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The map label for this gene is acsA [H]

Identifier: 116695047

GI number: 116695047

Start: 1247611

End: 1249263

Strand: Direct

Name: acsA [H]

Synonym: H16_B1102

Alternate gene names: 116695047

Gene position: 1247611-1249263 (Clockwise)

Preceding gene: 116695045

Following gene: 116695048

Centisome position: 42.84

GC content: 69.45

Gene sequence:

>1653_bases
ATGCGCGACTACGCCCAAGCCTTCGACGGATTTTCCTATGACGACGCCGTGGCACGGCAACTGCACGGCAGCCAGGAGGC
AATGAACGCCTGCGTCGAATGCTGCGACCGCCACGCGCTGCCGGGCCGTATCGCGCTGTTCTGGGAAGGGCGAGACGGCA
ATTCGCGCAGCTGGACCTTTACCGAGCTGCAGGCACTGTCCGCGCAGTTTGCCGGCTTCCTGAAGGCGCAGGGCGTGCAG
CCGGGCGACCGCGTGGCGGGCCTGCTGCCGCGCAATGCGGAACTGCTGGTGACGATTCTCGGCACCTGGCGCGCCGGCGC
GGTGTACCAGCCGCTGTTCACGGCCTTCGGCCCCAAGGCCATCGAGCACCGGCTCAATGCGTCCGGCGCGAAGGTTGTGG
TCACCGATGGCGCCAACCGCCCCAAGCTGGATGACGTGGATGGCTGTCCCGCCATTGTCACCGTGGCCGGCGACAAGGGC
CGCGGCCTGGTGCGCGGCGACTTCAGCTTCTGGGCCGAACTGGAACGCCAGCCGGCGTCGTTCGAGCCGGTGCCGCGCCG
GGGCGACGACCCCTTCCTGATGATGTTCACCTCCGGCACCACCGGCCCGGCCAAGCCGCTGCTGGTGCCGCTCAAGGCCA
TTGCCGCGTTTGCCGGCTATATGAGCGACGCGGTCGACCTGCGCGCGGAAGACGCTTTCTGGAACCTGGCCGATCCGGGC
TGGGCCTATGGCCTGTATTACGCGGTCACGGGCCCGCTGGCGCTGGGCCATCCCACCACCTTCTACGATGGCCCGTTCAC
CGTGGAGAGCACATGCCGTGTGATCCGCAAGTACGGCATCACCAACCTGGCCGGCTCGCCCACGGCATACCGGCTGCTGA
TCGCCGCGGGCGAGGCCGTGTCAGGCCCGCTGCGCGGGCGGCTGCGCGCGGTCAGCAGCGCGGGCGAGCCGCTCAACCCG
GAAGTGATCCGCTGGTTCGCCAGCGAGCTGGGCGTGACCATCCACGACCACTACGGCCAGACCGAGCTGGGCATGGTGCT
GTGCAACCACCATGCGCTGGCGCATCCGGTGCGCATGGGCGCGGCCGGCTTTGCCAGCCCCGGGCACCGCGTGGTGGTGG
TGGACGATGAACAGCGCGAACTGCCGCCGGGCCGGCCGGGCACGCTGGCGCTGGACCTGAAGCGCTCGCCGATGTGCTGG
TTCGGCGGCTATCACGGCACGCCCACCAGCGGGTTTGCCGGCGGCTACTACCTGACCGGCGATTCCGCCGAGCTGAATGA
CGACGGCAGCATCAGCTTCATAGGCCGGGCCGACGACGTCATCACCACCTCTGGCTACCGCGTGGGCCCGTTCGACGTGG
AAAGCGCGCTGATCGAGCACCCGGCCGTGGTCGAGGCCGCGGTGATCGGCAAGCCCGATCCGGAGCGCACCGAGCTGATC
AAGGCCTTTGTCGTGCTGGACCCGCAATATCGCGCCGCGCCGGAACTGGCCGAGGCGCTGCGCCAGCACGTGCGTAAGCG
CCTGGCCGCCCATGCCTACCCGCGCGAGATCGAGTTCGTCGTCGAGCTGCCCAAGACCCCCAGCGGCAAGGTCCAGCGCT
TTATCCTGCGCAACCAGGAAGTGGCCCGCGCGCGCGAGGCGGCCGCTGCCTGA

Upstream 100 bases:

>100_bases
CGTGGCGCTCGCGCACACTCTTGCGGCAGCCGTTGCGCGCCGGCACCCCGCGCGCAGCGGCCACCTACCAAAAGGCACCA
GCCGGAATACAGGAGACATC

Downstream 100 bases:

>100_bases
GGCCTGAGCCGTTCCCGGACCGCTTCCTATAATGAGGAAGCGGTTGCCAGGCCCCGGGGGTGAAGGAGCCTGCGGCGCCG
CGCAAGGCGCGCCTGCAGGC

Product: Acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MRDYAQAFDGFSYDDAVARQLHGSQEAMNACVECCDRHALPGRIALFWEGRDGNSRSWTFTELQALSAQFAGFLKAQGVQ
PGDRVAGLLPRNAELLVTILGTWRAGAVYQPLFTAFGPKAIEHRLNASGAKVVVTDGANRPKLDDVDGCPAIVTVAGDKG
RGLVRGDFSFWAELERQPASFEPVPRRGDDPFLMMFTSGTTGPAKPLLVPLKAIAAFAGYMSDAVDLRAEDAFWNLADPG
WAYGLYYAVTGPLALGHPTTFYDGPFTVESTCRVIRKYGITNLAGSPTAYRLLIAAGEAVSGPLRGRLRAVSSAGEPLNP
EVIRWFASELGVTIHDHYGQTELGMVLCNHHALAHPVRMGAAGFASPGHRVVVVDDEQRELPPGRPGTLALDLKRSPMCW
FGGYHGTPTSGFAGGYYLTGDSAELNDDGSISFIGRADDVITTSGYRVGPFDVESALIEHPAVVEAAVIGKPDPERTELI
KAFVVLDPQYRAAPELAEALRQHVRKRLAAHAYPREIEFVVELPKTPSGKVQRFILRNQEVARAREAAAA

Sequences:

>Translated_550_residues
MRDYAQAFDGFSYDDAVARQLHGSQEAMNACVECCDRHALPGRIALFWEGRDGNSRSWTFTELQALSAQFAGFLKAQGVQ
PGDRVAGLLPRNAELLVTILGTWRAGAVYQPLFTAFGPKAIEHRLNASGAKVVVTDGANRPKLDDVDGCPAIVTVAGDKG
RGLVRGDFSFWAELERQPASFEPVPRRGDDPFLMMFTSGTTGPAKPLLVPLKAIAAFAGYMSDAVDLRAEDAFWNLADPG
WAYGLYYAVTGPLALGHPTTFYDGPFTVESTCRVIRKYGITNLAGSPTAYRLLIAAGEAVSGPLRGRLRAVSSAGEPLNP
EVIRWFASELGVTIHDHYGQTELGMVLCNHHALAHPVRMGAAGFASPGHRVVVVDDEQRELPPGRPGTLALDLKRSPMCW
FGGYHGTPTSGFAGGYYLTGDSAELNDDGSISFIGRADDVITTSGYRVGPFDVESALIEHPAVVEAAVIGKPDPERTELI
KAFVVLDPQYRAAPELAEALRQHVRKRLAAHAYPREIEFVVELPKTPSGKVQRFILRNQEVARAREAAAA
>Mature_550_residues
MRDYAQAFDGFSYDDAVARQLHGSQEAMNACVECCDRHALPGRIALFWEGRDGNSRSWTFTELQALSAQFAGFLKAQGVQ
PGDRVAGLLPRNAELLVTILGTWRAGAVYQPLFTAFGPKAIEHRLNASGAKVVVTDGANRPKLDDVDGCPAIVTVAGDKG
RGLVRGDFSFWAELERQPASFEPVPRRGDDPFLMMFTSGTTGPAKPLLVPLKAIAAFAGYMSDAVDLRAEDAFWNLADPG
WAYGLYYAVTGPLALGHPTTFYDGPFTVESTCRVIRKYGITNLAGSPTAYRLLIAAGEAVSGPLRGRLRAVSSAGEPLNP
EVIRWFASELGVTIHDHYGQTELGMVLCNHHALAHPVRMGAAGFASPGHRVVVVDDEQRELPPGRPGTLALDLKRSPMCW
FGGYHGTPTSGFAGGYYLTGDSAELNDDGSISFIGRADDVITTSGYRVGPFDVESALIEHPAVVEAAVIGKPDPERTELI
KAFVVLDPQYRAAPELAEALRQHVRKRLAAHAYPREIEFVVELPKTPSGKVQRFILRNQEVARAREAAAA

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=518, Percent_Identity=37.2586872586873, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI122937307, Length=510, Percent_Identity=36.4705882352941, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI42544132, Length=519, Percent_Identity=35.2601156069364, Blast_Score=284, Evalue=1e-76,
Organism=Homo sapiens, GI58082049, Length=516, Percent_Identity=35.2713178294574, Blast_Score=275, Evalue=8e-74,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=34.6899224806202, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=34.6899224806202, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI115511026, Length=513, Percent_Identity=32.7485380116959, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI8923896, Length=571, Percent_Identity=30.4728546409807, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI253970489, Length=584, Percent_Identity=29.9657534246575, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI28416953, Length=561, Percent_Identity=31.5508021390374, Blast_Score=208, Evalue=1e-53,
Organism=Homo sapiens, GI13375727, Length=555, Percent_Identity=27.5675675675676, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI42544134, Length=354, Percent_Identity=29.6610169491525, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI195947378, Length=447, Percent_Identity=25.2796420581655, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI187761345, Length=533, Percent_Identity=25.703564727955, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI187761343, Length=533, Percent_Identity=25.703564727955, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI38524616, Length=540, Percent_Identity=25.3703703703704, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI156151445, Length=573, Percent_Identity=24.0837696335079, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1790505, Length=559, Percent_Identity=30.5903398926655, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI145693145, Length=521, Percent_Identity=27.2552783109405, Blast_Score=155, Evalue=8e-39,
Organism=Escherichia coli, GI1788107, Length=526, Percent_Identity=27.1863117870722, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1786529, Length=548, Percent_Identity=27.9197080291971, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI221142682, Length=512, Percent_Identity=24.21875, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786810, Length=534, Percent_Identity=25.6554307116105, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1786801, Length=443, Percent_Identity=23.9277652370203, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71983001, Length=565, Percent_Identity=32.212389380531, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI71982997, Length=562, Percent_Identity=32.0284697508897, Blast_Score=208, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI32563687, Length=529, Percent_Identity=24.5746691871456, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17557194, Length=547, Percent_Identity=22.4862888482633, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=495, Percent_Identity=23.6363636363636, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=532, Percent_Identity=23.6842105263158, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17559526, Length=550, Percent_Identity=25.2727272727273, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71994703, Length=516, Percent_Identity=22.6744186046512, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=516, Percent_Identity=22.6744186046512, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=516, Percent_Identity=22.6744186046512, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17560308, Length=375, Percent_Identity=25.3333333333333, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=360, Percent_Identity=26.6666666666667, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560140, Length=282, Percent_Identity=24.468085106383, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6319264, Length=566, Percent_Identity=32.3321554770318, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323182, Length=593, Percent_Identity=30.0168634064081, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6319699, Length=504, Percent_Identity=23.015873015873, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667955, Length=564, Percent_Identity=30.6737588652482, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI62472339, Length=534, Percent_Identity=30.5243445692884, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24667959, Length=497, Percent_Identity=29.9798792756539, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI21355225, Length=567, Percent_Identity=25.9259259259259, Blast_Score=152, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24581924, Length=525, Percent_Identity=24.952380952381, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21356947, Length=495, Percent_Identity=23.6363636363636, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859661, Length=527, Percent_Identity=25.2371916508539, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI21355181, Length=529, Percent_Identity=24.7637051039698, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24648260, Length=505, Percent_Identity=24.1584158415842, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI19922652, Length=506, Percent_Identity=23.7154150197628, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI21356441, Length=494, Percent_Identity=22.6720647773279, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20130357, Length=502, Percent_Identity=21.7131474103586, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24653035, Length=550, Percent_Identity=21.0909090909091, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24648257, Length=522, Percent_Identity=23.7547892720307, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24656500, Length=502, Percent_Identity=23.7051792828685, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24648253, Length=419, Percent_Identity=21.9570405727924, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648255, Length=416, Percent_Identity=22.1153846153846, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21358303, Length=468, Percent_Identity=21.7948717948718, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161076582, Length=552, Percent_Identity=20.2898550724638, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 59459; Mature: 59459

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDYAQAFDGFSYDDAVARQLHGSQEAMNACVECCDRHALPGRIALFWEGRDGNSRSWTF
CCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEH
TELQALSAQFAGFLKAQGVQPGDRVAGLLPRNAELLVTILGTWRAGAVYQPLFTAFGPKA
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHCCHHH
IEHRLNASGAKVVVTDGANRPKLDDVDGCPAIVTVAGDKGRGLVRGDFSFWAELERQPAS
HHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHCCCCC
FEPVPRRGDDPFLMMFTSGTTGPAKPLLVPLKAIAAFAGYMSDAVDLRAEDAFWNLADPG
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEECCCEEECCCCC
WAYGLYYAVTGPLALGHPTTFYDGPFTVESTCRVIRKYGITNLAGSPTAYRLLIAAGEAV
HHEEEEEEEECCEECCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCC
SGPLRGRLRAVSSAGEPLNPEVIRWFASELGVTIHDHYGQTELGMVLCNHHALAHPVRMG
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHEEECCCHHHHHHHHC
AAGFASPGHRVVVVDDEQRELPPGRPGTLALDLKRSPMCWFGGYHGTPTSGFAGGYYLTG
CCCCCCCCCEEEEECCCHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCEEEEC
DSAELNDDGSISFIGRADDVITTSGYRVGPFDVESALIEHPAVVEAAVIGKPDPERTELI
CCCCCCCCCCEEEEECCCCEEEECCEEECCCCHHHHHHCCCCCEEEEECCCCCCHHHHHH
KAFVVLDPQYRAAPELAEALRQHVRKRLAAHAYPREIEFVVELPKTPSGKVQRFILRNQE
EEHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCHH
VARAREAAAA
HHHHHHHHCC
>Mature Secondary Structure
MRDYAQAFDGFSYDDAVARQLHGSQEAMNACVECCDRHALPGRIALFWEGRDGNSRSWTF
CCCHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCEEH
TELQALSAQFAGFLKAQGVQPGDRVAGLLPRNAELLVTILGTWRAGAVYQPLFTAFGPKA
HHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHHHCCHHH
IEHRLNASGAKVVVTDGANRPKLDDVDGCPAIVTVAGDKGRGLVRGDFSFWAELERQPAS
HHHHCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEECCHHHHHHHHCCCCC
FEPVPRRGDDPFLMMFTSGTTGPAKPLLVPLKAIAAFAGYMSDAVDLRAEDAFWNLADPG
CCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCEECCCEEECCCCC
WAYGLYYAVTGPLALGHPTTFYDGPFTVESTCRVIRKYGITNLAGSPTAYRLLIAAGEAV
HHEEEEEEEECCEECCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCHHEEEEEECCCCC
SGPLRGRLRAVSSAGEPLNPEVIRWFASELGVTIHDHYGQTELGMVLCNHHALAHPVRMG
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCEEEECCCCCCHHHHEEECCCHHHHHHHHC
AAGFASPGHRVVVVDDEQRELPPGRPGTLALDLKRSPMCWFGGYHGTPTSGFAGGYYLTG
CCCCCCCCCEEEEECCCHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCCCCEEEEC
DSAELNDDGSISFIGRADDVITTSGYRVGPFDVESALIEHPAVVEAAVIGKPDPERTELI
CCCCCCCCCCEEEEECCCCEEEECCEEECCCCHHHHHHCCCCCEEEEECCCCCCHHHHHH
KAFVVLDPQYRAAPELAEALRQHVRKRLAAHAYPREIEFVVELPKTPSGKVQRFILRNQE
EEHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCHH
VARAREAAAA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]