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The map label for this gene is hsaA [H]

Identifier: 116694589

GI number: 116694589

Start: 712053

End: 713246

Strand: Direct

Name: hsaA [H]

Synonym: H16_B0638

Alternate gene names: 116694589

Gene position: 712053-713246 (Clockwise)

Preceding gene: 116694588

Following gene: 116694590

Centisome position: 24.45

GC content: 67.67

Gene sequence:

>1194_bases
GTGCATCACGACAACAATCCCAAGGAACTGGCGGCACGGCTGATCGCGCGTGCCGAGCAGATGATTCCGGTGCTGGCCGA
GCGCGCCGCGCAGGCCGAGGCCGAAGCGCGCATTCCCGCCGAGACCATTGCCGACATGCAGGCCGCGGGCTTCTTCAAGG
TGCTGCAGCCCCGCCGCCACGGCGGCTACGAACTCGATCCGCAGACCTTCTTCCGCATCCAGATGGCGCTGGCCAAGGGC
TGCATGTCCACCGCCTGGGTCTATGGCGTGGTCGGCGTGCACAACTGGCAGCTGGCACTGTTCGACGAGCGCGCGCAGCA
GGAAGTGTGGGGCAGCAACCCTGCCACGCTGATCGCCTCGACCTATATGCCGGTGGGCAAGGTCACGCCGGTCGAAGACG
GCTATCGCTTCTCCGGCCACTGGAAGTTCTCCAGCGGCAGCGAACTGTGCGACTGGATCTTCCTGGGCGGGCTGGTGCCG
CCGGCCGAGCCGGGCGGCGCCTATGACTACCGCACCTTCCTGCTGCCGCGCTCCGACTACAAGATCGTGCGCAACTGGGA
TGTGCTGGGCCTGCGCGCGACCGGCAGCCACGATATCGTGGTCGAGGACGTGTTCGTGCCCGAGTACCGCACCCACCGCG
CCGTCGATGGCGCCATGGGCACCAGCCCGGGGCTGGCGGTCAATGACGTTCCGCTGTACCGGCTGCCGTTCGCGCAGATC
TTCGTGCGCGCGGTGTGCACCGCCTGCATCGGCGCGCTGGAAGGCACGCTCGATGACTTTGTCGCCTATGCCGACGGCCG
CGTCAGCAGCAACGGTGGCGGAAAGACCGCGGAAGACGGCGGCGCGCAGATGGCTTGCGCCAACGCGCAGGTCGCCATCG
ACGAGATGCGGACCATCCTTGAGCGCAATTTCGACGAGCTGCTGGCCGTTGCGCGTGAAGGCGGCCAGGTGCAGACCCCG
CGCCGCCTGCATTTCCGCTACCAGTCCGCGCAAGTGGCCGAGCGCTGCGCGCAGCTGGCCAACGGCCTGCTGCGCTATGC
CGGCGGCAACGGCATCTACCGCAGCAACCCGATGGTGCGCCGCTTCCTCGACCTGCATGCGGCCCGCGCCCACTACGCCA
ACAACCTGGACCGCTTCGGCCAGAACCTGGGCGGCGTGATGATGGGCCGCGCCAACACTGACTTCTTCATTTGA

Upstream 100 bases:

>100_bases
ACCAAATCGCGACATAGCTAGTCCCAACAGACGATGGCACCCGGCCCCACCGGTGCAAACATCAAGGCCAGCTACAAGAC
CAAGCAACAAGGAGACCGCG

Downstream 100 bases:

>100_bases
GCCGCGCGCCGCACGGAGATCCAATATGAGCCAGAGCAGAGCGCGCATGCAGCCCAGCGAGTTCGACGTGGTGGTGGTCG
GCTCGGGCGCCGGCGGCATG

Product: Acyl-CoA dehydrogenase, short-chain specific

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MHHDNNPKELAARLIARAEQMIPVLAERAAQAEAEARIPAETIADMQAAGFFKVLQPRRHGGYELDPQTFFRIQMALAKG
CMSTAWVYGVVGVHNWQLALFDERAQQEVWGSNPATLIASTYMPVGKVTPVEDGYRFSGHWKFSSGSELCDWIFLGGLVP
PAEPGGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVEDVFVPEYRTHRAVDGAMGTSPGLAVNDVPLYRLPFAQI
FVRAVCTACIGALEGTLDDFVAYADGRVSSNGGGKTAEDGGAQMACANAQVAIDEMRTILERNFDELLAVAREGGQVQTP
RRLHFRYQSAQVAERCAQLANGLLRYAGGNGIYRSNPMVRRFLDLHAARAHYANNLDRFGQNLGGVMMGRANTDFFI

Sequences:

>Translated_397_residues
MHHDNNPKELAARLIARAEQMIPVLAERAAQAEAEARIPAETIADMQAAGFFKVLQPRRHGGYELDPQTFFRIQMALAKG
CMSTAWVYGVVGVHNWQLALFDERAQQEVWGSNPATLIASTYMPVGKVTPVEDGYRFSGHWKFSSGSELCDWIFLGGLVP
PAEPGGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVEDVFVPEYRTHRAVDGAMGTSPGLAVNDVPLYRLPFAQI
FVRAVCTACIGALEGTLDDFVAYADGRVSSNGGGKTAEDGGAQMACANAQVAIDEMRTILERNFDELLAVAREGGQVQTP
RRLHFRYQSAQVAERCAQLANGLLRYAGGNGIYRSNPMVRRFLDLHAARAHYANNLDRFGQNLGGVMMGRANTDFFI
>Mature_397_residues
MHHDNNPKELAARLIARAEQMIPVLAERAAQAEAEARIPAETIADMQAAGFFKVLQPRRHGGYELDPQTFFRIQMALAKG
CMSTAWVYGVVGVHNWQLALFDERAQQEVWGSNPATLIASTYMPVGKVTPVEDGYRFSGHWKFSSGSELCDWIFLGGLVP
PAEPGGAYDYRTFLLPRSDYKIVRNWDVLGLRATGSHDIVVEDVFVPEYRTHRAVDGAMGTSPGLAVNDVPLYRLPFAQI
FVRAVCTACIGALEGTLDDFVAYADGRVSSNGGGKTAEDGGAQMACANAQVAIDEMRTILERNFDELLAVAREGGQVQTP
RRLHFRYQSAQVAERCAQLANGLLRYAGGNGIYRSNPMVRRFLDLHAARAHYANNLDRFGQNLGGVMMGRANTDFFI

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 43722; Mature: 43722

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHHDNNPKELAARLIARAEQMIPVLAERAAQAEAEARIPAETIADMQAAGFFKVLQPRRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHC
GGYELDPQTFFRIQMALAKGCMSTAWVYGVVGVHNWQLALFDERAQQEVWGSNPATLIAS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECHHHHHHHCCCCCCEEEEE
TYMPVGKVTPVEDGYRFSGHWKFSSGSELCDWIFLGGLVPPAEPGGAYDYRTFLLPRSDY
CCCCCCCCCCCCCCCEECEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCC
KIVRNWDVLGLRATGSHDIVVEDVFVPEYRTHRAVDGAMGTSPGLAVNDVPLYRLPFAQI
EEEECCEEEEEEECCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCEECCCCCEECCHHHH
FVRAVCTACIGALEGTLDDFVAYADGRVSSNGGGKTAEDGGAQMACANAQVAIDEMRTIL
HHHHHHHHHHHHHHCCHHHHHHHCCCEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
ERNFDELLAVAREGGQVQTPRRLHFRYQSAQVAERCAQLANGLLRYAGGNGIYRSNPMVR
HCCHHHHHHHHHCCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RFLDLHAARAHYANNLDRFGQNLGGVMMGRANTDFFI
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC
>Mature Secondary Structure
MHHDNNPKELAARLIARAEQMIPVLAERAAQAEAEARIPAETIADMQAAGFFKVLQPRRH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHC
GGYELDPQTFFRIQMALAKGCMSTAWVYGVVGVHNWQLALFDERAQQEVWGSNPATLIAS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEEECHHHHHHHCCCCCCEEEEE
TYMPVGKVTPVEDGYRFSGHWKFSSGSELCDWIFLGGLVPPAEPGGAYDYRTFLLPRSDY
CCCCCCCCCCCCCCCEECEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCC
KIVRNWDVLGLRATGSHDIVVEDVFVPEYRTHRAVDGAMGTSPGLAVNDVPLYRLPFAQI
EEEECCEEEEEEECCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCEECCCCCEECCHHHH
FVRAVCTACIGALEGTLDDFVAYADGRVSSNGGGKTAEDGGAQMACANAQVAIDEMRTIL
HHHHHHHHHHHHHHCCHHHHHHHCCCEEECCCCCCCCCCCCCEEEECCCHHHHHHHHHHH
ERNFDELLAVAREGGQVQTPRRLHFRYQSAQVAERCAQLANGLLRYAGGNGIYRSNPMVR
HCCHHHHHHHHHCCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RFLDLHAARAHYANNLDRFGQNLGGVMMGRANTDFFI
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA