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The map label for this gene is fadH [C]

Identifier: 116696454

GI number: 116696454

Start: 2845077

End: 2846210

Strand: Direct

Name: fadH [C]

Synonym: H16_B2518

Alternate gene names: 116696454

Gene position: 2845077-2846210 (Clockwise)

Preceding gene: 116696453

Following gene: 116696456

Centisome position: 97.69

GC content: 69.49

Gene sequence:

>1134_bases
ATGACCACGCCCGCCGCGCCCTCACTGTTCGATACGCTGGCCCTGAACGGCGTGCCGCTGCGCAACCGGCTCGCGGTGGC
GCCGATGACGCGCATCAGCGCCACCGCCGCAGGCGTTCCCACCGAGGCCATGACGCGCTACTACGCAGGCTTTGCCCGCG
GCGGCTTTGGCCTCATCGTCACGGAGGGTATCTATACCGACCGTGCCTATACCCAGGGCTATGCCGGCCAGCCCGGTTTG
ACGGATGCGCAGCAAGTGGCCGCGTGGCGCCAGGTGGTTGCCGCGGTCCACCAGCAGGGCGGGCGCATCGTGGCCCAGCT
GATGCACGCCGGTGCGCTGTCGCAGGCCAACCGCTTCCGCGACCACACGGTCGGGCCCTCGGCGGTGCAGCCCAAGGGGC
TGCAAATGACCGTGTATGCCGGCAAGGGTCCATACCGGATGCCGCGCGCCATGGAAGAGGCGGACATCCTGCAGGCCATC
GAAGGCTTTGCGCAGGCCGCCCGGCTGGCCCGTGACGCGGGTTTCGACGGCGTTGAAATCCACGGTGCCAATGGCTATCT
GCTGGATCAGTTCCTGACGAGCTATACGAATCAACGCCAGGACGCCTGGGGCGGCAGCATCGCACAGCGCATGCGCCTGC
CGCTGGAAACCGTCCGCGCGGTGCGCGTTGCCGTGGGAGCTGGCTTCCCCGTCGGCGTGCGCATCTCGCAAGGCAAGGTC
AATGATTTCGTCCACAAGTGGCCGGAAGGCGCGGAAGGCGCGGCCGCCGTTTTCTCCGCGCTCGCGGCAAGCAGCGTGGA
CTACCTCCACGTGACGGAGCACGAAGCATGGCAGCCCGCCTTCGCGGACGACGGCGCGACGCTGGTGCAGCTTGCACGCC
GTGCCGCGCCCGGGCTCACGATCATGGCCAACGGCAGCCTGCATGAGCCATCGCGCGCGGCCAGCCTGCTGGACGATGGC
GCGACGCTGGTCGCGCTCGGACGCGGCGCCCTTGCGAATCCGGACTGGCCGGTGCTGGTGCGCGAGGGACAGCCGGTGCG
GCCGTTCGATGCGGCCGTCCTCGCGCCGCTGGGCAATATCAAGGATGCCGAGCAGGCGCTGCGCGAAGCACGCGCGACGG
TGACGCCAGGCTGA

Upstream 100 bases:

>100_bases
CCCCCTATCCGGCCGACACCATCGTCGAGGTCTCGGCGCTCTACTCGCCGGACGCGAAGATCGAGATCGAAGCCATCGCC
CTGGCCGCAGAAGCTGCGCG

Downstream 100 bases:

>100_bases
CGGCATCGCCCGCGCTAGCGTTGCGCGTGATCCCTGCGCCAGCTGGCCGGCGCCATCCCGAACTGCGCAGAAAACCACCG
GGTAAAGGAGCTGGCCGACC

Product: NADH-dependent flavin oxidoreductase yqiG

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MTTPAAPSLFDTLALNGVPLRNRLAVAPMTRISATAAGVPTEAMTRYYAGFARGGFGLIVTEGIYTDRAYTQGYAGQPGL
TDAQQVAAWRQVVAAVHQQGGRIVAQLMHAGALSQANRFRDHTVGPSAVQPKGLQMTVYAGKGPYRMPRAMEEADILQAI
EGFAQAARLARDAGFDGVEIHGANGYLLDQFLTSYTNQRQDAWGGSIAQRMRLPLETVRAVRVAVGAGFPVGVRISQGKV
NDFVHKWPEGAEGAAAVFSALAASSVDYLHVTEHEAWQPAFADDGATLVQLARRAAPGLTIMANGSLHEPSRAASLLDDG
ATLVALGRGALANPDWPVLVREGQPVRPFDAAVLAPLGNIKDAEQALREARATVTPG

Sequences:

>Translated_377_residues
MTTPAAPSLFDTLALNGVPLRNRLAVAPMTRISATAAGVPTEAMTRYYAGFARGGFGLIVTEGIYTDRAYTQGYAGQPGL
TDAQQVAAWRQVVAAVHQQGGRIVAQLMHAGALSQANRFRDHTVGPSAVQPKGLQMTVYAGKGPYRMPRAMEEADILQAI
EGFAQAARLARDAGFDGVEIHGANGYLLDQFLTSYTNQRQDAWGGSIAQRMRLPLETVRAVRVAVGAGFPVGVRISQGKV
NDFVHKWPEGAEGAAAVFSALAASSVDYLHVTEHEAWQPAFADDGATLVQLARRAAPGLTIMANGSLHEPSRAASLLDDG
ATLVALGRGALANPDWPVLVREGQPVRPFDAAVLAPLGNIKDAEQALREARATVTPG
>Mature_376_residues
TTPAAPSLFDTLALNGVPLRNRLAVAPMTRISATAAGVPTEAMTRYYAGFARGGFGLIVTEGIYTDRAYTQGYAGQPGLT
DAQQVAAWRQVVAAVHQQGGRIVAQLMHAGALSQANRFRDHTVGPSAVQPKGLQMTVYAGKGPYRMPRAMEEADILQAIE
GFAQAARLARDAGFDGVEIHGANGYLLDQFLTSYTNQRQDAWGGSIAQRMRLPLETVRAVRVAVGAGFPVGVRISQGKVN
DFVHKWPEGAEGAAAVFSALAASSVDYLHVTEHEAWQPAFADDGATLVQLARRAAPGLTIMANGSLHEPSRAASLLDDGA
TLVALGRGALANPDWPVLVREGQPVRPFDAAVLAPLGNIKDAEQALREARATVTPG

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=337, Percent_Identity=35.0148367952522, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1787939, Length=341, Percent_Identity=34.0175953079179, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17559804, Length=357, Percent_Identity=28.0112044817927, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540738, Length=353, Percent_Identity=26.9121813031161, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17564188, Length=357, Percent_Identity=26.6106442577031, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI72001454, Length=361, Percent_Identity=25.7617728531856, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17565138, Length=394, Percent_Identity=27.4111675126904, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559802, Length=360, Percent_Identity=27.2222222222222, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17566914, Length=344, Percent_Identity=27.6162790697674, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17566916, Length=235, Percent_Identity=26.8085106382979, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6325086, Length=367, Percent_Identity=30.2452316076294, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321973, Length=368, Percent_Identity=29.6195652173913, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 39842; Mature: 39710

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPAAPSLFDTLALNGVPLRNRLAVAPMTRISATAAGVPTEAMTRYYAGFARGGFGLIV
CCCCCCCHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
TEGIYTDRAYTQGYAGQPGLTDAQQVAAWRQVVAAVHQQGGRIVAQLMHAGALSQANRFR
ECCEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DHTVGPSAVQPKGLQMTVYAGKGPYRMPRAMEEADILQAIEGFAQAARLARDAGFDGVEI
CCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
HGANGYLLDQFLTSYTNQRQDAWGGSIAQRMRLPLETVRAVRVAVGAGFPVGVRISQGKV
ECCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCH
NDFVHKWPEGAEGAAAVFSALAASSVDYLHVTEHEAWQPAFADDGATLVQLARRAAPGLT
HHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEE
IMANGSLHEPSRAASLLDDGATLVALGRGALANPDWPVLVREGQPVRPFDAAVLAPLGNI
EEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHCCCCC
KDAEQALREARATVTPG
CHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TTPAAPSLFDTLALNGVPLRNRLAVAPMTRISATAAGVPTEAMTRYYAGFARGGFGLIV
CCCCCCHHHHHHHCCCCCCCCCEEECCHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
TEGIYTDRAYTQGYAGQPGLTDAQQVAAWRQVVAAVHQQGGRIVAQLMHAGALSQANRFR
ECCEECCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DHTVGPSAVQPKGLQMTVYAGKGPYRMPRAMEEADILQAIEGFAQAARLARDAGFDGVEI
CCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
HGANGYLLDQFLTSYTNQRQDAWGGSIAQRMRLPLETVRAVRVAVGAGFPVGVRISQGKV
ECCCCHHHHHHHHHHHCCHHHHCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCH
NDFVHKWPEGAEGAAAVFSALAASSVDYLHVTEHEAWQPAFADDGATLVQLARRAAPGLT
HHHHHHCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEE
IMANGSLHEPSRAASLLDDGATLVALGRGALANPDWPVLVREGQPVRPFDAAVLAPLGNI
EEECCCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCCCCHHHHHHHCCCCC
KDAEQALREARATVTPG
CHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]