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The map label for this gene is livM [H]

Identifier: 116694455

GI number: 116694455

Start: 568610

End: 569626

Strand: Direct

Name: livM [H]

Synonym: H16_B0504

Alternate gene names: 116694455

Gene position: 568610-569626 (Clockwise)

Preceding gene: 116694454

Following gene: 116694456

Centisome position: 19.52

GC content: 65.68

Gene sequence:

>1017_bases
ATGAGCGGACAATCTATCGCCGCAATCGGCATGCGGCAGCAGCAGGCGGCGGGGCGCCTGCCAAAGCAGGTGATGTACGG
CGTGGTGCTGGCGTGCCTGCTGGCCGCGCCGCTGGCCGGTGCGTATCCGGTGTTCGTGCTCAAGGTGATGTGCTTTGCGC
TGTTTGCGTGCGCCTTCAACCTGCTGATCGGTTATACCGGGCTGCTGTCGTTCGGCCATGCGGCCTTCTTCGGCGGCGCT
GGCTACGCGGCCGGCCATGCCATGAAGGTCTGGGGCGTGACCCCGGAAATCGGCCTGATCCTGGGCACCGGTGCGGGCGC
GCTGATCGGCTACGTGGTGGGCTCGCTGGCCATCCGCCGGCAGGGCATCTACTTCTCGATGATCACGCTGGCGCTGGCGC
AGATGCTGTTCTTTATCTGCCTGCAGGCGCCGTTCACCGGTGGCGAGGACGGCCTGCAGGGCATCCCGCGCGGCAAGCTG
TTCGGTGTGCTGCCGCTGTCGGACGACCTGACGCTGTACTACGTCGCGCTGGCGATCATCGTGGCCGCCTTTGCGCTGAT
CGTGCGCACGGTGCATTCGCCGTTCGGCCAGATCCTGAAGGCGATCAAGGAGAACGAGCCGCGCGCGGTGTCGCTGGGCT
ATGACGTCGACCGCTTCAAGCTCACGGCCTTCGTGCTGTCGGCGGCGCTGTCGGGGCTGGCCGGCTCGATCAAGGCGCTG
GTGCTGGGCTTCGAGACGCTGACCGACGTGCACTGGTCGATGTCCGGCATGGTGATCCTGATGACCCTGCTGGGGGGGCT
CGGCACACTCACCGGCCCGATCGTCGGCGCGTTTGTTGTGATCGCGCTGGAGAACAAGCTGGGCGAACTGGGCAGCTACC
TTGCGGCGGTGACGGACATCGACTGGTTCAACGGGCTCGGTGAATCGGTGTCGATGGTGACGGGCATCATCTTCATCGTA
TGTGTGCTGACCTTCCGCAAGGGGATTGTGGGGAGTTTGGGGCGCGGACCCGGATGA

Upstream 100 bases:

>100_bases
CCAAGGTGTTGTACCCGGAAGCATCTTCCACCGTTGTCTTCGTCATCATGGTGGTGGTGCTGTTGTTGCGCCCGGCAGGG
CTGTTCGGAAAGGAGAAGTG

Downstream 100 bases:

>100_bases
GGTGAAAGCCGTCCAAGGAGTTTCTCCTCTCTCGCGCTTGCGGGAGAGGGGCCGGGGAGAGGGTATCCCTCACGCAATGC
GGCCTACAAGATGGGGCTGG

Product: ABC-type transporter, permease component

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSGQSIAAIGMRQQQAAGRLPKQVMYGVVLACLLAAPLAGAYPVFVLKVMCFALFACAFNLLIGYTGLLSFGHAAFFGGA
GYAAGHAMKVWGVTPEIGLILGTGAGALIGYVVGSLAIRRQGIYFSMITLALAQMLFFICLQAPFTGGEDGLQGIPRGKL
FGVLPLSDDLTLYYVALAIIVAAFALIVRTVHSPFGQILKAIKENEPRAVSLGYDVDRFKLTAFVLSAALSGLAGSIKAL
VLGFETLTDVHWSMSGMVILMTLLGGLGTLTGPIVGAFVVIALENKLGELGSYLAAVTDIDWFNGLGESVSMVTGIIFIV
CVLTFRKGIVGSLGRGPG

Sequences:

>Translated_338_residues
MSGQSIAAIGMRQQQAAGRLPKQVMYGVVLACLLAAPLAGAYPVFVLKVMCFALFACAFNLLIGYTGLLSFGHAAFFGGA
GYAAGHAMKVWGVTPEIGLILGTGAGALIGYVVGSLAIRRQGIYFSMITLALAQMLFFICLQAPFTGGEDGLQGIPRGKL
FGVLPLSDDLTLYYVALAIIVAAFALIVRTVHSPFGQILKAIKENEPRAVSLGYDVDRFKLTAFVLSAALSGLAGSIKAL
VLGFETLTDVHWSMSGMVILMTLLGGLGTLTGPIVGAFVVIALENKLGELGSYLAAVTDIDWFNGLGESVSMVTGIIFIV
CVLTFRKGIVGSLGRGPG
>Mature_337_residues
SGQSIAAIGMRQQQAAGRLPKQVMYGVVLACLLAAPLAGAYPVFVLKVMCFALFACAFNLLIGYTGLLSFGHAAFFGGAG
YAAGHAMKVWGVTPEIGLILGTGAGALIGYVVGSLAIRRQGIYFSMITLALAQMLFFICLQAPFTGGEDGLQGIPRGKLF
GVLPLSDDLTLYYVALAIIVAAFALIVRTVHSPFGQILKAIKENEPRAVSLGYDVDRFKLTAFVLSAALSGLAGSIKALV
LGFETLTDVHWSMSGMVILMTLLGGLGTLTGPIVGAFVVIALENKLGELGSYLAAVTDIDWFNGLGESVSMVTGIIFIVC
VLTFRKGIVGSLGRGPG

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=272, Percent_Identity=25.7352941176471, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 35268; Mature: 35136

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGQSIAAIGMRQQQAAGRLPKQVMYGVVLACLLAAPLAGAYPVFVLKVMCFALFACAFN
CCCCCCHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLIGYTGLLSFGHAAFFGGAGYAAGHAMKVWGVTPEIGLILGTGAGALIGYVVGSLAIRR
HHHHHHHHHHHHHHHHHCCCCHHCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHH
QGIYFSMITLALAQMLFFICLQAPFTGGEDGLQGIPRGKLFGVLPLSDDLTLYYVALAII
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHH
VAAFALIVRTVHSPFGQILKAIKENEPRAVSLGYDVDRFKLTAFVLSAALSGLAGSIKAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLGFETLTDVHWSMSGMVILMTLLGGLGTLTGPIVGAFVVIALENKLGELGSYLAAVTDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DWFNGLGESVSMVTGIIFIVCVLTFRKGIVGSLGRGPG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SGQSIAAIGMRQQQAAGRLPKQVMYGVVLACLLAAPLAGAYPVFVLKVMCFALFACAFN
CCCCCHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLIGYTGLLSFGHAAFFGGAGYAAGHAMKVWGVTPEIGLILGTGAGALIGYVVGSLAIRR
HHHHHHHHHHHHHHHHHCCCCHHCCCEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHH
QGIYFSMITLALAQMLFFICLQAPFTGGEDGLQGIPRGKLFGVLPLSDDLTLYYVALAII
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEEEECCCCHHHHHHHHHHH
VAAFALIVRTVHSPFGQILKAIKENEPRAVSLGYDVDRFKLTAFVLSAALSGLAGSIKAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
VLGFETLTDVHWSMSGMVILMTLLGGLGTLTGPIVGAFVVIALENKLGELGSYLAAVTDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DWFNGLGESVSMVTGIIFIVCVLTFRKGIVGSLGRGPG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]