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The map label for this gene is aceE [H]

Identifier: 116695244

GI number: 116695244

Start: 1455029

End: 1457725

Strand: Direct

Name: aceE [H]

Synonym: H16_B1300

Alternate gene names: 116695244

Gene position: 1455029-1457725 (Clockwise)

Preceding gene: 116695243

Following gene: 116695245

Centisome position: 49.96

GC content: 68.85

Gene sequence:

>2697_bases
ATGACCGACCTTGCCTCCCCACACGCCCGCCTGCTCGCCCAGGCCATGCCCGACGGCGACGACGATCCGCAGGAGACGCG
CGAATGGCTGGACGCGCTGGAGGCAGTGGTGGCGCAATGCGGGCAGGAGCGCGCGCGCTTCCTGCTCGGCCGGCTGCTCG
ATGCCGCCCCCGCGCTGGGTGTGTCGACCACGGCTCAGAGCAACACGCCTTACCTGAACACCATCCCGGTCGAGTGCCAG
CCGCCTTATCCGGGGGATCTGGCGATGGAAGAGCGCATCACCGGCATCGTGCGCTGGAATGCCCTTGCCATGGTGGTGCG
CGCCAACCAGGCCTACGGTGAACTGGGCGGGCATATCTCCAGCTATGCCTCGGCGGCGGACCTGTTCGAGGTCGGCTTCA
ACCACTTCTTCCAGGGCGCCGATGCCGGCAACGGCGGCGACCTGGTCTACTTCCAGCCGCACTCGGCCCCGGGCGTGTAC
GCGCGCGCCTTCCTGGAAGGACGCCTGTCCGAGGCCCAGCTCGACAACTTCCGCCGCGAGGCGGGGGGGCAGGGCCTGTG
CTCGTATCCGCACCCCTGGCTGATGCCGGACTTCTGGCAGTTCCCGACCGGCTCGATGGGGCTGGGCCCGATCCAGTCGG
TCTACCAGGCGCGCTTCATGCGCTACATGGAGCACCGGGGGCTGCAGGCCACTTCGGGCCGGCACGTGTGGGGCGTGTTC
GGCGACGGCGAGATGGACGAGCCCGAATCGATCGCCGCGCTGCCGCTGGCAGCGCGCGAGAAGCTCGACAACCTGACCTT
TGTCATCAACTGCAACCTGCAGCGCCTGGACGGCCCGGTGCGCGGCAACGGCCAGATCGTGCAGGAGCTGGAAGCGCTGT
TCCGCGGCGCGGGCTGGAACGTGATCAAGGTGCTGTGGGGCAGCGCCTGGGACCCGATCTTCGCGCGCGATCACTCCGGC
GCGTTGCTGCGCGCCTTCGCCTCGACCATGGACGGCCAGTTCCAGACTTACAAGGCCAAGGACGGCCACTATGGGCGCGA
GCATTTCTTTGGCCAGAACGAAGCGCTGAAGGCACTGGTCGCGCATATGACGCCGGATGAGGTGGCGGCGCTGAACCGCG
GCGGACACGACCTGCGCAAGCTCCATGCGGCCTTTGCCGCGGCACGCGCGCACAAGGGCCAGCCCACGGTGATCCTGGCC
AAGACCATCAAGGGCTATGGCATGGGCAATGCCGGCCAGGCGCAGAACACCACGCACCAGCAGAAGAAGCTCGACATCGA
GGCGCTGAAGGCATTCCGCAGCCGCTTCGGCCTGGAGCTGTCCGACGAGGACCTGGAATCGATGCGCTTCTACCGCCCGG
CCGAGGACAGCGCTGAGCTGCGCTACCTGCGCGAACGCCGCCAGGTGCTGGGCGGCTACCTGCCGGCGCGCCAGCGCCAG
GCCGACACCGTGGCGGTGCCGCCGCTGGCGCAATACGGCCAGTTCGCGGTGGCGGCCGACCAGAAGGAGATGTCGACCAC
CATGGCAATGGTGCGCATGCTGACCGGCCTGCTCAAGGACAAGGCGCTCGGTCCGCGCGTGGTGCCCATCGTCGCCGACG
AGGCGCGCACCTTCGGCATGGCCAGCCTGTTCCGCCAGGTCGGCATCTATTCATCGCAGGGCCAGCTGTACGAGCCCGAG
GACGCCGGCTCGATGCTGTACTACCGCGAGGACATCCGCGGCCAGATCCTGGAAGAGGGCATCACCGAGGCCGGTGCGAT
GTCGTCGTGGATTGCCGCGGGCACCGCCTACAGCAACCATGGCACGGCCATGCTGCCGCTCTATATCTACTACTCGATGT
TCGGCTTCCAGCGCATCGGCGACCTGATCTGGGCCGCCGGCGACCAGCGTGCGCGCGGCTTCCTGGTGGGCGCTACGGCA
GGCCGCACCACGCTGTCCGGCGAAGGGCTGAAGCACCAGGACGGCACCAGCCACATCATTGCCGCCACCATCCCCAACTG
CCGCGCCTATGACCCCGCCTACGCCTATGAGCTGGCAGTCATCGTCGACGAGGGCATGCGCGCGATGATGGAGCGCCAGG
AGGACGTGTTCTATTACCTGACCGTGATGAACGAGAACTACGCCCAGCCGTCGATGCCGGCGGGCGTGGAGCGCGACATC
GTGCGCGGCATGTACCGGCTTGCGCAGGTGGAAGGCGGCGGGCGCGCCAGGGTGCGGCTGCTCGGCAGCGGCACCATCCT
GCGCGAGGTGGAGGCCGCGGCGCAGATGCTGGCCGAGGACTGGCAGGTCGACAGCGAGGTGTTCAGCGTCACCAGCTTCT
CCGAGCTGGAGCGCGAGGCGCGCGAGACCGCGCGCCAGCGCCTGCATCATCCGCAGGACAGCATCGCCCCCAGCCATGTG
GAAGCGCTGCTGGCCGGCGACGCGCCGGTGGTGGCGGCCACTGACTACGTGCGCGCCTATCCGCAGCTGATTGCGCCCTA
CGTGCCGGCTCCCTTCACGGTGCTGGGCACCGACGGCTATGGCCGCAGCGACAACCGGCCGTCGCTGCGCCGCTTCTTCG
AGGTCGATCGCGCCTATGTCTGCGTGGCGGCGCTGCGCGCGCTTGCGGCGCAGGGCACGGTGCCGGCGTCGGTGGTGGCC
GAGGCGATCACGCGCTACGGCATCGACACGGACAAGCCTGCGCCGTCCTCGCTCTGA

Upstream 100 bases:

>100_bases
AGTGGATTGTGCTGCCACCTGCCGGATAGGCAGTCAACTTCAGCACCTCATGCGGGAGGGCACTCCATAGAATGGGACAA
AACCCATTGGAGACTTCCCC

Downstream 100 bases:

>100_bases
TATCGCCGGCTTCACCTTGCAGGCCAGGCGGGGCGCTTCGGTGCGGGACTCCACATGCGACGGCGGCGGCTGTTAAGCTT
TGTCCTTCTGCAGCCGCTCC

Product: 2-oxoacid dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 898; Mature: 897

Protein sequence:

>898_residues
MTDLASPHARLLAQAMPDGDDDPQETREWLDALEAVVAQCGQERARFLLGRLLDAAPALGVSTTAQSNTPYLNTIPVECQ
PPYPGDLAMEERITGIVRWNALAMVVRANQAYGELGGHISSYASAADLFEVGFNHFFQGADAGNGGDLVYFQPHSAPGVY
ARAFLEGRLSEAQLDNFRREAGGQGLCSYPHPWLMPDFWQFPTGSMGLGPIQSVYQARFMRYMEHRGLQATSGRHVWGVF
GDGEMDEPESIAALPLAAREKLDNLTFVINCNLQRLDGPVRGNGQIVQELEALFRGAGWNVIKVLWGSAWDPIFARDHSG
ALLRAFASTMDGQFQTYKAKDGHYGREHFFGQNEALKALVAHMTPDEVAALNRGGHDLRKLHAAFAAARAHKGQPTVILA
KTIKGYGMGNAGQAQNTTHQQKKLDIEALKAFRSRFGLELSDEDLESMRFYRPAEDSAELRYLRERRQVLGGYLPARQRQ
ADTVAVPPLAQYGQFAVAADQKEMSTTMAMVRMLTGLLKDKALGPRVVPIVADEARTFGMASLFRQVGIYSSQGQLYEPE
DAGSMLYYREDIRGQILEEGITEAGAMSSWIAAGTAYSNHGTAMLPLYIYYSMFGFQRIGDLIWAAGDQRARGFLVGATA
GRTTLSGEGLKHQDGTSHIIAATIPNCRAYDPAYAYELAVIVDEGMRAMMERQEDVFYYLTVMNENYAQPSMPAGVERDI
VRGMYRLAQVEGGGRARVRLLGSGTILREVEAAAQMLAEDWQVDSEVFSVTSFSELEREARETARQRLHHPQDSIAPSHV
EALLAGDAPVVAATDYVRAYPQLIAPYVPAPFTVLGTDGYGRSDNRPSLRRFFEVDRAYVCVAALRALAAQGTVPASVVA
EAITRYGIDTDKPAPSSL

Sequences:

>Translated_898_residues
MTDLASPHARLLAQAMPDGDDDPQETREWLDALEAVVAQCGQERARFLLGRLLDAAPALGVSTTAQSNTPYLNTIPVECQ
PPYPGDLAMEERITGIVRWNALAMVVRANQAYGELGGHISSYASAADLFEVGFNHFFQGADAGNGGDLVYFQPHSAPGVY
ARAFLEGRLSEAQLDNFRREAGGQGLCSYPHPWLMPDFWQFPTGSMGLGPIQSVYQARFMRYMEHRGLQATSGRHVWGVF
GDGEMDEPESIAALPLAAREKLDNLTFVINCNLQRLDGPVRGNGQIVQELEALFRGAGWNVIKVLWGSAWDPIFARDHSG
ALLRAFASTMDGQFQTYKAKDGHYGREHFFGQNEALKALVAHMTPDEVAALNRGGHDLRKLHAAFAAARAHKGQPTVILA
KTIKGYGMGNAGQAQNTTHQQKKLDIEALKAFRSRFGLELSDEDLESMRFYRPAEDSAELRYLRERRQVLGGYLPARQRQ
ADTVAVPPLAQYGQFAVAADQKEMSTTMAMVRMLTGLLKDKALGPRVVPIVADEARTFGMASLFRQVGIYSSQGQLYEPE
DAGSMLYYREDIRGQILEEGITEAGAMSSWIAAGTAYSNHGTAMLPLYIYYSMFGFQRIGDLIWAAGDQRARGFLVGATA
GRTTLSGEGLKHQDGTSHIIAATIPNCRAYDPAYAYELAVIVDEGMRAMMERQEDVFYYLTVMNENYAQPSMPAGVERDI
VRGMYRLAQVEGGGRARVRLLGSGTILREVEAAAQMLAEDWQVDSEVFSVTSFSELEREARETARQRLHHPQDSIAPSHV
EALLAGDAPVVAATDYVRAYPQLIAPYVPAPFTVLGTDGYGRSDNRPSLRRFFEVDRAYVCVAALRALAAQGTVPASVVA
EAITRYGIDTDKPAPSSL
>Mature_897_residues
TDLASPHARLLAQAMPDGDDDPQETREWLDALEAVVAQCGQERARFLLGRLLDAAPALGVSTTAQSNTPYLNTIPVECQP
PYPGDLAMEERITGIVRWNALAMVVRANQAYGELGGHISSYASAADLFEVGFNHFFQGADAGNGGDLVYFQPHSAPGVYA
RAFLEGRLSEAQLDNFRREAGGQGLCSYPHPWLMPDFWQFPTGSMGLGPIQSVYQARFMRYMEHRGLQATSGRHVWGVFG
DGEMDEPESIAALPLAAREKLDNLTFVINCNLQRLDGPVRGNGQIVQELEALFRGAGWNVIKVLWGSAWDPIFARDHSGA
LLRAFASTMDGQFQTYKAKDGHYGREHFFGQNEALKALVAHMTPDEVAALNRGGHDLRKLHAAFAAARAHKGQPTVILAK
TIKGYGMGNAGQAQNTTHQQKKLDIEALKAFRSRFGLELSDEDLESMRFYRPAEDSAELRYLRERRQVLGGYLPARQRQA
DTVAVPPLAQYGQFAVAADQKEMSTTMAMVRMLTGLLKDKALGPRVVPIVADEARTFGMASLFRQVGIYSSQGQLYEPED
AGSMLYYREDIRGQILEEGITEAGAMSSWIAAGTAYSNHGTAMLPLYIYYSMFGFQRIGDLIWAAGDQRARGFLVGATAG
RTTLSGEGLKHQDGTSHIIAATIPNCRAYDPAYAYELAVIVDEGMRAMMERQEDVFYYLTVMNENYAQPSMPAGVERDIV
RGMYRLAQVEGGGRARVRLLGSGTILREVEAAAQMLAEDWQVDSEVFSVTSFSELEREARETARQRLHHPQDSIAPSHVE
ALLAGDAPVVAATDYVRAYPQLIAPYVPAPFTVLGTDGYGRSDNRPSLRRFFEVDRAYVCVAALRALAAQGTVPASVVAE
AITRYGIDTDKPAPSSL

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=888, Percent_Identity=54.7297297297297, Blast_Score=1008, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 98570; Mature: 98438

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00783 RIBOSOMAL_L13

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLASPHARLLAQAMPDGDDDPQETREWLDALEAVVAQCGQERARFLLGRLLDAAPALG
CCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VSTTAQSNTPYLNTIPVECQPPYPGDLAMEERITGIVRWNALAMVVRANQAYGELGGHIS
CCCCCCCCCCEEEEECCEECCCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHHHHCCHHH
SYASAADLFEVGFNHFFQGADAGNGGDLVYFQPHSAPGVYARAFLEGRLSEAQLDNFRRE
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHH
AGGQGLCSYPHPWLMPDFWQFPTGSMGLGPIQSVYQARFMRYMEHRGLQATSGRHVWGVF
CCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
GDGEMDEPESIAALPLAAREKLDNLTFVINCNLQRLDGPVRGNGQIVQELEALFRGAGWN
CCCCCCCCCHHHHCCHHHHHHCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCH
VIKVLWGSAWDPIFARDHSGALLRAFASTMDGQFQTYKAKDGHYGREHFFGQNEALKALV
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCHHHHHHHH
AHMTPDEVAALNRGGHDLRKLHAAFAAARAHKGQPTVILAKTIKGYGMGNAGQAQNTTHQ
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHH
QKKLDIEALKAFRSRFGLELSDEDLESMRFYRPAEDSAELRYLRERRQVLGGYLPARQRQ
HHHCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
ADTVAVPPLAQYGQFAVAADQKEMSTTMAMVRMLTGLLKDKALGPRVVPIVADEARTFGM
CCCEECCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
ASLFRQVGIYSSQGQLYEPEDAGSMLYYREDIRGQILEEGITEAGAMSSWIAAGTAYSNH
HHHHHHHCCCCCCCCEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCC
GTAMLPLYIYYSMFGFQRIGDLIWAAGDQRARGFLVGATAGRTTLSGEGLKHQDGTSHII
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEE
AATIPNCRAYDPAYAYELAVIVDEGMRAMMERQEDVFYYLTVMNENYAQPSMPAGVERDI
EEECCCCCCCCCHHHEEEEHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHH
VRGMYRLAQVEGGGRARVRLLGSGTILREVEAAAQMLAEDWQVDSEVFSVTSFSELEREA
HHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RETARQRLHHPQDSIAPSHVEALLAGDAPVVAATDYVRAYPQLIAPYVPAPFTVLGTDGY
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCC
GRSDNRPSLRRFFEVDRAYVCVAALRALAAQGTVPASVVAEAITRYGIDTDKPAPSSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLASPHARLLAQAMPDGDDDPQETREWLDALEAVVAQCGQERARFLLGRLLDAAPALG
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VSTTAQSNTPYLNTIPVECQPPYPGDLAMEERITGIVRWNALAMVVRANQAYGELGGHIS
CCCCCCCCCCEEEEECCEECCCCCCCCCHHHHHHHHHHHHHEEEEEECCHHHHHHCCHHH
SYASAADLFEVGFNHFFQGADAGNGGDLVYFQPHSAPGVYARAFLEGRLSEAQLDNFRRE
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHH
AGGQGLCSYPHPWLMPDFWQFPTGSMGLGPIQSVYQARFMRYMEHRGLQATSGRHVWGVF
CCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEE
GDGEMDEPESIAALPLAAREKLDNLTFVINCNLQRLDGPVRGNGQIVQELEALFRGAGWN
CCCCCCCCCHHHHCCHHHHHHCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCH
VIKVLWGSAWDPIFARDHSGALLRAFASTMDGQFQTYKAKDGHYGREHFFGQNEALKALV
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHCCCHHHHHHHH
AHMTPDEVAALNRGGHDLRKLHAAFAAARAHKGQPTVILAKTIKGYGMGNAGQAQNTTHQ
HHCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCHHH
QKKLDIEALKAFRSRFGLELSDEDLESMRFYRPAEDSAELRYLRERRQVLGGYLPARQRQ
HHHCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCC
ADTVAVPPLAQYGQFAVAADQKEMSTTMAMVRMLTGLLKDKALGPRVVPIVADEARTFGM
CCCEECCCHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHH
ASLFRQVGIYSSQGQLYEPEDAGSMLYYREDIRGQILEEGITEAGAMSSWIAAGTAYSNH
HHHHHHHCCCCCCCCEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCEECCC
GTAMLPLYIYYSMFGFQRIGDLIWAAGDQRARGFLVGATAGRTTLSGEGLKHQDGTSHII
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEE
AATIPNCRAYDPAYAYELAVIVDEGMRAMMERQEDVFYYLTVMNENYAQPSMPAGVERDI
EEECCCCCCCCCHHHEEEEHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCHHHH
VRGMYRLAQVEGGGRARVRLLGSGTILREVEAAAQMLAEDWQVDSEVFSVTSFSELEREA
HHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RETARQRLHHPQDSIAPSHVEALLAGDAPVVAATDYVRAYPQLIAPYVPAPFTVLGTDGY
HHHHHHHHCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCC
GRSDNRPSLRRFFEVDRAYVCVAALRALAAQGTVPASVVAEAITRYGIDTDKPAPSSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]