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The map label for this gene is ggt2c [H]

Identifier: 116694929

GI number: 116694929

Start: 1109618

End: 1111207

Strand: Direct

Name: ggt2c [H]

Synonym: H16_B0984

Alternate gene names: 116694929

Gene position: 1109618-1111207 (Clockwise)

Preceding gene: 116694928

Following gene: 116694931

Centisome position: 38.1

GC content: 68.81

Gene sequence:

>1590_bases
ATGTTGCCTTTCGACTGGACCTTTCCCTACCCGTCGCAAAAGATGCCGCTGCTGGCCGCCAACGCGGTCAGCACCAGCCA
GCCCCTCGCCGCGCAGGCGGGGCTGCGCATGCTGTACGAAGGCGGCAATGCCATCGACAGCGCCATTGCCAGTGCGATTG
CGCTGACCGTGGTGGAGCCGGTGATGAACGGCATTGGCGGGGACATGTTCGCGCTGGTCTGGCACGAGGGGCAGCTGTAC
GGGCTCAACTCCAGCGGCCGGGCGCCGGCGCGTTGGACCCTGGATCATTTCGCCGGGCACGACAGCATGCCCCAGGTGGG
CTGGGATACGGTCACCGTGCCGGGCCAGGTCGCGGGCTGGAAGGCGCTGTCGGTCCGCTTCGGCAAGCTGCCGTTCGCGC
GGCTGTTCGCGCCGGCCATCGAGTACGCTGAACAGGGCTTCCTGGTGTCGCCGCAGATCGCACGGCAATGGGCCGCACAG
GTGCCGGTGCTGGCCGGCCAGCCTGGCTTTGCCAAGGCGTTCCTGCGCGACGGCAGGGCACCGCAGGCGGGCGAGCGCTG
GCGCTTCCCGGAGCAGGCCGCCACGCTGCAGCGCATTGCCGAGAGCGATGGCGAGAGCTTCTACACGGGTGAACTCGCCG
CGCGCATCGTCGCGTTCGCCGAGGAAACCGGAGGCGCCATCCGTGCCGACGACCTGGCCGCACATCGCGCCGCCTGGGTC
CAGCCAATGGCGCAGCAGTTCCGCGGCTACACGCTCCATGAAATTCCCCCGAACGGCCAGGGCATCGCCGCGCTGATCGG
CCTTGGCATCCTGGACCGCTTCGACGTGGAAGGCATGGGCTGCGACAGCGCCGGCTTCTATCACGTCAGCATCGAGGCGA
TGAAGCTGGCCTTCGCCGACCTGCACCGCCACGTGTCGGACCCGTCCACCATGCAGCACGCGCCCGCCGCCTTCCTGGAT
CCGGCCTATCTTGCCGAGCGCGCGGCGCTGATCGACATGAAACGCGCCGGCACACCTACCGCTGGCATCCCGAAGAGCGG
CGGCACCGTCTACCTGTCCAGCGCGGATGCGGCGGGTTCGATGGTGTCGTATATCCAGTCCAACTACCGCGGCTTCGGCT
CCGGCGTGGTGGTGCCTGGCACCGGCATCGCGCTGCATAACCGCGGCGCGGGCTTCAACCTCAAGCCCGGCCACGCCAAC
TGCGTGGCGCCGGGCAAGCAGCCGATGCACACCATCATCCCGGGCTTCGTCACCCGCAATGGCGAGCCGGTGATGTCATT
CGGCGTGATGGGTGGCTCGATGCAGGCACAGGGCCACGTCCAGATGATGGCGCGGCTTGCCGCCTTCGGCCAGAATCCGC
AGGCCATGAGCGATGCCCCGCGCTTCCGCGTTGAGCACGGGCCGGTGGTCAATGTCGAGGCGCATCTGCCGCCGGATGTG
GTCGCCACGCTGCGCGGCATGGGCCATCGCGTTGAAGTGGCGCCGCGCGACAGCCTGGAGTTCGGCTCGGCGCAGCTCAT
CTACAAGGCGCCGGACGGCTACATCGCGGCCTCGGACTCGCGGCGCGACGGGCAGGCAGTGGGGTTTTAG

Upstream 100 bases:

>100_bases
AGCTGGTCAAGCAGTCCGGCGTGACCCTGCAATAAGCCGCGTGCAGCAACCCTGGGGCGCCGCCCGCGCGCCCCTTTACC
TGTTCTGAATGGAGTTCCCG

Downstream 100 bases:

>100_bases
GGGCGAGCCGCCCGCGGTCACAGCGGCGCCGGCTGAGGCTGGCTGGCAGGCGTGGCCGCGGCGGGCTTCTTGTTGTCAGT
GCCGCTATATGAGAAGTACT

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MLPFDWTFPYPSQKMPLLAANAVSTSQPLAAQAGLRMLYEGGNAIDSAIASAIALTVVEPVMNGIGGDMFALVWHEGQLY
GLNSSGRAPARWTLDHFAGHDSMPQVGWDTVTVPGQVAGWKALSVRFGKLPFARLFAPAIEYAEQGFLVSPQIARQWAAQ
VPVLAGQPGFAKAFLRDGRAPQAGERWRFPEQAATLQRIAESDGESFYTGELAARIVAFAEETGGAIRADDLAAHRAAWV
QPMAQQFRGYTLHEIPPNGQGIAALIGLGILDRFDVEGMGCDSAGFYHVSIEAMKLAFADLHRHVSDPSTMQHAPAAFLD
PAYLAERAALIDMKRAGTPTAGIPKSGGTVYLSSADAAGSMVSYIQSNYRGFGSGVVVPGTGIALHNRGAGFNLKPGHAN
CVAPGKQPMHTIIPGFVTRNGEPVMSFGVMGGSMQAQGHVQMMARLAAFGQNPQAMSDAPRFRVEHGPVVNVEAHLPPDV
VATLRGMGHRVEVAPRDSLEFGSAQLIYKAPDGYIAASDSRRDGQAVGF

Sequences:

>Translated_529_residues
MLPFDWTFPYPSQKMPLLAANAVSTSQPLAAQAGLRMLYEGGNAIDSAIASAIALTVVEPVMNGIGGDMFALVWHEGQLY
GLNSSGRAPARWTLDHFAGHDSMPQVGWDTVTVPGQVAGWKALSVRFGKLPFARLFAPAIEYAEQGFLVSPQIARQWAAQ
VPVLAGQPGFAKAFLRDGRAPQAGERWRFPEQAATLQRIAESDGESFYTGELAARIVAFAEETGGAIRADDLAAHRAAWV
QPMAQQFRGYTLHEIPPNGQGIAALIGLGILDRFDVEGMGCDSAGFYHVSIEAMKLAFADLHRHVSDPSTMQHAPAAFLD
PAYLAERAALIDMKRAGTPTAGIPKSGGTVYLSSADAAGSMVSYIQSNYRGFGSGVVVPGTGIALHNRGAGFNLKPGHAN
CVAPGKQPMHTIIPGFVTRNGEPVMSFGVMGGSMQAQGHVQMMARLAAFGQNPQAMSDAPRFRVEHGPVVNVEAHLPPDV
VATLRGMGHRVEVAPRDSLEFGSAQLIYKAPDGYIAASDSRRDGQAVGF
>Mature_529_residues
MLPFDWTFPYPSQKMPLLAANAVSTSQPLAAQAGLRMLYEGGNAIDSAIASAIALTVVEPVMNGIGGDMFALVWHEGQLY
GLNSSGRAPARWTLDHFAGHDSMPQVGWDTVTVPGQVAGWKALSVRFGKLPFARLFAPAIEYAEQGFLVSPQIARQWAAQ
VPVLAGQPGFAKAFLRDGRAPQAGERWRFPEQAATLQRIAESDGESFYTGELAARIVAFAEETGGAIRADDLAAHRAAWV
QPMAQQFRGYTLHEIPPNGQGIAALIGLGILDRFDVEGMGCDSAGFYHVSIEAMKLAFADLHRHVSDPSTMQHAPAAFLD
PAYLAERAALIDMKRAGTPTAGIPKSGGTVYLSSADAAGSMVSYIQSNYRGFGSGVVVPGTGIALHNRGAGFNLKPGHAN
CVAPGKQPMHTIIPGFVTRNGEPVMSFGVMGGSMQAQGHVQMMARLAAFGQNPQAMSDAPRFRVEHGPVVNVEAHLPPDV
VATLRGMGHRVEVAPRDSLEFGSAQLIYKAPDGYIAASDSRRDGQAVGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=536, Percent_Identity=28.3582089552239, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI73915090, Length=536, Percent_Identity=28.3582089552239, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI73915096, Length=536, Percent_Identity=28.3582089552239, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI73915094, Length=536, Percent_Identity=28.3582089552239, Blast_Score=172, Evalue=8e-43,
Organism=Homo sapiens, GI113429324, Length=546, Percent_Identity=27.4725274725275, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI113429326, Length=553, Percent_Identity=27.3056057866184, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI109148539, Length=510, Percent_Identity=27.4509803921569, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI153266885, Length=545, Percent_Identity=23.8532110091743, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI153266901, Length=546, Percent_Identity=23.8095238095238, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI153266907, Length=539, Percent_Identity=23.0055658627087, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI30581157, Length=202, Percent_Identity=29.7029702970297, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI30581155, Length=202, Percent_Identity=29.7029702970297, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1789856, Length=526, Percent_Identity=30.0380228136882, Blast_Score=210, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI212646519, Length=572, Percent_Identity=26.2237762237762, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI72000294, Length=572, Percent_Identity=26.2237762237762, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI193208245, Length=514, Percent_Identity=25.875486381323, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI193208247, Length=514, Percent_Identity=25.875486381323, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17506189, Length=540, Percent_Identity=24.8148148148148, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17542894, Length=549, Percent_Identity=25.5009107468124, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642670, Length=536, Percent_Identity=26.6791044776119, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24642666, Length=536, Percent_Identity=26.6791044776119, Blast_Score=135, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45551474, Length=536, Percent_Identity=26.6791044776119, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI161077878, Length=536, Percent_Identity=26.6791044776119, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI161077880, Length=536, Percent_Identity=26.865671641791, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18859893, Length=511, Percent_Identity=25.6360078277886, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI18859741, Length=545, Percent_Identity=25.5045871559633, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI161077496, Length=510, Percent_Identity=24.5098039215686, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56230; Mature: 56230

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPFDWTFPYPSQKMPLLAANAVSTSQPLAAQAGLRMLYEGGNAIDSAIASAIALTVVEP
CCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
VMNGIGGDMFALVWHEGQLYGLNSSGRAPARWTLDHFAGHDSMPQVGWDTVTVPGQVAGW
HHHCCCCCEEEEEEECCEEEEECCCCCCCCEEEHHHHCCCCCCCCCCCCEEECCCCCCCC
KALSVRFGKLPFARLFAPAIEYAEQGFLVSPQIARQWAAQVPVLAGQPGFAKAFLRDGRA
EEEEEEECCCCHHHHHHHHHHHHHCCCEECHHHHHHHHHCCCEEECCCCHHHHHHHCCCC
PQAGERWRFPEQAATLQRIAESDGESFYTGELAARIVAFAEETGGAIRADDLAAHRAAWV
CCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
QPMAQQFRGYTLHEIPPNGQGIAALIGLGILDRFDVEGMGCDSAGFYHVSIEAMKLAFAD
HHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHH
LHRHVSDPSTMQHAPAAFLDPAYLAERAALIDMKRAGTPTAGIPKSGGTVYLSSADAAGS
HHHHCCCCHHHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHH
MVSYIQSNYRGFGSGVVVPGTGIALHNRGAGFNLKPGHANCVAPGKQPMHTIIPGFVTRN
HHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEECCCCCCHHHHCCHHHCCC
GEPVMSFGVMGGSMQAQGHVQMMARLAAFGQNPQAMSDAPRFRVEHGPVVNVEAHLPPDV
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCEEECCCCEEEEECCCCHHH
VATLRGMGHRVEVAPRDSLEFGSAQLIYKAPDGYIAASDSRRDGQAVGF
HHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCC
>Mature Secondary Structure
MLPFDWTFPYPSQKMPLLAANAVSTSQPLAAQAGLRMLYEGGNAIDSAIASAIALTVVEP
CCCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHH
VMNGIGGDMFALVWHEGQLYGLNSSGRAPARWTLDHFAGHDSMPQVGWDTVTVPGQVAGW
HHHCCCCCEEEEEEECCEEEEECCCCCCCCEEEHHHHCCCCCCCCCCCCEEECCCCCCCC
KALSVRFGKLPFARLFAPAIEYAEQGFLVSPQIARQWAAQVPVLAGQPGFAKAFLRDGRA
EEEEEEECCCCHHHHHHHHHHHHHCCCEECHHHHHHHHHCCCEEECCCCHHHHHHHCCCC
PQAGERWRFPEQAATLQRIAESDGESFYTGELAARIVAFAEETGGAIRADDLAAHRAAWV
CCCCCCCCCHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHH
QPMAQQFRGYTLHEIPPNGQGIAALIGLGILDRFDVEGMGCDSAGFYHVSIEAMKLAFAD
HHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHH
LHRHVSDPSTMQHAPAAFLDPAYLAERAALIDMKRAGTPTAGIPKSGGTVYLSSADAAGS
HHHHCCCCHHHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHH
MVSYIQSNYRGFGSGVVVPGTGIALHNRGAGFNLKPGHANCVAPGKQPMHTIIPGFVTRN
HHHHHHHHCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEECCCCCCHHHHCCHHHCCC
GEPVMSFGVMGGSMQAQGHVQMMARLAAFGQNPQAMSDAPRFRVEHGPVVNVEAHLPPDV
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCEEECCCCEEEEECCCCHHH
VATLRGMGHRVEVAPRDSLEFGSAQLIYKAPDGYIAASDSRRDGQAVGF
HHHHHCCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]