| Definition | Listeria welshimeri serovar 6b str. SLCC5334, complete genome. |
|---|---|
| Accession | NC_008555 |
| Length | 2,814,130 |
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The map label for this gene is tilS/hprT [H]
Identifier: 116871602
GI number: 116871602
Start: 180983
End: 182929
Strand: Direct
Name: tilS/hprT [H]
Synonym: lwe0182
Alternate gene names: 116871602
Gene position: 180983-182929 (Clockwise)
Preceding gene: 116871601
Following gene: 116871603
Centisome position: 6.43
GC content: 36.52
Gene sequence:
>1947_bases ATGGAAGACATTGTAAAGCGAACACACAAATATATCGAGAAACATGACTTAATCCGATCCGATGATAAATTGCTTGTGGC AGTTTCTGGCGGGCCGGATTCTTTCGCGTTGTTGCATTTTTTATGGTCATCTAAATTGGTGCCAAAAGAATCCATCTCAG TAGCTCATCTAAACCACTGTTTACGAGAAGGTGCAGAAAAAGAACAATTGGTCGTTCAGACTTTTTGCGAAGAACACCAT ATTCCTTTTTTTGTGGAGGCAGTAGATATAAAGAAACATGCGGAGACAATACAAAAAGGGATAGAAGAAACAGCTCGCAT TGTTAGATATAAATTTTTTGAAAAAGTAATGACGGAGAACGATATAAATAAACTTGTACTAGCGCATCATGCGGATGATC AAATTGAAACAATCCTGATGCGATTAGTTCGAGGTAGCTCCAGTATCGGATGGTCAGGAATCCAACCAAAACGCAAAGTC ACAAAAGGTTATGCGATTCGTCCCTTCCTACCAATTACAAAAGCAGAAATCATTCAATACGCGAGTAAACATGATTTACC TTACGAAATTGATGAATCAAATGTTAGCCAAGAATATACTAGAAATCGCTATCGTACACAACTTTTACCATTTTTATCCA AAGAAAATCCGGCAGTATATGATCATTTCAACAGATTTTCCGAAGAAACGAGTGAGGATTTTCTGTTTTTGGAAGAGCTA GCGAACGATGTATTAAAGAAAAATCTTATCCAAAACGGCAAACAGACAACACTTTTACTTAGTAGTTTTAAAAATGAAGC GAATCCTTTACAACGTCGCGCAATTCATTTACTATTGAGATATCTGTACAATGACGATACCCGTATTATTACGGTTAATC ACATATATCAGATTATCCAGATGATTCAAAGCGAAAATCCATCAAGTTCTATTGATTTACCAAAAAAACTCACTGCTATC AGGTCGTACAACGAACTCCATTTCCAATTTGGAGAAAGACATGCTCCGTCTGAGTTTTATCATCAATTAGAAATAAATGA CCGCATTGAATTAGACGATAAAACAAGCATCCGTTTGAAATTAAAAAGTTCTGTTGTTCAAACTAATGGATTAAATGGAA TGCTGCTGGATGCAGAAGATATCACTCTTCCATTAATCGTTCGAAACCGTGTGAACGGAGATAGAATGACGATGAAAGGG CAAGTAGGTAGTAAAAAACTAAAAGATATTTTCATCGATGCCAAAATACCAAGGCAAGAACGCGACAATTTACCCGTAAT AACAGATTATACTGGGAAGATTCTTTGGGTTCCTGGTGTGAAAAAATCTGCCTATGACCGAGAATTTAGTCGTAGCAAAA AGCAATACATTATTAGGTACACTCGAAATATAGGAGGAAACGAGAGCATGCATAATGATATTCAGAAAGTACTGATATCG GAGGACGAATTACAAGAGAAAATTCGTGAACTCGGTCGTGAGTTGACAACGGAATATGAAGGACGTAACCCATTAGTAGT GGGCGTATTAAAAGGAGCAACACCTTTTATGACGGATTTACTTAAAAGAGTAGATACATACTTAGAAATGGACTTCATGG ATGTTTCCAGTTACGGAAATGGTACAGTATCCTCAGGGGAAGTAAAAATTATCAAAGACCTTAATGCTTCAGTAGAAGGT CGTGATGTGCTTGTAATTGAAGATATCATTGATAGTGGTCGTACACTTAGTTATTTAGTAGACCTAATCAAATACCGCAA AGCAAAATCTGTTAAATTAGTTACTTTGCTTGATAAACCAGCAGGAAGAAATGTAGCTATTGAAGCTGATTATGTGGGAT TTGTTGTACCTAATGAGTTTGTCGTAGGTTATGGTTTAGACTACGCTGAACGTTACCGAAACCTACCATATATTGGTGTT TTAAAACCAGAAATTTATAGTGAGTAA
Upstream 100 bases:
>100_bases ATTATTTTAAAGTATAGAAGGATGCACCGTATTGGATCATTAATACGGTGCACTTTTTGATAAAATGTGAGAGTCGAATT TCGAAGGAAGGGTTTCTTGA
Downstream 100 bases:
>100_bases AATTAATTAACAATCAGAACTATTTTTTCTTAAAAACTAATAGTTACCCTTTTCGAAAACAAAAAGAAAAAAATTGCAGC CAAACATGCAAAATAGTGGG
Product: hypothetical protein
Products: NA
Alternate protein names: tRNA(Ile)-lysidine synthase; tRNA(Ile)-2-lysyl-cytidine synthase; tRNA(Ile)-lysidine synthetase; Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; HGPRTase [H]
Number of amino acids: Translated: 648; Mature: 648
Protein sequence:
>648_residues MEDIVKRTHKYIEKHDLIRSDDKLLVAVSGGPDSFALLHFLWSSKLVPKESISVAHLNHCLREGAEKEQLVVQTFCEEHH IPFFVEAVDIKKHAETIQKGIEETARIVRYKFFEKVMTENDINKLVLAHHADDQIETILMRLVRGSSSIGWSGIQPKRKV TKGYAIRPFLPITKAEIIQYASKHDLPYEIDESNVSQEYTRNRYRTQLLPFLSKENPAVYDHFNRFSEETSEDFLFLEEL ANDVLKKNLIQNGKQTTLLLSSFKNEANPLQRRAIHLLLRYLYNDDTRIITVNHIYQIIQMIQSENPSSSIDLPKKLTAI RSYNELHFQFGERHAPSEFYHQLEINDRIELDDKTSIRLKLKSSVVQTNGLNGMLLDAEDITLPLIVRNRVNGDRMTMKG QVGSKKLKDIFIDAKIPRQERDNLPVITDYTGKILWVPGVKKSAYDREFSRSKKQYIIRYTRNIGGNESMHNDIQKVLIS EDELQEKIRELGRELTTEYEGRNPLVVGVLKGATPFMTDLLKRVDTYLEMDFMDVSSYGNGTVSSGEVKIIKDLNASVEG RDVLVIEDIIDSGRTLSYLVDLIKYRKAKSVKLVTLLDKPAGRNVAIEADYVGFVVPNEFVVGYGLDYAERYRNLPYIGV LKPEIYSE
Sequences:
>Translated_648_residues MEDIVKRTHKYIEKHDLIRSDDKLLVAVSGGPDSFALLHFLWSSKLVPKESISVAHLNHCLREGAEKEQLVVQTFCEEHH IPFFVEAVDIKKHAETIQKGIEETARIVRYKFFEKVMTENDINKLVLAHHADDQIETILMRLVRGSSSIGWSGIQPKRKV TKGYAIRPFLPITKAEIIQYASKHDLPYEIDESNVSQEYTRNRYRTQLLPFLSKENPAVYDHFNRFSEETSEDFLFLEEL ANDVLKKNLIQNGKQTTLLLSSFKNEANPLQRRAIHLLLRYLYNDDTRIITVNHIYQIIQMIQSENPSSSIDLPKKLTAI RSYNELHFQFGERHAPSEFYHQLEINDRIELDDKTSIRLKLKSSVVQTNGLNGMLLDAEDITLPLIVRNRVNGDRMTMKG QVGSKKLKDIFIDAKIPRQERDNLPVITDYTGKILWVPGVKKSAYDREFSRSKKQYIIRYTRNIGGNESMHNDIQKVLIS EDELQEKIRELGRELTTEYEGRNPLVVGVLKGATPFMTDLLKRVDTYLEMDFMDVSSYGNGTVSSGEVKIIKDLNASVEG RDVLVIEDIIDSGRTLSYLVDLIKYRKAKSVKLVTLLDKPAGRNVAIEADYVGFVVPNEFVVGYGLDYAERYRNLPYIGV LKPEIYSE >Mature_648_residues MEDIVKRTHKYIEKHDLIRSDDKLLVAVSGGPDSFALLHFLWSSKLVPKESISVAHLNHCLREGAEKEQLVVQTFCEEHH IPFFVEAVDIKKHAETIQKGIEETARIVRYKFFEKVMTENDINKLVLAHHADDQIETILMRLVRGSSSIGWSGIQPKRKV TKGYAIRPFLPITKAEIIQYASKHDLPYEIDESNVSQEYTRNRYRTQLLPFLSKENPAVYDHFNRFSEETSEDFLFLEEL ANDVLKKNLIQNGKQTTLLLSSFKNEANPLQRRAIHLLLRYLYNDDTRIITVNHIYQIIQMIQSENPSSSIDLPKKLTAI RSYNELHFQFGERHAPSEFYHQLEINDRIELDDKTSIRLKLKSSVVQTNGLNGMLLDAEDITLPLIVRNRVNGDRMTMKG QVGSKKLKDIFIDAKIPRQERDNLPVITDYTGKILWVPGVKKSAYDREFSRSKKQYIIRYTRNIGGNESMHNDIQKVLIS EDELQEKIRELGRELTTEYEGRNPLVVGVLKGATPFMTDLLKRVDTYLEMDFMDVSSYGNGTVSSGEVKIIKDLNASVEG RDVLVIEDIIDSGRTLSYLVDLIKYRKAKSVKLVTLLDKPAGRNVAIEADYVGFVVPNEFVVGYGLDYAERYRNLPYIGV LKPEIYSE
Specific function: Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionin
COG id: COG0037
COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family [H]
Homologues:
Organism=Homo sapiens, GI4504483, Length=179, Percent_Identity=34.6368715083799, Blast_Score=112, Evalue=1e-24, Organism=Homo sapiens, GI9910262, Length=181, Percent_Identity=34.2541436464088, Blast_Score=100, Evalue=5e-21, Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=49.3975903614458, Blast_Score=175, Evalue=6e-45, Organism=Escherichia coli, GI1786386, Length=423, Percent_Identity=26.4775413711584, Blast_Score=114, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17510817, Length=180, Percent_Identity=31.6666666666667, Blast_Score=98, Evalue=1e-20,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005904 - InterPro: IPR012094 - InterPro: IPR012796 - InterPro: IPR012795 - InterPro: IPR020825 - InterPro: IPR000836 - InterPro: IPR014729 - InterPro: IPR011063 [H]
Pfam domain/function: PF01171 ATP_bind_3; PF00156 Pribosyltran; PF11734 TilS_C [H]
EC number: =2.4.2.8 [H]
Molecular weight: Translated: 74546; Mature: 74546
Theoretical pI: Translated: 7.04; Mature: 7.04
Prosite motif: PS00103 PUR_PYR_PR_TRANSFER
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 1.7 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 1.7 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEDIVKRTHKYIEKHDLIRSDDKLLVAVSGGPDSFALLHFLWSSKLVPKESISVAHLNHC CHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHH LREGAEKEQLVVQTFCEEHHIPFFVEAVDIKKHAETIQKGIEETARIVRYKFFEKVMTEN HHCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC DINKLVLAHHADDQIETILMRLVRGSSSIGWSGIQPKRKVTKGYAIRPFLPITKAEIIQY CCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEECCCCCCHHHHHHHH ASKHDLPYEIDESNVSQEYTRNRYRTQLLPFLSKENPAVYDHFNRFSEETSEDFLFLEEL HHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH ANDVLKKNLIQNGKQTTLLLSSFKNEANPLQRRAIHLLLRYLYNDDTRIITVNHIYQIIQ HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH MIQSENPSSSIDLPKKLTAIRSYNELHFQFGERHAPSEFYHQLEINDRIELDDKTSIRLK HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCEEEECCCCEEEEE LKSSVVQTNGLNGMLLDAEDITLPLIVRNRVNGDRMTMKGQVGSKKLKDIFIDAKIPRQE EEHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCEEEEECCCCCHHHHHEEEECCCCCCC RDNLPVITDYTGKILWVPGVKKSAYDREFSRSKKQYIIRYTRNIGGNESMHNDIQKVLIS CCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC EDELQEKIRELGRELTTEYEGRNPLVVGVLKGATPFMTDLLKRVDTYLEMDFMDVSSYGN HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCC GTVSSGEVKIIKDLNASVEGRDVLVIEDIIDSGRTLSYLVDLIKYRKAKSVKLVTLLDKP CCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCC AGRNVAIEADYVGFVVPNEFVVGYGLDYAERYRNLPYIGVLKPEIYSE CCCEEEEEECEEEEECCCCEEEECCCCHHHHHCCCCEEEEECCHHCCC >Mature Secondary Structure MEDIVKRTHKYIEKHDLIRSDDKLLVAVSGGPDSFALLHFLWSSKLVPKESISVAHLNHC CHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCHHCCHHHHHHHH LREGAEKEQLVVQTFCEEHHIPFFVEAVDIKKHAETIQKGIEETARIVRYKFFEKVMTEN HHCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC DINKLVLAHHADDQIETILMRLVRGSSSIGWSGIQPKRKVTKGYAIRPFLPITKAEIIQY CCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEECCCCCCHHHHHHHH ASKHDLPYEIDESNVSQEYTRNRYRTQLLPFLSKENPAVYDHFNRFSEETSEDFLFLEEL HHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH ANDVLKKNLIQNGKQTTLLLSSFKNEANPLQRRAIHLLLRYLYNDDTRIITVNHIYQIIQ HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH MIQSENPSSSIDLPKKLTAIRSYNELHFQFGERHAPSEFYHQLEINDRIELDDKTSIRLK HHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHEECCCCEEEECCCCEEEEE LKSSVVQTNGLNGMLLDAEDITLPLIVRNRVNGDRMTMKGQVGSKKLKDIFIDAKIPRQE EEHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCEEEEECCCCCHHHHHEEEECCCCCCC RDNLPVITDYTGKILWVPGVKKSAYDREFSRSKKQYIIRYTRNIGGNESMHNDIQKVLIS CCCCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC EDELQEKIRELGRELTTEYEGRNPLVVGVLKGATPFMTDLLKRVDTYLEMDFMDVSSYGN HHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHEEECCCCCC GTVSSGEVKIIKDLNASVEGRDVLVIEDIIDSGRTLSYLVDLIKYRKAKSVKLVTLLDKP CCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCEEEEEEECCC AGRNVAIEADYVGFVVPNEFVVGYGLDYAERYRNLPYIGVLKPEIYSE CCCEEEEEECEEEEECCCCEEEECCCCHHHHHCCCCEEEEECCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11679669 [H]