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The map label for this gene is ahpC [C]

Identifier: 116696175

GI number: 116696175

Start: 2538217

End: 2538873

Strand: Direct

Name: ahpC [C]

Synonym: H16_B2239

Alternate gene names: 116696175

Gene position: 2538217-2538873 (Clockwise)

Preceding gene: 116696174

Following gene: 116696177

Centisome position: 87.15

GC content: 61.49

Gene sequence:

>657_bases
ATGGCGATTCGACTGGGCGAGCAAGCCCCTGATTTCACCGCCGACACCACGGAAGGCAAGATCAGCTTCCATGAATGGAT
CGGCGACAACTGGGCCATCCTGTTCTCGCATCCCAAGGACTTCACGCCGGTGTGCACCACCGAACTGGGCTATATGGCCC
GGCTCAAGCCCGAATTCGACAAGCGCAACACCAAGATCATCGGCCTGAGCATCGACCCGGTCGGCGACCACCAGCGCTGG
GTCAAGGACATCGAGGAAACGCAGAACTGCACCATCAACTATCCGATGATCGGCGACGCAGACCTGAAGGTGGCCAAGCT
CTACGACATGATCCACCCCGAGGCCAGTGGCAGCGGCCCGCGCACGGCGGTAGACAACGCCACCATCCGCTCGGTGTTCA
TCATCGGCCCGGACAAGAAGGTCAAGGCCATGCTGGTGTACCCGATGAGCGCCGGGCGCAATTTCGACGAGGTGCTGCGC
CTGCTGGATTCGCTGCAGCTCAATGCCAAGCACACCGTGGCCACGCCGGTGAACTGGAAGCCGGGCGAGGACGTCATCAT
CCCGACATCGGTCTCGGACGAGGAGGCCAAGAAGAAGTACCCGCAGGGCTTTAAGACCCTGAAGCCCTACCTGCGCACGG
TGGAGCAGCCCAAGTAA

Upstream 100 bases:

>100_bases
TCCGCTAGGCGGCCGGGCGAACAACGAGACAGCGCGATAGCGGGCAACAGTGCGCGGCGACGCGCGTTTCCAAACCACGC
CAACTGCAAGGAGCGCAACC

Downstream 100 bases:

>100_bases
GGGGAGCGAGAAGCGCCAGCACCAGGGAGTGCGGCCGGGCGTGGGGGTCACGCCGGCCGCCGCCGGGCCTCCCGGGCAGT
CACGGCCGGGAGGCCCGACT

Product: peroxiredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MAIRLGEQAPDFTADTTEGKISFHEWIGDNWAILFSHPKDFTPVCTTELGYMARLKPEFDKRNTKIIGLSIDPVGDHQRW
VKDIEETQNCTINYPMIGDADLKVAKLYDMIHPEASGSGPRTAVDNATIRSVFIIGPDKKVKAMLVYPMSAGRNFDEVLR
LLDSLQLNAKHTVATPVNWKPGEDVIIPTSVSDEEAKKKYPQGFKTLKPYLRTVEQPK

Sequences:

>Translated_218_residues
MAIRLGEQAPDFTADTTEGKISFHEWIGDNWAILFSHPKDFTPVCTTELGYMARLKPEFDKRNTKIIGLSIDPVGDHQRW
VKDIEETQNCTINYPMIGDADLKVAKLYDMIHPEASGSGPRTAVDNATIRSVFIIGPDKKVKAMLVYPMSAGRNFDEVLR
LLDSLQLNAKHTVATPVNWKPGEDVIIPTSVSDEEAKKKYPQGFKTLKPYLRTVEQPK
>Mature_217_residues
AIRLGEQAPDFTADTTEGKISFHEWIGDNWAILFSHPKDFTPVCTTELGYMARLKPEFDKRNTKIIGLSIDPVGDHQRWV
KDIEETQNCTINYPMIGDADLKVAKLYDMIHPEASGSGPRTAVDNATIRSVFIIGPDKKVKAMLVYPMSAGRNFDEVLRL
LDSLQLNAKHTVATPVNWKPGEDVIIPTSVSDEEAKKKYPQGFKTLKPYLRTVEQPK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4758638, Length=228, Percent_Identity=50, Blast_Score=211, Evalue=5e-55,
Organism=Homo sapiens, GI4505591, Length=203, Percent_Identity=30.0492610837438, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI32455266, Length=203, Percent_Identity=30.0492610837438, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI32455264, Length=203, Percent_Identity=30.0492610837438, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI32189392, Length=202, Percent_Identity=27.2277227722772, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI5453549, Length=171, Percent_Identity=30.4093567251462, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI5802974, Length=173, Percent_Identity=27.1676300578035, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI32483377, Length=173, Percent_Identity=27.1676300578035, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1786822, Length=160, Percent_Identity=28.125, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25153706, Length=228, Percent_Identity=40.3508771929825, Blast_Score=166, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI193204376, Length=201, Percent_Identity=27.8606965174129, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32565831, Length=201, Percent_Identity=27.8606965174129, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17554494, Length=170, Percent_Identity=25.8823529411765, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319407, Length=213, Percent_Identity=52.112676056338, Blast_Score=233, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6323613, Length=194, Percent_Identity=25.7731958762887, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320661, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24652434, Length=225, Percent_Identity=48.4444444444444, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24652436, Length=225, Percent_Identity=48.4444444444444, Blast_Score=198, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17975518, Length=225, Percent_Identity=48, Blast_Score=197, Evalue=6e-51,
Organism=Drosophila melanogaster, GI24581278, Length=223, Percent_Identity=43.4977578475336, Blast_Score=191, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17738015, Length=205, Percent_Identity=28.780487804878, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24656348, Length=183, Percent_Identity=30.0546448087432, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17864676, Length=183, Percent_Identity=30.0546448087432, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17157991, Length=171, Percent_Identity=29.8245614035088, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24641739, Length=171, Percent_Identity=29.8245614035088, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357347, Length=200, Percent_Identity=25, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR022915
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 24502; Mature: 24371

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIRLGEQAPDFTADTTEGKISFHEWIGDNWAILFSHPKDFTPVCTTELGYMARLKPEFD
CEEECCCCCCCCCCCCCCCEEEEHHHCCCCEEEEEECCCCCCCCHHHHHCHHEECCCCCC
KRNTKIIGLSIDPVGDHQRWVKDIEETQNCTINYPMIGDADLKVAKLYDMIHPEASGSGP
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCC
RTAVDNATIRSVFIIGPDKKVKAMLVYPMSAGRNFDEVLRLLDSLQLNAKHTVATPVNWK
CCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC
PGEDVIIPTSVSDEEAKKKYPQGFKTLKPYLRTVEQPK
CCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AIRLGEQAPDFTADTTEGKISFHEWIGDNWAILFSHPKDFTPVCTTELGYMARLKPEFD
EEECCCCCCCCCCCCCCCEEEEHHHCCCCEEEEEECCCCCCCCHHHHHCHHEECCCCCC
KRNTKIIGLSIDPVGDHQRWVKDIEETQNCTINYPMIGDADLKVAKLYDMIHPEASGSGP
CCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCCCCHHHHHHHHHCCCCCCCCC
RTAVDNATIRSVFIIGPDKKVKAMLVYPMSAGRNFDEVLRLLDSLQLNAKHTVATPVNWK
CCCCCCCEEEEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC
PGEDVIIPTSVSDEEAKKKYPQGFKTLKPYLRTVEQPK
CCCCEEEECCCCCHHHHHHCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]