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The map label for this gene is gltC [H]

Identifier: 116696431

GI number: 116696431

Start: 2818182

End: 2819144

Strand: Direct

Name: gltC [H]

Synonym: H16_B2495

Alternate gene names: 116696431

Gene position: 2818182-2819144 (Clockwise)

Preceding gene: 116696422

Following gene: 116696432

Centisome position: 96.76

GC content: 71.03

Gene sequence:

>963_bases
ATGCGAGACCTCGACCTCACCAGCCTGCGCCTGTTCGTCGCCGTCTGCGAAACCCGCAACATGGCGCGTGCGGGCGAGCA
GGAGCACATCGTGGCATCGGCCATCAGCAAGCGGCTGGCGCAACTGGAAGGGACGGTTGGCGCAACCCTGCTGGAGCGGC
GCCGCCGCGGCGTGATCCCGACGCCCGCGGGCGAAATGGTGCTGGCGCATGCGCGCGCCATGCTGGCGGCGGCGGACCGC
GTCGCGCGCGACATGGCCGACTACGGCGCAGGCATACGCGGGCAGGTGCGGCTGCTGGCGACGGTGTCCTCAATGGCGGA
ATCGCTGCCGGACGATATTGCCGCCTTCCTGCAGCAGCCGGCCAACCGCGATGTGCGCGTGACCATCGAGGAAAGCCTGA
GCAGTGACGTGGTGCGAGCGCTGCGCGAGGGCTCGGCGCCGCTGGGCATCTGCTGGGACGCGGCCGACCTGGAAGGCTTC
CAGACCCGGCCCTACCGCACCGACCAGCTCGCGGCAGTGGTCCACGCCTCGCATCCGCTGGCGCAGGCCGAGGACTGCCG
CTTCGAGGACACGCTGGACTACGACCATATCGGCATGCCCGCCCAGACCGCGGTGCAGACCATGCTGACGCGCTATGCGG
CCATCCTCGGGCGCGGCATTGGCTACCGCGCGGTGGTCTCGACCTTCGACGCTGCGCTGCGCTGTGTGCGTGCCGACCTG
GGCATCACCATCATCCCGGCCGAGATCGCCGCGCCGATCGCGCCTACCTTCGGCCTGCGCGTGATCCCGCTGCGCAACGA
CTGGGCGCGGCGGCGCTTTGCGATCTGCTTCCGCGACCTGGAACTGCTGTCGCCGGCGGCGCGGCTGCTGGTGGCCTTCC
TTGAACAGACCGCGGCGGCGGAAGCGGCGGCCGCCCCCGCGGACACCACGCCAGCGCGCAAGCCACGGCGCAATCGGCAA
TGA

Upstream 100 bases:

>100_bases
GCCGGGCGCCGCACAGCTACATCCAGAAATTCCCGGATGAATGATTACCGGCAACCAAAGGGGCTTAACATTCCATTCCG
GAAACACGCAGCCCCTTACC

Downstream 100 bases:

>100_bases
CGCGGCGTGGCGCGCAACTTCCTGTGCCGTTCAAGGGTTAGCCCGAGGCAATTTCGCAAGCAAATGTTGGGGAGCGGTGC
GTAGACTGGCTTGCGTTTTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MRDLDLTSLRLFVAVCETRNMARAGEQEHIVASAISKRLAQLEGTVGATLLERRRRGVIPTPAGEMVLAHARAMLAAADR
VARDMADYGAGIRGQVRLLATVSSMAESLPDDIAAFLQQPANRDVRVTIEESLSSDVVRALREGSAPLGICWDAADLEGF
QTRPYRTDQLAAVVHASHPLAQAEDCRFEDTLDYDHIGMPAQTAVQTMLTRYAAILGRGIGYRAVVSTFDAALRCVRADL
GITIIPAEIAAPIAPTFGLRVIPLRNDWARRRFAICFRDLELLSPAARLLVAFLEQTAAAEAAAAPADTTPARKPRRNRQ

Sequences:

>Translated_320_residues
MRDLDLTSLRLFVAVCETRNMARAGEQEHIVASAISKRLAQLEGTVGATLLERRRRGVIPTPAGEMVLAHARAMLAAADR
VARDMADYGAGIRGQVRLLATVSSMAESLPDDIAAFLQQPANRDVRVTIEESLSSDVVRALREGSAPLGICWDAADLEGF
QTRPYRTDQLAAVVHASHPLAQAEDCRFEDTLDYDHIGMPAQTAVQTMLTRYAAILGRGIGYRAVVSTFDAALRCVRADL
GITIIPAEIAAPIAPTFGLRVIPLRNDWARRRFAICFRDLELLSPAARLLVAFLEQTAAAEAAAAPADTTPARKPRRNRQ
>Mature_320_residues
MRDLDLTSLRLFVAVCETRNMARAGEQEHIVASAISKRLAQLEGTVGATLLERRRRGVIPTPAGEMVLAHARAMLAAADR
VARDMADYGAGIRGQVRLLATVSSMAESLPDDIAAFLQQPANRDVRVTIEESLSSDVVRALREGSAPLGICWDAADLEGF
QTRPYRTDQLAAVVHASHPLAQAEDCRFEDTLDYDHIGMPAQTAVQTMLTRYAAILGRGIGYRAVVSTFDAALRCVRADL
GITIIPAEIAAPIAPTFGLRVIPLRNDWARRRFAICFRDLELLSPAARLLVAFLEQTAAAEAAAAPADTTPARKPRRNRQ

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693105, Length=290, Percent_Identity=25.1724137931034, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787879, Length=295, Percent_Identity=25.0847457627119, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788748, Length=303, Percent_Identity=25.0825082508251, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=202, Percent_Identity=30.1980198019802, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786713, Length=190, Percent_Identity=29.4736842105263, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788297, Length=95, Percent_Identity=33.6842105263158, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34791; Mature: 34791

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: PS50931 HTH_LYSR ; PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLDLTSLRLFVAVCETRNMARAGEQEHIVASAISKRLAQLEGTVGATLLERRRRGVIP
CCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCC
TPAGEMVLAHARAMLAAADRVARDMADYGAGIRGQVRLLATVSSMAESLPDDIAAFLQQP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCC
ANRDVRVTIEESLSSDVVRALREGSAPLGICWDAADLEGFQTRPYRTDQLAAVVHASHPL
CCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCC
AQAEDCRFEDTLDYDHIGMPAQTAVQTMLTRYAAILGRGIGYRAVVSTFDAALRCVRADL
CCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
GITIIPAEIAAPIAPTFGLRVIPLRNDWARRRFAICFRDLELLSPAARLLVAFLEQTAAA
CEEEECHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAAAAPADTTPARKPRRNRQ
HHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRDLDLTSLRLFVAVCETRNMARAGEQEHIVASAISKRLAQLEGTVGATLLERRRRGVIP
CCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCC
TPAGEMVLAHARAMLAAADRVARDMADYGAGIRGQVRLLATVSSMAESLPDDIAAFLQQP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHCC
ANRDVRVTIEESLSSDVVRALREGSAPLGICWDAADLEGFQTRPYRTDQLAAVVHASHPL
CCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCC
AQAEDCRFEDTLDYDHIGMPAQTAVQTMLTRYAAILGRGIGYRAVVSTFDAALRCVRADL
CCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
GITIIPAEIAAPIAPTFGLRVIPLRNDWARRRFAICFRDLELLSPAARLLVAFLEQTAAA
CEEEECHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAAAAPADTTPARKPRRNRQ
HHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]