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The map label for this gene is ilvD1 [H]

Identifier: 116694235

GI number: 116694235

Start: 315251

End: 317110

Strand: Direct

Name: ilvD1 [H]

Synonym: H16_B0280

Alternate gene names: 116694235

Gene position: 315251-317110 (Clockwise)

Preceding gene: 116694232

Following gene: 116694240

Centisome position: 10.82

GC content: 66.56

Gene sequence:

>1860_bases
ATGCCCACATACCGTTCCAAAACCTCCACCGCCGGCCGCAACATGGCGGGGGCGCGCTCGCTGTGGCGCGCCACCGGCAT
GAAAGACGAAGATTTTTCCAAGCCCATCGTCGCGGTGGTCAATTCCTTCACCCAGTTCGTGCCCGGGCACGTGCACCTGA
AGGACCTGGGCCAGCTGGTCGCGCGCGAGATCGAGGCCGCGGGCGGCGTGGCCAAGGAGTTCAACACCATTGCGGTCGAT
GACGGCATCGCCATGGGCCACGACGGCATGCTGTATTCGCTGCCCAGCCGCGACATCATCGCGGACTCGGTGGAGTACAT
GGTCAACGCGCACTGCGCCGACGCCATGGTGTGCATCTCCAACTGCGACAAGATCACCCCGGGCATGCTGATGGCCGCAA
TGCGGCTCAACATCCCGGTGATCTTCGTCTCCGGCGGCCCGATGGAAGCCGGCAAGACGCGCCTGGCCAACCCCGTCACC
AAGGCCATGGAGTTCAAGAAGCTCGACCTCGTGGACGCCATGGTGATCGCCGCCGACAGCGCCTATTCCGACGCCGACGT
GGCCGAGGTGGAGCGCTCCGCCTGCCCCACCTGCGGTTCGTGCTCGGGCATGTTCACCGCCAACTCCATGAACTGCCTGA
CCGAGGCGCTGGGCCTGTCGCTGCCCGGCAACGGCACCGTGGTGGCCACCCACGCCGACCGCGAGCAGCTGTTCAAGCGC
GCGGGCAGCCGCATCGTGGAACTGGCGCGCCAGTACTACGAGCAGGAAGACGAGCGCATCCTGCCGCGCTCGGTAGGCTT
CAAGGCGTTCGAGAACGCCATGACGCTGGACATTGCCATGGGCGGTTCCACCAACACCATCCTGCACCTGCTGGCGATCG
CGCGCGAGGCCGACATCGACTTCAGCATGACCGATATCGACCGCCTCTCGCGCGTGGTGCCGCAGCTGTGCAAGGTGGCG
CCCAACACCAACAAGTACCACATCGAAGACGTGCACCGCGCAGGGGGCATCATGGCCATCCTGGGCGAGCTGGAGCGCGC
CGGCAAGCTGCACACTGATGTGCCCACGGTGCATGCCCCCACGCTCAGGGACGCGCTGGAGCAGTGGGACATCAGCCGGA
CCCGGGACGAAGCCGTCAGGAACTTCTACCTGGCCGGCCCGGCGGGTGTTCCCACCCAGGTGGCGTTCAGCCAGAACACG
CGCTGGCCCAGCCTGGACCTGGACCGCGCCGAGGGCTGCATCCGCTCCTACGAGCACGCCTTCTCCAAGGAAGGCGGCCT
GGCGGTGCTGACGGGCAATATCGCGCTCGACGGCTGCGTGGTGAAGACCGCCGGCGTGGACGAGAGCATCCTCGTGTTCG
AAGGCACGGCCCACGTCACCGAGTCGCAGGACGAGGCGGTGGAGAACATCCTCAACGACAAGGTCAAGGCCGGTGACGTG
GTGATCGTGCGCTACGAAGGCCCCAAGGGCGGCCCCGGCATGCAGGAGATGCTCTACCCGACCAGCTACATCAAGTCCAA
GGGCCTGGGCAAGGCCTGCGCGCTGCTGACCGACGGCCGCTTCTCCGGCGGCACCTCGGGTTTGTCCATCGGCCACTGCT
CGCCCGAAGCTGCGGCCGGCGGCGCCATCGGCCTGGTGCGCGACGGCGACAAGATCCGCATCGACATTCCCAACCGCACC
ATCAACGTGCTGCTGTCCGACGAGGAACTGGCGAGCCGCCGCGAAGAGCAGAACGCCAGGGGGTGGAAGCCGGCCAAGGC
GCGTCCGCGCAAGGTGTCTGCTGCGCTGAAGGCTTATGCCAAGCTGGTGATGTCGGCGGATAAGGGGGCTGTGCGGGACT
TGTCGTTGCTGGATGACTGA

Upstream 100 bases:

>100_bases
TTTGCCCAGGGCGCAGCTCAAGAGGTTGTTCGCACGGGCGCGCAAGGGTCCTTATTCCTGTGGCCCGCTTCCTTTCTGCG
ATATTCCTTCAGCAATAAAA

Downstream 100 bases:

>100_bases
TCCCGGGGCGAAGCTTTGCTTCGTTTGCCGATAAGGCCGCTCTTTGGAGCGGCTTTTTTTTGGTTCTTATAAGAACGCGC
CCCGTGGCTGGCCTTCGATC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1 [H]

Number of amino acids: Translated: 619; Mature: 618

Protein sequence:

>619_residues
MPTYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIVAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVT
KAMEFKKLDLVDAMVIAADSAYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGSRIVELARQYYEQEDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAREADIDFSMTDIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPTLRDALEQWDISRTRDEAVRNFYLAGPAGVPTQVAFSQNT
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVENILNDKVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRT
INVLLSDEELASRREEQNARGWKPAKARPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Sequences:

>Translated_619_residues
MPTYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIVAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVT
KAMEFKKLDLVDAMVIAADSAYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
AGSRIVELARQYYEQEDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAREADIDFSMTDIDRLSRVVPQLCKVA
PNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPTLRDALEQWDISRTRDEAVRNFYLAGPAGVPTQVAFSQNT
RWPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVENILNDKVKAGDV
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRT
INVLLSDEELASRREEQNARGWKPAKARPRKVSAALKAYAKLVMSADKGAVRDLSLLDD
>Mature_618_residues
PTYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIVAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTK
AMEFKKLDLVDAMVIAADSAYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKRA
GSRIVELARQYYEQEDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAREADIDFSMTDIDRLSRVVPQLCKVAP
NTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAPTLRDALEQWDISRTRDEAVRNFYLAGPAGVPTQVAFSQNTR
WPSLDLDRAEGCIRSYEHAFSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVENILNDKVKAGDVV
IVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAGGAIGLVRDGDKIRIDIPNRTI
NVLLSDEELASRREEQNARGWKPAKARPRKVSAALKAYAKLVMSADKGAVRDLSLLDD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=621, Percent_Identity=73.9130434782609, Blast_Score=939, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=543, Percent_Identity=30.2025782688766, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI2367371, Length=525, Percent_Identity=31.8095238095238, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1786464, Length=532, Percent_Identity=31.390977443609, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6322476, Length=614, Percent_Identity=37.1335504885993, Blast_Score=345, Evalue=1e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 66496; Mature: 66364

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIVAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTKAMEFKKLDLVDAMVIAADS
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHEECCC
AYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGSRIVELARQYYEQEDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAREADID
HHHHHHHHHHHHHHCHHHCCCCHHCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
FSMTDIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLRDALEQWDISRTRDEAVRNFYLAGPAGVPTQVAFSQNTRWPSLDLDRAEGCIRSYEHA
HHHHHHHHCCCCCHHHHHHHEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVENILNDKVKAGDV
HCCCCCEEEEECCEEECCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDKIRIDIPNRTINVLLSDEELASRREEQNARGWKPAKARPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC
>Mature Secondary Structure 
PTYRSKTSTAGRNMAGARSLWRATGMKDEDFSKPIVAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVIFVSGGPMEAGKTRLANPVTKAMEFKKLDLVDAMVIAADS
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHEECCC
AYSDADVAEVERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGTVVATHADREQLFKR
CCCCCHHHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHH
AGSRIVELARQYYEQEDERILPRSVGFKAFENAMTLDIAMGGSTNTILHLLAIAREADID
HHHHHHHHHHHHHHCHHHCCCCHHCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
FSMTDIDRLSRVVPQLCKVAPNTNKYHIEDVHRAGGIMAILGELERAGKLHTDVPTVHAP
CCHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
TLRDALEQWDISRTRDEAVRNFYLAGPAGVPTQVAFSQNTRWPSLDLDRAEGCIRSYEHA
HHHHHHHHCCCCCHHHHHHHEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHH
FSKEGGLAVLTGNIALDGCVVKTAGVDESILVFEGTAHVTESQDEAVENILNDKVKAGDV
HCCCCCEEEEECCEEECCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCCE
VIVRYEGPKGGPGMQEMLYPTSYIKSKGLGKACALLTDGRFSGGTSGLSIGHCSPEAAAG
EEEEECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCC
GAIGLVRDGDKIRIDIPNRTINVLLSDEELASRREEQNARGWKPAKARPRKVSAALKAYA
CCEEEEECCCEEEEECCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
KLVMSADKGAVRDLSLLDD
HHHHHCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA