Click here to switch to the map view.

The map label for this gene is betA1 [H]

Identifier: 116696067

GI number: 116696067

Start: 2411005

End: 2412741

Strand: Direct

Name: betA1 [H]

Synonym: H16_B2131

Alternate gene names: 116696067

Gene position: 2411005-2412741 (Clockwise)

Preceding gene: 116696066

Following gene: 116696068

Centisome position: 82.78

GC content: 67.47

Gene sequence:

>1737_bases
ATGCAGGCAATCCATGAGTACGACTACATCATCGTCGGCGCAGGCTCGGCCGGCTGCGTGCTGGCCGCGCGGCTGACCGA
GGATGCCGATGTCTCGGTGCTGCTGCTGGAAGCGGGCGGCCCCGACTGGCGCCTGGACTGGCGCACCCAGATGCCGGCCG
CGCTGGCGTATCCGCTGCAGGGCACCACCTATAACTGGGCCTACGTGACCGAGCCCGAGCCGCATATGAACAACCGGCGC
ATGACGCAGGGCCGCGGCAAGGGGCTGGGCGGTTCGTCGCTGATCAACGGCATGGTCTATATCCGCGGCAACGCGATGGA
CTACGACGGCTGGGCCGAAAACCGTTCGCTGGAGAACTGGAGCTACGCCGACTGCCTGCCCTATTTCCGCAAGGCCGAGA
CCTATGACAAGGGCGCCAACGACTACCACGGCGGCAACGGCCCGCTGCACGTGACCACGCCCAAGGCCGATATCAGCCCG
CTGTTCCGCGCCTTTATCAAGGCCGGCGAGCAGGCCGGCTATGGCCAGACCGATGACCTGAACGGCTACAAGCAGGAAGG
CTTCGGCCCGATGGACCGCACCACCACCGCGCGCGGGCGCCGCTGTAGCACCTCGCTGGCCTATCTGGACCAGGCCAAGG
ACCGGCCCAACCTGACCGTGCATACGCGCGCGCTGGCGGACCGCATCCTGTTCTCCGGCCAGCGCGCCATCGGCGTCTCG
TACATCCAGGGCGACCATGTGCGCGAAGCGCGTGCGCGCCGGGAAGTGATCGTCAGCAACGGCGCGATCGCCTCGCCGCA
ACTGCTGCTGCGCTCGGGCGTGGGCAATGCGGACGAGCTGCGCGCATTTGGCATCGAGTCGGTGGCAGACCTGAAGGGCG
TCGGCGAGAACCTGCAGGACCACCTCGAGATGTACCTGCAGTACGAATGCACCAAGCCCGTATCGCTGTACCCGGCGCTG
AAGTGGTGGAACAAGCCCGCGATTGGCGTCGAATGGTACCTGCGCGGCACCGGCACCGCGGCCTCCAACCACTTCGAGGC
GGGCGGCTTTATCCGCAGCAGCGATGACTTTGCCTGGCCCAACCTGCAGTACCACTTCATCCCGCTGGCGATGAACTACG
ACGGCAGCAACCCGGTGCAGTCGCATGGCTTCCAGTGCCACGTGGGCTCGATGCGCTCGCCCAGCACCGGCTTTGTCAAG
CTGGCCAGCCGCGACCCGCGCGTGAAGCCGCGCCTGCTGTTCAACTACATGGCGCACGACGTCGACTGGCGCGAGTTCCG
CGCCGCGGTGCGCCTGACGCGCGAGATCATCGGCCAGCAGGCGATGGACCAGTTCCGCGGCCGCGAGATCAAGCCCGGCA
TGATGATCCAGAGCGATGCCGAGATCGACGCCTTCGTGCGCGAGCATGCCGAGACCGCGCTGCACCCGTCCTGCACCTGC
AAGATGGGCGACGCTTCCGACCCGATGGCGGTGGTCGACAACCAGGGCCGCGTGCACGGGCTGTCTGGCCTGCGCGTGGT
CGATGCCTCGATCATGCCGAAGATCATCACCGGCAACCTGAACGCGCCCACCATCATGATGGCCGAGAAGCTGGCCGACG
TGATCCGCGGCCGCGCACCGCTGCAACGCTCGACGGCGCCTTACTACAAGGCCGCCACCGCGCGCGGCGGGGCGCAGGCA
GACGCGGAGCGGCATCCGCCAGCCACTGCGCGAATGCCGATGCCGATGCCCGCCTGA

Upstream 100 bases:

>100_bases
TGGTTCGGCGCCTGAGCGCAGCTGACTTCGCAATCGCGCGCGCGGCAGGCCCTCCCCCGGGCCGCCACGCACGGCGTCAA
GCAAACAAGGAGATTGCACC

Downstream 100 bases:

>100_bases
CCAGGCGGCGCGGCGCGCGGGCTTCCCGCCAGAACCCCTGACCGACGCATGTGCTGCCGGGACTTCGGTCCCCGGCGGGC
AGCGTGCGTCCGGTCGGCGC

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MQAIHEYDYIIVGAGSAGCVLAARLTEDADVSVLLLEAGGPDWRLDWRTQMPAALAYPLQGTTYNWAYVTEPEPHMNNRR
MTQGRGKGLGGSSLINGMVYIRGNAMDYDGWAENRSLENWSYADCLPYFRKAETYDKGANDYHGGNGPLHVTTPKADISP
LFRAFIKAGEQAGYGQTDDLNGYKQEGFGPMDRTTTARGRRCSTSLAYLDQAKDRPNLTVHTRALADRILFSGQRAIGVS
YIQGDHVREARARREVIVSNGAIASPQLLLRSGVGNADELRAFGIESVADLKGVGENLQDHLEMYLQYECTKPVSLYPAL
KWWNKPAIGVEWYLRGTGTAASNHFEAGGFIRSSDDFAWPNLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVK
LASRDPRVKPRLLFNYMAHDVDWREFRAAVRLTREIIGQQAMDQFRGREIKPGMMIQSDAEIDAFVREHAETALHPSCTC
KMGDASDPMAVVDNQGRVHGLSGLRVVDASIMPKIITGNLNAPTIMMAEKLADVIRGRAPLQRSTAPYYKAATARGGAQA
DAERHPPATARMPMPMPA

Sequences:

>Translated_578_residues
MQAIHEYDYIIVGAGSAGCVLAARLTEDADVSVLLLEAGGPDWRLDWRTQMPAALAYPLQGTTYNWAYVTEPEPHMNNRR
MTQGRGKGLGGSSLINGMVYIRGNAMDYDGWAENRSLENWSYADCLPYFRKAETYDKGANDYHGGNGPLHVTTPKADISP
LFRAFIKAGEQAGYGQTDDLNGYKQEGFGPMDRTTTARGRRCSTSLAYLDQAKDRPNLTVHTRALADRILFSGQRAIGVS
YIQGDHVREARARREVIVSNGAIASPQLLLRSGVGNADELRAFGIESVADLKGVGENLQDHLEMYLQYECTKPVSLYPAL
KWWNKPAIGVEWYLRGTGTAASNHFEAGGFIRSSDDFAWPNLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVK
LASRDPRVKPRLLFNYMAHDVDWREFRAAVRLTREIIGQQAMDQFRGREIKPGMMIQSDAEIDAFVREHAETALHPSCTC
KMGDASDPMAVVDNQGRVHGLSGLRVVDASIMPKIITGNLNAPTIMMAEKLADVIRGRAPLQRSTAPYYKAATARGGAQA
DAERHPPATARMPMPMPA
>Mature_578_residues
MQAIHEYDYIIVGAGSAGCVLAARLTEDADVSVLLLEAGGPDWRLDWRTQMPAALAYPLQGTTYNWAYVTEPEPHMNNRR
MTQGRGKGLGGSSLINGMVYIRGNAMDYDGWAENRSLENWSYADCLPYFRKAETYDKGANDYHGGNGPLHVTTPKADISP
LFRAFIKAGEQAGYGQTDDLNGYKQEGFGPMDRTTTARGRRCSTSLAYLDQAKDRPNLTVHTRALADRILFSGQRAIGVS
YIQGDHVREARARREVIVSNGAIASPQLLLRSGVGNADELRAFGIESVADLKGVGENLQDHLEMYLQYECTKPVSLYPAL
KWWNKPAIGVEWYLRGTGTAASNHFEAGGFIRSSDDFAWPNLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVK
LASRDPRVKPRLLFNYMAHDVDWREFRAAVRLTREIIGQQAMDQFRGREIKPGMMIQSDAEIDAFVREHAETALHPSCTC
KMGDASDPMAVVDNQGRVHGLSGLRVVDASIMPKIITGNLNAPTIMMAEKLADVIRGRAPLQRSTAPYYKAATARGGAQA
DAERHPPATARMPMPMPA

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=553, Percent_Identity=51.1754068716094, Blast_Score=552, Evalue=1e-157,
Organism=Escherichia coli, GI1786503, Length=548, Percent_Identity=68.7956204379562, Blast_Score=798, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17532301, Length=551, Percent_Identity=49.0018148820327, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642048, Length=587, Percent_Identity=37.4787052810903, Blast_Score=314, Evalue=1e-85,
Organism=Drosophila melanogaster, GI45551458, Length=572, Percent_Identity=37.0629370629371, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI45549471, Length=572, Percent_Identity=37.0629370629371, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24642042, Length=609, Percent_Identity=37.1100164203612, Blast_Score=302, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24642059, Length=575, Percent_Identity=37.0434782608696, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24642055, Length=578, Percent_Identity=39.1003460207612, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24650267, Length=570, Percent_Identity=35.9649122807018, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI17137792, Length=559, Percent_Identity=34.7048300536673, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24642039, Length=577, Percent_Identity=37.6083188908146, Blast_Score=275, Evalue=8e-74,
Organism=Drosophila melanogaster, GI18859995, Length=578, Percent_Identity=36.8512110726644, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI18859993, Length=574, Percent_Identity=33.1010452961672, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24642035, Length=576, Percent_Identity=32.6388888888889, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24642037, Length=572, Percent_Identity=33.3916083916084, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24642051, Length=570, Percent_Identity=31.5789473684211, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24645930, Length=579, Percent_Identity=26.4248704663212, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24642057, Length=596, Percent_Identity=28.1879194630872, Blast_Score=129, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 63780; Mature: 63780

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAIHEYDYIIVGAGSAGCVLAARLTEDADVSVLLLEAGGPDWRLDWRTQMPAALAYPLQ
CCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCCCEECCCC
GTTYNWAYVTEPEPHMNNRRMTQGRGKGLGGSSLINGMVYIRGNAMDYDGWAENRSLENW
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCCCCCCCCCC
SYADCLPYFRKAETYDKGANDYHGGNGPLHVTTPKADISPLFRAFIKAGEQAGYGQTDDL
CHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
NGYKQEGFGPMDRTTTARGRRCSTSLAYLDQAKDRPNLTVHTRALADRILFSGQRAIGVS
CCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCEEEEE
YIQGDHVREARARREVIVSNGAIASPQLLLRSGVGNADELRAFGIESVADLKGVGENLQD
EECCCHHHHHHHHHHEEEECCCCCCHHHHHHCCCCCHHHHHHHCCHHHHHHHHCCHHHHH
HLEMYLQYECTKPVSLYPALKWWNKPAIGVEWYLRGTGTAASNHFEAGGFIRSSDDFAWP
HHHHHHEEECCCCCEECHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCC
NLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVKLASRDPRVKPRLLFNYMAHD
CCEEEEEEEEEECCCCCCHHHCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCC
VDWREFRAAVRLTREIIGQQAMDQFRGREIKPGMMIQSDAEIDAFVREHAETALHPSCTC
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEE
KMGDASDPMAVVDNQGRVHGLSGLRVVDASIMPKIITGNLNAPTIMMAEKLADVIRGRAP
ECCCCCCCEEEECCCCCEECCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCC
LQRSTAPYYKAATARGGAQADAERHPPATARMPMPMPA
CCCCCCCCHHHHCCCCCCCCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQAIHEYDYIIVGAGSAGCVLAARLTEDADVSVLLLEAGGPDWRLDWRTQMPAALAYPLQ
CCCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCCEEEECCCCCCCCEECCCC
GTTYNWAYVTEPEPHMNNRRMTQGRGKGLGGSSLINGMVYIRGNAMDYDGWAENRSLENW
CCEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCEEEEECCCCCCCCCCCCCCCCCC
SYADCLPYFRKAETYDKGANDYHGGNGPLHVTTPKADISPLFRAFIKAGEQAGYGQTDDL
CHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
NGYKQEGFGPMDRTTTARGRRCSTSLAYLDQAKDRPNLTVHTRALADRILFSGQRAIGVS
CCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCEEEEE
YIQGDHVREARARREVIVSNGAIASPQLLLRSGVGNADELRAFGIESVADLKGVGENLQD
EECCCHHHHHHHHHHEEEECCCCCCHHHHHHCCCCCHHHHHHHCCHHHHHHHHCCHHHHH
HLEMYLQYECTKPVSLYPALKWWNKPAIGVEWYLRGTGTAASNHFEAGGFIRSSDDFAWP
HHHHHHEEECCCCCEECHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCCCC
NLQYHFIPLAMNYDGSNPVQSHGFQCHVGSMRSPSTGFVKLASRDPRVKPRLLFNYMAHD
CCEEEEEEEEEECCCCCCHHHCCEEEEECCCCCCCCCEEEEECCCCCCCHHHHHHHHHCC
VDWREFRAAVRLTREIIGQQAMDQFRGREIKPGMMIQSDAEIDAFVREHAETALHPSCTC
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEE
KMGDASDPMAVVDNQGRVHGLSGLRVVDASIMPKIITGNLNAPTIMMAEKLADVIRGRAP
ECCCCCCCEEEECCCCCEECCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCC
LQRSTAPYYKAATARGGAQADAERHPPATARMPMPMPA
CCCCCCCCHHHHCCCCCCCCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA