAAAAAG

Downstream 100 bases:

>100_bases
AAGAGTAGTAGGCAGAAAGGATGGGAAATAATGGATCTAGTTCTTCGAGTAGCAATTTTAATAGGAATTGGCTTAATTCT
AAAAACAGCCACTTTAATTT

Product: phosphoglycerate dehydrogenase family protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKIVVVGDALVASSDLEKAAQELNVNEEVQVEKFEWYSDLSKEAFQEKILAIEKGGSEAVEIPAGICEALVDADILLVHI
APVSKKMIASAKKLRLIGASRGGMENVAVEAATERKIPVIHVIRNAEPVADFTVALMYAETRNIARAHLSIKNGRWDKGF
SNDAYKTTLAKHTVGLIGLGYIGKLVAKRLNGLGVKVIAYDPFIDPKKLVDEGLDIELKGLHEVFREADIISLHMRVTKE
TTNMINAELIGMMKPSAYLINTARAAVLDESALINALEAKQIAGAAIDVFWEEPIPSHSPLLTLDNITLTTHIAGDTIDA
IPHSPYLLRDVINDYFEKGVSDMQVNLKS

Sequences:

>Translated_349_residues
MKIVVVGDALVASSDLEKAAQELNVNEEVQVEKFEWYSDLSKEAFQEKILAIEKGGSEAVEIPAGICEALVDADILLVHI
APVSKKMIASAKKLRLIGASRGGMENVAVEAATERKIPVIHVIRNAEPVADFTVALMYAETRNIARAHLSIKNGRWDKGF
SNDAYKTTLAKHTVGLIGLGYIGKLVAKRLNGLGVKVIAYDPFIDPKKLVDEGLDIELKGLHEVFREADIISLHMRVTKE
TTNMINAELIGMMKPSAYLINTARAAVLDESALINALEAKQIAGAAIDVFWEEPIPSHSPLLTLDNITLTTHIAGDTIDA
IPHSPYLLRDVINDYFEKGVSDMQVNLKS
>Mature_349_residues
MKIVVVGDALVASSDLEKAAQELNVNEEVQVEKFEWYSDLSKEAFQEKILAIEKGGSEAVEIPAGICEALVDADILLVHI
APVSKKMIASAKKLRLIGASRGGMENVAVEAATERKIPVIHVIRNAEPVADFTVALMYAETRNIARAHLSIKNGRWDKGF
SNDAYKTTLAKHTVGLIGLGYIGKLVAKRLNGLGVKVIAYDPFIDPKKLVDEGLDIELKGLHEVFREADIISLHMRVTKE
TTNMINAELIGMMKPSAYLINTARAAVLDESALINALEAKQIAGAAIDVFWEEPIPSHSPLLTLDNITLTTHIAGDTIDA
IPHSPYLLRDVINDYFEKGVSDMQVNLKS

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=253, Percent_Identity=33.9920948616601, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI6912396, Length=237, Percent_Identity=29.535864978903, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI61743967, Length=246, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4557497, Length=246, Percent_Identity=28.4552845528455, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=28.8617886178862, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=28.8617886178862, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=28.8617886178862, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789279, Length=243, Percent_Identity=34.5679012345679, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87082289, Length=237, Percent_Identity=32.4894514767932, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787645, Length=217, Percent_Identity=29.9539170506912, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788660, Length=260, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081824, Length=148, Percent_Identity=29.7297297297297, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=237, Percent_Identity=35.4430379746835, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=29.296875, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=292, Percent_Identity=29.4520547945205, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=278, Percent_Identity=29.4964028776978, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322116, Length=278, Percent_Identity=28.4172661870504, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=224, Percent_Identity=29.9107142857143, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324980, Length=183, Percent_Identity=26.775956284153, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921140, Length=252, Percent_Identity=30.952380952381, Blast_Score=121, Evalue=7e-28,
Organism=Drosophila melanogaster, GI28574286, Length=232, Percent_Identity=31.0344827586207, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI45552429, Length=232, Percent_Identity=31.0344827586207, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24585514, Length=232, Percent_Identity=31.0344827586207, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28574282, Length=232, Percent_Identity=31.0344827586207, Blast_Score=111, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45551003, Length=232, Percent_Identity=31.0344827586207, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI28574284, Length=232, Percent_Identity=31.0344827586207, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24585516, Length=252, Percent_Identity=28.1746031746032, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646446, Length=251, Percent_Identity=32.2709163346614, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646448, Length=251, Percent_Identity=32.2709163346614, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646452, Length=251, Percent_Identity=32.2709163346614, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24646450, Length=251, Percent_Identity=32.2709163346614, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI62472511, Length=230, Percent_Identity=33.0434782608696, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571528, Length=179, Percent_Identity=34.0782122905028, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 38101; Mature: 38101

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVVVGDALVASSDLEKAAQELNVNEEVQVEKFEWYSDLSKEAFQEKILAIEKGGSEAV
CEEEEEECHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHEEECCCCCEE
EIPAGICEALVDADILLVHIAPVSKKMIASAKKLRLIGASRGGMENVAVEAATERKIPVI
ECCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHEEEEECCCCCCCHHEEEECCCCCCCEE
HVIRNAEPVADFTVALMYAETRNIARAHLSIKNGRWDKGFSNDAYKTTLAKHTVGLIGLG
EEECCCCCHHHHEEEEEEHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YIGKLVAKRLNGLGVKVIAYDPFIDPKKLVDEGLDIELKGLHEVFREADIISLHMRVTKE
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCCCEEEHHHHHHHHCCCEEEEEEEEEHH
TTNMINAELIGMMKPSAYLINTARAAVLDESALINALEAKQIAGAAIDVFWEEPIPSHSP
HHHHHHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
LLTLDNITLTTHIAGDTIDAIPHSPYLLRDVINDYFEKGVSDMQVNLKS
EEEECCEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MKIVVVGDALVASSDLEKAAQELNVNEEVQVEKFEWYSDLSKEAFQEKILAIEKGGSEAV
CEEEEEECHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHEEECCCCCEE
EIPAGICEALVDADILLVHIAPVSKKMIASAKKLRLIGASRGGMENVAVEAATERKIPVI
ECCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHEEEEECCCCCCCHHEEEECCCCCCCEE
HVIRNAEPVADFTVALMYAETRNIARAHLSIKNGRWDKGFSNDAYKTTLAKHTVGLIGLG
EEECCCCCHHHHEEEEEEHHHHHHEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YIGKLVAKRLNGLGVKVIAYDPFIDPKKLVDEGLDIELKGLHEVFREADIISLHMRVTKE
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCCCEEEHHHHHHHHCCCEEEEEEEEEHH
TTNMINAELIGMMKPSAYLINTARAAVLDESALINALEAKQIAGAAIDVFWEEPIPSHSP
HHHHHHHHHHEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCC
LLTLDNITLTTHIAGDTIDAIPHSPYLLRDVINDYFEKGVSDMQVNLKS
EEEECCEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]