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The map label for this gene is yxbG [H]

Identifier: 116694664

GI number: 116694664

Start: 803038

End: 803820

Strand: Direct

Name: yxbG [H]

Synonym: H16_B0713

Alternate gene names: 116694664

Gene position: 803038-803820 (Clockwise)

Preceding gene: 116694662

Following gene: 116694665

Centisome position: 27.57

GC content: 69.22

Gene sequence:

>783_bases
ATGGAACTCAATGCATCGGTATCGGCAGTGGTGACGGGGGGCGCTTCGGGCCTGGGCGCGGCGACGGCACGTGCGCTGGC
AGCGCAGGGCGTGCGCGTGGCGCTGTTCGACCTCAACGTGGAGAAGGGCGAAGCGCTGGCGCGTGAACTGGGCGGCGTGT
TCTGCCAGGTCAACGTCACCTCAGAGGCCGAGGTCGAGGCCGGCTTTGCCAGGGCGCGCGCCGCCATCGGCCAGGAACGC
ATCCTGGTCAACTGCGCCGGCACCGGCAACGCCATCAAGACCGCCTCGCGTTCCAAGGAAGCGCCGGACCAGATCAAGCA
TTTCCCGACCGATGCCTTCGAGCGCATCATCCAGATCAACCTGATCGGCACCTTCCGCTGCATCGCGCGCTCGGCCGCGG
GCATGCTGACGCTGGACAGCGCCGGCGGCGAGCGCGGCGTGATCATCAATACCGCGTCGGTGGCGGCGCAGGACGGCCAG
ATGGGCCAGGCCGCGTACTCGGCATCGAAGGCCGGCGTGGTCGGCATGACGCTGCCGATCGCGCGCGACCTGGCGGGCGA
AGGCATCCGCGTCAACACCATCCTGCCGGGCATCTTCAATACCCCGCTGCTGCAGGGCGCGGCAGAGAACGTCAAGGCCG
CGCTGGCGGCTTCGGTGCCGTTCCCCAAGCGCCTGGGGCAGCCGGAAGAGTTCGCCTCGCTGGCCGTCGAGATGTGCCGC
AACGGCTATTTCAACGGCGAGTCGGTGCGCCTCGACGGCGCCATCCGCATGGCGCCGCGCTGA

Upstream 100 bases:

>100_bases
CCACTCCGGTACAGGCGATTCTTGCGCCTGCCGGCTTTATCAGACCGCGGGGCCGCGCTGGATCCGGCCGGGCCAGGAAC
AAGAGACAAGGGAAAGACAT

Downstream 100 bases:

>100_bases
GCGTAGCGCCAGCACATCGTCGTGTCCGGGCCCCGCGCACCGCTGGTCCGGACACTATCAAAATCAGGAGACGCGGATGG
ACTTCAGCTATCTGACGACA

Product: Short-chain alcohol dehydrogenase

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MELNASVSAVVTGGASGLGAATARALAAQGVRVALFDLNVEKGEALARELGGVFCQVNVTSEAEVEAGFARARAAIGQER
ILVNCAGTGNAIKTASRSKEAPDQIKHFPTDAFERIIQINLIGTFRCIARSAAGMLTLDSAGGERGVIINTASVAAQDGQ
MGQAAYSASKAGVVGMTLPIARDLAGEGIRVNTILPGIFNTPLLQGAAENVKAALAASVPFPKRLGQPEEFASLAVEMCR
NGYFNGESVRLDGAIRMAPR

Sequences:

>Translated_260_residues
MELNASVSAVVTGGASGLGAATARALAAQGVRVALFDLNVEKGEALARELGGVFCQVNVTSEAEVEAGFARARAAIGQER
ILVNCAGTGNAIKTASRSKEAPDQIKHFPTDAFERIIQINLIGTFRCIARSAAGMLTLDSAGGERGVIINTASVAAQDGQ
MGQAAYSASKAGVVGMTLPIARDLAGEGIRVNTILPGIFNTPLLQGAAENVKAALAASVPFPKRLGQPEEFASLAVEMCR
NGYFNGESVRLDGAIRMAPR
>Mature_260_residues
MELNASVSAVVTGGASGLGAATARALAAQGVRVALFDLNVEKGEALARELGGVFCQVNVTSEAEVEAGFARARAAIGQER
ILVNCAGTGNAIKTASRSKEAPDQIKHFPTDAFERIIQINLIGTFRCIARSAAGMLTLDSAGGERGVIINTASVAAQDGQ
MGQAAYSASKAGVVGMTLPIARDLAGEGIRVNTILPGIFNTPLLQGAAENVKAALAASVPFPKRLGQPEEFASLAVEMCR
NGYFNGESVRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=52.5490196078431, Blast_Score=230, Evalue=9e-61,
Organism=Homo sapiens, GI83715985, Length=256, Percent_Identity=50, Blast_Score=210, Evalue=8e-55,
Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=32.8125, Blast_Score=114, Evalue=8e-26,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=30.5220883534137, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI31542939, Length=250, Percent_Identity=30.8, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI59889578, Length=235, Percent_Identity=28.936170212766, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI224922801, Length=185, Percent_Identity=32.972972972973, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI19923817, Length=268, Percent_Identity=26.865671641791, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI5031737, Length=260, Percent_Identity=28.0769230769231, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=30.4347826086957, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789057, Length=205, Percent_Identity=32.6829268292683, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788459, Length=258, Percent_Identity=29.4573643410853, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=30.188679245283, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI2367175, Length=259, Percent_Identity=30.1158301158301, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=26.3565891472868, Blast_Score=74, Evalue=7e-15,
Organism=Escherichia coli, GI1787905, Length=237, Percent_Identity=29.957805907173, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=28.8537549407115, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789378, Length=239, Percent_Identity=29.2887029288703, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=50.8, Blast_Score=241, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=31.1284046692607, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17555706, Length=259, Percent_Identity=32.046332046332, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=27.3408239700375, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17563726, Length=271, Percent_Identity=26.9372693726937, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=25.5639097744361, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17561272, Length=257, Percent_Identity=30.7392996108949, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI193203117, Length=220, Percent_Identity=25, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=203, Percent_Identity=29.064039408867, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=52.5490196078431, Blast_Score=246, Evalue=8e-66,
Organism=Drosophila melanogaster, GI24639444, Length=254, Percent_Identity=32.2834645669291, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21355319, Length=252, Percent_Identity=30.952380952381, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=28.6792452830189, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24644339, Length=266, Percent_Identity=28.1954887218045, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26800; Mature: 26800

Theoretical pI: Translated: 7.92; Mature: 7.92

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELNASVSAVVTGGASGLGAATARALAAQGVRVALFDLNVEKGEALARELGGVFCQVNVT
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEC
SEAEVEAGFARARAAIGQERILVNCAGTGNAIKTASRSKEAPDQIKHFPTDAFERIIQIN
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCHHHHCCCHHHHHHEEEEE
LIGTFRCIARSAAGMLTLDSAGGERGVIINTASVAAQDGQMGQAAYSASKAGVVGMTLPI
EHHHHHHHHHHCCCEEEEECCCCCCCEEEEEHHHCCCCCCCCHHHHHCCCCCEEEEEHHH
ARDLAGEGIRVNTILPGIFNTPLLQGAAENVKAALAASVPFPKRLGQPEEFASLAVEMCR
HHHHCCCCEEEEEECCCHHCCHHHHCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHH
NGYFNGESVRLDGAIRMAPR
CCCCCCCEEEECCEEEECCC
>Mature Secondary Structure
MELNASVSAVVTGGASGLGAATARALAAQGVRVALFDLNVEKGEALARELGGVFCQVNVT
CCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCEEEEEEEC
SEAEVEAGFARARAAIGQERILVNCAGTGNAIKTASRSKEAPDQIKHFPTDAFERIIQIN
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHCCCCCCCCCHHHHCCCHHHHHHEEEEE
LIGTFRCIARSAAGMLTLDSAGGERGVIINTASVAAQDGQMGQAAYSASKAGVVGMTLPI
EHHHHHHHHHHCCCEEEEECCCCCCCEEEEEHHHCCCCCCCCHHHHHCCCCCEEEEEHHH
ARDLAGEGIRVNTILPGIFNTPLLQGAAENVKAALAASVPFPKRLGQPEEFASLAVEMCR
HHHHCCCCEEEEEECCCHHCCHHHHCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHH
NGYFNGESVRLDGAIRMAPR
CCCCCCCEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584049; 9384377 [H]