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The map label for this gene is ccdA [H]

Identifier: 116695429

GI number: 116695429

Start: 1670269

End: 1670970

Strand: Direct

Name: ccdA [H]

Synonym: H16_B1487

Alternate gene names: 116695429

Gene position: 1670269-1670970 (Clockwise)

Preceding gene: 116695428

Following gene: 116695430

Centisome position: 57.35

GC content: 71.51

Gene sequence:

>702_bases
ATGATCGACGCCTTCCTTGCCTTTGCCGCCGGCGTGCTGACTATTGCCTCGCCCTGTGTGCTGCCGGTGCTGCCCATGCT
GCTGGCCGGCTCGGTGGGCGAATCCGGCCGGCTGCGCCCGCTGGCGATAGCGCTTGGCTTCGTCAGCGCGTTTTCCGCGC
TGGGCATAGTCTTTGGCGCACTGTCCAGCGCCTTCAGCGAAGCCCCAGGCGTGGTGCGCAACGCGGCCATCCTGTTGCTG
CTGGGTGCCGGCCTGGCACGGCTCTGGCCGGCGGGCTTCGAGCGCCTGGCGGCCCCGTTAGCCGGCGTGGTCGACCGCCT
GGCGGGCGCCGGCGGCCGGACCGGCACCGGCGTGGCCGGCGGCTTTGTGCTGGGCATGACGCTGGGCGCGGTGTGGACCC
CGTGCGCCGGGCCGGTGCTGGCGTCGATCCTCGCGCTGGTGGCCAAGGCGCAAGACCTGCATCGCGCCGCCGGCCTGCTG
GCGCTGTTCGCGGCTGGCGCGGCCATCCCGATGCTGGGCATTGCCTATGGCGGCCAGTTCGCCACCACTCACGTGCGCCG
GCTGGCGCGTCACACGCACCGGCTGCAGCAAGGCTTCGGCGTGCTGGTGGTGGCGACCGCCATCGCCATGTACTTCCAGT
ACGACACCCTTGCCGTCGCCTGGCTGACCTCCCTTTTCCCTGCCTCCCAACCTGGAGCCTGA

Upstream 100 bases:

>100_bases
GGGAGTTCTCCGCCATGTCCGTCGTCGCCATCCATCCGCCGCCGCCCTGCCCCTGCTATCGTGCCTGCCACGACACCGCG
CACGCCGACGGAAGCCATCC

Downstream 100 bases:

>100_bases
ACCATGCATCGCTTGCTTCGTACCCTGCTTGCCACTACCGCCATCGTCGCCGCCCAGCATGCCGCCGCCGCCCCTGCCGA
CTATGGCAAGGCGCCGGAAT

Product: cytochrome c biogenesis protein

Products: DsbDoxidized; DsbGreduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MIDAFLAFAAGVLTIASPCVLPVLPMLLAGSVGESGRLRPLAIALGFVSAFSALGIVFGALSSAFSEAPGVVRNAAILLL
LGAGLARLWPAGFERLAAPLAGVVDRLAGAGGRTGTGVAGGFVLGMTLGAVWTPCAGPVLASILALVAKAQDLHRAAGLL
ALFAAGAAIPMLGIAYGGQFATTHVRRLARHTHRLQQGFGVLVVATAIAMYFQYDTLAVAWLTSLFPASQPGA

Sequences:

>Translated_233_residues
MIDAFLAFAAGVLTIASPCVLPVLPMLLAGSVGESGRLRPLAIALGFVSAFSALGIVFGALSSAFSEAPGVVRNAAILLL
LGAGLARLWPAGFERLAAPLAGVVDRLAGAGGRTGTGVAGGFVLGMTLGAVWTPCAGPVLASILALVAKAQDLHRAAGLL
ALFAAGAAIPMLGIAYGGQFATTHVRRLARHTHRLQQGFGVLVVATAIAMYFQYDTLAVAWLTSLFPASQPGA
>Mature_233_residues
MIDAFLAFAAGVLTIASPCVLPVLPMLLAGSVGESGRLRPLAIALGFVSAFSALGIVFGALSSAFSEAPGVVRNAAILLL
LGAGLARLWPAGFERLAAPLAGVVDRLAGAGGRTGTGVAGGFVLGMTLGAVWTPCAGPVLASILALVAKAQDLHRAAGLL
ALFAAGAAIPMLGIAYGGQFATTHVRRLARHTHRLQQGFGVLVVATAIAMYFQYDTLAVAWLTSLFPASQPGA

Specific function: Cytochrome c oxidase activity is partially restored by mutations in bdbC or bdbD that are defective in the synthesis of disulfide bond containing proteins. The same mutations abrogate the need for CcdA in sporulation [H]

COG id: COG0785

COG function: function code O; Cytochrome c biogenesis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DsbD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834 [H]

Pfam domain/function: PF02683 DsbD [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 23486; Mature: 23486

Theoretical pI: Translated: 10.69; Mature: 10.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDAFLAFAAGVLTIASPCVLPVLPMLLAGSVGESGRLRPLAIALGFVSAFSALGIVFGA
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LSSAFSEAPGVVRNAAILLLLGAGLARLWPAGFERLAAPLAGVVDRLAGAGGRTGTGVAG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GFVLGMTLGAVWTPCAGPVLASILALVAKAQDLHRAAGLLALFAAGAAIPMLGIAYGGQF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ATTHVRRLARHTHRLQQGFGVLVVATAIAMYFQYDTLAVAWLTSLFPASQPGA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIDAFLAFAAGVLTIASPCVLPVLPMLLAGSVGESGRLRPLAIALGFVSAFSALGIVFGA
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LSSAFSEAPGVVRNAAILLLLGAGLARLWPAGFERLAAPLAGVVDRLAGAGGRTGTGVAG
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
GFVLGMTLGAVWTPCAGPVLASILALVAKAQDLHRAAGLLALFAAGAAIPMLGIAYGGQF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ATTHVRRLARHTHRLQQGFGVLVVATAIAMYFQYDTLAVAWLTSLFPASQPGA
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DsbGoxidized; DsbDreduced/thiol:disulfide reductase [C]

Specific reaction: DsbDreduced/thiol:disulfide reductase + DsbCoxidized = DsbDoxidized + DsbCreduced DsbGoxidized + DsbDreduced/thiol:disulfide reductase = DsbGreduced + DsbDoxidized [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969507; 9068642; 9384377; 10781554; 11844773 [H]