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The map label for this gene is lvr [H]

Identifier: 116694624

GI number: 116694624

Start: 749377

End: 750132

Strand: Direct

Name: lvr [H]

Synonym: H16_B0673

Alternate gene names: 116694624

Gene position: 749377-750132 (Clockwise)

Preceding gene: 116694623

Following gene: 116694628

Centisome position: 25.73

GC content: 71.03

Gene sequence:

>756_bases
ATGGGCGCGGCCGTGCGCCAGCGCATGCTCGCCGACGGCTGCCGGGTCATCGGCATCGACCTGCGCGATGCCGACATCGT
TGCCGACCTGTCCAGCCCGCAGGGCCGCGCTGCCGCGATCGACGCCGTACTGTCGCGGTCAGGCGGCCGCATCGACCGGC
TGGTCTGCTGCGCCGGCCTGGGCCCGCATGTCGAACCCGCAACGCTGGTGGCATCGGTCAACTACTTCGGCTTGGTAGCA
CTGCTGGATGGCCTGTTCGAGGCGCTGCGCCAGGGCTCGGATCCGTGCGCCGTGGTGGTGTCGTCCAACTCGGCCACGCT
CCAGTCCTGGGAGGGCAGCCCGCTGCGTGATGCCTACCTTGCCGGCGATGAGCCAGGCGTGTGCACGATGGTGGCGGCCG
CCGCGGCGGCGGAAGCCACCCGGGACCAGGCTGGCTATATCGCCTATGCCAGTTCCAAGCATGCGGTGGCGGCGGCCGCG
CGGCAACGTGCGGCCGCGTGGGGACAGGCCGGCGTGCGCCTCAACGTGGTCGCGCCGGGGGCGGTGGAAACGCCGCTGCT
GCAGGCCGGGCTGAAGGATCCGCGCTATGGCGATGCCATTCGCGATTTCCTGCCGCCGCTTGGGCGCCGCGCCCAGCCTG
AAGAGGTGGCCGCGCTGATCGCGTTCCTGTGCGGGCCGCACGCTGCCTACATCCATGGCAACGTGGTGTTCATCGACGGC
GGCCTGGATGCCGCGCAGCGACCGCTGAACTTCTGA

Upstream 100 bases:

>100_bases
TCGAACCGCCGGCGCTGCGGCATGTGTTCGAGGCCTGATGGCAACCTCCACGGAACCTCGCACCATGAAAACCGTCGTCA
TTACCGGAGCCGCGTCCGGT

Downstream 100 bases:

>100_bases
TCTCCTGGCCAATGGGGCATCCGCCGCGAGCCGCGGCGGATGCCCCATTTTTGTTCGATGGCGCTCCGGACTTACGTGAC
CATGACATCGTCCTGCATCC

Product: 3alpha-hydroxysteroid dehydrogenase

Products: NA

Alternate protein names: (6R)-2,2,6-trimethyl-1,4-cyclohexanedione reductase [H]

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MGAAVRQRMLADGCRVIGIDLRDADIVADLSSPQGRAAAIDAVLSRSGGRIDRLVCCAGLGPHVEPATLVASVNYFGLVA
LLDGLFEALRQGSDPCAVVVSSNSATLQSWEGSPLRDAYLAGDEPGVCTMVAAAAAAEATRDQAGYIAYASSKHAVAAAA
RQRAAAWGQAGVRLNVVAPGAVETPLLQAGLKDPRYGDAIRDFLPPLGRRAQPEEVAALIAFLCGPHAAYIHGNVVFIDG
GLDAAQRPLNF

Sequences:

>Translated_251_residues
MGAAVRQRMLADGCRVIGIDLRDADIVADLSSPQGRAAAIDAVLSRSGGRIDRLVCCAGLGPHVEPATLVASVNYFGLVA
LLDGLFEALRQGSDPCAVVVSSNSATLQSWEGSPLRDAYLAGDEPGVCTMVAAAAAAEATRDQAGYIAYASSKHAVAAAA
RQRAAAWGQAGVRLNVVAPGAVETPLLQAGLKDPRYGDAIRDFLPPLGRRAQPEEVAALIAFLCGPHAAYIHGNVVFIDG
GLDAAQRPLNF
>Mature_250_residues
GAAVRQRMLADGCRVIGIDLRDADIVADLSSPQGRAAAIDAVLSRSGGRIDRLVCCAGLGPHVEPATLVASVNYFGLVAL
LDGLFEALRQGSDPCAVVVSSNSATLQSWEGSPLRDAYLAGDEPGVCTMVAAAAAAEATRDQAGYIAYASSKHAVAAAAR
QRAAAWGQAGVRLNVVAPGAVETPLLQAGLKDPRYGDAIRDFLPPLGRRAQPEEVAALIAFLCGPHAAYIHGNVVFIDGG
LDAAQRPLNF

Specific function: Catalyzes the regio- and stereoselective reversible NAD- dependent reduction of (6R)-2,2,6-trimethyl-1,4-cyclohexanedione (levodione) to (4R,6R)-4-hydroxy-2,2,6-trimethylcyclohexanone (actinol) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI66933014, Length=118, Percent_Identity=34.7457627118644, Blast_Score=68, Evalue=6e-12,
Organism=Escherichia coli, GI2367365, Length=258, Percent_Identity=31.3953488372093, Blast_Score=64, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=121, Percent_Identity=32.2314049586777, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24639444, Length=242, Percent_Identity=26.8595041322314, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 25927; Mature: 25796

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAAVRQRMLADGCRVIGIDLRDADIVADLSSPQGRAAAIDAVLSRSGGRIDRLVCCAGL
CCHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCC
GPHVEPATLVASVNYFGLVALLDGLFEALRQGSDPCAVVVSSNSATLQSWEGSPLRDAYL
CCCCCHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCHHEE
AGDEPGVCTMVAAAAAAEATRDQAGYIAYASSKHAVAAAARQRAAAWGQAGVRLNVVAPG
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCC
AVETPLLQAGLKDPRYGDAIRDFLPPLGRRAQPEEVAALIAFLCGPHAAYIHGNVVFIDG
CCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEEC
GLDAAQRPLNF
CCHHHCCCCCC
>Mature Secondary Structure 
GAAVRQRMLADGCRVIGIDLRDADIVADLSSPQGRAAAIDAVLSRSGGRIDRLVCCAGL
CHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCC
GPHVEPATLVASVNYFGLVALLDGLFEALRQGSDPCAVVVSSNSATLQSWEGSPLRDAYL
CCCCCHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCHHEE
AGDEPGVCTMVAAAAAAEATRDQAGYIAYASSKHAVAAAARQRAAAWGQAGVRLNVVAPG
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCC
AVETPLLQAGLKDPRYGDAIRDFLPPLGRRAQPEEVAALIAFLCGPHAAYIHGNVVFIDG
CCCCHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEECCEEEEEC
GLDAAQRPLNF
CCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11388460; 10508066 [H]