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The map label for this gene is acdA [H]

Identifier: 116694337

GI number: 116694337

Start: 435912

End: 437009

Strand: Direct

Name: acdA [H]

Synonym: H16_B0384

Alternate gene names: 116694337

Gene position: 435912-437009 (Clockwise)

Preceding gene: 116694336

Following gene: 116694338

Centisome position: 14.97

GC content: 70.04

Gene sequence:

>1098_bases
ATGAACCTGCAACTGAACGACGTCCAGCAGCAACTGCAGGACAGCCTGGGGCGGCTGCTGGCCCGCGAGTACGACTTCGG
CCGCCGCCAGCAATATGCGGCGTCCGCTGCCGGGCATTCGCCCGAGGCGTGGGCGCAACTGGCCGGTCTGGGCGTAACGG
CCGCGGCCATCGGCGAGGCGCATGACGGCTTCGGCGGCGACGCCGTCGACCACATGATGATCTCCGAGGCACTCGGCAAG
TGCCTGTCGCTGGAGCCGTATCACGGCACCGTGGTCATGGCGGCCACGGCCATCGAACAGCTGGGCTCGCCCACGCAGCA
GTCCAGCCTGTTGCCGCGGATCGCGCGGGGCGAACTCCAGGTGGCGTGGGCACATGGCGAATCGGTGCCCGGGCGCATCG
CCACGCGCGCTGCCCATGGCGTGGATGGCTGGCGGCTCTATGGCACCAAGCCCTGCGTGCTGCATGGCACCGGGGCGGAT
TACTTCCTCGTGACCGCGCAGGCGCCGAATGAGGGCGTCCAGCTGTTCCTGGTCAATGCCAGCACCACGGGCGTGCGCAA
CGCCGGCGGCCGCCTGATCGATGGCACCCCGGCGGCGGACCTGGCGCTGGATGACGCCGAGGGCGAGCGGCTTGGCACGC
TGACGCCCGCGCTGCTGACCCGTCTGCTGGAAACCGGCATCAGTGCCGCCTGCGCCGAGATGGTCGGCGCGATGGATGGC
GCCTGCGCGCTCACCGTCGCGTACCTGAAGACGCGCTCGCAGTTCGGTCGCGTGATCGGAGCGAATCAGGCGCTGCAGCA
CCGCGTCGTCGACATGCTGACCGCGCTGGAGCAGAGCCGCAGCATGTCGGTCTCGCTGGCGCTTGCACTGGCAGGGCGCA
ATGACCTGACCGGCGCCGAGGTGCCGGTCCACGCGGCCAAGGTGCTGGTGACGCAGAACGCGCGCCACGTCGCGCAGGAA
GCCATCCAGCTGCACGGCGGCATCGGCATGACCGAGGAGTACGCCGTGGGGCACTACCTGCGCCGCATCCTCGTGCTCGA
CCAGCTGCACGGCGACATGCAATACCACCTCGGCTACCTCGAGCGGCGCGCCGCCTGA

Upstream 100 bases:

>100_bases
CGCTGACCCGGTCCTACCTGTACTCGCGCGCCGTCTCGATCTTCGGCGGTACCACCGAAGTGCAGAAGAATATCCTTTCC
GCTTCCCTCCTGGATCTGTC

Downstream 100 bases:

>100_bases
TCGGCTGGCAGCGCCACCCCAAAGCAATCCCCATACATCCCAAGGAGACAAACCATGTCTGACATCATGTCCCTGGCCGG
CAAGGTCATCATCGTTACCG

Product: Acyl-CoA dehydrogenase

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MNLQLNDVQQQLQDSLGRLLAREYDFGRRQQYAASAAGHSPEAWAQLAGLGVTAAAIGEAHDGFGGDAVDHMMISEALGK
CLSLEPYHGTVVMAATAIEQLGSPTQQSSLLPRIARGELQVAWAHGESVPGRIATRAAHGVDGWRLYGTKPCVLHGTGAD
YFLVTAQAPNEGVQLFLVNASTTGVRNAGGRLIDGTPAADLALDDAEGERLGTLTPALLTRLLETGISAACAEMVGAMDG
ACALTVAYLKTRSQFGRVIGANQALQHRVVDMLTALEQSRSMSVSLALALAGRNDLTGAEVPVHAAKVLVTQNARHVAQE
AIQLHGGIGMTEEYAVGHYLRRILVLDQLHGDMQYHLGYLERRAA

Sequences:

>Translated_365_residues
MNLQLNDVQQQLQDSLGRLLAREYDFGRRQQYAASAAGHSPEAWAQLAGLGVTAAAIGEAHDGFGGDAVDHMMISEALGK
CLSLEPYHGTVVMAATAIEQLGSPTQQSSLLPRIARGELQVAWAHGESVPGRIATRAAHGVDGWRLYGTKPCVLHGTGAD
YFLVTAQAPNEGVQLFLVNASTTGVRNAGGRLIDGTPAADLALDDAEGERLGTLTPALLTRLLETGISAACAEMVGAMDG
ACALTVAYLKTRSQFGRVIGANQALQHRVVDMLTALEQSRSMSVSLALALAGRNDLTGAEVPVHAAKVLVTQNARHVAQE
AIQLHGGIGMTEEYAVGHYLRRILVLDQLHGDMQYHLGYLERRAA
>Mature_365_residues
MNLQLNDVQQQLQDSLGRLLAREYDFGRRQQYAASAAGHSPEAWAQLAGLGVTAAAIGEAHDGFGGDAVDHMMISEALGK
CLSLEPYHGTVVMAATAIEQLGSPTQQSSLLPRIARGELQVAWAHGESVPGRIATRAAHGVDGWRLYGTKPCVLHGTGAD
YFLVTAQAPNEGVQLFLVNASTTGVRNAGGRLIDGTPAADLALDDAEGERLGTLTPALLTRLLETGISAACAEMVGAMDG
ACALTVAYLKTRSQFGRVIGANQALQHRVVDMLTALEQSRSMSVSLALALAGRNDLTGAEVPVHAAKVLVTQNARHVAQE
AIQLHGGIGMTEEYAVGHYLRRILVLDQLHGDMQYHLGYLERRAA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=371, Percent_Identity=25.3369272237197, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4501859, Length=262, Percent_Identity=27.8625954198473, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=24, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=326, Percent_Identity=27.9141104294479, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=279, Percent_Identity=28.3154121863799, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=313, Percent_Identity=24.6006389776358, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17506239, Length=383, Percent_Identity=23.2375979112272, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI21355753, Length=325, Percent_Identity=27.0769230769231, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=22.9946524064171, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 38670; Mature: 38670

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQLNDVQQQLQDSLGRLLAREYDFGRRQQYAASAAGHSPEAWAQLAGLGVTAAAIGEA
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHCCC
HDGFGGDAVDHMMISEALGKCLSLEPYHGTVVMAATAIEQLGSPTQQSSLLPRIARGELQ
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCHHHHHCCHHHCCCEE
VAWAHGESVPGRIATRAAHGVDGWRLYGTKPCVLHGTGADYFLVTAQAPNEGVQLFLVNA
EEEECCCCCCCHHHHHHHCCCCCEEEECCCCEEEEECCCCEEEEEECCCCCCCEEEEEEC
STTGVRNAGGRLIDGTPAADLALDDAEGERLGTLTPALLTRLLETGISAACAEMVGAMDG
CCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCC
ACALTVAYLKTRSQFGRVIGANQALQHRVVDMLTALEQSRSMSVSLALALAGRNDLTGAE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCC
VPVHAAKVLVTQNARHVAQEAIQLHGGIGMTEEYAVGHYLRRILVLDQLHGDMQYHLGYL
CCHHHHHHEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ERRAA
HHCCC
>Mature Secondary Structure
MNLQLNDVQQQLQDSLGRLLAREYDFGRRQQYAASAAGHSPEAWAQLAGLGVTAAAIGEA
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHCCC
HDGFGGDAVDHMMISEALGKCLSLEPYHGTVVMAATAIEQLGSPTQQSSLLPRIARGELQ
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCHHHHHCCHHHCCCEE
VAWAHGESVPGRIATRAAHGVDGWRLYGTKPCVLHGTGADYFLVTAQAPNEGVQLFLVNA
EEEECCCCCCCHHHHHHHCCCCCEEEECCCCEEEEECCCCEEEEEECCCCCCCEEEEEEC
STTGVRNAGGRLIDGTPAADLALDDAEGERLGTLTPALLTRLLETGISAACAEMVGAMDG
CCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHCCCC
ACALTVAYLKTRSQFGRVIGANQALQHRVVDMLTALEQSRSMSVSLALALAGRNDLTGAE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCC
VPVHAAKVLVTQNARHVAQEAIQLHGGIGMTEEYAVGHYLRRILVLDQLHGDMQYHLGYL
CCHHHHHHEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ERRAA
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]