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The map label for this gene is alkK [H]

Identifier: 116695279

GI number: 116695279

Start: 1480611

End: 1482299

Strand: Direct

Name: alkK [H]

Synonym: H16_B1335

Alternate gene names: 116695279

Gene position: 1480611-1482299 (Clockwise)

Preceding gene: 116695274

Following gene: 116695280

Centisome position: 50.84

GC content: 63.06

Gene sequence:

>1689_bases
GTGACACGGCCTACCCCAATCCACCGCACGCCGTCGGCGTATGCCTATCCGCTGCTGATCAAGCAGCTCCTGCACGCGCC
GCTGGCGGTCAATCCGGAACAGGAAATCGTCTACCGCGGTCAGGTGCGGCACAGCTACTGGACCATGCGGCACCGAATCG
GCCAACTGGCCAGCGGCCTGCAATCGCTCGGCATTGCACAGGGCGATACGGTGGCAGTCATGGACTGGGACAGCCACCGC
TACCTCGAAAGCTACTTCGGCATCCCCATGATGGGGGCGGTGCTGATGACGGTAAATGTGCGCCTGTCGCCGGAACAGAT
CGCCTACACACTGAACCACGCTGGCGTTAGGCTTCTGATGGTCCACGCCGACTTCCTGCCGGTCGTAGCGGCAATCCGCG
ACCAGCTGGAATCCGTCGAGTGCCTGGTGCTGATCGGCGACGACACGCTCTCTCTCGAGAGCGCGCCGTTGGCCGAAGGC
TTTGTCGCCGAGTACGAAACGCTGTTGGCCGCTTCGCCACCAGACTATCCCTTTCCCGACTTCGACGAGAACGCACGGGC
AACTACCTTCTATACGACCGGCACCACCGGTTTGCCCAAGGGGGTGTATTTCAGCCATCGGCAGATTGTTCTCCATACGC
TGGCGACCATGGCGGCACTGACCAGCGCGCCAACTCAGGGACGCGTGCATCGGGACGATGTCTACATGCCGCTGACGCCG
ATGTTCCATGTGCATGCGTGGGGAATGCCCTTCGTGGCAACGGCGCTTGGTATGAAACAGGTCTATCCGGGGCGCTATGC
TGCGGACCAACTCCTTCAGCTGGTGCAGAGCGAGCGCATCACCTTCTCCCACGGAGTGCCTACGCTGCTCAACATGATCC
TGTCGCACCCGGATTCGGCCGCGGTCGATCTGAGCGGCATGAAGATTATCGTGGGCGGGTCGGCGCTGCCCCGCGGCCTG
GCGCAGGCCGCCATCGACCGCGGCATCGACGTGTTCACCGGCTACGGCATGTCGGAGACCTGCCCCATCCTCACACTGGC
GCAGGTGAAGACCTCGCTGCTTGGCAATGCCACCACCGAACTCGACGTCCGCACCAAGACAGGCTTGCCGGTTCCGCTGG
TCGACCTGCGCATCGTCGATGACGAGATGCGCGACATTGCGCACGATGGCAAGGCCAGCGGCGAAATCGTGGTCCGCGCG
CCATGGCTCACGCAAGGCTATTTCGGCAATGCGGCGGAGTCCGAGCACCTGTGGGCCGGTGGCTACCTCCATACCAACGA
CATTGGCTCGATCGACAGCGATGGCTATTTGCAGGTCACCGACCGCATCAAGGATGTGATCAAGAGCGGTGGCGAGTGGG
TGTCGTCACTGGAGCTCGAAGACCTGATTTCGCGTCACGCCGCGGTGAGCGAAGTGGCGGTTATCGGCATCAAGGATGCG
CGGTGGGGCGAACGCCCGCTGCCGTTGATCGTATTGCGGCCGGGACAGTCGGCCGGAGCAGAAGAGATCCAGGAGCATCT
GCGCGATTTCGTCCGCCGTGGCGCGATCTCGAAGTATGCGGTACCGGAACGGGTGCTCTTTGTCGAGGCGATCGAAAAGA
CCAGCGTGGGCAAGATCAACAAGCGCCTGCTCCGCGACAAGTACCAGGCCGCCCCGCCCCCCTCCCCCAATTCCGGCACC
CACCCATGA

Upstream 100 bases:

>100_bases
ACGGCGCTTACGCTGGCAGGCATCCGGCGTCCCTGGCGCTGCATGCAAGTCATGGCGCATGCTGCCCAGGCCGCTGCCAC
AGCGATCAAGGAGCTCCTCC

Downstream 100 bases:

>100_bases
GCCGGTAGCCAATGCCGGCGTGGCAAGTGCGTTCTCACTAGAAAACCCGCTTCAGGAGACAAAGCAATGCAAGCTTTCAC
CACAACAGAGCGCATCAGGC

Product: Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 562; Mature: 561

Protein sequence:

>562_residues
MTRPTPIHRTPSAYAYPLLIKQLLHAPLAVNPEQEIVYRGQVRHSYWTMRHRIGQLASGLQSLGIAQGDTVAVMDWDSHR
YLESYFGIPMMGAVLMTVNVRLSPEQIAYTLNHAGVRLLMVHADFLPVVAAIRDQLESVECLVLIGDDTLSLESAPLAEG
FVAEYETLLAASPPDYPFPDFDENARATTFYTTGTTGLPKGVYFSHRQIVLHTLATMAALTSAPTQGRVHRDDVYMPLTP
MFHVHAWGMPFVATALGMKQVYPGRYAADQLLQLVQSERITFSHGVPTLLNMILSHPDSAAVDLSGMKIIVGGSALPRGL
AQAAIDRGIDVFTGYGMSETCPILTLAQVKTSLLGNATTELDVRTKTGLPVPLVDLRIVDDEMRDIAHDGKASGEIVVRA
PWLTQGYFGNAAESEHLWAGGYLHTNDIGSIDSDGYLQVTDRIKDVIKSGGEWVSSLELEDLISRHAAVSEVAVIGIKDA
RWGERPLPLIVLRPGQSAGAEEIQEHLRDFVRRGAISKYAVPERVLFVEAIEKTSVGKINKRLLRDKYQAAPPPSPNSGT
HP

Sequences:

>Translated_562_residues
MTRPTPIHRTPSAYAYPLLIKQLLHAPLAVNPEQEIVYRGQVRHSYWTMRHRIGQLASGLQSLGIAQGDTVAVMDWDSHR
YLESYFGIPMMGAVLMTVNVRLSPEQIAYTLNHAGVRLLMVHADFLPVVAAIRDQLESVECLVLIGDDTLSLESAPLAEG
FVAEYETLLAASPPDYPFPDFDENARATTFYTTGTTGLPKGVYFSHRQIVLHTLATMAALTSAPTQGRVHRDDVYMPLTP
MFHVHAWGMPFVATALGMKQVYPGRYAADQLLQLVQSERITFSHGVPTLLNMILSHPDSAAVDLSGMKIIVGGSALPRGL
AQAAIDRGIDVFTGYGMSETCPILTLAQVKTSLLGNATTELDVRTKTGLPVPLVDLRIVDDEMRDIAHDGKASGEIVVRA
PWLTQGYFGNAAESEHLWAGGYLHTNDIGSIDSDGYLQVTDRIKDVIKSGGEWVSSLELEDLISRHAAVSEVAVIGIKDA
RWGERPLPLIVLRPGQSAGAEEIQEHLRDFVRRGAISKYAVPERVLFVEAIEKTSVGKINKRLLRDKYQAAPPPSPNSGT
HP
>Mature_561_residues
TRPTPIHRTPSAYAYPLLIKQLLHAPLAVNPEQEIVYRGQVRHSYWTMRHRIGQLASGLQSLGIAQGDTVAVMDWDSHRY
LESYFGIPMMGAVLMTVNVRLSPEQIAYTLNHAGVRLLMVHADFLPVVAAIRDQLESVECLVLIGDDTLSLESAPLAEGF
VAEYETLLAASPPDYPFPDFDENARATTFYTTGTTGLPKGVYFSHRQIVLHTLATMAALTSAPTQGRVHRDDVYMPLTPM
FHVHAWGMPFVATALGMKQVYPGRYAADQLLQLVQSERITFSHGVPTLLNMILSHPDSAAVDLSGMKIIVGGSALPRGLA
QAAIDRGIDVFTGYGMSETCPILTLAQVKTSLLGNATTELDVRTKTGLPVPLVDLRIVDDEMRDIAHDGKASGEIVVRAP
WLTQGYFGNAAESEHLWAGGYLHTNDIGSIDSDGYLQVTDRIKDVIKSGGEWVSSLELEDLISRHAAVSEVAVIGIKDAR
WGERPLPLIVLRPGQSAGAEEIQEHLRDFVRRGAISKYAVPERVLFVEAIEKTSVGKINKRLLRDKYQAAPPPSPNSGTH
P

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=562, Percent_Identity=26.1565836298932, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI187761345, Length=547, Percent_Identity=25.9597806215722, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI187761343, Length=547, Percent_Identity=25.9597806215722, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI115511026, Length=530, Percent_Identity=23.5849056603774, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI42544132, Length=467, Percent_Identity=23.3404710920771, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI38505220, Length=470, Percent_Identity=26.1702127659574, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI122937307, Length=524, Percent_Identity=23.8549618320611, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI58082049, Length=531, Percent_Identity=23.728813559322, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI157311624, Length=532, Percent_Identity=23.6842105263158, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI157311622, Length=532, Percent_Identity=23.6842105263158, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI62865631, Length=551, Percent_Identity=23.956442831216, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI13325055, Length=551, Percent_Identity=23.956442831216, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI13375727, Length=542, Percent_Identity=23.6162361623616, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI28416953, Length=550, Percent_Identity=24.9090909090909, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI8923896, Length=371, Percent_Identity=24.5283018867925, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI145693145, Length=517, Percent_Identity=25.7253384912959, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI221142682, Length=510, Percent_Identity=26.078431372549, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1788107, Length=521, Percent_Identity=26.295585412668, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=23.9171374764595, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790505, Length=545, Percent_Identity=22.9357798165138, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788595, Length=358, Percent_Identity=24.0223463687151, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=527, Percent_Identity=26.5654648956357, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560308, Length=559, Percent_Identity=23.4347048300537, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71994690, Length=573, Percent_Identity=22.6876090750436, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI71994694, Length=573, Percent_Identity=22.3385689354276, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=573, Percent_Identity=22.6876090750436, Blast_Score=128, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI17538037, Length=521, Percent_Identity=23.4165067178503, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17531443, Length=518, Percent_Identity=22.2007722007722, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17557194, Length=523, Percent_Identity=24.282982791587, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=535, Percent_Identity=23.9252336448598, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17558820, Length=516, Percent_Identity=24.2248062015504, Blast_Score=118, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17560140, Length=498, Percent_Identity=22.4899598393574, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=366, Percent_Identity=25.4098360655738, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25141359, Length=369, Percent_Identity=24.6612466124661, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319699, Length=547, Percent_Identity=23.217550274223, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319264, Length=542, Percent_Identity=23.2472324723247, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323182, Length=533, Percent_Identity=23.4521575984991, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355181, Length=511, Percent_Identity=25.2446183953033, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18859661, Length=521, Percent_Identity=25.5278310940499, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24581924, Length=549, Percent_Identity=25.3187613843352, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922652, Length=506, Percent_Identity=22.7272727272727, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24653035, Length=366, Percent_Identity=24.5901639344262, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24648253, Length=497, Percent_Identity=22.9376257545272, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21356947, Length=519, Percent_Identity=22.7360308285164, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24648255, Length=497, Percent_Identity=23.1388329979879, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI161076582, Length=373, Percent_Identity=24.9329758713137, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20130357, Length=375, Percent_Identity=23.2, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648257, Length=549, Percent_Identity=22.7686703096539, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24656500, Length=498, Percent_Identity=22.289156626506, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24648260, Length=506, Percent_Identity=22.1343873517787, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281365686, Length=362, Percent_Identity=21.5469613259669, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358303, Length=320, Percent_Identity=23.4375, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24667955, Length=558, Percent_Identity=23.6559139784946, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI62472339, Length=558, Percent_Identity=23.6559139784946, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24667959, Length=383, Percent_Identity=25.065274151436, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356441, Length=356, Percent_Identity=21.9101123595506, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 61533; Mature: 61402

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPTPIHRTPSAYAYPLLIKQLLHAPLAVNPEQEIVYRGQVRHSYWTMRHRIGQLASGL
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHEEEECCHHHHHHHHHHHHHHHHHHH
QSLGIAQGDTVAVMDWDSHRYLESYFGIPMMGAVLMTVNVRLSPEQIAYTLNHAGVRLLM
HHCCCCCCCEEEEEECCCHHHHHHHCCCHHHHHEEEEEEEEECHHHHEEEECCCCEEEEE
VHADFLPVVAAIRDQLESVECLVLIGDDTLSLESAPLAEGFVAEYETLLAASPPDYPFPD
EEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
FDENARATTFYTTGTTGLPKGVYFSHRQIVLHTLATMAALTSAPTQGRVHRDDVYMPLTP
CCCCCCEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCEECCCEEECCCC
MFHVHAWGMPFVATALGMKQVYPGRYAADQLLQLVQSERITFSHGVPTLLNMILSHPDSA
CCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCC
AVDLSGMKIIVGGSALPRGLAQAAIDRGIDVFTGYGMSETCPILTLAQVKTSLLGNATTE
EEEECCCEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
LDVRTKTGLPVPLVDLRIVDDEMRDIAHDGKASGEIVVRAPWLTQGYFGNAAESEHLWAG
EEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEC
GYLHTNDIGSIDSDGYLQVTDRIKDVIKSGGEWVSSLELEDLISRHAAVSEVAVIGIKDA
CEEECCCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHEEEEEEECC
RWGERPLPLIVLRPGQSAGAEEIQEHLRDFVRRGAISKYAVPERVLFVEAIEKTSVGKIN
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHH
KRLLRDKYQAAPPPSPNSGTHP
HHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TRPTPIHRTPSAYAYPLLIKQLLHAPLAVNPEQEIVYRGQVRHSYWTMRHRIGQLASGL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHEEEECCHHHHHHHHHHHHHHHHHHH
QSLGIAQGDTVAVMDWDSHRYLESYFGIPMMGAVLMTVNVRLSPEQIAYTLNHAGVRLLM
HHCCCCCCCEEEEEECCCHHHHHHHCCCHHHHHEEEEEEEEECHHHHEEEECCCCEEEEE
VHADFLPVVAAIRDQLESVECLVLIGDDTLSLESAPLAEGFVAEYETLLAASPPDYPFPD
EEHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
FDENARATTFYTTGTTGLPKGVYFSHRQIVLHTLATMAALTSAPTQGRVHRDDVYMPLTP
CCCCCCEEEEEECCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCEECCCEEECCCC
MFHVHAWGMPFVATALGMKQVYPGRYAADQLLQLVQSERITFSHGVPTLLNMILSHPDSA
CCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEECCCHHHHHHHHHCCCCCC
AVDLSGMKIIVGGSALPRGLAQAAIDRGIDVFTGYGMSETCPILTLAQVKTSLLGNATTE
EEEECCCEEEECCCCCHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCE
LDVRTKTGLPVPLVDLRIVDDEMRDIAHDGKASGEIVVRAPWLTQGYFGNAAESEHLWAG
EEEEECCCCCCCEEEEEECCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEC
GYLHTNDIGSIDSDGYLQVTDRIKDVIKSGGEWVSSLELEDLISRHAAVSEVAVIGIKDA
CEEECCCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHEEEEEEECC
RWGERPLPLIVLRPGQSAGAEEIQEHLRDFVRRGAISKYAVPERVLFVEAIEKTSVGKIN
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHH
KRLLRDKYQAAPPPSPNSGTHP
HHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]