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The map label for this gene is mhpF

Identifier: 116694502

GI number: 116694502

Start: 620617

End: 621561

Strand: Direct

Name: mhpF

Synonym: H16_B0551

Alternate gene names: 116694502

Gene position: 620617-621561 (Clockwise)

Preceding gene: 116694501

Following gene: 116694503

Centisome position: 21.31

GC content: 67.94

Gene sequence:

>945_bases
ATGGACATGAAAGCAAGCGGCCACCACAAGGTGGCCATCATCGGCTCCGGCAATATCGGCACCGACCTGATGATCAAGGT
AATGCGCCACGGCCGGAGCCTGGAGATGGGCGCCATGGTGGGCATCGATGCCGCGTCGGACGGGCTGGCCCGCGCCGCGC
GCCTGGGCGTGCCGACCACGGCCGAGGGCATCGACGGGCTGGTCGGCATGCCGGGCTTCGGCGATATCCGCATCGCCTTC
GATGCCACCTCGGCCGGTGCTCATGCGCATCACAACCGCGTGCTGCAGCAGCACGGCGTGCGCGTGATCGACCTGACGCC
GGCGTCGATCGGCCCGTACGTGGTGCCCGTGGTCAACCTGGACCAGCACCTGGATGCCCCCAACATCAATATGGTCACCT
GCGGCGGCCAGGCCACCATCCCCATGGTGGCGGCGGTGTCGCGCGTGGCCAGAGTGCACTACGCCGAGATCGTGGCGTCG
ATCTCGAGCAGGTCGGCCGGGCCGGGCACGCGCGCCAATATCGACGAGTTCACCGAGACCACCAGCCAGGCGCTGTGCTC
GGTGGGCGGCGCCGCGCGCGGCAAGGCCATCATCGTGCTCAACCCGGCGGAACCGCCGCTGATGATGCGCGACACGGTCT
TCACGTTGTCGGAGGACGGCGATGAAGCGGAAATTGCGGCGAGCGTCGAAGCGATGGCGCAGGCAGTGCAGGGCTACGTA
CCGGGTTACCGGCTCAAGCAGCGCGTGCAGTTCGAGCGTATCGCCGCGTCGGCGCCATTGAATATCCCCGGACTGGGACC
GATGAGCGGGCTCAAGACCTCGATCTTCCTGGAAGTGGAGGGCGCCGCCCATTACCTGCCGGCCTATGCCGGCAACCTCG
ACATCATGACCAGCGCCGCACTGGCCTGCGCCGAGCGCCTGGCCGAGACCCGGCTGTCCGCATGA

Upstream 100 bases:

>100_bases
GCGCGTGATGATCACCGAGGTGCCGAAGGCGCAGTTCGGCATCGGCGGCAAGACCGCCACGGAACTGGGCCGCTGACGCC
CACGCGATAAGGACAACGAC

Downstream 100 bases:

>100_bases
GCCGCAGGGAGACAAAGATGACCGCACAACCCACCAAGAAGCTCTACATCTCGGACGTGACGCTGCGCGACGGCAGCCAC
GCCATCCGCCACCAGTACAG

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Acetaldehyde dehydrogenase [acetylating] 1

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MDMKASGHHKVAIIGSGNIGTDLMIKVMRHGRSLEMGAMVGIDAASDGLARAARLGVPTTAEGIDGLVGMPGFGDIRIAF
DATSAGAHAHHNRVLQQHGVRVIDLTPASIGPYVVPVVNLDQHLDAPNINMVTCGGQATIPMVAAVSRVARVHYAEIVAS
ISSRSAGPGTRANIDEFTETTSQALCSVGGAARGKAIIVLNPAEPPLMMRDTVFTLSEDGDEAEIAASVEAMAQAVQGYV
PGYRLKQRVQFERIAASAPLNIPGLGPMSGLKTSIFLEVEGAAHYLPAYAGNLDIMTSAALACAERLAETRLSA

Sequences:

>Translated_314_residues
MDMKASGHHKVAIIGSGNIGTDLMIKVMRHGRSLEMGAMVGIDAASDGLARAARLGVPTTAEGIDGLVGMPGFGDIRIAF
DATSAGAHAHHNRVLQQHGVRVIDLTPASIGPYVVPVVNLDQHLDAPNINMVTCGGQATIPMVAAVSRVARVHYAEIVAS
ISSRSAGPGTRANIDEFTETTSQALCSVGGAARGKAIIVLNPAEPPLMMRDTVFTLSEDGDEAEIAASVEAMAQAVQGYV
PGYRLKQRVQFERIAASAPLNIPGLGPMSGLKTSIFLEVEGAAHYLPAYAGNLDIMTSAALACAERLAETRLSA
>Mature_314_residues
MDMKASGHHKVAIIGSGNIGTDLMIKVMRHGRSLEMGAMVGIDAASDGLARAARLGVPTTAEGIDGLVGMPGFGDIRIAF
DATSAGAHAHHNRVLQQHGVRVIDLTPASIGPYVVPVVNLDQHLDAPNINMVTCGGQATIPMVAAVSRVARVHYAEIVAS
ISSRSAGPGTRANIDEFTETTSQALCSVGGAARGKAIIVLNPAEPPLMMRDTVFTLSEDGDEAEIAASVEAMAQAVQGYV
PGYRLKQRVQFERIAASAPLNIPGLGPMSGLKTSIFLEVEGAAHYLPAYAGNLDIMTSAALACAERLAETRLSA

Specific function: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds

COG id: COG4569

COG function: function code Q; Acetaldehyde dehydrogenase (acetylating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetaldehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786547, Length=305, Percent_Identity=71.4754098360656, Blast_Score=449, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDH1_CUPNH (Q0K3S6)

Other databases:

- EMBL:   AM260480
- RefSeq:   YP_728713.1
- ProteinModelPortal:   Q0K3S6
- SMR:   Q0K3S6
- STRING:   Q0K3S6
- GeneID:   4456316
- GenomeReviews:   AM260480_GR
- KEGG:   reh:H16_B0551
- eggNOG:   COG4569
- HOGENOM:   HBG300125
- OMA:   HAMVERM
- ProtClustDB:   PRK08300
- BioCyc:   REUT381666:H16_B0551-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01657
- InterPro:   IPR003361
- InterPro:   IPR015426
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21123
- PIRSF:   PIRSF015689
- SMART:   SM00859
- TIGRFAMs:   TIGR03215

Pfam domain/function: PF09290 AcetDehyd-dimer; PF01118 Semialdhyde_dh

EC number: =1.2.1.10

Molecular weight: Translated: 32642; Mature: 32642

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: BINDING 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMKASGHHKVAIIGSGNIGTDLMIKVMRHGRSLEMGAMVGIDAASDGLARAARLGVPTT
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCCCC
AEGIDGLVGMPGFGDIRIAFDATSAGAHAHHNRVLQQHGVRVIDLTPASIGPYVVPVVNL
HHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECH
DQHLDAPNINMVTCGGQATIPMVAAVSRVARVHYAEIVASISSRSAGPGTRANIDEFTET
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TSQALCSVGGAARGKAIIVLNPAEPPLMMRDTVFTLSEDGDEAEIAASVEAMAQAVQGYV
HHHHHHHCCCCCCCCEEEEECCCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHCC
PGYRLKQRVQFERIAASAPLNIPGLGPMSGLKTSIFLEVEGAAHYLPAYAGNLDIMTSAA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHCCCCHHHHHHH
LACAERLAETRLSA
HHHHHHHHHHHCCC
>Mature Secondary Structure
MDMKASGHHKVAIIGSGNIGTDLMIKVMRHGRSLEMGAMVGIDAASDGLARAARLGVPTT
CCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHCCCCCC
AEGIDGLVGMPGFGDIRIAFDATSAGAHAHHNRVLQQHGVRVIDLTPASIGPYVVPVVNL
HHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECH
DQHLDAPNINMVTCGGQATIPMVAAVSRVARVHYAEIVASISSRSAGPGTRANIDEFTET
HHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TSQALCSVGGAARGKAIIVLNPAEPPLMMRDTVFTLSEDGDEAEIAASVEAMAQAVQGYV
HHHHHHHCCCCCCCCEEEEECCCCCCEEEECEEEEECCCCCHHHHHHHHHHHHHHHHHCC
PGYRLKQRVQFERIAASAPLNIPGLGPMSGLKTSIFLEVEGAAHYLPAYAGNLDIMTSAA
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHCCCCHHHHHHH
LACAERLAETRLSA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA