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The map label for this gene is fadA [H]

Identifier: 116694619

GI number: 116694619

Start: 742165

End: 743367

Strand: Direct

Name: fadA [H]

Synonym: H16_B0668

Alternate gene names: 116694619

Gene position: 742165-743367 (Clockwise)

Preceding gene: 116694618

Following gene: 116694620

Centisome position: 25.48

GC content: 70.66

Gene sequence:

>1203_bases
ATGAAAGAAGCAGTCATTGTCGCCGTCGCGCGCACACCGATCGGCAAGGCCTTCCGCGGTGCCTTCAACGACACCGAGGC
CCCGGTGCTGGGCGGCCACGTGGTGCGCGCGGTGGTGGAGCGCGCCGGCGTGGATCCGTCCGAGGTGGAAGATGTGCTGA
TCGGCGCGGCCGCGCAGCAGGGCACCCAGGGCTACAACCTGGGCCGCCTGTGCGCTGTGGCGGCCGGCCTGCCGGACAGC
GTGCCCGGCATGACCATGGACCGTATGTGCGGCTCGGGCCTGATGACGATCGCTGCGGGCGCCCGCGCGATCCAGTGCGG
CGAGGCCGACATCATCATCGCCGGCGGCGCGGAATCTATCTCGCTGACGCAGACCAGGCACAAGAACAGCTACCGCGCCC
AGTCCGAAGCGGTGCTGGCGCGGCAGCCGGCAGCCTATATGGCAATGATCGAGACCGCCGAGGTGGTGGCGCGCCGCTAT
GGCATCAGCCGCGCCGAGCAGGACGCCTACGCCTGGCGCAGCCAGCAGCGCACCGCCGAGGCGCAGCGGCGCGGTGCCTT
CGATGACGAGATCGTGCCGCTGGAAACGCGCCGCGCGCTGTTCGACAAGGCCGGCACGCTGACCGGCCACGAGACCGTTC
GGCTTGCGCACGACGAGTGCAACCGGCCCGATACCACGGCCAGCAGCCTGGAGGCGCTGAAGCCGGTCTGGAGCGGCGGC
CAGGCGGTGGCCGCCGGCGAGCACATCACTGCCGGCAATGCCTCGCAGTTGTCGGACGGCGCCGCCGCGGTGCTGATGAT
GAGTGCCGACGAGGCCCGCCGGCGCGGCCTGCGCCCGCTGGGCCGCTACCGCGGCATGGCGGTGGCGGGCTGCGCGCCGG
ACGAGATGGGGATCGGCCCGGTATTCGCCGTACCCAGGCTGCTCGCGCGCCATGGCATGACGGTGGCCGACGTGGGCCTG
TGGGAGCTGAACGAGGCCTTTGCCTGCCAGGTGCTGTACTGCCAGCAGAAGCTGGGCATCCCGGATGCGCGCCTGAATGT
CAACGGCGGCGCGATCTCGATCGGCCATCCGTTCGGCATGTCGGGTGCGCGCATGACCGCGCATGCATTGATTGAAGGCC
GGCGCCGCGGCGTGCAGCAGGCAGTGGTGACCATGTGCATCGGTGGCGGCATGGGTGCCGCCGCGCTGTTCGACGTTCTG
TAA

Upstream 100 bases:

>100_bases
CAGTCGGTGGTGCGCATGACCGTGGAAATCGAAGGCGGAGACAAGCCGGCCTGCGTGGCCGAGACCATCAGCCGCTATTA
CTTCTGAACAGGAATCCAGA

Downstream 100 bases:

>100_bases
TTACAAGCAGCCCCTGCAGGGACGGCCCGCAACGAGGCCGCCTGCCATCACTCCAACCGGAGGAGACATCATGAAACGAC
TGATCGGCGTCGCCATGTCG

Product: Acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MKEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPSEVEDVLIGAAAQQGTQGYNLGRLCAVAAGLPDS
VPGMTMDRMCGSGLMTIAAGARAIQCGEADIIIAGGAESISLTQTRHKNSYRAQSEAVLARQPAAYMAMIETAEVVARRY
GISRAEQDAYAWRSQQRTAEAQRRGAFDDEIVPLETRRALFDKAGTLTGHETVRLAHDECNRPDTTASSLEALKPVWSGG
QAVAAGEHITAGNASQLSDGAAAVLMMSADEARRRGLRPLGRYRGMAVAGCAPDEMGIGPVFAVPRLLARHGMTVADVGL
WELNEAFACQVLYCQQKLGIPDARLNVNGGAISIGHPFGMSGARMTAHALIEGRRRGVQQAVVTMCIGGGMGAAALFDVL

Sequences:

>Translated_400_residues
MKEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPSEVEDVLIGAAAQQGTQGYNLGRLCAVAAGLPDS
VPGMTMDRMCGSGLMTIAAGARAIQCGEADIIIAGGAESISLTQTRHKNSYRAQSEAVLARQPAAYMAMIETAEVVARRY
GISRAEQDAYAWRSQQRTAEAQRRGAFDDEIVPLETRRALFDKAGTLTGHETVRLAHDECNRPDTTASSLEALKPVWSGG
QAVAAGEHITAGNASQLSDGAAAVLMMSADEARRRGLRPLGRYRGMAVAGCAPDEMGIGPVFAVPRLLARHGMTVADVGL
WELNEAFACQVLYCQQKLGIPDARLNVNGGAISIGHPFGMSGARMTAHALIEGRRRGVQQAVVTMCIGGGMGAAALFDVL
>Mature_400_residues
MKEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPSEVEDVLIGAAAQQGTQGYNLGRLCAVAAGLPDS
VPGMTMDRMCGSGLMTIAAGARAIQCGEADIIIAGGAESISLTQTRHKNSYRAQSEAVLARQPAAYMAMIETAEVVARRY
GISRAEQDAYAWRSQQRTAEAQRRGAFDDEIVPLETRRALFDKAGTLTGHETVRLAHDECNRPDTTASSLEALKPVWSGG
QAVAAGEHITAGNASQLSDGAAAVLMMSADEARRRGLRPLGRYRGMAVAGCAPDEMGIGPVFAVPRLLARHGMTVADVGL
WELNEAFACQVLYCQQKLGIPDARLNVNGGAISIGHPFGMSGARMTAHALIEGRRRGVQQAVVTMCIGGGMGAAALFDVL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=40.9547738693467, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI167614485, Length=407, Percent_Identity=36.3636363636364, Blast_Score=246, Evalue=2e-65,
Organism=Homo sapiens, GI148539872, Length=402, Percent_Identity=36.0696517412935, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI4557237, Length=409, Percent_Identity=34.9633251833741, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI194353979, Length=397, Percent_Identity=30.9823677581864, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4504327, Length=446, Percent_Identity=28.9237668161435, Blast_Score=155, Evalue=4e-38,
Organism=Escherichia coli, GI1787663, Length=416, Percent_Identity=41.5865384615385, Blast_Score=262, Evalue=2e-71,
Organism=Escherichia coli, GI48994986, Length=403, Percent_Identity=38.7096774193548, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI87082165, Length=404, Percent_Identity=43.0693069306931, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1788554, Length=412, Percent_Identity=39.5631067961165, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=29.3269230769231, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=407, Percent_Identity=36.3636363636364, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI25147385, Length=401, Percent_Identity=33.9152119700748, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=420, Percent_Identity=34.2857142857143, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=443, Percent_Identity=29.1196388261851, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=30.379746835443, Blast_Score=154, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6322031, Length=403, Percent_Identity=37.468982630273, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6325229, Length=405, Percent_Identity=32.5925925925926, Blast_Score=172, Evalue=8e-44,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=41.9354838709677, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=33.743842364532, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17648125, Length=405, Percent_Identity=34.5679012345679, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI17137578, Length=415, Percent_Identity=28.6746987951807, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41994; Mature: 41994

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPSEVEDVLIGAAAQQ
CCCEEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
GTQGYNLGRLCAVAAGLPDSVPGMTMDRMCGSGLMTIAAGARAIQCGEADIIIAGGAESI
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHCCCCEEECCCCCEEEECCCCCE
SLTQTRHKNSYRAQSEAVLARQPAAYMAMIETAEVVARRYGISRAEQDAYAWRSQQRTAE
EEHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQRRGAFDDEIVPLETRRALFDKAGTLTGHETVRLAHDECNRPDTTASSLEALKPVWSGG
HHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHCCC
QAVAAGEHITAGNASQLSDGAAAVLMMSADEARRRGLRPLGRYRGMAVAGCAPDEMGIGP
CEEECCCEEECCCHHHCCCCCEEEEEECCHHHHHCCCCHHHHHCCEEEECCCCCCCCCCH
VFAVPRLLARHGMTVADVGLWELNEAFACQVLYCQQKLGIPDARLNVNGGAISIGHPFGM
HHHHHHHHHHCCCEEEECCHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCC
SGARMTAHALIEGRRRGVQQAVVTMCIGGGMGAAALFDVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure
MKEAVIVAVARTPIGKAFRGAFNDTEAPVLGGHVVRAVVERAGVDPSEVEDVLIGAAAQQ
CCCEEEEEEECCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHC
GTQGYNLGRLCAVAAGLPDSVPGMTMDRMCGSGLMTIAAGARAIQCGEADIIIAGGAESI
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHCCCCEEECCCCCEEEECCCCCE
SLTQTRHKNSYRAQSEAVLARQPAAYMAMIETAEVVARRYGISRAEQDAYAWRSQQRTAE
EEHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQRRGAFDDEIVPLETRRALFDKAGTLTGHETVRLAHDECNRPDTTASSLEALKPVWSGG
HHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHCCC
QAVAAGEHITAGNASQLSDGAAAVLMMSADEARRRGLRPLGRYRGMAVAGCAPDEMGIGP
CEEECCCEEECCCHHHCCCCCEEEEEECCHHHHHCCCCHHHHHCCEEEECCCCCCCCCCH
VFAVPRLLARHGMTVADVGLWELNEAFACQVLYCQQKLGIPDARLNVNGGAISIGHPFGM
HHHHHHHHHHCCCEEEECCHHHCCHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCC
SGARMTAHALIEGRRRGVQQAVVTMCIGGGMGAAALFDVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]