Click here to switch to the map view.

The map label for this gene is caa [H]

Identifier: 116696339

GI number: 116696339

Start: 2712756

End: 2713505

Strand: Direct

Name: caa [H]

Synonym: H16_B2403

Alternate gene names: 116696339

Gene position: 2712756-2713505 (Clockwise)

Preceding gene: 116696338

Following gene: 116696347

Centisome position: 93.14

GC content: 66.8

Gene sequence:

>750_bases
ATGAACACCAGGCTGCCGATTATCACGGTTTGCACCGCCTTGCTTGCACCTGCCGCGTGGGCCGGCAATGACCCGCACTG
GAGCTACACCGGACCGACCGGTACCAGCCACTGGGCCGAGCTCGACCAGGACTACAAGACCTGTGCGCTGGGCAAGCACC
AGTCGCCCATCGATATCCGCACCAGCAAGGCCCGGCCTGCGGACCTGAAGCCGATCGGCTTTGGCTACGCCGCGGCGCCC
GCCACCGTGGTCAACAACGGCCACACCGTACAGGTCAACCTGCCCGCAGCGGGGCAGATCGAACTCGACGGCGTGCCCTA
CAAGCTGCTGCAGTTCCACTTCCATACGCCCAGCGAAGAGAAGATCAACGGCAAGGCCTATCCGCTGGTCGCGCACCTGG
TGCACCAGAATGCAGAAGGCAAGCTGGCGGTGGTGGCGGTGCTGTTCAAGTCCGGGCGGGAGAATGCGGCGCTGAAACCG
GTCTTCGCGAGCCTGCCGGCCAAGGCCGGAGAGTCGCGCGAACTGACGGCGCCGCTGGATGTGGCGGCGTTGCTGCCGGC
CCGGCAGTCGTACTGGGCCTTCACCGGCTCGCTGACCACGCCGCCGTGCAGCGAGGACGTGCGCTGGCAGGTGCTGAAGA
CCCCGGTGGAAGTGTCGCCGGCGCAGTTGGCCGCATTCCGTCAGCTTTATCCGATGAACGCCCGCCCGGTGCAGCCGCTC
AACGGCCGCACGGTGCAGGTCAGCCACTAG

Upstream 100 bases:

>100_bases
GATTTCCGGCCCGGGCAAAAGACCCGGCACTCAAGACGGGGACAGCTTGACAACACCACGTCGGAAACCAAGGGGTTACC
AACACTAGGACGCATCGACA

Downstream 100 bases:

>100_bases
AGGACGGCGCCCGATAGAAGTACCAATCGGGCGGCAATGACCGACTGTGCGCTCCCTCTCCCGCTTGCGGGAGAGGGGAG
CAAGCCAGCGGCAGGGTCAG

Product: periplasmic alpha-carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MNTRLPIITVCTALLAPAAWAGNDPHWSYTGPTGTSHWAELDQDYKTCALGKHQSPIDIRTSKARPADLKPIGFGYAAAP
ATVVNNGHTVQVNLPAAGQIELDGVPYKLLQFHFHTPSEEKINGKAYPLVAHLVHQNAEGKLAVVAVLFKSGRENAALKP
VFASLPAKAGESRELTAPLDVAALLPARQSYWAFTGSLTTPPCSEDVRWQVLKTPVEVSPAQLAAFRQLYPMNARPVQPL
NGRTVQVSH

Sequences:

>Translated_249_residues
MNTRLPIITVCTALLAPAAWAGNDPHWSYTGPTGTSHWAELDQDYKTCALGKHQSPIDIRTSKARPADLKPIGFGYAAAP
ATVVNNGHTVQVNLPAAGQIELDGVPYKLLQFHFHTPSEEKINGKAYPLVAHLVHQNAEGKLAVVAVLFKSGRENAALKP
VFASLPAKAGESRELTAPLDVAALLPARQSYWAFTGSLTTPPCSEDVRWQVLKTPVEVSPAQLAAFRQLYPMNARPVQPL
NGRTVQVSH
>Mature_249_residues
MNTRLPIITVCTALLAPAAWAGNDPHWSYTGPTGTSHWAELDQDYKTCALGKHQSPIDIRTSKARPADLKPIGFGYAAAP
ATVVNNGHTVQVNLPAAGQIELDGVPYKLLQFHFHTPSEEKINGKAYPLVAHLVHQNAEGKLAVVAVLFKSGRENAALKP
VFASLPAKAGESRELTAPLDVAALLPARQSYWAFTGSLTTPPCSEDVRWQVLKTPVEVSPAQLAAFRQLYPMNARPVQPL
NGRTVQVSH

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=262, Percent_Identity=36.6412213740458, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI192447434, Length=262, Percent_Identity=36.6412213740458, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI192447432, Length=262, Percent_Identity=36.6412213740458, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI192447430, Length=262, Percent_Identity=36.6412213740458, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4502517, Length=262, Percent_Identity=36.6412213740458, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4885101, Length=260, Percent_Identity=35, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4502521, Length=236, Percent_Identity=37.7118644067797, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI4557395, Length=260, Percent_Identity=35.3846153846154, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4885099, Length=258, Percent_Identity=32.5581395348837, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI38348436, Length=260, Percent_Identity=32.3076923076923, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI6005723, Length=235, Percent_Identity=35.3191489361702, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI4502515, Length=265, Percent_Identity=32.0754716981132, Blast_Score=110, Evalue=9e-25,
Organism=Homo sapiens, GI45935383, Length=265, Percent_Identity=32.0754716981132, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI194097398, Length=271, Percent_Identity=32.4723247232472, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI169636420, Length=259, Percent_Identity=34.3629343629344, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI62240989, Length=203, Percent_Identity=34.9753694581281, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI6912284, Length=283, Percent_Identity=31.8021201413428, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI70167127, Length=258, Percent_Identity=33.3333333333333, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI22027500, Length=243, Percent_Identity=30.4526748971193, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI4502519, Length=266, Percent_Identity=30.0751879699248, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI130979954, Length=256, Percent_Identity=25.78125, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI130979679, Length=256, Percent_Identity=25.78125, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI9910366, Length=256, Percent_Identity=25.78125, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI91208428, Length=237, Percent_Identity=28.6919831223629, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17568715, Length=243, Percent_Identity=36.2139917695473, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71995280, Length=262, Percent_Identity=32.0610687022901, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17569163, Length=231, Percent_Identity=28.1385281385281, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17569165, Length=228, Percent_Identity=28.0701754385965, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21358169, Length=279, Percent_Identity=33.6917562724014, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737413, Length=253, Percent_Identity=35.5731225296443, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24650523, Length=243, Percent_Identity=30.0411522633745, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645604, Length=230, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI161079350, Length=266, Percent_Identity=27.4436090225564, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI116008410, Length=261, Percent_Identity=28.3524904214559, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI18858185, Length=267, Percent_Identity=23.9700374531835, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161079354, Length=257, Percent_Identity=26.0700389105058, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 26879; Mature: 26879

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRLPIITVCTALLAPAAWAGNDPHWSYTGPTGTSHWAELDQDYKTCALGKHQSPIDIR
CCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHCCHHHHHCCCCCCCCEEE
TSKARPADLKPIGFGYAAAPATVVNNGHTVQVNLPAAGQIELDGVPYKLLQFHFHTPSEE
ECCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCEEEECCCCEEEEEEEECCCCCC
KINGKAYPLVAHLVHQNAEGKLAVVAVLFKSGRENAALKPVFASLPAKAGESRELTAPLD
CCCCCHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCC
VAALLPARQSYWAFTGSLTTPPCSEDVRWQVLKTPVEVSPAQLAAFRQLYPMNARPVQPL
HHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
NGRTVQVSH
CCCEEEECC
>Mature Secondary Structure
MNTRLPIITVCTALLAPAAWAGNDPHWSYTGPTGTSHWAELDQDYKTCALGKHQSPIDIR
CCCCCHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHHCCHHHHHCCCCCCCCEEE
TSKARPADLKPIGFGYAAAPATVVNNGHTVQVNLPAAGQIELDGVPYKLLQFHFHTPSEE
ECCCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCCEEEECCCCEEEEEEEECCCCCC
KINGKAYPLVAHLVHQNAEGKLAVVAVLFKSGRENAALKPVFASLPAKAGESRELTAPLD
CCCCCHHHHHHHHHHCCCCCCEEEEEEEHHCCCCCCCCCHHHHHCCCCCCCCCCCCCCCC
VAALLPARQSYWAFTGSLTTPPCSEDVRWQVLKTPVEVSPAQLAAFRQLYPMNARPVQPL
HHHHCCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
NGRTVQVSH
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]