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The map label for this gene is ccmA2 [H]

Identifier: 116694897

GI number: 116694897

Start: 1074615

End: 1075271

Strand: Direct

Name: ccmA2 [H]

Synonym: H16_B0952

Alternate gene names: 116694897

Gene position: 1074615-1075271 (Clockwise)

Preceding gene: 116694896

Following gene: 116694898

Centisome position: 36.9

GC content: 68.8

Gene sequence:

>657_bases
ATGCTGGAAGCAGTGTCACTGACCGCCGCGCGCGGCGACCGGCCGATTTTCATCAGGCTGGGGCTGCGCGTGGAGCCCGG
GCAAGCGGTGCATGTCACAGGCGCCAACGGCAGCGGCAAGACTACCCTGCTGCGAATCCTGGCTGGCCTGCTGCGCCCGG
AATCGGGCGAGATCCGATGGAACGGGTGTGCGGTGGCGGCGAGCCGGCCGCTGCCCGATTCCGCATACCTCGGTCACCGC
AACGGCCTGAAAGCGGAGCTGAGCGCGCTGGAGAACCTGCGCAGTGCCTGCGCGCTGTACGGTTGCCGCACGGATCGTGC
GCACCTGCAGCGGGTGCTGGCACAAGTCGGGCTGGCCGCTGGTGCCGACACCGCTCTCGGGCTGTTGTCGCAGGGGCAGC
AGCGCCGGGTTGCGCTGGCGCGTGTGCTGTCCAGTGGCGCGAAGCTATGGCTGCTCGACGAGCCGACCACCGCACTCGAC
CAGTCCAGCATCCGGGCCTTTGAGGGATTGTGCGAACACCATCTGCAGTCGGGCGGCATGCTGGTGTTTGCGAACCACTA
CCCGCTGCGGCTGGTGGCCGCGCGGATGCGCGAGCTTGCCATCCCGGCGATCGCCGATCGATCGCAGCAGGAGGCGGCAT
GCTGGATCCGGTCCTGA

Upstream 100 bases:

>100_bases
TGAGGTGAAGGGCGCCTGGACCAGCGCCTACGTGATCCTGGCCGGGGCCATGAAAGACGCCGCCGCGACCGCCTGGGACT
GACTCAGGAGGAATGAGGCC

Downstream 100 bases:

>100_bases
AACTGATCGCGCGTGAGCTGCTGCTGGCGTGGCGTCGCCCGTCGGCGGTGCTGACACCGCTCGCCTTTTTTGTCGCGGTG
GTCAGCCTGTTTCCGCTGGC

Product: ABC transporter ATPase

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MLEAVSLTAARGDRPIFIRLGLRVEPGQAVHVTGANGSGKTTLLRILAGLLRPESGEIRWNGCAVAASRPLPDSAYLGHR
NGLKAELSALENLRSACALYGCRTDRAHLQRVLAQVGLAAGADTALGLLSQGQQRRVALARVLSSGAKLWLLDEPTTALD
QSSIRAFEGLCEHHLQSGGMLVFANHYPLRLVAARMRELAIPAIADRSQQEAACWIRS

Sequences:

>Translated_218_residues
MLEAVSLTAARGDRPIFIRLGLRVEPGQAVHVTGANGSGKTTLLRILAGLLRPESGEIRWNGCAVAASRPLPDSAYLGHR
NGLKAELSALENLRSACALYGCRTDRAHLQRVLAQVGLAAGADTALGLLSQGQQRRVALARVLSSGAKLWLLDEPTTALD
QSSIRAFEGLCEHHLQSGGMLVFANHYPLRLVAARMRELAIPAIADRSQQEAACWIRS
>Mature_218_residues
MLEAVSLTAARGDRPIFIRLGLRVEPGQAVHVTGANGSGKTTLLRILAGLLRPESGEIRWNGCAVAASRPLPDSAYLGHR
NGLKAELSALENLRSACALYGCRTDRAHLQRVLAQVGLAAGADTALGLLSQGQQRRVALARVLSSGAKLWLLDEPTTALD
QSSIRAFEGLCEHHLQSGGMLVFANHYPLRLVAARMRELAIPAIADRSQQEAACWIRS

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI62526033, Length=172, Percent_Identity=30.2325581395349, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI105990541, Length=179, Percent_Identity=31.2849162011173, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI11967969, Length=159, Percent_Identity=34.5911949685535, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI87082064, Length=203, Percent_Identity=39.9014778325123, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1789991, Length=200, Percent_Identity=31, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1788761, Length=169, Percent_Identity=33.7278106508876, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788225, Length=155, Percent_Identity=33.5483870967742, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787029, Length=200, Percent_Identity=31.5, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI87081709, Length=163, Percent_Identity=33.7423312883436, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790190, Length=188, Percent_Identity=28.7234042553192, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1786563, Length=164, Percent_Identity=32.9268292682927, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI87081782, Length=180, Percent_Identity=30, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1787105, Length=178, Percent_Identity=30.8988764044944, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786253, Length=151, Percent_Identity=34.4370860927152, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786872, Length=143, Percent_Identity=37.7622377622378, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI2367384, Length=225, Percent_Identity=29.7777777777778, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081834, Length=197, Percent_Identity=30.9644670050761, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788165, Length=201, Percent_Identity=29.3532338308458, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789873, Length=182, Percent_Identity=27.4725274725275, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786398, Length=161, Percent_Identity=32.2981366459627, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788540, Length=208, Percent_Identity=28.3653846153846, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790544, Length=206, Percent_Identity=30.0970873786408, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI48994997, Length=159, Percent_Identity=32.0754716981132, Blast_Score=61, Evalue=5e-11,
Organism=Escherichia coli, GI1786703, Length=214, Percent_Identity=30.3738317757009, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1789593, Length=194, Percent_Identity=27.319587628866, Blast_Score=60, Evalue=9e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=151, Percent_Identity=30.4635761589404, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533608, Length=174, Percent_Identity=29.3103448275862, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559834, Length=158, Percent_Identity=34.8101265822785, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983523, Length=165, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983516, Length=165, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71983510, Length=165, Percent_Identity=30.3030303030303, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641342, Length=175, Percent_Identity=33.7142857142857, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24666092, Length=171, Percent_Identity=32.7485380116959, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19920532, Length=174, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24580930, Length=174, Percent_Identity=31.0344827586207, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 23360; Mature: 23360

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEAVSLTAARGDRPIFIRLGLRVEPGQAVHVTGANGSGKTTLLRILAGLLRPESGEIRW
CCCCEEEEECCCCCEEEEEECCEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
NGCAVAASRPLPDSAYLGHRNGLKAELSALENLRSACALYGCRTDRAHLQRVLAQVGLAA
CCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
GADTALGLLSQGQQRRVALARVLSSGAKLWLLDEPTTALDQSSIRAFEGLCEHHLQSGGM
CCHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCE
LVFANHYPLRLVAARMRELAIPAIADRSQQEAACWIRS
EEEECCCCHHHHHHHHHHHCCCHHCCCCCCHHHHCCCC
>Mature Secondary Structure
MLEAVSLTAARGDRPIFIRLGLRVEPGQAVHVTGANGSGKTTLLRILAGLLRPESGEIRW
CCCCEEEEECCCCCEEEEEECCEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEE
NGCAVAASRPLPDSAYLGHRNGLKAELSALENLRSACALYGCRTDRAHLQRVLAQVGLAA
CCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
GADTALGLLSQGQQRRVALARVLSSGAKLWLLDEPTTALDQSSIRAFEGLCEHHLQSGGM
CCHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCE
LVFANHYPLRLVAARMRELAIPAIADRSQQEAACWIRS
EEEECCCCHHHHHHHHHHHCCCHHCCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]