Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 116694650

GI number: 116694650

Start: 785571

End: 786707

Strand: Direct

Name: acdA [H]

Synonym: H16_B0699

Alternate gene names: 116694650

Gene position: 785571-786707 (Clockwise)

Preceding gene: 116694649

Following gene: 116694651

Centisome position: 26.97

GC content: 63.41

Gene sequence:

>1137_bases
ATGACCGAAGACCTGGGGATGTTCCAGGAAACCGTGCGCCGCTTCATCGAGCGCGAACTGGCGCCCAACGAGGCCCGCTG
GGCCGACCAGGGCTATATCGACCGCGAGGTCTGGCGCCGCGCCGGCCAGATCGGGCTGCTGTGCGCCAGCATCCCCGAGG
AATACGGCGGCGGTGGCGGCACCTTTGCCCACGAGGCCGTCATCACCCAGGAAATGTCGCGCGCCGTCTGCACCAGCCTT
GGCAATAATGTGCACAGCGGCATCGTGGCACATTACCTGCTCAACTACGGCACGGAAGCGCAGAAGAAGAAATGGCTGCC
GCAAATGGCCAGCGGCGAAATGGTGGCGGCCATTGCCATGTCGGAACCTGGCGCCGGTTCCGACCTCAAAGCGATACGCA
CCCGCGCGGTGCGCGAACAGACCGAAAACGGAGACTGCTATCGCATAAACGGTGCAAAGACCTTCATCACGAACGGGTAT
CACGCCGACCTGGTCTGCGTGGTGGCCAAGACCGATCCGGAAGCCGGTTCGCGCGGCGTGTCGCTGGTCATGGTGGAGAC
GCGCGACCTGCCGGGTTTCCGTCGTGGCCGCATTCTCGAGAAGATCGGGCAGAAAGGGCAAGACACCGCCGAGCTCTTCT
TCGACGACGTGCTGGTGCCGTGCGACAACCTGCTGGGCACGCAGGAAGGTCAGGGTTTCTACCAGCTTATGCAGCAGCTG
CCGCAAGAGCGCATGATCATTGCGCTCGGGGCCGTGGCGACCATGCAGCGCGCCATCGAGCTGACCACCGAATACGTGCG
CGAGCGCAAGGTGTTTGGCCAGCCGCTGGCCGATCTGCAGAACACGCGCTTCAAGCTGGCGGAGTGCAAGACGGTCGCCA
CCATTGCCGCGACCTTCGTCGACGATTGCATGCTGCGCCTGATGGACGGCAAGCTCGACGCTGCCACGGCCGCCATGGCC
AAGTGGTGGTGCACGCAGCAGAACTGCCAGGTCATCGACGAGTGCCTGCAGTTGCACGGCGGCTACGGCTACATGCTTGA
ATACCCGATCGCGCGTATGTATGCGAATGCACGCGTGAGCAAGATCTTCGGCGGCTCCAACGAGATCATGAAGGAGCTGG
TCGCGCGCACGCTTTGA

Upstream 100 bases:

>100_bases
TACCGGTCGCCTGTTCATTTTCTCGTTTACCCTGATACCAGCACACCATATGGGATCCCACGACCAGCACACGGCGCCCG
CCGTACGCCAGACCCCCTGG

Downstream 100 bases:

>100_bases
CGCGCCTGCTATCAGCAGTGTGCGCGTGCTAGTGCGCGCAAACGCGTAAGAAAATGCGGAAAAACGAAAGCCGACACCAG
TGCCGGCCTTCGTGCGTATG

Product: Acyl-CoA dehydrogenase, long-chain specific

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTEDLGMFQETVRRFIERELAPNEARWADQGYIDREVWRRAGQIGLLCASIPEEYGGGGGTFAHEAVITQEMSRAVCTSL
GNNVHSGIVAHYLLNYGTEAQKKKWLPQMASGEMVAAIAMSEPGAGSDLKAIRTRAVREQTENGDCYRINGAKTFITNGY
HADLVCVVAKTDPEAGSRGVSLVMVETRDLPGFRRGRILEKIGQKGQDTAELFFDDVLVPCDNLLGTQEGQGFYQLMQQL
PQERMIIALGAVATMQRAIELTTEYVRERKVFGQPLADLQNTRFKLAECKTVATIAATFVDDCMLRLMDGKLDAATAAMA
KWWCTQQNCQVIDECLQLHGGYGYMLEYPIARMYANARVSKIFGGSNEIMKELVARTL

Sequences:

>Translated_378_residues
MTEDLGMFQETVRRFIERELAPNEARWADQGYIDREVWRRAGQIGLLCASIPEEYGGGGGTFAHEAVITQEMSRAVCTSL
GNNVHSGIVAHYLLNYGTEAQKKKWLPQMASGEMVAAIAMSEPGAGSDLKAIRTRAVREQTENGDCYRINGAKTFITNGY
HADLVCVVAKTDPEAGSRGVSLVMVETRDLPGFRRGRILEKIGQKGQDTAELFFDDVLVPCDNLLGTQEGQGFYQLMQQL
PQERMIIALGAVATMQRAIELTTEYVRERKVFGQPLADLQNTRFKLAECKTVATIAATFVDDCMLRLMDGKLDAATAAMA
KWWCTQQNCQVIDECLQLHGGYGYMLEYPIARMYANARVSKIFGGSNEIMKELVARTL
>Mature_377_residues
TEDLGMFQETVRRFIERELAPNEARWADQGYIDREVWRRAGQIGLLCASIPEEYGGGGGTFAHEAVITQEMSRAVCTSLG
NNVHSGIVAHYLLNYGTEAQKKKWLPQMASGEMVAAIAMSEPGAGSDLKAIRTRAVREQTENGDCYRINGAKTFITNGYH
ADLVCVVAKTDPEAGSRGVSLVMVETRDLPGFRRGRILEKIGQKGQDTAELFFDDVLVPCDNLLGTQEGQGFYQLMQQLP
QERMIIALGAVATMQRAIELTTEYVRERKVFGQPLADLQNTRFKLAECKTVATIAATFVDDCMLRLMDGKLDAATAAMAK
WWCTQQNCQVIDECLQLHGGYGYMLEYPIARMYANARVSKIFGGSNEIMKELVARTL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=46.524064171123, Blast_Score=352, Evalue=3e-97,
Organism=Homo sapiens, GI226958412, Length=383, Percent_Identity=32.8981723237598, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI226958414, Length=347, Percent_Identity=34.0057636887608, Blast_Score=208, Evalue=8e-54,
Organism=Homo sapiens, GI7656849, Length=381, Percent_Identity=32.5459317585302, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI4557233, Length=380, Percent_Identity=33.1578947368421, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4501859, Length=379, Percent_Identity=29.5514511873351, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=32.8083989501312, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=32.8083989501312, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI21361497, Length=385, Percent_Identity=31.9480519480519, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4557235, Length=390, Percent_Identity=32.8205128205128, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=32.7319587628866, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI4503943, Length=386, Percent_Identity=27.2020725388601, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=28.021978021978, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI48976061, Length=397, Percent_Identity=27.7078085642317, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI211971008, Length=397, Percent_Identity=27.7078085642317, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI38505218, Length=292, Percent_Identity=27.7397260273973, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87081958, Length=388, Percent_Identity=28.6082474226804, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1786223, Length=342, Percent_Identity=28.0701754385965, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=29.9638989169675, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=32.620320855615, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17551932, Length=373, Percent_Identity=33.5120643431635, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17533517, Length=372, Percent_Identity=34.1397849462366, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=32.3529411764706, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17534899, Length=374, Percent_Identity=31.283422459893, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=31.0704960835509, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=382, Percent_Identity=30.6282722513089, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=28.6103542234332, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17506239, Length=381, Percent_Identity=28.8713910761155, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71985184, Length=364, Percent_Identity=31.043956043956, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71990804, Length=286, Percent_Identity=32.1678321678322, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=311, Percent_Identity=32.7974276527331, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=26.6318537859008, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=32.618025751073, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI71982178, Length=280, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17562446, Length=336, Percent_Identity=27.0833333333333, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17531909, Length=238, Percent_Identity=25.2100840336134, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=279, Percent_Identity=27.9569892473118, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI86563383, Length=279, Percent_Identity=27.9569892473118, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=33.6814621409922, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI21356377, Length=381, Percent_Identity=33.5958005249344, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24646207, Length=382, Percent_Identity=33.5078534031414, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=30.8900523560209, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI281363737, Length=355, Percent_Identity=31.830985915493, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24666513, Length=384, Percent_Identity=29.6875, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI19920834, Length=383, Percent_Identity=26.3707571801567, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41937; Mature: 41805

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDLGMFQETVRRFIERELAPNEARWADQGYIDREVWRRAGQIGLLCASIPEEYGGGGG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEHHHCCHHHCCCCC
TFAHEAVITQEMSRAVCTSLGNNVHSGIVAHYLLNYGTEAQKKKWLPQMASGEMVAAIAM
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCHHCCCCEEEEEEE
SEPGAGSDLKAIRTRAVREQTENGDCYRINGAKTFITNGYHADLVCVVAKTDPEAGSRGV
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEECCCCCCCCCE
SLVMVETRDLPGFRRGRILEKIGQKGQDTAELFFDDVLVPCDNLLGTQEGQGFYQLMQQL
EEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHC
PQERMIIALGAVATMQRAIELTTEYVRERKVFGQPLADLQNTRFKLAECKTVATIAATFV
CHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHH
DDCMLRLMDGKLDAATAAMAKWWCTQQNCQVIDECLQLHGGYGYMLEYPIARMYANARVS
HHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KIFGGSNEIMKELVARTL
HHCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TEDLGMFQETVRRFIERELAPNEARWADQGYIDREVWRRAGQIGLLCASIPEEYGGGGG
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEHHHCCHHHCCCCC
TFAHEAVITQEMSRAVCTSLGNNVHSGIVAHYLLNYGTEAQKKKWLPQMASGEMVAAIAM
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHCCCHHCCCCEEEEEEE
SEPGAGSDLKAIRTRAVREQTENGDCYRINGAKTFITNGYHADLVCVVAKTDPEAGSRGV
CCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEEECCCCCCCCCE
SLVMVETRDLPGFRRGRILEKIGQKGQDTAELFFDDVLVPCDNLLGTQEGQGFYQLMQQL
EEEEEEECCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHC
PQERMIIALGAVATMQRAIELTTEYVRERKVFGQPLADLQNTRFKLAECKTVATIAATFV
CHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCHHHHHHHHHHHHHHHHHH
DDCMLRLMDGKLDAATAAMAKWWCTQQNCQVIDECLQLHGGYGYMLEYPIARMYANARVS
HHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
KIFGGSNEIMKELVARTL
HHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]