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The map label for this gene is tenA [H]

Identifier: 116871706

GI number: 116871706

Start: 311757

End: 312431

Strand: Direct

Name: tenA [H]

Synonym: lwe0286

Alternate gene names: 116871706

Gene position: 311757-312431 (Clockwise)

Preceding gene: 116871705

Following gene: 116871707

Centisome position: 11.08

GC content: 45.19

Gene sequence:

>675_bases
GTGTTTGTACATGGTTTTCAAGAAGAAGTAGGAGATTTATGGCAAGAAACGTTGTGTCATCCATTTGTTCAGAGTTTGGC
GGATGGGACGCTTGAGAAGGAGGCGTTTTATTATTATTTGCTTCAAGATGATTATTATTTATCGCATTTTGAGAAGGTGA
TTGAGAAAAGTGTAGTGCAAGCGGGGACGGAGGAACTTGCTGCTGAGATGAGGCAAGTGCGGGAGAGGCTTCGGCAGTCG
GAATTGTTGATGCGCGAACAGTTTTATCCACGGGTTGGGCTAACGGAGCGTGATTTTTCCGAGCGAAAACCAGCGCCAAC
TGCTTATCATTATACTTCTCATCTTTACCGGATGGCGGATTTTGGTAGTTTTGGGGTGACAATTGCGGCGCTTTTGCCGT
GTTATGCGCTTTATGCGGATATGGGGAAAATGTACGAAACGGCGCGGAGTTCGGAGCCATTTTATCAAGAGTTACTGGAT
AGTTATGTGGATGAAAATTATCAACAAGTGGTGTTGAAGCAGAAGCGATTGGTGGAACAGGCGGCGAGTATGGCGGATGC
GCGGGAACTTGCTCTCATGAAGCAGGCTTTTCACATCAGTGTGGAAATGGAATGGGCGTTTTTTGATATGGCTTATAAAA
AACAAAATTGGCGTGGGAGTGTGAATTATGTTTGA

Upstream 100 bases:

>100_bases
AATGTGAAAGTAACCGGAAAATTTATCGCGGCTGCTGTTTCTTTGCTTATGCTAAGAGACAGTGGGCGCTTTTTTTATTG
TTTAAAAAGGAGGAGTTTGA

Downstream 100 bases:

>100_bases
TTTTATGACGTTGGAAAAGGTGCAAGAAAGAGGGCCGTTGGTACATAATATTACAAACATCGTGGTTGCAAATGACTCGG
CAAACGGATTGCTGGCGATT

Product: TENA/THI-4 family transcriptional activator protein

Products: NA

Alternate protein names: Thiaminase II; Transcriptional activator tenA [H]

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MFVHGFQEEVGDLWQETLCHPFVQSLADGTLEKEAFYYYLLQDDYYLSHFEKVIEKSVVQAGTEELAAEMRQVRERLRQS
ELLMREQFYPRVGLTERDFSERKPAPTAYHYTSHLYRMADFGSFGVTIAALLPCYALYADMGKMYETARSSEPFYQELLD
SYVDENYQQVVLKQKRLVEQAASMADARELALMKQAFHISVEMEWAFFDMAYKKQNWRGSVNYV

Sequences:

>Translated_224_residues
MFVHGFQEEVGDLWQETLCHPFVQSLADGTLEKEAFYYYLLQDDYYLSHFEKVIEKSVVQAGTEELAAEMRQVRERLRQS
ELLMREQFYPRVGLTERDFSERKPAPTAYHYTSHLYRMADFGSFGVTIAALLPCYALYADMGKMYETARSSEPFYQELLD
SYVDENYQQVVLKQKRLVEQAASMADARELALMKQAFHISVEMEWAFFDMAYKKQNWRGSVNYV
>Mature_224_residues
MFVHGFQEEVGDLWQETLCHPFVQSLADGTLEKEAFYYYLLQDDYYLSHFEKVIEKSVVQAGTEELAAEMRQVRERLRQS
ELLMREQFYPRVGLTERDFSERKPAPTAYHYTSHLYRMADFGSFGVTIAALLPCYALYADMGKMYETARSSEPFYQELLD
SYVDENYQQVVLKQKRLVEQAASMADARELALMKQAFHISVEMEWAFFDMAYKKQNWRGSVNYV

Specific function: Stimulates the production of several extracellular degradative enzymes at the transcriptional level, probably by interfering with degS and degU, which are required for this effect. Is not an essential protein, but affects the sporulation frequency [H]

COG id: COG0819

COG function: function code K; Putative transcription activator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiaminase-2 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016084
- InterPro:   IPR004305 [H]

Pfam domain/function: PF03070 TENA_THI-4 [H]

EC number: =3.5.99.2 [H]

Molecular weight: Translated: 26362; Mature: 26362

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVHGFQEEVGDLWQETLCHPFVQSLADGTLEKEAFYYYLLQDDYYLSHFEKVIEKSVVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHH
AGTEELAAEMRQVRERLRQSELLMREQFYPRVGLTERDFSERKPAPTAYHYTSHLYRMAD
HCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHH
FGSFGVTIAALLPCYALYADMGKMYETARSSEPFYQELLDSYVDENYQQVVLKQKRLVEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AASMADARELALMKQAFHISVEMEWAFFDMAYKKQNWRGSVNYV
HHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MFVHGFQEEVGDLWQETLCHPFVQSLADGTLEKEAFYYYLLQDDYYLSHFEKVIEKSVVQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHH
AGTEELAAEMRQVRERLRQSELLMREQFYPRVGLTERDFSERKPAPTAYHYTSHLYRMAD
HCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHH
FGSFGVTIAALLPCYALYADMGKMYETARSSEPFYQELLDSYVDENYQQVVLKQKRLVEQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AASMADARELALMKQAFHISVEMEWAFFDMAYKKQNWRGSVNYV
HHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1898926; 9384377 [H]