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The map label for this gene is ilvX [H]

Identifier: 116694540

GI number: 116694540

Start: 661988

End: 663532

Strand: Direct

Name: ilvX [H]

Synonym: H16_B0589

Alternate gene names: 116694540

Gene position: 661988-663532 (Clockwise)

Preceding gene: 116694539

Following gene: 116694541

Centisome position: 22.73

GC content: 72.17

Gene sequence:

>1545_bases
ATGAACGGCGCCGAGAGCCTGGTCAAGACCCTGCTCGCCAACGGCGTGGACACCTGCTTTGCCAACCCGGGCACCAGCGA
GATGCACTTCGTCGCGGCGCTGGACCGCATCCCGGGCATGCGCTGCGTGCTGGGCCTGTTCGAAGGCGTGGTCACCGGCG
CGGCCGATGGCTATGCGCGCATGGCCGGCAAGCCCGCCGCCACGCTGCTGCATTGCGGCCCGGGGCTGGCCAACGGCCTG
GCCAACCTGCACAACGCGCGCCGCGCGCAGACGCCGGTGGTCAACATCATCGGCGACCAGGCCACCTACCACCGGCCGCT
GGACGCACCGCTGACCGCGGATACCGAAGGCTGGGCCCGTCCGGTCTCGGTGTGGACGCGCACGGCCACGCAGGCTGCGT
CCGTCGGCGCCGATGCCTCGTCCGCGGTGCAGGCCGCATGCGCCGCGCCGGGCGGGGTCGCCAGCCTGATCCTGCCTTCC
GATGTGTGCTGGGATGCGGGCGGCGTGGTGGCCGCGCCGCTGCCGCCGCTGGCGGTGCCCAAGGTCTCGCCCGACGCCGT
GCAGCAGGCCGCGCGCGTGCTGCGCTCGGGCCAGCCCACGCTGGTGGTGCTGGGGGGCAGCGCGCTGCGCGAGGCGCCGC
TGGCCGATGCGCACCGCATTGCCGCGGCCACCGGCGCCCGCCTGATCTCGCCCATGTCCAATGCGCGCGTGTCGCGCGGC
AGCGGCCGCCTGGCGGTGGACCGCGTGCCATATTCGGGCGACGTCGCGCGCGACAAGCTGGCCGGCATCCGCAACGTGAT
CCTGGTCGGCGCACCGGCGCCGGTGACGTTCTTTGCCTACCCGGGCAAGTCGCCGCGCCCGTATCCGGAAGATGCCGTGA
TCCACGTGCTGGCACGCCCGGAGGAAGACCTTGCCGAAGCGCTGGCCCGCCTGGCCGACGAGGTGGGTGCACGCAATGCA
CCGCTGCCGGCTGCCGTAGCGCCCGCATCCGTTGAGCCCGCCCGCGGCGCGGTCACGTCCGAGGCGGTGGCACGTACGCT
GACCGCCTTGCTGCCCGAACAGGCGATCGTGGTGGAAGAGAGCATCAGCTTCGGCCGCGCCTTCTATCCGGGCACGGTCC
ATGCGGCCCCGCACGACTGGCTGCAACTGACCGGCGGCGCCATCGGCGAAGGCCTGCCGCTGGCCGTGGGCGCGGCGGTG
GCGGCGCCGGACCGGCGCGTGGTGGCACTGCAGGCCGATGGCTCGGCCATGTACACGCTGCAGTCGCTGTGGACCATGGC
GCGCGAGCAGCTCGACGTCACCGTGGTGCTGCTGGCCAATCGCAAGTACGCCATCCTGCTGGGCGAGCTCGCGGGCGTAG
GCGCCAACCCGGGCAAGACCGCGCTGGACATGCTGGATATCGGCAATCCCGACCTGGACTGGGTCAAGCTGGCCAACGGC
ATGGGCGTGGAGGGCGCGCAGGCCAGGGACATGGAAAGTTTTGCCGACCTGTTCCGCATGGCCAATGCGCGCAGGGGGCC
GTTTGTGATCGAACTGGTGATCTGA

Upstream 100 bases:

>100_bases
GCGGCGCGGCCGTGCCCGGCCTGACGCCTCCCGTGCAACCAATGCCAACCTGCTGACCCAGAACCTGAGCGGAACCCGAG
ACATGGAAACTACCCAACCG

Downstream 100 bases:

>100_bases
GCGCAGCGCTTTCCGGATTCAAAAATCCAGCCTTCGGCAGATGTGAATTGTTGCAATGCACAGACTGCGGCAAGCTGATT
GCTGTGCCATGGCAGGTCCA

Product: hypothetical protein

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase large subunit; AHAS [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MNGAESLVKTLLANGVDTCFANPGTSEMHFVAALDRIPGMRCVLGLFEGVVTGAADGYARMAGKPAATLLHCGPGLANGL
ANLHNARRAQTPVVNIIGDQATYHRPLDAPLTADTEGWARPVSVWTRTATQAASVGADASSAVQAACAAPGGVASLILPS
DVCWDAGGVVAAPLPPLAVPKVSPDAVQQAARVLRSGQPTLVVLGGSALREAPLADAHRIAAATGARLISPMSNARVSRG
SGRLAVDRVPYSGDVARDKLAGIRNVILVGAPAPVTFFAYPGKSPRPYPEDAVIHVLARPEEDLAEALARLADEVGARNA
PLPAAVAPASVEPARGAVTSEAVARTLTALLPEQAIVVEESISFGRAFYPGTVHAAPHDWLQLTGGAIGEGLPLAVGAAV
AAPDRRVVALQADGSAMYTLQSLWTMAREQLDVTVVLLANRKYAILLGELAGVGANPGKTALDMLDIGNPDLDWVKLANG
MGVEGAQARDMESFADLFRMANARRGPFVIELVI

Sequences:

>Translated_514_residues
MNGAESLVKTLLANGVDTCFANPGTSEMHFVAALDRIPGMRCVLGLFEGVVTGAADGYARMAGKPAATLLHCGPGLANGL
ANLHNARRAQTPVVNIIGDQATYHRPLDAPLTADTEGWARPVSVWTRTATQAASVGADASSAVQAACAAPGGVASLILPS
DVCWDAGGVVAAPLPPLAVPKVSPDAVQQAARVLRSGQPTLVVLGGSALREAPLADAHRIAAATGARLISPMSNARVSRG
SGRLAVDRVPYSGDVARDKLAGIRNVILVGAPAPVTFFAYPGKSPRPYPEDAVIHVLARPEEDLAEALARLADEVGARNA
PLPAAVAPASVEPARGAVTSEAVARTLTALLPEQAIVVEESISFGRAFYPGTVHAAPHDWLQLTGGAIGEGLPLAVGAAV
AAPDRRVVALQADGSAMYTLQSLWTMAREQLDVTVVLLANRKYAILLGELAGVGANPGKTALDMLDIGNPDLDWVKLANG
MGVEGAQARDMESFADLFRMANARRGPFVIELVI
>Mature_514_residues
MNGAESLVKTLLANGVDTCFANPGTSEMHFVAALDRIPGMRCVLGLFEGVVTGAADGYARMAGKPAATLLHCGPGLANGL
ANLHNARRAQTPVVNIIGDQATYHRPLDAPLTADTEGWARPVSVWTRTATQAASVGADASSAVQAACAAPGGVASLILPS
DVCWDAGGVVAAPLPPLAVPKVSPDAVQQAARVLRSGQPTLVVLGGSALREAPLADAHRIAAATGARLISPMSNARVSRG
SGRLAVDRVPYSGDVARDKLAGIRNVILVGAPAPVTFFAYPGKSPRPYPEDAVIHVLARPEEDLAEALARLADEVGARNA
PLPAAVAPASVEPARGAVTSEAVARTLTALLPEQAIVVEESISFGRAFYPGTVHAAPHDWLQLTGGAIGEGLPLAVGAAV
AAPDRRVVALQADGSAMYTLQSLWTMAREQLDVTVVLLANRKYAILLGELAGVGANPGKTALDMLDIGNPDLDWVKLANG
MGVEGAQARDMESFADLFRMANARRGPFVIELVI

Specific function: Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Escherichia coli, GI1790104, Length=560, Percent_Identity=24.4642857142857, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI87081685, Length=200, Percent_Identity=28, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19922626, Length=485, Percent_Identity=25.979381443299, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012001
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 52991; Mature: 52991

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGAESLVKTLLANGVDTCFANPGTSEMHFVAALDRIPGMRCVLGLFEGVVTGAADGYAR
CCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHH
MAGKPAATLLHCGPGLANGLANLHNARRAQTPVVNIIGDQATYHRPLDAPLTADTEGWAR
HCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCH
PVSVWTRTATQAASVGADASSAVQAACAAPGGVASLILPSDVCWDAGGVVAAPLPPLAVP
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCHHCCCCCCEEECCCCCCCCC
KVSPDAVQQAARVLRSGQPTLVVLGGSALREAPLADAHRIAAATGARLISPMSNARVSRG
CCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHCCHHHCCEECC
SGRLAVDRVPYSGDVARDKLAGIRNVILVGAPAPVTFFAYPGKSPRPYPEDAVIHVLARP
CCCEEEECCCCCCCHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCC
EEDLAEALARLADEVGARNAPLPAAVAPASVEPARGAVTSEAVARTLTALLPEQAIVVEE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEH
SISFGRAFYPGTVHAAPHDWLQLTGGAIGEGLPLAVGAAVAAPDRRVVALQADGSAMYTL
HHCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCHHHHH
QSLWTMAREQLDVTVVLLANRKYAILLGELAGVGANPGKTALDMLDIGNPDLDWVKLANG
HHHHHHHHHHCCEEEEEEECCCEEEEEEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHCCC
MGVEGAQARDMESFADLFRMANARRGPFVIELVI
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure
MNGAESLVKTLLANGVDTCFANPGTSEMHFVAALDRIPGMRCVLGLFEGVVTGAADGYAR
CCHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHH
MAGKPAATLLHCGPGLANGLANLHNARRAQTPVVNIIGDQATYHRPLDAPLTADTEGWAR
HCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCH
PVSVWTRTATQAASVGADASSAVQAACAAPGGVASLILPSDVCWDAGGVVAAPLPPLAVP
HHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEECCCHHCCCCCCEEECCCCCCCCC
KVSPDAVQQAARVLRSGQPTLVVLGGSALREAPLADAHRIAAATGARLISPMSNARVSRG
CCCHHHHHHHHHHHHCCCCEEEEECCHHHHCCCCHHHHHHHHHHHHHHHCCHHHCCEECC
SGRLAVDRVPYSGDVARDKLAGIRNVILVGAPAPVTFFAYPGKSPRPYPEDAVIHVLARP
CCCEEEECCCCCCCHHHHHHHCCCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEECCC
EEDLAEALARLADEVGARNAPLPAAVAPASVEPARGAVTSEAVARTLTALLPEQAIVVEE
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEH
SISFGRAFYPGTVHAAPHDWLQLTGGAIGEGLPLAVGAAVAAPDRRVVALQADGSAMYTL
HHCCCCEECCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHCCCCCCEEEEEEECCCHHHHH
QSLWTMAREQLDVTVVLLANRKYAILLGELAGVGANPGKTALDMLDIGNPDLDWVKLANG
HHHHHHHHHHCCEEEEEEECCCEEEEEEHHHCCCCCCCCHHHHHHCCCCCCHHHHHHCCC
MGVEGAQARDMESFADLFRMANARRGPFVIELVI
CCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]