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The map label for this gene is serA6 [H]

Identifier: 116695755

GI number: 116695755

Start: 2055579

End: 2056661

Strand: Direct

Name: serA6 [H]

Synonym: H16_B1819

Alternate gene names: 116695755

Gene position: 2055579-2056661 (Clockwise)

Preceding gene: 116695754

Following gene: 116695756

Centisome position: 70.58

GC content: 71.56

Gene sequence:

>1083_bases
ATGAACGCGCCCGTCCTGCTGATGCCTGCCGCCGGCACGGTGGTCCGTTTCGACCACTGGCTGGACGCAGCCTTTGACCG
CATCATTACGGCCACGCCAGGCCTGACGCTGCACACCTGCGCCCGCGAAGGCGCCGACGCGGCCGCCTGGGACCGGCTGT
CCGGCGCCCATGTCTACCAGATCTCGGCCGCCAAGGACGAGATCCCGCGCCGCTGGTTCGCCGACGCCGCGCTGCTGGCG
CGCTGCCCGAACCTGCTGGCGGTGTCGTCCAGCGGCTCCGGCTGCGACACCATCGACATCGATGCCTGCACCGAGGCCGG
CGTCGCGGTGCTCAACCAGGCCGGCGGCAACGCCGACTCGGTGGCGGAGATGACGCTGGGCCTGATGCTCGCGGTACTGC
GCCGCATCGCCGAATCCGACCGCAGCCTGCGCGCGCACAACTGCGAGAGCCGTGAGGACCTGATGGGCCACGAACTGCGC
GGCCGCACGCTCGGCCTGGTCGGCGTGGGCCACGCGGGCCGCCGCGTCGCCGCACTCGGCCGCGCCTTGGGCATGCGCGT
GATCGGGTGCGACCCGGCGCTGGATGCGGCGGAGCTGTCCGCACGCGGCGCACAGGCCGTGTCCTTCGAGGAATTGCTGC
GCAGTGCCGACATCGTCTCGCTGCATTGCCCGCGCGATGCCACCACGCTGCGCATGATGGATGGCGCCGCCTTTGCCGCG
ATGCGGCCGGGCAGCATCTTCGTCAGCACCGCGCGCGGCGGCATCCACGATGAGGGCGCGCTGCATGCGGCGCTGGCCAG
CGGCCATCTTGCCGGCGCCGGTCTGGACGTGTGGGACCAGGAGCCGCCACCACGCGCCCACCCCTTGCTCGCGCTGGACA
ACGTCGTCGCCACCTTCCACACCGCTGGCGTTACTCACGAGGCACGGCGCAGGAACGCCGAACTGGCCGCCACTCAAATC
GTCACGCTGCTGACCAGTGGCGAGCGGCCCGAGCGGCTGGTCAATCCCGAAGTCTGGCCGCGAGCGCGCCTGCGCATTGC
GGCGGTGATGCAGGCTGCCGCCCTGTCATCGGTCACACCTTAG

Upstream 100 bases:

>100_bases
ACGTACAACGCACCGAAGCAGCGGTGCTCGAGTCGATCGCGCAAGGCCGCGCCGATCGGAGCTGGGTCGAGCGCACGCTG
CGCGAAAAGGGGGTGGTCGT

Downstream 100 bases:

>100_bases
CCCCCGATTCCGCAGACTATTCTTTACACATAACACGCTGGCATACCAGACCGGCGAGGAGACACCAACCATGCACCCGA
CCCAAGACCAATGGCGCCGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MNAPVLLMPAAGTVVRFDHWLDAAFDRIITATPGLTLHTCAREGADAAAWDRLSGAHVYQISAAKDEIPRRWFADAALLA
RCPNLLAVSSSGSGCDTIDIDACTEAGVAVLNQAGGNADSVAEMTLGLMLAVLRRIAESDRSLRAHNCESREDLMGHELR
GRTLGLVGVGHAGRRVAALGRALGMRVIGCDPALDAAELSARGAQAVSFEELLRSADIVSLHCPRDATTLRMMDGAAFAA
MRPGSIFVSTARGGIHDEGALHAALASGHLAGAGLDVWDQEPPPRAHPLLALDNVVATFHTAGVTHEARRRNAELAATQI
VTLLTSGERPERLVNPEVWPRARLRIAAVMQAAALSSVTP

Sequences:

>Translated_360_residues
MNAPVLLMPAAGTVVRFDHWLDAAFDRIITATPGLTLHTCAREGADAAAWDRLSGAHVYQISAAKDEIPRRWFADAALLA
RCPNLLAVSSSGSGCDTIDIDACTEAGVAVLNQAGGNADSVAEMTLGLMLAVLRRIAESDRSLRAHNCESREDLMGHELR
GRTLGLVGVGHAGRRVAALGRALGMRVIGCDPALDAAELSARGAQAVSFEELLRSADIVSLHCPRDATTLRMMDGAAFAA
MRPGSIFVSTARGGIHDEGALHAALASGHLAGAGLDVWDQEPPPRAHPLLALDNVVATFHTAGVTHEARRRNAELAATQI
VTLLTSGERPERLVNPEVWPRARLRIAAVMQAAALSSVTP
>Mature_360_residues
MNAPVLLMPAAGTVVRFDHWLDAAFDRIITATPGLTLHTCAREGADAAAWDRLSGAHVYQISAAKDEIPRRWFADAALLA
RCPNLLAVSSSGSGCDTIDIDACTEAGVAVLNQAGGNADSVAEMTLGLMLAVLRRIAESDRSLRAHNCESREDLMGHELR
GRTLGLVGVGHAGRRVAALGRALGMRVIGCDPALDAAELSARGAQAVSFEELLRSADIVSLHCPRDATTLRMMDGAAFAA
MRPGSIFVSTARGGIHDEGALHAALASGHLAGAGLDVWDQEPPPRAHPLLALDNVVATFHTAGVTHEARRRNAELAATQI
VTLLTSGERPERLVNPEVWPRARLRIAAVMQAAALSSVTP

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=241, Percent_Identity=37.7593360995851, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI145580578, Length=265, Percent_Identity=35.4716981132075, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4557499, Length=265, Percent_Identity=35.4716981132075, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI145580575, Length=252, Percent_Identity=36.5079365079365, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI61743967, Length=252, Percent_Identity=34.9206349206349, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4557497, Length=252, Percent_Identity=34.9206349206349, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI6912396, Length=256, Percent_Identity=30.078125, Blast_Score=108, Evalue=8e-24,
Organism=Escherichia coli, GI1789279, Length=259, Percent_Identity=33.976833976834, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082289, Length=267, Percent_Identity=32.2097378277154, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787645, Length=256, Percent_Identity=30.078125, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788660, Length=243, Percent_Identity=31.6872427983539, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=248, Percent_Identity=34.6774193548387, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=261, Percent_Identity=31.4176245210728, Blast_Score=114, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=276, Percent_Identity=30.0724637681159, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322116, Length=274, Percent_Identity=29.9270072992701, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324055, Length=324, Percent_Identity=27.4691358024691, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324964, Length=268, Percent_Identity=27.2388059701493, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324980, Length=207, Percent_Identity=24.6376811594203, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19921140, Length=250, Percent_Identity=36.8, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24646446, Length=274, Percent_Identity=33.5766423357664, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646448, Length=274, Percent_Identity=33.5766423357664, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646452, Length=274, Percent_Identity=33.5766423357664, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24646450, Length=274, Percent_Identity=33.5766423357664, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI62472511, Length=261, Percent_Identity=34.4827586206897, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28571528, Length=252, Percent_Identity=32.9365079365079, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI28574286, Length=245, Percent_Identity=30.6122448979592, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24585516, Length=250, Percent_Identity=31.2, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585514, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574282, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45552429, Length=264, Percent_Identity=28.7878787878788, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37917; Mature: 37917

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPVLLMPAAGTVVRFDHWLDAAFDRIITATPGLTLHTCAREGADAAAWDRLSGAHVYQ
CCCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHCCCCCEEEE
ISAAKDEIPRRWFADAALLARCPNLLAVSSSGSGCDTIDIDACTEAGVAVLNQAGGNADS
EECCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHCCCCHHH
VAEMTLGLMLAVLRRIAESDRSLRAHNCESREDLMGHELRGRTLGLVGVGHAGRRVAALG
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCHHHCCCEEEEEECCCCCHHHHHHH
RALGMRVIGCDPALDAAELSARGAQAVSFEELLRSADIVSLHCPRDATTLRMMDGAAFAA
HHHCCEEEECCCCCCHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCEEEEECCCEEEE
MRPGSIFVSTARGGIHDEGALHAALASGHLAGAGLDVWDQEPPPRAHPLLALDNVVATFH
ECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TAGVTHEARRRNAELAATQIVTLLTSGERPERLVNPEVWPRARLRIAAVMQAAALSSVTP
HCCCCHHHHHCCHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNAPVLLMPAAGTVVRFDHWLDAAFDRIITATPGLTLHTCAREGADAAAWDRLSGAHVYQ
CCCCEEEEECCCCEEEHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCHHHHHCCCCCEEEE
ISAAKDEIPRRWFADAALLARCPNLLAVSSSGSGCDTIDIDACTEAGVAVLNQAGGNADS
EECCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCEEECCHHHHHHHHHHHHCCCCHHH
VAEMTLGLMLAVLRRIAESDRSLRAHNCESREDLMGHELRGRTLGLVGVGHAGRRVAALG
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCHHHCCCEEEEEECCCCCHHHHHHH
RALGMRVIGCDPALDAAELSARGAQAVSFEELLRSADIVSLHCPRDATTLRMMDGAAFAA
HHHCCEEEECCCCCCHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCEEEEECCCEEEE
MRPGSIFVSTARGGIHDEGALHAALASGHLAGAGLDVWDQEPPPRAHPLLALDNVVATFH
ECCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TAGVTHEARRRNAELAATQIVTLLTSGERPERLVNPEVWPRARLRIAAVMQAAALSSVTP
HCCCCHHHHHCCHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]