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The map label for this gene is hmp [H]

Identifier: 116694594

GI number: 116694594

Start: 718050

End: 719117

Strand: Direct

Name: hmp [H]

Synonym: H16_B0643

Alternate gene names: 116694594

Gene position: 718050-719117 (Clockwise)

Preceding gene: 116694593

Following gene: 116694595

Centisome position: 24.65

GC content: 71.54

Gene sequence:

>1068_bases
ATGGCGCCAGTGCAATTCCACCGGCTGCAGATCGCCGAAGTCGTCACGGAAACGGACCAGGCGCATTCGCTGGTATTCGC
GCTGCCGGACGGCCTGCGCGATGCGTTTGCCTACCGTCCCGGGCAGTTCCTGACCCTGCGCGTGCCCGTGGACGGCGTGC
CGCTGCAGCGCTGCTATTCGCTGTCGAGCACGCCTGAGGTGGACAACGCCCTGCGCGTGACGATCAAGCGCGTGCAGAGC
GGGCGCGTGTCCAACTGGATCTGCGACCACCTGGGCGCGGGCGATACGGTCGAGGTAATGCCGCCCGCCGGGGTGTTCAC
CCCGCCCGCGCTGCATGGCGATTTCCTGCTGCTGGCCGGCGGCAGCGGCATCACCCCGGTGCTGTCGATCGCCAAGGCGG
CGCTGCGCCACGGGCGCGGCGCGGTCACGCTGGTCTATGCCAACCGCGACGAGCGCTCCATCATCTTCCGCGAGGCGCTT
GCGGAACTGGCGCGCAACCACCCCGGCCGGCTGCGCGTGATCCACTGGTTGGACAGCGTGCAGGGGCCGCCCACGCAGCG
CCAGATCGAGGAACTGGTGCGGCCGTGGAGCATGGCGCAATGCTTTGTCTGCGGGCCCGGCCCGTTCATGGACGGCGCCC
AGGCCGCGCTTCAGGCCCTGGGGGTGCCGCGCGGGCAACTGCACGTCGAGCGCTTCGTGTCCTTGCCCGATGTGCCGGCG
GCCAAGGCACCGGCAAGCGGGGCCGCCAGCGCGGGGGACACCGCCACGGCATCGCCCGCGCCCGCGATGCGCGGCGCCGC
ACTGACCGTGCAGCTCGACGGCGAGATCCACCACGTCGGCGTGGCGCTGGACGAAACCGTGCTCGACGCGTTGCAGCGCG
CCGGCGTGGCCGCGCCCAATTCCTGCCGCGCCGGGCTGTGCGGCGCCTGCATGTGCCAGGTGACGCAGGGCGACGTGACG
CTCGGCGAGAACCATGTGCTCGACCGCGCCGACCTGGAGGCGGGCTGGACCCTGGCTTGCCAGGCCCGCCCGTCCAGCGC
CGAAATCCACCTGAAGTTCCCGGATTGA

Upstream 100 bases:

>100_bases
GACGAATCGCGCTTTATCAACGGTGCGGAACTGCGTATCGACAACGCGCAGACCATCATGGGCGTGGCCTGACCCCGCCC
TCAAGCAATAGAAGGACATC

Downstream 100 bases:

>100_bases
CATGACCCCATCTGACATCATCGACGCCATTGCGGCACCGGCCGGCCTCGACCTCGACCTCGCCGCCGCCAACGACGACA
TTGCCGCGACCATTCCCGAG

Product: flavodoxin reductase (ferredoxin-NADPH reductase) family protein 1

Products: NA

Alternate protein names: Rieske-type oxygenase; RO [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MAPVQFHRLQIAEVVTETDQAHSLVFALPDGLRDAFAYRPGQFLTLRVPVDGVPLQRCYSLSSTPEVDNALRVTIKRVQS
GRVSNWICDHLGAGDTVEVMPPAGVFTPPALHGDFLLLAGGSGITPVLSIAKAALRHGRGAVTLVYANRDERSIIFREAL
AELARNHPGRLRVIHWLDSVQGPPTQRQIEELVRPWSMAQCFVCGPGPFMDGAQAALQALGVPRGQLHVERFVSLPDVPA
AKAPASGAASAGDTATASPAPAMRGAALTVQLDGEIHHVGVALDETVLDALQRAGVAAPNSCRAGLCGACMCQVTQGDVT
LGENHVLDRADLEAGWTLACQARPSSAEIHLKFPD

Sequences:

>Translated_355_residues
MAPVQFHRLQIAEVVTETDQAHSLVFALPDGLRDAFAYRPGQFLTLRVPVDGVPLQRCYSLSSTPEVDNALRVTIKRVQS
GRVSNWICDHLGAGDTVEVMPPAGVFTPPALHGDFLLLAGGSGITPVLSIAKAALRHGRGAVTLVYANRDERSIIFREAL
AELARNHPGRLRVIHWLDSVQGPPTQRQIEELVRPWSMAQCFVCGPGPFMDGAQAALQALGVPRGQLHVERFVSLPDVPA
AKAPASGAASAGDTATASPAPAMRGAALTVQLDGEIHHVGVALDETVLDALQRAGVAAPNSCRAGLCGACMCQVTQGDVT
LGENHVLDRADLEAGWTLACQARPSSAEIHLKFPD
>Mature_354_residues
APVQFHRLQIAEVVTETDQAHSLVFALPDGLRDAFAYRPGQFLTLRVPVDGVPLQRCYSLSSTPEVDNALRVTIKRVQSG
RVSNWICDHLGAGDTVEVMPPAGVFTPPALHGDFLLLAGGSGITPVLSIAKAALRHGRGAVTLVYANRDERSIIFREALA
ELARNHPGRLRVIHWLDSVQGPPTQRQIEELVRPWSMAQCFVCGPGPFMDGAQAALQALGVPRGQLHVERFVSLPDVPAA
KAPASGAASAGDTATASPAPAMRGAALTVQLDGEIHHVGVALDETVLDALQRAGVAAPNSCRAGLCGACMCQVTQGDVTL
GENHVLDRADLEAGWTLACQARPSSAEIHLKFPD

Specific function: Catalyzes the opening of ring B of 1,4-androstadiene- 3,17,-dione (ADD) and 4-androstene-3,17-dione (ADD) with concomitant aromatization of ring A. The ring B is subsequently hydroxylated to yield a catechol and then subject to meta- cleavage [H]

COG id: COG1018

COG function: function code C; Flavodoxin reductases (ferredoxin-NADPH reductases) family 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI49574502, Length=258, Percent_Identity=27.1317829457364, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787658, Length=364, Percent_Identity=35.1648351648352, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI1787098, Length=342, Percent_Identity=28.9473684210526, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788903, Length=210, Percent_Identity=30, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788104, Length=348, Percent_Identity=22.4137931034483, Blast_Score=69, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323510, Length=192, Percent_Identity=30.2083333333333, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322146, Length=235, Percent_Identity=24.2553191489362, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24655635, Length=214, Percent_Identity=28.9719626168224, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR017927
- InterPro:   IPR001041
- InterPro:   IPR001709
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR001221
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00970 FAD_binding_6; PF00111 Fer2; PF00175 NAD_binding_1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 37645; Mature: 37514

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2 ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPVQFHRLQIAEVVTETDQAHSLVFALPDGLRDAFAYRPGQFLTLRVPVDGVPLQRCYS
CCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHC
LSSTPEVDNALRVTIKRVQSGRVSNWICDHLGAGDTVEVMPPAGVFTPPALHGDFLLLAG
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEC
GSGITPVLSIAKAALRHGRGAVTLVYANRDERSIIFREALAELARNHPGRLRVIHWLDSV
CCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHCC
QGPPTQRQIEELVRPWSMAQCFVCGPGPFMDGAQAALQALGVPRGQLHVERFVSLPDVPA
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AKAPASGAASAGDTATASPAPAMRGAALTVQLDGEIHHVGVALDETVLDALQRAGVAAPN
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHCCCCCCC
SCRAGLCGACMCQVTQGDVTLGENHVLDRADLEAGWTLACQARPSSAEIHLKFPD
CCCCCCCCHHEEEEECCCEEECCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCC
>Mature Secondary Structure 
APVQFHRLQIAEVVTETDQAHSLVFALPDGLRDAFAYRPGQFLTLRVPVDGVPLQRCYS
CCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCEEEEEECCCCCCHHHHHC
LSSTPEVDNALRVTIKRVQSGRVSNWICDHLGAGDTVEVMPPAGVFTPPALHGDFLLLAG
CCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEC
GSGITPVLSIAKAALRHGRGAVTLVYANRDERSIIFREALAELARNHPGRLRVIHWLDSV
CCCCHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHCC
QGPPTQRQIEELVRPWSMAQCFVCGPGPFMDGAQAALQALGVPRGQLHVERFVSLPDVPA
CCCCCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCC
AKAPASGAASAGDTATASPAPAMRGAALTVQLDGEIHHVGVALDETVLDALQRAGVAAPN
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEHHHHHHHHHHHCCCCCCC
SCRAGLCGACMCQVTQGDVTLGENHVLDRADLEAGWTLACQARPSSAEIHLKFPD
CCCCCCCCHHEEEEECCCEEECCCCCCCCCCCCCCCEEEEECCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD [C]

Metal ions: Iron-Sulfur [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]