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The map label for this gene is acdA [H]

Identifier: 116694920

GI number: 116694920

Start: 1098279

End: 1099418

Strand: Direct

Name: acdA [H]

Synonym: H16_B0975

Alternate gene names: 116694920

Gene position: 1098279-1099418 (Clockwise)

Preceding gene: 116694919

Following gene: 116694922

Centisome position: 37.71

GC content: 69.39

Gene sequence:

>1140_bases
ATGCATAAACGACTGGGCGTAGAGCCGGGCGATCTTGAGATTGCCGATGCCATCGGACGCTTCGCGCAAAGCGAACTGGC
GCCGAAGGCGGCCGAGGTGGACCGGGCCGAAGCCTCCACCACGTGCTATGTGCCGCAACTTGCCGAGCTCGGCCTGATGG
GGATGAACCTGCCGGAGCGCTGGGGCGGGACCGAGACTTCGCCGGTGGCACTGATCCTGTCGTTGGCGGAGGTTGCCAAG
GCCTGCGCCTCGACCTCGTCGATGATCGGCGCGCACTACCTGGCTACCGATTCCATCCTGATCGGCGGCGACGACAGCCT
GCGCGAGCGCCACCTGCCGGATGCGGCCGCCGGCGGCAAGCTGGGCGCCTTTGCGCTGACCGAGCCGCGCGCCGGCTCCA
ACCCGGCGGACATGGCCACGCGCGCCACCCCGGAGGGCGACGGCTACCGCCTGCGCGGGGTCAAGCACTTCATCTCCAAT
GCGGACGCTGCGGACTTTATCGTCGTCTACGCCAAGACCGATCCCGCCGCCGGCACGCGCGGTATCAGCGCCTTCGTGGT
GGACCGGCACAGCGAGGGCGTGCAGATCGCGCCCGCCGAGAAACTGATGGGAATTCGCGGGGCGCCGGCCCATGAGGTGG
CGCTGGACTGCTTCGTTCCCGCCGCCAACCGGCTGGGGCCGGAAGGCACGGGCTTCCGTACCGCGATGAAGGTGCTGGAC
AACAGCCGCCTGGACGTGGCTGCCACCAGCCTGGGCATTGCCGAGGCAGCGCTGGCGTGCGCGGCGGACTGGGCCAGGCA
GCGCCAGGTCGGCGGCGAGCCGCTGGCGCGCAAGCAAGGCCTGCAATGGATGTTTGCCGACATGCGCACGCGGCTGGAGG
CGGCCTGGCTGCTGACCCTGCAGGCGGCGGTGCGGCGCCGGGACGGAGAGCCCTTCACCGAGCAGGCATCGATGGCCAAG
CTCTATGCCTCGGAGATGGTCGGCTTTGTCACCGACGCCGCGCTACAGATCCACGGCGGCTACGGCTTCACGCGCGAAAT
GCCGCTGGAGCGCCTGGTGCGCGATGCGCGGATCCTGCGCATCTATGAAGGCTCGTCGGAAATCCAGCGGACGGTGATCG
CGCGCGCGGTGCTGGCGTAA

Upstream 100 bases:

>100_bases
ACGCCCGCGCCGGCGCTGGGGCAGCACACCGAAGCCATCCTGGCCGAGCTGGCCAACGCTGCCACGGCGCATCCGCAAGT
GTTCAGCAAGGAGAAACAAC

Downstream 100 bases:

>100_bases
GCGCCGCTGCAGATCCGACGGTGGGGATCAGGGCGTGGCAGGCGTGTCGGGGCTGTCAGGCGTGGCGTCGGGCGCGGCAG
GGGTGTCAGGCGTGGCAGCG

Product: Acyl-CoA dehydrogenase

Products: 2-butenoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MHKRLGVEPGDLEIADAIGRFAQSELAPKAAEVDRAEASTTCYVPQLAELGLMGMNLPERWGGTETSPVALILSLAEVAK
ACASTSSMIGAHYLATDSILIGGDDSLRERHLPDAAAGGKLGAFALTEPRAGSNPADMATRATPEGDGYRLRGVKHFISN
ADAADFIVVYAKTDPAAGTRGISAFVVDRHSEGVQIAPAEKLMGIRGAPAHEVALDCFVPAANRLGPEGTGFRTAMKVLD
NSRLDVAATSLGIAEAALACAADWARQRQVGGEPLARKQGLQWMFADMRTRLEAAWLLTLQAAVRRRDGEPFTEQASMAK
LYASEMVGFVTDAALQIHGGYGFTREMPLERLVRDARILRIYEGSSEIQRTVIARAVLA

Sequences:

>Translated_379_residues
MHKRLGVEPGDLEIADAIGRFAQSELAPKAAEVDRAEASTTCYVPQLAELGLMGMNLPERWGGTETSPVALILSLAEVAK
ACASTSSMIGAHYLATDSILIGGDDSLRERHLPDAAAGGKLGAFALTEPRAGSNPADMATRATPEGDGYRLRGVKHFISN
ADAADFIVVYAKTDPAAGTRGISAFVVDRHSEGVQIAPAEKLMGIRGAPAHEVALDCFVPAANRLGPEGTGFRTAMKVLD
NSRLDVAATSLGIAEAALACAADWARQRQVGGEPLARKQGLQWMFADMRTRLEAAWLLTLQAAVRRRDGEPFTEQASMAK
LYASEMVGFVTDAALQIHGGYGFTREMPLERLVRDARILRIYEGSSEIQRTVIARAVLA
>Mature_379_residues
MHKRLGVEPGDLEIADAIGRFAQSELAPKAAEVDRAEASTTCYVPQLAELGLMGMNLPERWGGTETSPVALILSLAEVAK
ACASTSSMIGAHYLATDSILIGGDDSLRERHLPDAAAGGKLGAFALTEPRAGSNPADMATRATPEGDGYRLRGVKHFISN
ADAADFIVVYAKTDPAAGTRGISAFVVDRHSEGVQIAPAEKLMGIRGAPAHEVALDCFVPAANRLGPEGTGFRTAMKVLD
NSRLDVAATSLGIAEAALACAADWARQRQVGGEPLARKQGLQWMFADMRTRLEAAWLLTLQAAVRRRDGEPFTEQASMAK
LYASEMVGFVTDAALQIHGGYGFTREMPLERLVRDARILRIYEGSSEIQRTVIARAVLA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=360, Percent_Identity=41.1111111111111, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI4501859, Length=369, Percent_Identity=35.230352303523, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=35.8839050131926, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=33.2439678284182, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI187960098, Length=360, Percent_Identity=34.1666666666667, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4557231, Length=360, Percent_Identity=34.1666666666667, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=33.4319526627219, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=34.6456692913386, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI4557235, Length=386, Percent_Identity=34.4559585492228, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI21361497, Length=341, Percent_Identity=33.4310850439883, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=29.1891891891892, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4503943, Length=374, Percent_Identity=28.0748663101604, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI7669494, Length=360, Percent_Identity=28.0555555555556, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI211971008, Length=286, Percent_Identity=29.7202797202797, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI48976061, Length=286, Percent_Identity=29.7202797202797, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI38505218, Length=283, Percent_Identity=25.4416961130742, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87081958, Length=338, Percent_Identity=31.0650887573964, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1786223, Length=351, Percent_Identity=29.0598290598291, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87082384, Length=275, Percent_Identity=28.7272727272727, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508101, Length=366, Percent_Identity=33.879781420765, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17506239, Length=370, Percent_Identity=32.7027027027027, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI17570075, Length=364, Percent_Identity=34.6153846153846, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17569725, Length=370, Percent_Identity=34.5945945945946, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=32.3607427055703, Blast_Score=207, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17534899, Length=370, Percent_Identity=33.7837837837838, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=31.8302387267904, Blast_Score=197, Evalue=8e-51,
Organism=Caenorhabditis elegans, GI71985184, Length=344, Percent_Identity=36.3372093023256, Blast_Score=188, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=31.9727891156463, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17534353, Length=361, Percent_Identity=29.3628808864266, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=34.8547717842324, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71982178, Length=265, Percent_Identity=30.9433962264151, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71985192, Length=262, Percent_Identity=35.8778625954198, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17551932, Length=371, Percent_Identity=28.5714285714286, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=366, Percent_Identity=27.5956284153005, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI32563615, Length=229, Percent_Identity=29.6943231441048, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI86563381, Length=321, Percent_Identity=28.0373831775701, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI86563383, Length=321, Percent_Identity=28.0373831775701, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=31.25, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=283, Percent_Identity=28.6219081272085, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356377, Length=360, Percent_Identity=39.4444444444444, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24646207, Length=359, Percent_Identity=39.8328690807799, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI24666513, Length=366, Percent_Identity=31.4207650273224, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24660351, Length=368, Percent_Identity=32.6086956521739, Blast_Score=199, Evalue=4e-51,
Organism=Drosophila melanogaster, GI21355753, Length=366, Percent_Identity=34.1530054644809, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI281363737, Length=345, Percent_Identity=35.0724637681159, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI19920834, Length=378, Percent_Identity=29.8941798941799, Blast_Score=135, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.2

Molecular weight: Translated: 40400; Mature: 40400

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKRLGVEPGDLEIADAIGRFAQSELAPKAAEVDRAEASTTCYVPQLAELGLMGMNLPER
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECHHHHHHCCCCCCCCHH
WGGTETSPVALILSLAEVAKACASTSSMIGAHYLATDSILIGGDDSLRERHLPDAAAGGK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEECCCHHHHHHCCCCCCCCCC
LGAFALTEPRAGSNPADMATRATPEGDGYRLRGVKHFISNADAADFIVVYAKTDPAAGTR
CCEEEEECCCCCCCHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
GISAFVVDRHSEGVQIAPAEKLMGIRGAPAHEVALDCFVPAANRLGPEGTGFRTAMKVLD
CCEEEEEECCCCCCEECCHHHHHCCCCCCHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHC
NSRLDVAATSLGIAEAALACAADWARQRQVGGEPLARKQGLQWMFADMRTRLEAAWLLTL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
QAAVRRRDGEPFTEQASMAKLYASEMVGFVTDAALQIHGGYGFTREMPLERLVRDARILR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHEEE
IYEGSSEIQRTVIARAVLA
EECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHKRLGVEPGDLEIADAIGRFAQSELAPKAAEVDRAEASTTCYVPQLAELGLMGMNLPER
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEECHHHHHHCCCCCCCCHH
WGGTETSPVALILSLAEVAKACASTSSMIGAHYLATDSILIGGDDSLRERHLPDAAAGGK
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEECCCHHHHHHCCCCCCCCCC
LGAFALTEPRAGSNPADMATRATPEGDGYRLRGVKHFISNADAADFIVVYAKTDPAAGTR
CCEEEEECCCCCCCHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCEEEEEEECCCCCCCC
GISAFVVDRHSEGVQIAPAEKLMGIRGAPAHEVALDCFVPAANRLGPEGTGFRTAMKVLD
CCEEEEEECCCCCCEECCHHHHHCCCCCCHHHHHHHHHHCHHHHCCCCCCCHHHHHHHHC
NSRLDVAATSLGIAEAALACAADWARQRQVGGEPLARKQGLQWMFADMRTRLEAAWLLTL
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHH
QAAVRRRDGEPFTEQASMAKLYASEMVGFVTDAALQIHGGYGFTREMPLERLVRDARILR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHEEE
IYEGSSEIQRTVIARAVLA
EECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: butanoyl-CoA; acceptor

Specific reaction: butanoyl-CoA + acceptor = 2-butenoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]