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The map label for this gene is gabP [H]

Identifier: 116695826

GI number: 116695826

Start: 2135956

End: 2137392

Strand: Direct

Name: gabP [H]

Synonym: H16_B1890

Alternate gene names: 116695826

Gene position: 2135956-2137392 (Clockwise)

Preceding gene: 116695822

Following gene: 116695827

Centisome position: 73.34

GC content: 66.53

Gene sequence:

>1437_bases
ATGATCCAACAACCAGAGTCCGGCAACGGGCTATCCCACGGCCTGAAGCAACGCCACATGACCATGATCGCGCTGGGTGG
CGTGATCGGCGCAGGCCTCTTTGTCGGCAGCGGCGTCGTCATCAAGTCCGCCGGCCCGGCCGCGGTCCTTTCCTTCCTGA
TCACCGGCCTGCTGGTGGTGCTGGTGATGCGCATGCTGGGCGAGATGGCCTGCGCCATGCCCGGCACCGGCGGTTTCTAT
GAGTATGCGCGCGAAGCCTGGCGCGACCGCCCGGCGGTGGGCAACCTGGCCGGCTTCCTGACCGGCTGGATGTACTGGTA
CTTCTGGGTCATCGTGGTGGCGCTGGAAGCCGTGGCCGGTGCCGACCTGGTGCGCTACTGGCTGCCCGACGTGCCCAACT
GGATCATCAGCCTGGTGCTGCTGGTGATGCTGACGCTGACCAACCTGGTGTCGGTCAAGTCCTTCGGCGAGTTCGAGTTC
TGGTTCGCGTCGATCAAGGTGGCCGCGATCATCGTGTTCCTGTTCGTCGCCGGCGTCTATGTGCTGGGCCTGGCGCCCGG
TGCCCATGGCATGCAGGTGGCCAACCTGACCGCCAACGGCGGCTTCATGCCGCACGGCATCGTACCGGTGCTGACCGGAG
CGGTAGCCGCCACGGGCTTCTACTTCGGGGCCGAGATCGTCACCATCGCCGCCGCCGAGACCGCCGAGCCGCAGAAGGCA
GTGGCCAAGGCCACCAGCTCGGTGATCACGCGCGTGCTGGTTTTCTATGTGGGTTCGATCCTGCTGGTGGTCTGCCTGGT
ACCGTGGAACTCCAACAGCATCGCCACGCCGTACGTCAGCGCGCTGAACGTGATGGGCGTGCCGGCGGCCGCGCAGATCA
TGAACGCGATCGTGCTGACCGCGGTGCTGTCGGCGCTTAACTCGGGCCTCTATGCCTCGTCGCGCATGCTGTTCGCGCTG
ACCCGCCGTGGCGACGCCCCCAAGTCGCTGGCCCGCGTGAGCCGCAACGGCGTGCCGGTGCGCGCCATCCTGGTGGCGAC
CCTGTTCGGCTACGGTGCGGTGGTGATGTCCTATGTCTCGCCTGATACGGTGTTTGCCTTCCTGGTGAACTCGTACGGCA
CGGTGGCGATCTTCGTCTACATCCTGATCGCGATCTCGCAGCTGCGCCTGCGTTCCCGCCTGGAGCGCGAAGCGCCGGGC
CAGCTGCGCGTGCGCATGTGGTGCTACCCGTACCTCACCTACCTGGCGATCGTCGGCATGATCGGCATCGTGGTGGCGAT
GGCCTTCATCCCCGACCAGCGCACGCCGCTTGCGCTGGGTGTGGTGAGCCTGGGCATCCTGCTGGTGGCCTACGCCGCGC
GGCACCTGTTTCGCGGTAGCGTGGATCCGGTAGTGCCGCTGGCGGAGATGCCGCGCCCGGACCTGCATGAGTATTGA

Upstream 100 bases:

>100_bases
TGCCTGCCATCTATACCGAAGAGAAGCCGTGGCGCCTGCCTTAAACGCTGTACTGGCTGCAACGCAGTACCGACAGCTAG
CGCAGCACAGGAGACACAAC

Downstream 100 bases:

>100_bases
TGACTGACCATGACTGACGTGGCGCGCCGGTGCGGTATGCTGGCGCGCTTCGCCGTCTAGGCAACGCCCCTGCCCCATGA
GCCTGAAGTCTCCCACCACC

Product: amino acid ABC transporter permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MIQQPESGNGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVVLVMRMLGEMACAMPGTGGFY
EYAREAWRDRPAVGNLAGFLTGWMYWYFWVIVVALEAVAGADLVRYWLPDVPNWIISLVLLVMLTLTNLVSVKSFGEFEF
WFASIKVAAIIVFLFVAGVYVLGLAPGAHGMQVANLTANGGFMPHGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
VAKATSSVITRVLVFYVGSILLVVCLVPWNSNSIATPYVSALNVMGVPAAAQIMNAIVLTAVLSALNSGLYASSRMLFAL
TRRGDAPKSLARVSRNGVPVRAILVATLFGYGAVVMSYVSPDTVFAFLVNSYGTVAIFVYILIAISQLRLRSRLEREAPG
QLRVRMWCYPYLTYLAIVGMIGIVVAMAFIPDQRTPLALGVVSLGILLVAYAARHLFRGSVDPVVPLAEMPRPDLHEY

Sequences:

>Translated_478_residues
MIQQPESGNGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVVLVMRMLGEMACAMPGTGGFY
EYAREAWRDRPAVGNLAGFLTGWMYWYFWVIVVALEAVAGADLVRYWLPDVPNWIISLVLLVMLTLTNLVSVKSFGEFEF
WFASIKVAAIIVFLFVAGVYVLGLAPGAHGMQVANLTANGGFMPHGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
VAKATSSVITRVLVFYVGSILLVVCLVPWNSNSIATPYVSALNVMGVPAAAQIMNAIVLTAVLSALNSGLYASSRMLFAL
TRRGDAPKSLARVSRNGVPVRAILVATLFGYGAVVMSYVSPDTVFAFLVNSYGTVAIFVYILIAISQLRLRSRLEREAPG
QLRVRMWCYPYLTYLAIVGMIGIVVAMAFIPDQRTPLALGVVSLGILLVAYAARHLFRGSVDPVVPLAEMPRPDLHEY
>Mature_478_residues
MIQQPESGNGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVVLVMRMLGEMACAMPGTGGFY
EYAREAWRDRPAVGNLAGFLTGWMYWYFWVIVVALEAVAGADLVRYWLPDVPNWIISLVLLVMLTLTNLVSVKSFGEFEF
WFASIKVAAIIVFLFVAGVYVLGLAPGAHGMQVANLTANGGFMPHGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
VAKATSSVITRVLVFYVGSILLVVCLVPWNSNSIATPYVSALNVMGVPAAAQIMNAIVLTAVLSALNSGLYASSRMLFAL
TRRGDAPKSLARVSRNGVPVRAILVATLFGYGAVVMSYVSPDTVFAFLVNSYGTVAIFVYILIAISQLRLRSRLEREAPG
QLRVRMWCYPYLTYLAIVGMIGIVVAMAFIPDQRTPLALGVVSLGILLVAYAARHLFRGSVDPVVPLAEMPRPDLHEY

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=371, Percent_Identity=27.4932614555256, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI181337167, Length=421, Percent_Identity=23.7529691211401, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI258614003, Length=370, Percent_Identity=25.9459459459459, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI258614005, Length=370, Percent_Identity=25.9459459459459, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789017, Length=446, Percent_Identity=45.7399103139013, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1786302, Length=460, Percent_Identity=36.9565217391304, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI87081708, Length=457, Percent_Identity=36.1050328227571, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1786789, Length=434, Percent_Identity=36.6359447004608, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI48994972, Length=444, Percent_Identity=36.4864864864865, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1788480, Length=393, Percent_Identity=38.9312977099237, Blast_Score=261, Evalue=6e-71,
Organism=Escherichia coli, GI1790653, Length=462, Percent_Identity=33.1168831168831, Blast_Score=258, Evalue=8e-70,
Organism=Escherichia coli, GI87081915, Length=450, Percent_Identity=36.6666666666667, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1786602, Length=454, Percent_Identity=35.9030837004405, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17532491, Length=378, Percent_Identity=21.957671957672, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=35.4545454545455, Blast_Score=234, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6324061, Length=476, Percent_Identity=31.9327731092437, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6324924, Length=476, Percent_Identity=30.0420168067227, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6324059, Length=451, Percent_Identity=32.3725055432373, Blast_Score=188, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=30.5623471882641, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6322892, Length=485, Percent_Identity=29.8969072164948, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=448, Percent_Identity=29.0178571428571, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321053, Length=402, Percent_Identity=31.592039800995, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6324990, Length=487, Percent_Identity=30.8008213552361, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319543, Length=405, Percent_Identity=31.358024691358, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6321629, Length=500, Percent_Identity=28.2, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6324553, Length=401, Percent_Identity=31.6708229426434, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319542, Length=418, Percent_Identity=28.7081339712919, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320251, Length=408, Percent_Identity=27.4509803921569, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6322967, Length=402, Percent_Identity=29.6019900497512, Blast_Score=150, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=434, Percent_Identity=25.3456221198157, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324981, Length=468, Percent_Identity=28.8461538461538, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6320364, Length=509, Percent_Identity=23.5756385068762, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24666159, Length=419, Percent_Identity=21.0023866348449, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221512776, Length=419, Percent_Identity=21.0023866348449, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51114; Mature: 51114

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQQPESGNGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
LVMRMLGEMACAMPGTGGFYEYAREAWRDRPAVGNLAGFLTGWMYWYFWVIVVALEAVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLVRYWLPDVPNWIISLVLLVMLTLTNLVSVKSFGEFEFWFASIKVAAIIVFLFVAGVY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLGLAPGAHGMQVANLTANGGFMPHGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
HHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
VAKATSSVITRVLVFYVGSILLVVCLVPWNSNSIATPYVSALNVMGVPAAAQIMNAIVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AVLSALNSGLYASSRMLFALTRRGDAPKSLARVSRNGVPVRAILVATLFGYGAVVMSYVS
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PDTVFAFLVNSYGTVAIFVYILIAISQLRLRSRLEREAPGQLRVRMWCYPYLTYLAIVGM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
IGIVVAMAFIPDQRTPLALGVVSLGILLVAYAARHLFRGSVDPVVPLAEMPRPDLHEY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MIQQPESGNGLSHGLKQRHMTMIALGGVIGAGLFVGSGVVIKSAGPAAVLSFLITGLLVV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHH
LVMRMLGEMACAMPGTGGFYEYAREAWRDRPAVGNLAGFLTGWMYWYFWVIVVALEAVAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADLVRYWLPDVPNWIISLVLLVMLTLTNLVSVKSFGEFEFWFASIKVAAIIVFLFVAGVY
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLGLAPGAHGMQVANLTANGGFMPHGIVPVLTGAVAATGFYFGAEIVTIAAAETAEPQKA
HHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHH
VAKATSSVITRVLVFYVGSILLVVCLVPWNSNSIATPYVSALNVMGVPAAAQIMNAIVLT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHH
AVLSALNSGLYASSRMLFALTRRGDAPKSLARVSRNGVPVRAILVATLFGYGAVVMSYVS
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
PDTVFAFLVNSYGTVAIFVYILIAISQLRLRSRLEREAPGQLRVRMWCYPYLTYLAIVGM
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHH
IGIVVAMAFIPDQRTPLALGVVSLGILLVAYAARHLFRGSVDPVVPLAEMPRPDLHEY
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8951816; 8969499; 9384377 [H]