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The map label for this gene is cpx [H]

Identifier: 116695432

GI number: 116695432

Start: 1674399

End: 1675730

Strand: Direct

Name: cpx [H]

Synonym: H16_B1490

Alternate gene names: 116695432

Gene position: 1674399-1675730 (Clockwise)

Preceding gene: 116695431

Following gene: 116695434

Centisome position: 57.49

GC content: 66.89

Gene sequence:

>1332_bases
ATGGCGCCCTTGCTATTCAAGGTGGAAGACCGCCCCCCTCGGCTGACGACGTTTTTGCTTGCGCTCCAGCATCTGCTGGC
CGCCCTGGGCGGCATCATTGCGGTGCCGCTGGTCATTGGCGGTGCGCTGAAGCTGCCGCCGGACCAGGTCATTGCCCTGG
TGAATGCGGCCCTGCTTGGCTCGGGCATCGTCACCATCATCCAGTGCAAGGGCATTGGCCCGGTGGGCATCCGCATGCCA
TGCGTGATGGGCACCAGCTTCGCCTTTGTCGGCGCGGCCATCAGCGTGGGCGTCGAACACGGCGTGGCTGGCATCCTGGG
CTCGGCGCTGGCGGGTTCGCTGGTGATGATCCTGGGCAGCTTCTTCATGCCGGCGATCCGCAAGCTGTTTCCGCATACCG
TCACCAGCGTGGTAGTCACCATGATCGGCCTGTCGCTGATTCCGGTGGCCATCGACTGGGCCGCAGGCGGCCAGGGCAGC
AGCCGCTATGGCGCACCCGGCAACCTGGCGATTGCCGTCGCGGTGCTGGCGCTGGTGGTCGCGGTGGTGCAGTGGGGCAA
GGGCATGCTGTCGGCCTCGGCCATTGTGGTCGGCATTGCCGGCGGCTACCTGCTCTGCCTGGCGCTGGGCCTGGTCGACT
TCACCCAGTTTCACCAGGCGCCGATCATCGCGGTGCCGCAGCCGCTGCACTTCGGGATGTCGTTCCCAATCTCCGGCATC
GTCGCCATGTCGATCGCTTTCCTGGTGACCATCGTCGAATCCACGGGCACGTTCATGGCACTGGGCGCGGCCACGCAGCG
GCCGATTTCCGGTAAATGCCTGTCGCGCGGCATCCTGTGCGATGGCTTTGGCTCGGCCTTTGCGGCACTGGTGTCGAGCC
CGCCGCTGTCCACCTTTGCGCAGAACGTCGGCGTGGTTTCGCTGACCGGCGTGGCCAGCCGCCATGTGGTCGCGCTGACC
GGCGTCATGCTGCTGCTGGCGGGGCTGTTCCCGGTGCTGGGCGCGCTGGTGGTGACGATTCCGCAGCCGGTGCTGGGCGG
CGCCGGCCTGATGATGTTCGCGATGATCGTGTCGGGCGGGATCCAGATGCTCAGCACCGTCAAGTTCACGCAGCGCAATA
CCCTGATCGTGGCCGTGTCGATCGGCTGCGGCCTGGCGGTGACGTTCCGCCCGGAACTGCTGTCCAAGCTGCCTGCCTTC
GTCCATGAAGTGTTTGGCTCCGGCATCACGGTGGGCTCGCTGTCGGCGGTGATCCTCAACCTGCTGCTGCCCGGCGGCAA
GGACGAGCCTGCCGAACAAGCCGGCCACGGCACCGTCGGCGAGGCTGCCTGA

Upstream 100 bases:

>100_bases
CGTCAGCGCGCAATGACAGGGCCCGGGGGCAGCCCCTTCCCCGGCGCCAGAAGAACAAGACAGTCCGGAAACCTATCCGG
CCAGACAACAGGAGACATGA

Downstream 100 bases:

>100_bases
GCAGCCTGCCTTGAAGCCCGCGGGCGCGCGCTAGCGTGCGCCGCCTCGCGCGGCCGCCCCGCCCCCTGGCGCGGGCGCCT
TCAGCAGCGGGTAGGGATTG

Product: NCS2 family nucleobase/cation symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAPLLFKVEDRPPRLTTFLLALQHLLAALGGIIAVPLVIGGALKLPPDQVIALVNAALLGSGIVTIIQCKGIGPVGIRMP
CVMGTSFAFVGAAISVGVEHGVAGILGSALAGSLVMILGSFFMPAIRKLFPHTVTSVVVTMIGLSLIPVAIDWAAGGQGS
SRYGAPGNLAIAVAVLALVVAVVQWGKGMLSASAIVVGIAGGYLLCLALGLVDFTQFHQAPIIAVPQPLHFGMSFPISGI
VAMSIAFLVTIVESTGTFMALGAATQRPISGKCLSRGILCDGFGSAFAALVSSPPLSTFAQNVGVVSLTGVASRHVVALT
GVMLLLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSGGIQMLSTVKFTQRNTLIVAVSIGCGLAVTFRPELLSKLPAF
VHEVFGSGITVGSLSAVILNLLLPGGKDEPAEQAGHGTVGEAA

Sequences:

>Translated_443_residues
MAPLLFKVEDRPPRLTTFLLALQHLLAALGGIIAVPLVIGGALKLPPDQVIALVNAALLGSGIVTIIQCKGIGPVGIRMP
CVMGTSFAFVGAAISVGVEHGVAGILGSALAGSLVMILGSFFMPAIRKLFPHTVTSVVVTMIGLSLIPVAIDWAAGGQGS
SRYGAPGNLAIAVAVLALVVAVVQWGKGMLSASAIVVGIAGGYLLCLALGLVDFTQFHQAPIIAVPQPLHFGMSFPISGI
VAMSIAFLVTIVESTGTFMALGAATQRPISGKCLSRGILCDGFGSAFAALVSSPPLSTFAQNVGVVSLTGVASRHVVALT
GVMLLLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSGGIQMLSTVKFTQRNTLIVAVSIGCGLAVTFRPELLSKLPAF
VHEVFGSGITVGSLSAVILNLLLPGGKDEPAEQAGHGTVGEAA
>Mature_442_residues
APLLFKVEDRPPRLTTFLLALQHLLAALGGIIAVPLVIGGALKLPPDQVIALVNAALLGSGIVTIIQCKGIGPVGIRMPC
VMGTSFAFVGAAISVGVEHGVAGILGSALAGSLVMILGSFFMPAIRKLFPHTVTSVVVTMIGLSLIPVAIDWAAGGQGSS
RYGAPGNLAIAVAVLALVVAVVQWGKGMLSASAIVVGIAGGYLLCLALGLVDFTQFHQAPIIAVPQPLHFGMSFPISGIV
AMSIAFLVTIVESTGTFMALGAATQRPISGKCLSRGILCDGFGSAFAALVSSPPLSTFAQNVGVVSLTGVASRHVVALTG
VMLLLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSGGIQMLSTVKFTQRNTLIVAVSIGCGLAVTFRPELLSKLPAFV
HEVFGSGITVGSLSAVILNLLLPGGKDEPAEQAGHGTVGEAA

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680143, Length=504, Percent_Identity=26.5873015873016, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI44680145, Length=500, Percent_Identity=26.2, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI44680148, Length=532, Percent_Identity=24.4360902255639, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI40316845, Length=532, Percent_Identity=24.4360902255639, Blast_Score=102, Evalue=1e-21,
Organism=Escherichia coli, GI87082181, Length=436, Percent_Identity=39.4495412844037, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI87082178, Length=444, Percent_Identity=36.4864864864865, Blast_Score=255, Evalue=5e-69,
Organism=Escherichia coli, GI1790087, Length=444, Percent_Identity=34.9099099099099, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788843, Length=381, Percent_Identity=27.8215223097113, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87081818, Length=404, Percent_Identity=27.7227722772277, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87081750, Length=434, Percent_Identity=23.0414746543779, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17558856, Length=500, Percent_Identity=25.8, Blast_Score=98, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI17542262, Length=472, Percent_Identity=25, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71993493, Length=486, Percent_Identity=24.0740740740741, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17541904, Length=495, Percent_Identity=24.2424242424242, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17542260, Length=225, Percent_Identity=27.5555555555556, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356175, Length=227, Percent_Identity=28.1938325991189, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44759; Mature: 44628

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPLLFKVEDRPPRLTTFLLALQHLLAALGGIIAVPLVIGGALKLPPDQVIALVNAALLG
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SGIVTIIQCKGIGPVGIRMPCVMGTSFAFVGAAISVGVEHGVAGILGSALAGSLVMILGS
CCCEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFMPAIRKLFPHTVTSVVVTMIGLSLIPVAIDWAAGGQGSSRYGAPGNLAIAVAVLALVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
AVVQWGKGMLSASAIVVGIAGGYLLCLALGLVDFTQFHQAPIIAVPQPLHFGMSFPISGI
HHHHHCCCHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCHHHH
VAMSIAFLVTIVESTGTFMALGAATQRPISGKCLSRGILCDGFGSAFAALVSSPPLSTFA
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCEECCHHHHHHHHHCCCCHHHHH
QNVGVVSLTGVASRHVVALTGVMLLLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSGG
HCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHH
IQMLSTVKFTQRNTLIVAVSIGCGLAVTFRPELLSKLPAFVHEVFGSGITVGSLSAVILN
HHHHHHHHEECCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LLLPGGKDEPAEQAGHGTVGEAA
HHCCCCCCCCHHHCCCCCCCCCC
>Mature Secondary Structure 
APLLFKVEDRPPRLTTFLLALQHLLAALGGIIAVPLVIGGALKLPPDQVIALVNAALLG
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHC
SGIVTIIQCKGIGPVGIRMPCVMGTSFAFVGAAISVGVEHGVAGILGSALAGSLVMILGS
CCCEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFMPAIRKLFPHTVTSVVVTMIGLSLIPVAIDWAAGGQGSSRYGAPGNLAIAVAVLALVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
AVVQWGKGMLSASAIVVGIAGGYLLCLALGLVDFTQFHQAPIIAVPQPLHFGMSFPISGI
HHHHHCCCHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHCCCCCCHHHH
VAMSIAFLVTIVESTGTFMALGAATQRPISGKCLSRGILCDGFGSAFAALVSSPPLSTFA
HHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCEECCHHHHHHHHHCCCCHHHHH
QNVGVVSLTGVASRHVVALTGVMLLLAGLFPVLGALVVTIPQPVLGGAGLMMFAMIVSGG
HCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHH
IQMLSTVKFTQRNTLIVAVSIGCGLAVTFRPELLSKLPAFVHEVFGSGITVGSLSAVILN
HHHHHHHHEECCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LLLPGGKDEPAEQAGHGTVGEAA
HHCCCCCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]