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The map label for this gene is pcaK2 [H]

Identifier: 116694823

GI number: 116694823

Start: 994245

End: 995585

Strand: Direct

Name: pcaK2 [H]

Synonym: H16_B0877

Alternate gene names: 116694823

Gene position: 994245-995585 (Clockwise)

Preceding gene: 116694822

Following gene: 116694825

Centisome position: 34.14

GC content: 68.46

Gene sequence:

>1341_bases
ATGCCTGCCAGCCAACCCCTGAACGTCACCGCGTTCATCGACCGCCAGCCGCTGTCGGCGTTCCAGGTGAGCATCGTCGT
GCTGTGCTTCCTGATCGTTGCGGTCGATGGCTTCGATACCGCGGCGATCGGCTTCATCGCACCAGCCATCCGCGCGGAAT
GGCAGCTGACGCCGGCCCAGCTGGCGCCGCTGTTCGGCGCCGGACTCGGCGGCCTGATGGTCGGCGCCTTCCTCTTCGGC
CCGCTGGCCGACCGCTTCGGCCGCAAGGGCGTGCTGGTGCTGTCGGTGCTGTTCTTCGGTGCCGCCAGCCTGGCCTCGGC
CTGGTCGCAGGACCTGTGGATGCTGGTGCTGCTGCGCTTCCTGACCGGCCTGGGCCTGGGCGGAGCCATGCCCAACGCCA
TCACGCTGACCTCGGAGTTCTGTCCGGAAAAGCGGCGCTCGTTCCTGGTCACGACCATGTTTTGCGGCTTCACGCTGGGC
TCGGCTTTCGGCGGCCTGGCTTCCGCCGGGCTGATCGATGCCTTTGGCTGGCGCTCGGTGCTGGTGGCCGGCGGGGTCAT
GCCGCTGGTGCTGGCGGCGCTGCTGCTGTGGCTGCTGCCGGAATCGGTGCGCTACCTCGTGCTGGCCGGCAAGCAGCGCG
AACGCATCGTCGCCACGCTGCAGAAGATCGCGCCGCAAGCCGACCTGCGCGACGCCACCTTCGTGGTCGGCGAACAGCGC
AGCACCAGCTCGCCCGTGCGGCACCTGTTCCGGCCCGAGCTGCTGCGGGGCACGCTGCTGTTCTGGCTGACGTTCTTCAT
GAGCCTGCTGGTGATCTACCTGCTGTCCAGCTGGCTGCCGACGCTGCTGCGCACCGCGGGCCATTCGCTGCGCACGGCCG
CGCTGGTGACAACCATGTTCCAGGTCGGCGGGACGGTGGGGGCGATTGCGCTGGGTTGGCTGATGGACCGGATCAATCCG
CACTATGTGCTGGCGTCCAGCTACTCACTGGCGGCGCTTGGCATCGCGGCGGTGGGCAGCGTTGCTTCCGAGCCGGTGGC
TGCGGGCATGGCGGTGTTCCTTGCGGGCTTCTGCGTCTCAGGGTCGCAGGTGGGTGCGAATGCGCTGTCAGCCAGCTTCT
ATCCGACCGACTGCCGTGCCACAGGCGTGAGCTGGGCCAACGGCGTTGGCCGGATGGGGTCGGTGGTGGGGTCGGTCGGC
GGGGCGACGATGCTGTCGATGGGGTTGGGGATGCCGGCGTTGTTTGCACTGATCGGCGTGCCGGCACTGGTCGCAGGGTT
GTCGATGTTCTCGTTGGGGATGGTCAGGCGTCAGAGGGCGGTGGAGCGCCTGGCAGTCTGA

Upstream 100 bases:

>100_bases
TCGCAGCTTTTCTTCGCAGTCAATCCGTCGATCTGGCGGCCGCGCATAAGGCAGCCGGACGTGACTCGCCCCTAATCCTG
GCATCAAGGAGGAGACCACC

Downstream 100 bases:

>100_bases
AGGCGGGCGGCCGCGGGAGCCATTGACTGAGGGGGAGGCGCATGGTCGGTCGTCGGGAACACGCTGACCGAGGTCTTCTG
CAACACCGTGTGATGCGCGG

Product: 4-hydroxybenzoate transporter

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MPASQPLNVTAFIDRQPLSAFQVSIVVLCFLIVAVDGFDTAAIGFIAPAIRAEWQLTPAQLAPLFGAGLGGLMVGAFLFG
PLADRFGRKGVLVLSVLFFGAASLASAWSQDLWMLVLLRFLTGLGLGGAMPNAITLTSEFCPEKRRSFLVTTMFCGFTLG
SAFGGLASAGLIDAFGWRSVLVAGGVMPLVLAALLLWLLPESVRYLVLAGKQRERIVATLQKIAPQADLRDATFVVGEQR
STSSPVRHLFRPELLRGTLLFWLTFFMSLLVIYLLSSWLPTLLRTAGHSLRTAALVTTMFQVGGTVGAIALGWLMDRINP
HYVLASSYSLAALGIAAVGSVASEPVAAGMAVFLAGFCVSGSQVGANALSASFYPTDCRATGVSWANGVGRMGSVVGSVG
GATMLSMGLGMPALFALIGVPALVAGLSMFSLGMVRRQRAVERLAV

Sequences:

>Translated_446_residues
MPASQPLNVTAFIDRQPLSAFQVSIVVLCFLIVAVDGFDTAAIGFIAPAIRAEWQLTPAQLAPLFGAGLGGLMVGAFLFG
PLADRFGRKGVLVLSVLFFGAASLASAWSQDLWMLVLLRFLTGLGLGGAMPNAITLTSEFCPEKRRSFLVTTMFCGFTLG
SAFGGLASAGLIDAFGWRSVLVAGGVMPLVLAALLLWLLPESVRYLVLAGKQRERIVATLQKIAPQADLRDATFVVGEQR
STSSPVRHLFRPELLRGTLLFWLTFFMSLLVIYLLSSWLPTLLRTAGHSLRTAALVTTMFQVGGTVGAIALGWLMDRINP
HYVLASSYSLAALGIAAVGSVASEPVAAGMAVFLAGFCVSGSQVGANALSASFYPTDCRATGVSWANGVGRMGSVVGSVG
GATMLSMGLGMPALFALIGVPALVAGLSMFSLGMVRRQRAVERLAV
>Mature_445_residues
PASQPLNVTAFIDRQPLSAFQVSIVVLCFLIVAVDGFDTAAIGFIAPAIRAEWQLTPAQLAPLFGAGLGGLMVGAFLFGP
LADRFGRKGVLVLSVLFFGAASLASAWSQDLWMLVLLRFLTGLGLGGAMPNAITLTSEFCPEKRRSFLVTTMFCGFTLGS
AFGGLASAGLIDAFGWRSVLVAGGVMPLVLAALLLWLLPESVRYLVLAGKQRERIVATLQKIAPQADLRDATFVVGEQRS
TSSPVRHLFRPELLRGTLLFWLTFFMSLLVIYLLSSWLPTLLRTAGHSLRTAALVTTMFQVGGTVGAIALGWLMDRINPH
YVLASSYSLAALGIAAVGSVASEPVAAGMAVFLAGFCVSGSQVGANALSASFYPTDCRATGVSWANGVGRMGSVVGSVGG
ATMLSMGLGMPALFALIGVPALVAGLSMFSLGMVRRQRAVERLAV

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=430, Percent_Identity=27.2093023255814, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI213021148, Length=460, Percent_Identity=26.9565217391304, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI8923870, Length=364, Percent_Identity=27.7472527472527, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI166064021, Length=337, Percent_Identity=26.7062314540059, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI296080734, Length=348, Percent_Identity=26.1494252873563, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI296080721, Length=352, Percent_Identity=26.1363636363636, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI296080719, Length=157, Percent_Identity=31.2101910828025, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI24497499, Length=157, Percent_Identity=31.2101910828025, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI73695465, Length=268, Percent_Identity=25, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI4507005, Length=383, Percent_Identity=26.3707571801567, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI7662270, Length=196, Percent_Identity=26.0204081632653, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI216548223, Length=156, Percent_Identity=29.4871794871795, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081723, Length=417, Percent_Identity=38.6091127098321, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI87082159, Length=389, Percent_Identity=27.2493573264781, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788068, Length=463, Percent_Identity=23.9740820734341, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87082231, Length=438, Percent_Identity=24.8858447488584, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786229, Length=353, Percent_Identity=23.5127478753541, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788074, Length=363, Percent_Identity=23.6914600550964, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082404, Length=283, Percent_Identity=22.6148409893993, Blast_Score=73, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI32564663, Length=451, Percent_Identity=26.3858093126386, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71980582, Length=330, Percent_Identity=25.4545454545455, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980584, Length=330, Percent_Identity=25.4545454545455, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19922874, Length=424, Percent_Identity=25.2358490566038, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24640198, Length=454, Percent_Identity=23.568281938326, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24640196, Length=454, Percent_Identity=23.568281938326, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24640200, Length=454, Percent_Identity=23.568281938326, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922616, Length=397, Percent_Identity=24.6851385390428, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24668456, Length=348, Percent_Identity=28.735632183908, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI161077756, Length=435, Percent_Identity=25.2873563218391, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI62484254, Length=163, Percent_Identity=33.1288343558282, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647488, Length=207, Percent_Identity=31.8840579710145, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46844; Mature: 46713

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS00318 HMG_COA_REDUCTASE_2 ; PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASQPLNVTAFIDRQPLSAFQVSIVVLCFLIVAVDGFDTAAIGFIAPAIRAEWQLTPAQ
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHH
LAPLFGAGLGGLMVGAFLFGPLADRFGRKGVLVLSVLFFGAASLASAWSQDLWMLVLLRF
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGLGLGGAMPNAITLTSEFCPEKRRSFLVTTMFCGFTLGSAFGGLASAGLIDAFGWRSV
HHCCCCCCCCCCCEEECHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAGGVMPLVLAALLLWLLPESVRYLVLAGKQRERIVATLQKIAPQADLRDATFVVGEQR
HHHCCHHHHHHHHHHHHHHHHHHHEEHCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
STSSPVRHLFRPELLRGTLLFWLTFFMSLLVIYLLSSWLPTLLRTAGHSLRTAALVTTMF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QVGGTVGAIALGWLMDRINPHYVLASSYSLAALGIAAVGSVASEPVAAGMAVFLAGFCVS
HHCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
GSQVGANALSASFYPTDCRATGVSWANGVGRMGSVVGSVGGATMLSMGLGMPALFALIGV
CCHHCCHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHH
PALVAGLSMFSLGMVRRQRAVERLAV
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PASQPLNVTAFIDRQPLSAFQVSIVVLCFLIVAVDGFDTAAIGFIAPAIRAEWQLTPAQ
CCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHH
LAPLFGAGLGGLMVGAFLFGPLADRFGRKGVLVLSVLFFGAASLASAWSQDLWMLVLLRF
HHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LTGLGLGGAMPNAITLTSEFCPEKRRSFLVTTMFCGFTLGSAFGGLASAGLIDAFGWRSV
HHCCCCCCCCCCCEEECHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVAGGVMPLVLAALLLWLLPESVRYLVLAGKQRERIVATLQKIAPQADLRDATFVVGEQR
HHHCCHHHHHHHHHHHHHHHHHHHEEHCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCC
STSSPVRHLFRPELLRGTLLFWLTFFMSLLVIYLLSSWLPTLLRTAGHSLRTAALVTTMF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
QVGGTVGAIALGWLMDRINPHYVLASSYSLAALGIAAVGSVASEPVAAGMAVFLAGFCVS
HHCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
GSQVGANALSASFYPTDCRATGVSWANGVGRMGSVVGSVGGATMLSMGLGMPALFALIGV
CCHHCCHHHCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHH
PALVAGLSMFSLGMVRRQRAVERLAV
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]